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Immunopathology in Toxicology and Drug Development
by George A. ParkerThis book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide organ system-based summaries of spontaneous pathology and common responses to xenobiotics. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 1, Immunobiology, Investigative Techniques, and Special Studies, offers an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Immunopathology in Toxicology and Drug Development
by George A. ParkerThis book provides a fundamental understanding of immunopathology and immunopathologic processes, with particular attention to nonclinical toxicology studies. Chapters provide an overview of general immunobiology, cells of the immune system, signaling and effector molecules, and immunopathology assays. A companion volume, Immunopathology in Toxicology and Drug Development: Volume 2, Organ Systems, offers summaries of organ-specific immunobiology and immunopathology as well as common responses to xenobiotics. These informative and strategic books were created in response to the large segment of drug development that focuses on chronic diseases, many of which involve alterations to the immune system. Therapies that target these diseases commonly involve some form of immunomodulation. As a result, the two volumes of Immunopathology in Toxicology and Drug Development are critical texts for individuals involved in diverse aspects of drug development. Readers will acquire a thorough understanding of immunopathology for detection and accurate interpretation of pathologic effects of xenobiotics on the immune system.
Immunopatient: The New Frontier of Curing Cancer
by Peter RooneyWhen an X-ray of a sore arm quickly leads to a diagnosis of Stage IV kidney cancer—one which would soon affect his bones, his lungs, lymph nodes, and brain—Peter Rooney’s life will never be the same. Faced with the prognosis of an incurable disease and armed only with the will to fight back, Immunopatient chronicles Peter’s desperate quest for hope and healing, and the experimental treatment that will give him a chance to strike back at his disease. Detailing both the medical breakthroughs that provided Peter with cutting-edge treatment and his inspirational quest to conquer both his fear and his illness through mindfulness and positive visualization, Immunopatient is a gripping memoir, one that offers new hope to cancer patients everywhere to never give up looking for answers. Peter’s story, both humble and human, showcases the heights of medical science and the depths of human endurance, proving that anything is possible as long as you keep moving forward.
Immunotherapy
by Aung Naing Joud HajjarIn the last decade, immunotherapy has revolutionized the practice of medicine in the field of oncology. This book, Immunotherapy, highlights the immunotherapeutic approaches currently in use and strategies to overcome the associated challenges. As comprehensive knowledge of basic immunology in the context of tumor biology is required to move further along the line of development in translational science, this book provides an overview of the cellular components of the immune system that interact with each other to provide a successful immune response. Immunotherapy offers promising antitumor activity across multiple cancer types as it does not attack the tumor but primarily revitalizes a suppressed immune system. It is beyond the scope of this book to discuss the immunotherapeutic approaches across the tumor board. However, the book features the role of immune-oncology in acute myeloid leukemia, non-small cell lung cancer, and sarcomas to showcase the recent advances in the management of cancer broadly classified as hematological malignancies, solid tumors, and tumors arising in the connective tissue. The book also discusses alternative formulations and combinatorial approaches to enhance the therapeutic index of these agents. As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. In this book, we discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies, and clinical implications. The book also outlines how recent advances in medical imaging technology have the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Importantly, the book attempts to increase the awareness to immune related adverse events and the need for aggressive and judicious management of toxicities to improve treatment outcomes in patients on immunotherapy In short, this book provides a broad understanding of immunotherapy and ways to leverage the immune system to make inroads in the fight against cancer.
Immunotherapy (Advances in Experimental Medicine and Biology #995)
by Aung Naing and Joud HajjarIn the last decade, immunotherapy has revolutionized the practice of medicine in the field of oncology. This book, Immunotherapy, highlights the immunotherapeutic approaches currently in use and strategies to overcome the associated challenges. As comprehensive knowledge of basic immunology in the context of tumor biology is required to move further along the line of development in translational science, this book provides an overview of the cellular components of the immune system that interact with each other to provide a successful immune response.Immunotherapy offers promising antitumor activity across multiple cancer types as it does not attack the tumor but primarily revitalizes a suppressed immune system. It is beyond the scope of this book to discuss the immunotherapeutic approaches across the tumor board. However, the book features the role of immune-oncology in acute myeloid leukemia, non-small cell lung cancer, and sarcomas to showcase the recent advances in the management of cancer broadly classified as hematological malignancies, solid tumors, and tumors arising in the connective tissue. The book also discusses alternative formulations and combinatorial approaches to enhance the therapeutic index of these agents.As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. In this book, we discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies, and clinical implications. The book also outlines how recent advances in medical imaging technology have the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Importantly, the book attempts to increase the awareness to immune related adverse events and the need for aggressive and judicious management of toxicities to improve treatment outcomes in patients on immunotherapy In short, this book provides a broad understanding of immunotherapy and ways to leverage the immune system to make inroads in the fight against cancer.
Immunotherapy of Hepatocellular Carcinoma
by Tim F. GretenIn this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer.Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Immunotherapy of Melanoma
by Anand Rotte Madhuri BhandaruMetastatic melanoma are introduced to the readers, giving details of the diagnosis, clinical symptoms, types and AJCC staging, followed by a discussion of problems in the treatment of melanoma and how immunotherapy provided the solution. Next an account of the immune system is given, describing its role in cancer prevention and discussing how immune check points are circumvented in cancer. Approved drugs are discussed together with their molecular mechanisms of action, response rates, survival benefits, pharmacokinetics and adverse effects. Finally this book discusses the most promising candidates from ongoing clinical trials and highlights challenges faced by immunotherapeutic drugs as well as strategies to overcome them. Metastatic melanoma is a deadly type of skin cancer, known for its resistance to conventional treatments. For decades, patients were managed with a handful of drugs that had minimal survival benefits. The scenario changed with the approval of inhibitors of BrafV600E and MEK, and monoclonal antibodies against CTLA4. While the kinase inhibitors were promising in the initial studies, they suffered with the development of lethal resistance. Anti-CTLA4 monoclonal antibodies (Ipilimumab) on the other hand provided long term survival benefits in responding patients and there were no reports of resistance. However, response rate for Ipilimumab was very low. Recently, monoclonal antibodies against PD-1 receptors (Nivolumab, Pembrolizumab) were approved by FDA for the treatment of melanoma, extending the hope for melanoma patients. This book provides detailed information on immunotherapeutic drugs for melanoma management - it describes melanoma, discusses issues in melanoma treatment and highlights the successes of immunotherapy in the treatment.
Imperfect Pregnancies: A History of Birth Defects and Prenatal Diagnosis
by Ilana Löwy<p>In the 1960s, thanks to the development of prenatal diagnosis, medicine found a new object of study: the living fetus. At first, prenatal testing was proposed only to women at a high risk of giving birth to an impaired child. But in the following decades, such testing has become routine. <p>In Imperfect Pregnancies, Ilana Löwy argues that the generalization of prenatal diagnosis has radically changed the experience of pregnancy for tens of millions of women worldwide. Although most women are reassured that their future child is developing well, others face a stressful period of waiting for results, uncertain prognosis, and difficult decisions. Löwy follows the rise of biomedical technologies that made prenatal diagnosis possible and investigates the institutional, sociocultural, economic, legal, and political consequences of their widespread diffusion. <p>Because prenatal diagnosis is linked to the contentious issue of selective termination of pregnancy for a fetal anomaly, debates on this topic have largely centered on the rejection of human imperfection and the notion that we are now perched on a slippery slope that will lead to new eugenics. Imperfect Pregnancies tells a more complicated story, emphasizing that there is no single standardized way to scrutinize the fetus, but there are a great number of historically conditioned and situated approaches. This book will interest students, scholars, health professionals, administrators, and activists interested in issues surrounding new medical technologies, screening, risk management, pregnancy, disability, and the history and social politics of women’s bodies.</p>
Imperfect Pregnancies: A History of Birth Defects and Prenatal Diagnosis
by Ilana LöwyHow has prenatal testing, once offered only for high-risk pregnancies, become standard medical care for pregnant women today?In the 1960s, thanks to the development of prenatal diagnosis, medicine found a new object of study: the living fetus. At first, prenatal testing was proposed only to women at a high risk of giving birth to an impaired child. But in the following decades, such testing has become routine. In Imperfect Pregnancies, Ilana Löwy argues that the generalization of prenatal diagnosis has radically changed the experience of pregnancy for tens of millions of women worldwide. Although most women are reassured that their future child is developing well, others face a stressful period of waiting for results, uncertain prognosis, and difficult decisions. Löwy follows the rise of biomedical technologies that made prenatal diagnosis possible and investigates the institutional, sociocultural, economic, legal, and political consequences of their widespread diffusion. Because prenatal diagnosis is linked to the contentious issue of selective termination of pregnancy for a fetal anomaly, debates on this topic have largely centered on the rejection of human imperfection and the notion that we are now perched on a slippery slope that will lead to new eugenics. Imperfect Pregnancies tells a more complicated story, emphasizing that there is no single standardized way to scrutinize the fetus, but there are a great number of historically conditioned and situated approaches. This book will interest students, scholars, health professionals, administrators, and activists interested in issues surrounding new medical technologies, screening, risk management, pregnancy, disability, and the history and social politics of women’s bodies.
Implant Aesthetics: Keys to Diagnosis and Treatment
by Edward Dwayne KarateewThis book, written by acknowledged experts with international reputations, provides clinicians with detailed guidelines on the nature of the ideal anterior dental implant and, more importantly, how the desired aesthetic outcome is to be achieved. It reflects the incredible paradigm shift that has taken place within implant dentistry during the past 5 years, with recognition of the importance of a 'crown down' approach to diagnosis, planning, and treatment, especially in the anterior zone. In order to ensure reproducibility and predictability of treatment outcomes, the fabrication of an aesthetic dental implant must follow a complex algorithm, which is reviewed in a stepwise approach. Sections are devoted to evaluation of the aesthetic implant patient, immediate implant placement, staged implant placement, and restoration. Readers will come to appreciate how the final emergence profile of the definitive restoration reflects the complex interplay of components below the visible smile zone. Helpful flow charts are included that will assist in optimal performance of the described procedures.
Implant Dentistry at a Glance (At a Glance (Dentistry) #60)
by Jacques Malet Francis Mora Philippe BouchardThe second edition of Implant Dentistry at a Glance, in the highly popular at a Glance series, provides an accessible, thoroughly revised and updated comprehensive introduction that covers all the essential sub-topics that comprise implant dentistry. Features an easy-to-use double-page spread, with text and corresponding images Expanded and updated throughout, with 13 new chapters and coverage of many advances Includes access to a companion website with self-assessment questions and illustrative case studies
Implementatie: Effectieve verbetering van de patiëntenzorg
by Richard Grol Michel WensingDit boek helpt zorgverleners, leidinggevenden, staffunctionarissen, beleidsmakers en onderzoekers om pati#65533;ntenzorg op een effectieve manier te verbeteren. Het geeft een praktische, stapsgewijze aanpak voor de implementatie van innovatie in de gezondheidszorg, die rekening houdt met de weerbarstigheid van de praktijk. In Implementatie ligt de nadruk op het verbeteren van het handelen van artsen, verpleegkundigen, paramedici, andere zorgverleners, en de teams waarin zij werken. De pati#65533;nt staat hierbij centraal. Deze geactualiseerde uitgave geeft een toegankelijk overzicht van het wetenschappelijk onderzoek op het gebied van implementatie. Het beantwoordt bijvoorbeeld de vraag hoe het komt dat veel waardevolle inzichten, hulpmiddelen, programma's en best practices de weg naar de praktijk niet vinden. En andersom hoe het kan dat er soms werkwijzen gebruikt worden waarvan is aangetoond dat ze geen meerwaarde hebben voor pati#65533;nten of burgers. Implementatie beschrijft vele concrete voorbeelden van verandertrajecten in Nederland en daarbuiten. Bij het boek horen digitale verrijkingen, zoals samenvattingen van de hoofdstukken en toetsen met multiplechoicevragen en stellingen.
Implementation of Lung Cancer Screening: Proceedings of a Workshop
by Engineering Medicine National Academies of SciencesThe public health burden from lung cancer is substantial: it is the second most commonly diagnosed cancer and the leading cause of cancer-related deaths in the United States. Given the individual and population health burden of lung cancer, especially when it is diagnosed at later stages, there has been a push to develop and implement screening strategies for early detection. However, many factors need to be considered for broad implementation of lung cancer screening in clinical practice. Effective implementation will entail understanding the balance of potential benefits and harms of lung cancer screening, defining and reaching eligible populations, addressing health disparities, and many more considerations. In recognition of the substantial challenges to developing effective lung cancer screening programs in clinical practice, the National Academies of Sciences, Engineering, and Medicine held a workshop in June 2016. At the workshop, experts described the current evidence base for lung cancer screening, the current challenges of implementation, and opportunities to overcome them. Workshop participants also explored capacity and access issues; best practices for screening programs; assessment of patient outcomes, quality, and value in lung cancer screening; and research needs that could improve implementation efforts. This publication summarizes the presentations and discussions from the workshop.
Improving Healthcare: A Handbook for Practitioners
by Lesley Baillie Elaine MaxwellGood intentions to do our best in healthcare are not enough. Healthcare professionals need to know how to close the gap between best evidence and practice, by understanding and applying quality improvement principles and processes. Improving Healthcare is a practical guide, providing healthcare staff with the knowledge and skills that enable them to implement, evaluate and disseminate a quality improvement project in their own workplace. With a comprehensive coverage, chapters cover the history, selection and application of quality improvement philosophies and methods in clinical healthcare at team, unit, organisational and system levels. The book also considers social processes of implementation as well as technical aspects of measuring and improving quality. As an essential guide for healthcare practitioners at any level who are new to service improvement, Improving Healthcare includes practical examples and case studies of healthcare improvements that illustrate the concepts discussed.
Improving Healthcare Operations
by Sharon J WilliamsThis book examines the design of two care pathways to establish how key principles associated with systems thinking, quality improvement, and supply chain management can improve the design of these services. 'Lean' has typically been the prominent approach when improving the design of healthcare systems and is often selected by healthcare professionals to standardize and improve the delivery of care. Previous literature shows there has been varying success in the application of 'Lean', the author presents a study which examines the benefits of introducing 'Agile' as an alternative and complementary approach. Improving Healthcare Operations explores when 'Lean' and 'Agile' are most applicable, and instances where a hybrid approach can be employed. Including empirical qualitative data collected from two care pathways, it intends to provide organizations with an alternative in order to produce the level and quality of care that is expected by patients.
Improving Population Health Using Electronic Health Records: Methods for Data Management and Epidemiological Analysis
by Neal D. GoldsteinElectronic health records (EHRs) have become commonplace in the medical profession. Health data are readily captured and permanently stored in a digital fashion, and consequently, are increasingly being utilized in health research. The quality of this research depends upon the investigator’s ability to obtain the correct data to answer the correct question. It is easy to churn out poor quality research from the EHR; it is much harder to produce meaningful results that influence the population’s health. Improving Population Health Using Electronic Health Records takes the reader through the process of conducting meaningful research from data in the EHR. It de-mystifies the entire research process, from how to ask the right kind of research questions, to obtaining data with particular emphasis on data management and manipulation, to performing a valid statistical analyses, and interpreting and presenting the results in a clear, concise fashion that has the potential to improve population health. This book can be used as a hands-on how-to guide of performing research from EHR data in either a piece-meal fashion, selecting only the topics of greatest interest, or a complete guide to the entire research process. Readers will benefit from the intuitive presentation of complex methods with a multitude of examples. It is invaluable reading for researchers and clinicians who are not otherwise familiar with the complexities of working with large data sets.
Improving Psychiatric Care for Older People
by Claire HiltonThis book is open access under a CC BY 4. 0 license. This book tells the story of Barbara Robb and her pressure group, Aid for the Elderly in Government Institutions (AEGIS). In 1965, Barbara visited 73-year-old Amy Gibbs in a dilapidated and overcrowded National Health Service psychiatric hospital back-ward. She was so appalled by the low standards that she set out to make improvements. Barbara's book Sans Everything: A case to answer was publicly discredited by a complacent and self-righteous Ministry of Health. However, inspired by her work, staff in other hospitals 'whistle-blew' about events they witnessed, which corroborated her allegations. Barbara influenced government policy, to improve psychiatric care and health service complaints procedures, and to establish a hospitals' inspectorate and ombudsman. The book will appeal to campaigners, health and social care staff and others working with older people, and those with an interest in policy development in England, the 1960s, women's history and the history of psychiatry and nursing.
In Pursuit of Memory: The Fight Against Alzheimer's
by Joseph JebelliFor readers of Atul Gawande, Siddhartha Mukherjee, and Henry Marsh, a riveting, gorgeously written biography of one of history's most fascinating and confounding diseases--Alzheimer's--from its discovery more than 100 years ago to today's race towards a cure.SHORTLISTED FOR THE ROYAL SOCIETY SCIENCE BOOK PRIZE 2017Named "Science Book of the Month" by BooksellerAlzheimer's is the great global epidemic of our time, affecting millions worldwide -- there are more than 5 million people diagnosed in the US alone. And as our population ages, scientists are working against the clock to find a cure.Neuroscientist Joseph Jebelli is among them. His beloved grandfather had Alzheimer's and now he's written the book he needed then -- a very human history of this frightening disease. But In Pursuit of Memory is also a thrilling scientific detective story that takes you behind the headlines. Jebelli's quest takes us from nineteenth-century Germany and post-war England, to the jungles of Papua New Guinea and the technological proving grounds of Japan; through America, India, China, Iceland, Sweden, and Colombia. Its heroes are scientists from around the world -- many of whom he's worked with -- and the brave patients and families who have changed the way that researchers think about the disease.This compelling insider's account shows vividly why Jebelli feels so hopeful about a cure, but also why our best defense in the meantime is to understand the disease. In Pursuit of Memory is a clever, moving, eye-opening guide to the threat one in three of us faces now.
In Pursuit of Memory: The Fight Against Alzheimer's: Shortlisted for the Royal Society Prize
by Dr Joseph JebelliWhen Joseph Jebelli was twelve, his beloved grandfather began to act very strangely. It started with inexplicable walks, and gradually his bright smiles were replaced by a fearful, withdrawn expression. Before long, he didn't recognise his family any more. Dr Jebelli has dedicated his career to understanding Alzheimer's disease, which affects millions worldwide and 850,000 people in the UK alone. In this, his first book, Jebelli explores the past, present and future of Alzheimer's disease starting from the very beginning - the first recorded case more than one hundred years ago - right up to the cutting-edge research being done today. It is a story as good as any detective novel, taking us to nineteenth-century Germany and post-war England; to the jungles of Papua New Guinea and the technological proving grounds of Japan; to America, India, China, Iceland, Sweden, and Colombia; and to the cloud-capped spires of the most elite academic institutions. Its heroes are expert scientists from around the world - but also the incredibly brave patients and families who have changed the way scientists think about Alzheimer's, unveiling a pandemic that took us centuries to track down, and above all, reminding everyone never to take memory - our most prized possession - for granted. Based upon years of meticulous research, In Pursuit of Memory is a compelling insider's account of this terrible disease and the scientists who are trying to find a cure against the clock.
In Pursuit of Memory: The Fight Against Alzheimer's: Shortlisted for the Royal Society Prize
by Dr Joseph JebelliWhen Joseph Jebelli was twelve, his beloved grandfather began to act very strangely. It started with inexplicable walks, and gradually his bright smiles were replaced by a fearful, withdrawn expression. Before long, he didn't recognise his family any more. Dr Jebelli has dedicated his career to understanding Alzheimer's disease, which affects millions worldwide and 850,000 people in the UK alone. In this, his first book, Jebelli explores the past, present and future of Alzheimer's disease starting from the very beginning - the first recorded case more than one hundred years ago - right up to the cutting-edge research being done today. It is a story as good as any detective novel, taking us to nineteenth-century Germany and post-war England; to the jungles of Papua New Guinea and the technological proving grounds of Japan; to America, India, China, Iceland, Sweden, and Colombia; and to the cloud-capped spires of the most elite academic institutions. Its heroes are expert scientists from around the world - but also the incredibly brave patients and families who have changed the way scientists think about Alzheimer's, unveiling a pandemic that took us centuries to track down, and above all, reminding everyone never to take memory - our most prized possession - for granted. Based upon years of meticulous research, In Pursuit of Memory is a compelling insider's account of this terrible disease and the scientists who are trying to find a cure against the clock.(P)2017 John Murray Press
In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope
by Rana AwdishA riveting first-hand account of a physician who's suddenly a dying patient and her revelation of the horribly misguided standard of care in the medical worldDr. Rana Awdish never imagined that an emergency trip to the hospital would result in hemorrhaging nearly all of her blood volume and losing her unborn first child. But after her first visit, Dr. Awdish spent months fighting for her life, enduring consecutive major surgeries and experiencing multiple overlapping organ failures. At each step of the recovery process, Awdish was faced with something even more unexpected: repeated cavalier behavior from her fellow physicians—indifference following human loss, disregard for anguish and suffering, and an exacting emotional distance. Hauntingly perceptive and beautifully written, In Shock allows the reader to transform alongside Awidsh and watch what she discovers in our carefully-cultivated, yet often misguided, standard of care. Awdish comes to understand the fatal flaws in her profession and in her own past actions as a physician while achieving, through unflinching presence, a crystalline vision of a new and better possibility for us all. As Dr. Awdish finds herself up against the same self-protective partitions she was trained to construct as a medical student and physician, she artfully illuminates the dysfunction of disconnection. Shatteringly personal, and yet wholly universal, she offers a brave road map for anyone navigating illness while presenting physicians with a new paradigm and rationale for embracing the emotional bond between doctor and patient.
In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
by Raghu Chandrashekhar H Dhanya Sunil Pooja R KamathThis comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials. <P><P>In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates in a wide category of anticancer assays demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules. The major emphasis of the book is to present those bioassays which can be readily set up and practiced in any laboratory with limited funds, facilities or technical know-how.
In Vivo Neuropharmacology and Neurophysiology
by Athineos PhilippuThis volume presents classical approaches to in vivo neuropharmacology and neurophysiology, such as c-fos, electrochemistry, microdialysis microstimulation, and push-up superfusion. It also explores exciting new methods for behavioral analysis, and techniques based on optogenetics and non-invasive magnetic resonance imaging. The chapters of this book cover topics such as principles of stereotaxy, pharmaco-based fMRI and neurophysiology in humans and non-human primates, electrical nerve stimulation and central microstimulation, involvement of neurotransmitters in mnemonic processes, the impact of cannabinoids on motor activity, as well as the involvement of nitric oxide in neurotoxicity produced by psychostimulant drugs. Each chapter also discusses difficulties, tips, tricks, and precautions to take. Neuromethods series style chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.Cutting-edge and practical, In Vivo Neuropharmacology and Neurophysiology is a valuable resource for experienced and less experienced investigators of brain function and brain disorders.
In Vivo Reprogramming in Regenerative Medicine
by Açelya YilmazerThis new volume reviews current progress on different approaches of in vivo reprogramming technology. Leaders in the field discuss how in vivo cell lineage reprogramming can be used for tissue repair and regeneration in different organs, including brain, spinal cord, pancreas, liver and heart. Recent studies on in vivo cell reprogramming towards pluripotency are reviewed; examples are given to show its potential in regenerative medicine. In each chapter, the regenerative potential of different in vivo reprogramming approaches is discussed in detail. More specifically, how different tissue failures or damages can be treated with this technology is explained. Examples from various animal models are given and the regenerative potential of in vivo reprogramming is compared to that of cell transplantation studies. The last chapter discusses current challenges of these preclinical studies and gives suggestions in order to improve the current strategies. Future directions are indicated for the transition of in vivo reprogramming technology to clinical settings. This is among the first books in the literature which specifically focuses on the in vivo reprogramming technology in regenerative medicine and these chapters collectively cover one of the most important and exciting topics of regenerative medicine.
Incarnate: A Novel
by Josh StolbergAn ambitious and sharp-witted clinical psychiatrist turns detective when one of her patients comes under investigation for a series of brutal murders—is she a psychopath or a victim herself?Brilliant psychiatric resident Dr. Kim Patterson has one major flaw: she is too committed to her patients. Her willingness to break the rules and use unconventional methods to help her patients heal has already gotten her thrown out of several hospitals. And when Scarlett Hascall is brought into the psychiatric ward, Kim can’t resist getting involved, even if it means breaking protocol—because Kim can see what the other doctors cannot. Scarlett is suffering from a rare condition: Dissociative Identity Disorder, otherwise known as Multiple Personalities. But even Kim is at a loss when she realizes that some of Scarlett’s alternate identities are claiming to be people who have gone missing from their town. And when Scarlett’s alter identity “Izzi” knows way too much about the whereabouts of the missing Isabel Wilcox, the police begin to suspect that Scarlett may have been involved with Isabel’s disappearance. Only Kim defends Scarlett, certain of the girl’s innocence. But her new theory is a radical one, one she can hardly believe herself: What if Kim is channeling the troubled souls of these victims? With the help of local police officer Zack Trainor, Kim digs further into Isabel’s case, trying to find proof that Scarlett wasn’t involved. The more they discover, the more it becomes apparent that something strange and frightening is going on with Scarlett. Is it possible she is truly harboring lost souls? Or is Scarlett playing a twisted game with her doctors and the police?