Metabolism of Drugs and Other Xenobiotics

By: Pavel Anzenbacher and Ulrich M. Zanger

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Synopsis: A practice-oriented desktop reference for medical professionals, toxicologists and pharmaceutical researchers, this handbook providessystematic coverage of the metabolic pathways of all major classes of xenobiotics in the human body. The first part comprehensively reviewsthe main enzyme systems involved in biotransformation and how they are orchestrated in the body, while parts two to four cover the threemain classes of xenobiotics: drugs, natural products, environmental pollutants. The part on drugs includes more than 300 substances fromfive major therapeutic groups (central nervous system, cardiovascular system, cancer, infection, and pain) as well as most drugs of abuseincluding nicotine, alcohol and "designer" drugs. Selected, well-documented case studies from the most important xenobiotics classes illustrate general principles of metabolism, making this equally useful for teaching courses on pharmacology, drug metabolism or moleculartoxicology.Of particular interest, and unique to this volume is the inclusion of a wide range of additional xenobiotic compounds, including food supplements, herbal preparations, and agrochemicals.