SCN2A-Related Disorders (Elements in Genetics in Epilepsy)

By: null Megan Abbott and null Kevin J. Bender and null Andreas Brunklaus and null Scott Demarest and null Shawn Egan and null Isabel Haviland and null Jennifer A. Kearney and null Leah Schust Myers and null Heather E. Olson and null Stephan J. Sanders and null Christina SanInocencio and null Joseph Symonds and null Christopher H. Thompson

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Synopsis: SCN2A encodes a voltage-gated sodium channel (designated NaV1.2) vital for generating neuronal action potentials. Pathogenic SCN2A variants are associated with a diverse array of neurodevelopmental disorders featuring neonatal or infantile onset epilepsy, developmental delay, autism, intellectual disability and movement disorders. SCN2A is a high confidence risk gene for autism spectrum disorder and a commonly discovered cause of neonatal onset epilepsy. This remarkable clinical heterogeneity is mirrored by extensive allelic heterogeneity and complex genotype-phenotype relationships partially explained by divergent functional consequences of pathogenic variants. Emerging therapeutic strategies targeted to specific patterns of NaV1.2 dysfunction offer hope to improving the lives of individuals affected by SCN2A-related disorders. This Element provides a review of the clinical features, genetic basis, pathophysiology, pharmacology and treatment of these genetic conditions authored by leading experts in the field and accompanied by perspectives shared by affected families. This title is also available as Open Access on Cambridge Core.

Book Quality:: Publisher Quality
ISBN-13:: 9781009530354
Related ISBNs:: 9781009530330, 9781009530330
Publisher:: Cambridge University Press
Date of Addition:: 12/31/24
Copyrighted By:: Alfred L. George, Jr., Megan Abbott, Kevin J. Bender, Andreas Brunklaus, Scott Demarest, Shawn Egan, Isabel Haviland, Jennifer A. Kearney, Leah Schust Myers, Heather E. Olson, Stephan J. Sanders, Christina SanInocencio, Joseph Symonds, and Christopher H. T
Adult content:: No
Language:: English
Has Image Descriptions:: No
Categories:: Nonfiction, Medicine
Submitted By:: Bookshare Staff
Usage Restrictions:: This is a copyrighted book.
Edited by:: null Alfred L. George, Jr.