The Chemical Biology of Thrombin

Synopsis

This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin

Copyright:

2021

Book Details

Book Quality:

Publisher Quality

Book Size:

268 Pages

ISBN-13:

9781351677721

Related ISBNs:

9781138055902, 9781032203300, 9781315165646

Publisher:

CRC Press

Date of Addition:

04/11/22

Copyrighted By:

Taylor & Francis Group, LLC. Reasonable efforts have been made to publish reliable data and information, but the author and publisher cannot assume responsibility for the validity of all materials or the consequences of their use. The authors and publisher

Adult content:

No

Language:

English

Has Image Descriptions:

No

Categories:

Nonfiction, Science, Medicine

Submitted By:

Bookshare Staff

Usage Restrictions:

This is a copyrighted book.