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Antibacterial Drug Discovery to Combat MDR: Natural Compounds, Nanotechnology and Novel Synthetic Sources
by Iqbal Ahmad Shamim Ahmad Kendra P. RumbaughThis book compiles the latest information in the field of antibacterial discovery, especially with regard to the looming threat of multi-drug resistance. The respective chapters highlight the discovery of new antibacterial and anti-infective compounds derived from microbes, plants, and other natural sources. The potential applications of nanotechnology to the fields of antibacterial discovery and drug delivery are also discussed, and one section of the book is dedicated to the use of computational tools and metagenomics in antibiotic drug discovery. Techniques for efficient drug delivery are also covered. The book provides a comprehensive overview of the progress made in both antibacterial discovery and delivery, making it a valuable resource for academic researchers, as well as those working in the pharmaceutical industry.
Preterm Labor and Delivery (Comprehensive Gynecology and Obstetrics)
by Hiroshi SameshimaThis splendid volume presents numerous aspects of preterm labor and delivery, from its fundamental mechanism to clinically focused approaches. The incidence of preterm delivery is 6-7% in Japan, while globally up to 10% of pregnancies with preterm labor result in premature delivery. The rates of overall survival and intact survival of the premature infants are also excellent in Japan. Thus Japan’s approach to preterm labor and delivery has long attracted attention. In each chapter, experts describe specific issues unique to conditions in Japan, including diagnosis, tocolytic agents, definition of clinical chorioamnionitis, treatment of bacterial vaginosis, role of amniocentesis, management of preterm premature membrane rupture and also placental pathology, presenting definitive evidence of the reduced incidence of preterm delivery in Japan. This book benefits not only obstetricians, pediatricians and gynecologist, but also midwives, nurse practitioners, and medical and associated staffs in the field of obstetrics, pediatrics, as well as neonatal and perinatal medicine who are involved in delivery.
Antibiotic Resistant Bacteria: A Challenge to Modern Medicine
by Rajesh Kumar Amar Jyoti Das Sadhana Sagar Shilpa KaisthaThis book summarizes the emerging trends in the field of antibiotic resistance of various gram-negative and gram-positive bacterial species. The ability of different species of bacteria to resist the antimicrobial agent has become a global problem. As such, the book provides a comprehensive overview of the advances in our understanding of the origin and mechanism of resistance, discusses the modern concept of the biochemical and genetic basis of antibacterial resistance and highlights the clinical and economic implications of the increased prevalence of antimicrobial resistant pathogens and their ecotoxic effects. It also reviews various strategies to curtail the emergence and examines a number of innovative therapeutic approaches, such as CRISPR, phage therapy, nanoparticles and natural antimicrobials, to combat the spread of resistance.
Bronchial Branch Tracing
by Noriaki Kurimoto Katsuhiko MoritaThis book summarizes the branch tracing method for bronchoscopic diagnosis. Cytopathological and histopathological diagnoses are essential to making prognoses and selecting appropriate treatment for peripheral pulmonary lesions, notably lung cancer. In order to collect cell and tissue samples from peripheral pulmonary lesions for cytopathological and histopathological diagnoses, exfoliative cytodiagnosis and biopsy under bronchoscopy with endobronchial ultrasonography (EBUS) are currently used worldwide. Bronchial Branch Tracing highlights how to identify the bronchial branches that lead to peripheral pulmonary lesions and offers a valuable guide for all respiratory physicians, as well as surgeons, who frequently perform bronchoscopies, helping them understand the method and improve their technique.
Neuroglia in Neurodegenerative Diseases (Advances in Experimental Medicine and Biology #1175)
by Alexei Verkhratsky Margaret S. Ho Robert Zorec Vladimir ParpuraThis book provides a comprehensive overview of the role of neuroglia in neurodegenerative diseases. Neuroglia are the most abundant cells in the nervous system and consist of several distinct cell types, such as astrocytes, oligodendrocytes,and microglia. Accumulating evidence suggests that neuroglia participate in the neurodegenerative process, and as such are essential players in a variety of diseases, including Alzheimer’s, Parkinson’s, and Huntington’s. Intended for researchers and students, the book presents recent advances concerning the biology of neuroglia as well as their interaction with neurons during disease progression. In addition, to highlight the function of neuroglia in different types of neurodegenerative disease, it also discusses their mechanisms and effects on protecting or damaging neurons.
Bone Tumor Imaging: Case Studies in Hip and Knee
by Xiaoguang Cheng Yongbin Su Mingqian HuangThis book covers typical imaging features of benign and malignant bone tumors in the hip and knee. Illustrative cases have been carefully selected from thousands processed at the Orthopedic Department of Beijing Jishuitan Hospital, which holds a leading position in orthopedics in China. The chapters are organized by major bone tumour diseases: osteosarcoma, osteochondroma, Ewing sarcoma, bone metastases, etc. Comprehensive imaging information, including X-ray, CT and MRI, is presented in each chapter, and is accompanied by a brief clinical history, imaging findings, differential diagnoses, in-depth analysis and key insights from respected bone tumor specialists. Given its scope, the book offers a valuable guide for musculoskeletal radiologists, orthopedic surgeons, general radiologists, and oncologists alike.
Biomaterials in Orthopaedics and Bone Regeneration: Design and Synthesis (Materials Horizons: From Nature to Nanomaterials)
by Preetkanwal Singh Bains Sarabjeet Singh Sidhu Marjan Bahraminasab Chander PrakashThis book focuses on the recent advances in the field of orthopaedic biomaterials, with a particular emphasis on their design and fabrication. Biomimetic materials, having similar properties and functions to that of the natural tissue, are becoming a popular choice for making customized orthopaedic implants and bone scaffolds. The acceptability of these materials in the human body depends on the right balance between their mechanical and biological properties. This book provides a comprehensive overview of the state-of-the-art research in this rapidly evolving field. The chapters cover different aspects of multi-functional biomaterials design, and cutting-edge methods for the synthesis and processing of these materials. Advanced manufacturing techniques, like additive manufacturing, used for developing new biomimetic materials are highlighted in the book. This book is a valuable reference for students and researchers interested in biomaterials for orthopaedic applications.
Paediatric Kawasaki Disease: Clinical Analysis and Cases
by Hong WangThis book introduces the clinical analysis and accompany cases of paediatric Kawasaki disease. It has 14 chapters about typical Kawasaki disease, atypical Kawasaki disease, recurrent, misdiagnosis, and complications involved different systems, such as cardiovascular, digestive, nervous, blood, respiratory, urinary, bone and joints, and endocrine systems complications. In this book, 53 Kawasaki cases are presented with clinical history, physical examination, laboratory findings, diagnosis, treatment and discussion. This book is helpful for clinicians, ultrasonologist, and radiologist to support early diagnosis and proper treatment, which can significantly improve the prognosis of Kawasaki disease.
Pairwise Multiple Comparisons: Theory and Computation (SpringerBriefs in Statistics)
by Taka-aki Shiraishi Shin-ichi Matsuda Hiroshi SugiuraThis book focuses on all-pairwise multiple comparisons of means in multi-sample models, introducing closed testing procedures based on maximum absolute values of some two-sample t-test statistics and on F-test statistics in homoscedastic multi-sample models. It shows that (1) the multi-step procedures are more powerful than single-step procedures and the Ryan/Einot–Gabriel/Welsh tests, and (2) the confidence regions induced by the multi-step procedures are equivalent to simultaneous confidence intervals. Next, it describes the multi-step test procedure in heteroscedastic multi-sample models, which is superior to the single-step Games–Howell procedure. In the context of simple ordered restrictions of means, the authors also discuss closed testing procedures based on maximum values of two-sample one-sided t-test statistics and based on Bartholomew's statistics. Furthermore, the book presents distribution-free procedures and describes simulation studies performed under the null hypothesis and some alternative hypotheses. Although single-step multiple comparison procedures are generally used, the closed testing procedures described are more powerful than the single-step procedures. In order to execute the multiple comparison procedures, the upper 100α percentiles of the complicated distributions are required. Classical integral formulas such as Simpson's rule and the Gaussian rule have been used for the calculation of the integral transform that appears in statistical calculations. However, these formulas are not effective for the complicated distribution. As such, the authors introduce the sinc method, which is optimal in terms of accuracy and computational cost.
Practical Radiation Oncology
by Supriya Mallick Goura K. Rath Rony BensonThis book addresses the most relevant aspects of radiation oncology in terms of technical integrity, dose parameters, machine and software specifications, as well as regulatory requirements. Radiation oncology is a unique field that combines physics and biology. As a result, it has not only a clinical aspect, but also a physics aspect and biology aspect, all three of which are inter-related and critical to optimal radiation treatment planning. In addition, radiation oncology involves a host of machines/software. One needs to have a firm command of these machines and their specifications to deliver comprehensive treatment. However, this information is not readily available, which poses serious challenges for students learning the planning aspect of radiation therapy. In response, this book compiles these relevant aspects in a single source. Radiation oncology is a dynamic field, and is continuously evolving. However, tracking down the latest findings is both difficult and time-consuming. Consequently, the book also comprehensively covers the most important trials. Offering an essential ready reference work, it represents a value asset for all radiation oncology practitioners, trainees and students.
Advances in Synthetic Biology
by Vijai SinghThis book addresses the design of emerging conceptual tools, technologies and systems including novel synthetic parts, devices, circuits, oscillators, biological gates, and small regulatory RNAs (riboregulators and riboswitches), which serve as versatile control elements for regulating gene expression. Synthetic biology, a rapidly growing field that involves the application of engineering principles in biology, is now being used to develop novel systems for a wide range of applications including diagnostics, cell reprogramming, therapeutics, enzymes, vaccines, biomaterials, biofuels, fine chemicals and many more. The book subsequently summarizes recent developments in technologies for assembling synthetic genomes, minimal genomes, synthetic biology toolboxes, CRISPR-Cas systems, cell-free protein synthesis systems and microfluidics. Accordingly, it offers a valuable resource not only for beginners in synthetic biology, but also for researchers, students, scientists, clinicians, stakeholders and policymakers interested in the potential held by synthetic biology.
Numerical Methods for Fractional Differentiation (Springer Series in Computational Mathematics #54)
by Kolade M. Owolabi Abdon AtanganaThis book discusses numerical methods for solving partial differential and integral equations, as well as ordinary differential and integral equations, involving fractional differential and integral operators. Differential and integral operators presented in the book include those with exponential decay law, known as Caputo–Fabrizio differential and integral operators, those with power law, known as Riemann–Liouville fractional operators, and those for the generalized Mittag–Leffler function, known as the Atangana–Baleanu fractional operators. The book reviews existing numerical schemes associated with fractional operators including those with power law, while also highlighting new trends in numerical schemes for recently introduced differential and integral operators. In addition, the initial chapters address useful properties of each differential and integral fractional operator. Methods discussed in the book are subsequently used to solved problems arising in many fields of science, technology, and engineering, including epidemiology, chaos, solitons, fractals, diffusion, groundwater, and fluid mechanics. Given its scope, the book offers a valuable resource for graduate students of mathematics and engineering, and researchers in virtually all fields of science, technology, and engineering, as well as an excellent addition to libraries.
Women's Health in Autoimmune Diseases
by Shefali Khanna SharmaThis book focuses on conveying autoimmune disease expertise to gynecologists and other clinicians, allowing them to approach the treatment of each disease in a pragmatic manner. Each chapter reviews the current literature on treatments for autoimmune diseases, especially under special circumstances like pregnancy; rating disease severity; and providing practical guidelines based on the current state of knowledge. How autoimmune diseases affect fertility, and how to best prepare patients with these diseases for pregnancy, is also addressed. Unfortunately the current literature does not provide effective guidelines. This book addresses that shortcoming, and will help clinicians to implement appropriate treatments, while also outlining possible alternatives in order to provide effective treatment for women living with autoimmune diseases. It also explores important issues concerning autoimmune diseases in women such as: lupus nephritis, vasculitis, Sjogren’s syndrome, anti phospholipid syndrome and systemic sclerosis, and their potential effects on unborn children. Given its scope, the book offers a valuable reference guide for Practicing Clinicians, Rheumatologists and Gynecologists, among others.
HIV Transmission: Statistical Modelling
by D. M. Basavarajaiah Bhamidipati Narasimha MurthyThis book presents models describing HIV transmission rates at population level, discussing the main statistical methods and analytical interventions. It also assesses the practical applicability of the various modelling techniques, offering readers insights into what methods are available and, more importantly, when they should be used to address HIV transmission at global level. The book includes realistic simulation models fitted to clarify the rate of HIV mother-to-child transmission (HIV MTCT), and substantiates the conclusions that can be drawn as well as the appropriate time for making global-level clinical decisions concerning people living with HIV/AIDS (PLHIVs). Intended for students, academics and researchers, the book offers more than just an introduction to the topic – it also features in-depth, yet easy-to-understand, descriptions of a new mathematical/statistical HIV mother-to-child transmission model, making it a useful resource for clinicians, public health workers and policymakers involved in implementing HIV-prevention programmes at national /global level.
Cardioprotection Against Acute Myocardial Infarction
by Shinya MinatoguchiThis book will provide readers with a detailed understanding of the ischemic damage to the myocardium after myocardial infarction, as well as essential tools for the treatment of damaged heart after myocardial infarction. It discusses various methods such as pharmacological pre- and post-conditioning, cytokine therapy, and cell therapy especially using Muse cells.The coverage of Muse cell therapy, which includes the latest work done by the author and his collaborators, is a unique feature of the book. Muse cells have self-renewability and have ability to differentiate into cells with the characteristics of all three germ layers from a single cell, while they are non-tumorigenic. It is the first book to feature the Muse cell therapy, which may offer the new promising therapeutic strategy for acute myocardial infarction.
Microalgae Biotechnology for Food, Health and High Value Products
by Md. Asraful Alam Zhongming Wang Jing-Liang Xu"Microalgae Biotechnology for Food, Health and High Value Products” presents the latest technological innovations in microalgae production, market status of algal biomass-based products, and future prospects for microalgal applications. It provides stimulating overviews from different perspectives of application that demonstrate how rapidly the commercial production of microalgae-based food, health and high value products is advancing. It also addresses a range of open questions and challenges in this field. The book highlights the latest advances of interest to those already working in the field, while providing a comprehensive overview for those readers just beginning to learn about the promise of microalgae as a sustainable source of both specialty and commercial products. It offers a valuable asset for commercial algae producers, algae product developers, scientific researchers and students who are dedicated to the advancement of microalgae biotechnology for applications in health, diet, nutrition, cosmetics, biomaterials etc.
Functional Chitosan: Drug Delivery and Biomedical Applications
by Sougata Jana Subrata JanaThanks to their unique properties, chitosan and chitosan-based materials have numerous applications in the field of biomedicine, especially in drug delivery. This book examines biomedical applications of functional chitosan, exploring the various functions and applications in the development of chitosan-based biomaterials. It also describes the chemical structure of chitosan and discusses the relationship between their structure and functions, providing a theoretical basis for the design of biomaterials. Lastly, it reviews chemically modified and composite materials of chitin and chitosan derivatives for biomedical applications, such as tissue engineering, nanomedicine, drug delivery, and gene delivery.
Interpenetrating Polymer Network: Biomedical Applications
by Sougata Jana Subrata JanaThe book focuses on novel interpenetrating polymer network (IPN)/semi-IPN technologies for drug delivery and biomedical applications. The dynamism of the design and development of interpenetrating network polymers is based on their ability to provide free volume for the easy encapsulation of drugs in the three-dimensional network structure obtained by cross-linking two or more polymer networks. Natural polymer-based IPNs can deliver drugs at a controlled rate over an extended period of time, while novel IPNs ensure better mechanical strength and sustained/ controlled drug-delivery properties. This book presents an overview of the use of this technology to fabricate nanomedicine, hydrogels, nanoparticles, and microparticles, thereby unlocking IPN’s potential in the area of drug delivery and biomedical engineering. It also discusses applications of IPN systems in cancer therapy and tissue engineering, and describes the various IPN systems and their wide usage and applications in drug delivery.
Uveitis (Current Practices in Ophthalmology)
by Phoebe LinThis book discusses the main clinical aspects of common uveitic infectious and non-infectious entities, the diagnostic work-up, and the treatment/management options based on the literature, where available, and clinical experience. Providing a quick reference guide to uveitis and retina fellows as well as general ophthalmologists, this comprehensive book includes chapters on diagnostic biopsy and pediatric uveitis, as well as reference tables and figures.As part of the series “Current Practices in Ophthalmology” this book is intended for residents, fellows-in-training, generalist ophthalmologists and specialists alike.
Dynamics of Trust in Doctor-Patient Relationship in India: A Clinical, Social and Ethical Analysis (SpringerBriefs in Ethics)
by Vijayaprasad GopichandranThis book offers an easy-to-read, yet comprehensive introduction to practical issues in doctor–patient relationships in a typical low- and middle-income country setting in India, examining in detail the reasons for erosion of trust and providing guidance on potential research areas in the field. It strikes a balance between empirical work and theoretical normative analysis, while adopting mixed-method research in exploring important constructs in the doctor–patient relationship, such as trust, solidarity, advocacy, patient-centeredness, privacy, and confidentiality. Since the concept of trust has direct implications for the ethical practice of medicine, the book is a valuable resource for academics and researchers in the field of medical, clinical, and applied ethics.
Nanoparticles and their Biomedical Applications
by Ashutosh Kumar ShuklaNanotechnology is expected to bring revolutionary changes in a variety of fields. This volume describes nanoparticles and their biomedical applications, and covers metal nanoparticles, metal oxide nanoparticles, rare earth based nanoparticles and graphene oxide nanoparticles. It elaborates on a number of biomedical applications, including therapeutic applications. It addresses the topic of green synthesis, in view of increasing health and environmental concerns.
Intraocular Tumors
by Vikas KhetanThis book aims to cover all aspects of intraocular tumors. The chapters explain diagnosis and treatment plan in detail with the aid of step-by-step descriptions in the form of flow charts. An additional chapter covers imaging modalities that help in diagnosing these conditions. The book is written by subject experts from all over the world. The book includes latest treatment protocols and changing trends in management of ocular tumors. Chapter with special focus on genetics is included to help clinicians understand the condition better.
Emerging and Transboundary Animal Viruses (Livestock Diseases and Management)
by Yashpal Singh Malik Raj Kumar Singh Mahendra Pal YadavThis book, which is the first volume of the book series-Livestock Diseases and Management, summarizes the prominence and implications of the emerging and transboundary animal viruses. Although the livestock plays an important role in the economy of many countries, the emerging and transboundary animal viral diseases possess a serious risk to the animal-agriculture sector and food security globally. The book describes the precise and up-to-date information on animal viral diseases which have emerged in the recent past or are re-emerging due to various environmental factors and those which are not bounded in restricted national boundaries and attained the transboundary status. The chapters summarize the recent advancements in the molecular state-of-art tools towards the development of diagnostics, prophylactics, and therapeutics of these viruses. It also explicitly describes the challenges imposed by the emerging and transboundary viral infections and our preparedness to counter them.
Ways of Home Making in Care for Later Life (Health, Technology and Society)
by Bernike Pasveer Oddgeir Synnes Ingunn MoserThis is a book on how home is made when care enters the lives of people as they grow old at home or in ‘homely’ institutions. Throughout the book, contributors show how home is a verb: it is something people do. Home is thus always in the making, temporal, contested, and open to negotiation and experimentation. By bringing together approaches from STS, anthropology, health humanities and health care studies, the book points to the importance of people's tinkerings and experiments with making home, as it is here that home is being made and unmade.
Hereditary Chorioretinal Disorders (Retina Atlas)
by Gemmy CheungThis volume of the retina atlas focuses on hereditary chorioretinal disorders. The topics covered include retinitis pigmentosa, Best disease, congenital X-linked retinoschisis, cone dystrophy, Stargardt’s disease, pattern dystrophy, North Carolina macular dystrophy, choroideremia, Mallattia Leventinese, Bietti’s crystalline dystrophy, and albinism. All clinical features are clearly illustrated with multimodal imaging techniques. The utility of some of the latest imaging tools such as OCT angiography, adaptive optics-scanning laser ophthalmoscopy, and microperimetery is discussed. Readers will gain valuable new insights into pathogenesis at the molecular level, which have been facilitated by recent genetic discoveries. The use of genetic testing and the latest advances in and challenges of gene therapy and cell-based therapy are also covered in detail.Hereditary Chorioretinal Disorders atlas is one of nine volumes in the series Retina Atlas. The series provides validated and comprehensive information on vitreoretinal diseases, covering imaging basics, retinal vascular diseases, macular disorders, ocular inflammatory and infectious disorders, retinal degeneration, the surgical retina, ocular oncology, pediatric retina and trauma.