Boolean Networks as Predictive Models of Emergent Biological Behaviors (Elements in the Structure and Dynamics of Complex Networks)

By: null Jordan C. Rozum and null Colin Campbell and null Eli Newby and null Fatemeh Sadat Nasrollahi and null Réka Albert

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Synopsis: Interacting biological systems at all organizational levels display emergent behavior. Modeling these systems is made challenging by the number and variety of biological components and interactions – from molecules in gene regulatory networks to species in ecological networks – and the often-incomplete state of system knowledge, such as the unknown values of kinetic parameters for biochemical reactions. Boolean networks have emerged as a powerful tool for modeling these systems. This Element provides a methodological overview of Boolean network models of biological systems. After a brief introduction, the authors describe the process of building, analyzing, and validating a Boolean model. They then present the use of the model to make predictions about the system's response to perturbations and about how to control its behavior. The Element emphasizes the interplay between structural and dynamical properties of Boolean networks and illustrates them in three case studies from disparate levels of biological organization.

Book Quality:: Publisher Quality
ISBN-13:: 9781009292948
Related ISBNs:: 9781009478717, 9781009478717
Publisher:: Cambridge University Press
Date of Addition:: 03/28/24
Copyrighted By:: Jordan C. Rozum, Colin Campbell, Eli Newby, Fatemeh Sadat Fatemi Nasrollahi, and Réka Albert
Adult content:: No
Language:: English
Has Image Descriptions:: No
Categories:: Nonfiction, Earth Sciences, Mathematics and Statistics
Submitted By:: Bookshare Staff
Usage Restrictions:: This is a copyrighted book.