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Immunotherapy Against Lung Cancer: Emerging Opportunities and Challenges
by Kamal Dua Shvetank Bhatt Terezinha de Jesus Andreoli Pinto Keshav Raj Paudel Rajaraman Eri Eri Bey-Hing GohThis book provides insight into the various immunotherapeutic approaches for the treatment of lung cancers. The chapters of the book discuss the detailed mechanisms of checkpoint inhibitors, co-stimulatory molecules, drugs working in the immunosuppressive environment, and various vaccines for lung cancer. A chapter of the book explores the recent applications of the oncolytic virus in lung cancer treatment and discusses the potential and direction of oncolytic virus-based therapeutic vaccines. The chapter also elucidates the current understanding of the role of Toll-Like Receptors (TLRs) in tumor progression, and the recent progress in utilizing TLR agonists as potential therapeutic agents in lung cancer treatment. Towards the end, the book reviews the applications of stereotactic body radiation therapy (SBRT) and immunotherapy for the treatment of lung cancer. This book provides useful information to a range of audiences including clinical researchers working in the field of lung cancer, and undergraduate and postgraduate students from various disciplines such as pharmacy, microbiology, immunology, pharmacology, biotechnology, and health sciences.
Immunotherapy for Head and Neck Cancer (Cancer Immunotherapy #1)
by Anthony T. C. Chan Brigette B. Y. MaThis book is a comprehensive summary of the literature on the scientific rationale and clinical development of immunotherapy for head and neck cancers.Head and neck cancer is a biologically diverse group of cancers that bear a common hallmark - evasion of host immune surveillance through innate or acquired mechanisms. The etiological association between the Human Papilloma virus (HPV) and some squamous head and neck cancers, the Epstein-Barr virus (EBV) and nasopharyngeal cancer has provided further impetus for evaluating immunotherapy in this group of cancers. The successful development of anti-programmed cell death protein-1 (PD-1)/ ligand (PD-L1) and CTLA-4 antibodies in solid tumours has gradually brought immunotherapy into mainstream oncological practice in recent years. Besides immune-checkpoint proteins inhibitors, other forms of immunotherapy such as vaccines, EBV or HPV-targeting therapies and cellular therapies are actively being investigated in clinical trials, either alone or in combination with other conventional treatments such as radiotherapy, chemotherapy and surgery. In clinical setting, the practicing oncologist need to be familiar with some unusual patterns of immunological response such as pseudo-progression and hyper-progression in patients with head and neck cancers who are undergoing treatment with immune-checkpoint inhibitors. Furthermore, the unique side effects of immune-checkpoint inhibitors such as autoimmune toxicities need to be recognized early and treated expediently. The development of biomarkers in predicting response to immune-checkpoint inhibitors has played pivotal roles in selecting patients for immunotherapy in practice or as an enrichment strategy in clinical trials. There are now emerging data on the clinical utility of biomarkers such as PD-L1 expression (Combined Positive Score), gene signatures and tumor mutational burden. This book is an invaluable companion to all those who are involved in research and clinical management of patients with head and neck cancers from any endemic regions.
Impact of COVID-19 Lockdown on Environmental Health: Exploring the Situation of the Lower Gangetic Delta
by Abhijit MitraThis book examines the impacts that the COVID-19 lockdown has had on environmental and ecological health, with a focus on coastal ecosystems in the Lower Gangetic Delta. The book begins with an overview of COVID-19's spread and impact before and after the lockdown in the focus region, then addresses the specific impacts that the lockdown period had and continues to have on air quality, marine and estuarine water quality, coastal biodiversity, and the livelihoods of the region's inhabitants, especially those who live below the poverty line. The decrease in human activity combined with the complete closure of various sectors, including air travel, oil and gas drilling, and construction, has had a pronounced effect on biodiversity and overall environmental health that is yet to be fully realized. The book sheds light on these changes and assesses how biodiversity, ambient air quality, and ecosystem functioning will progress as COVID-19 remains a threat and the lockdown persists. The study will be of interest to researchers, government officials and professionals dealing with disaster management, environmental science, biological science, and health.
Impact of Climate Change on Health in Africa: A Focus on Liver and Gastrointestinal Tract
by Amal Saad-Hussein Reda Elwakil Kenza KhomsiThis book provides detailed information on the impact of climate change on gastrointestinal and liver health and disease patterns on the African continent. It also discusses the adaptation measures required to mitigate these impacts and highlights the complex interplay between climate change and various forms of gut diseases, ranging from the spread of infectious diseases to emerging parasites. This volume is intended for both public health researchers, climate epidemiologists, gastroenterologists, hapatologists, and tropical medicine physicians seeking to develop a comprehensive understanding of the links between climate change and disease patterns in Africa. The ideas and findings covered in this book contribute to UN Sustainable Development Goal 3: Good Health and Well-Being and SDG 13: Climate Action.
Impact-Techniken in der Einzel- und Gruppenpsychotherapie: Multisensorische Methoden - Fallbeispiele aus dem psychotherapeutischen Alltag (Psychotherapie: Praxis)
by Katrin VaderDieses Fallbuch beschreibt Impact-Techniken im Einzel-und Gruppensetting. Die effizienten multisensorischen emotionsaktivierenden Elemente verschiedener Therapieverfahren werden mit Humor eingesetzt, um Patienten nachhaltig auf der emotionalen Ebene zu erreichen. Gearbeitet wird mit allem, was gerade zur Verfügung steht: der Raum, Stühle, Papier, Tassen, Gläser, innere Bilder, Metaphern, Bewegung, Objekte. In diesem Buch ermöglicht Katrin Vader mit vielen verschiedenen Beispielen den Transfer in die eigene Praxis. Stichworte aus den Fallbeispielen: Patient erreicht sein Ziel nicht. Patient stagniert in dem Zustand, in dem er gekommen ist oder an einer bestimmten Stelle in der Therapie. Patient versteht seine Kommunikationsmuster nicht. Patient ist sich seines sekundären Krankheitsgewinnes nicht bewusst. Therapeut kann sich besseren Überblick über die Problembereiche des Patienten verschaffen. Therapeut kann sich besser vom Patienten und dessen Problemen abgrenzen. Über die Autorin: Dipl.-Psych. Katrin Vader ist niedergelassene Psychotherapeutin für Erwachsene (Schwerpunkt Verhaltenstherapie) in eigener Praxis in Jena. Sie wirkt als Lehrpraxisinhaberin, Supervisorin, Selbsterfahrungsleiterin und Dozentin für verschiedene psychotherapeutische Ausbildungsinstitute in Thüringen und Sachsen, auf Kongressen und für psyCultus® Fortbildungen.
Impacted Third Molars
by John WaylandIMPACTED THIRD MOLARS Gain confidence in third molar extractions, with advice relevant to general, specialty, and mobile third molar practice dentists Impacted Third Molars, Second Edition, provides dentists with all the information they need to confidently remove impacted third molars, from case selection and imaging to sedation and patient management. Step-by-step surgical procedures support dentists in the successful surgical removal of third molars. The second edition has been updated throughout with new information and advances, and seven new chapters cover local anesthesia, imaging, patient management, platelet rich fibrin, case studies, and mobile third molar practices. The book includes all the information dentists need to efficiently, profitably, and safely remove impacted third molars. Photographs and illustrations depict the concepts described, and a companion website offers video clips. Impacted Third Molars: Gives dentists all the information they need to consider mobile third molar practice, which provides more freedom, less stress, less overhead, and more profitability Helps dentists stop referring third molars and remove them early in the teen years before roots develop Features the author’s seven-step procedure for removing impacted third molars Includes a chapter describing the author’s mobile third molar practice, with a procedure manual Offers procedural videos on a companion website Impacted Third Molars, Second Edition is an essential reference for general dentists and specialists alike.
Impfung bei Frauen: Ein Leitfaden für Gynäkologie und Hausarztpraxis (essentials)
by Marianne Röbl-Mathieu Ariane KunsteinAufgrund von Besonderheiten des Immunsystems weisen sowohl Schwangere, Ungeborene und Neugeborene als auch ältere Frauen eine erhöhte infektionsbedingte Morbidität und Mortalität auf, die durch Impfungen reduziert werden kann.Das essential vermittelt ärztlich Tätigen die wichtigsten immunologischen Grundlagen und konkrete Praxistipps, um Frauen und Mädchen in den unterschiedlichen Lebensphasen sachgerechte Impfempfehlungen zu geben, sie fundiert zu Impffragen zu beraten und Impfungen sicher anzuwenden. Der Leitfaden basiert auf den aktuellen STIKO-Empfehlungen.
Implantable Medical Devices and Healthcare Affordability: Exposing the Spiderweb
by Mark C. West Michael Georgulis, Jr.The United States spends more than 17% of its GDP on healthcare, while other developed countries average 8.7% of GDP on healthcare expenditures. All this spending doesn’t equate to value, quality, or performance, however. Among 11 high-income countries, the United States healthcare industry ranked last during the past seven years in four key performance categories: administrative efficiency, access to care, equity, and healthcare outcomes. This book presents the implantable medical device (IMD) supply chain ecosystem as a microcosm of how these challenges of affordability and healthcare outcomes are created and are allowed to fester. The IMD Spiderweb, as the authors call it, is exposed as an example of how a wide range of participants—including physicians, health system CEOs, group purchasing organizations, health insurance companies, and supply chain executives—become ensnared in a web designed to benefit only one player. Health systems in the United States pay as much as six times more for some IMDs than their counterparts do in Europe, and prices for the same IMD model vary even among different U.S. hospitals. While there is a fascination with the latest and greatest device, there is also a shroud around visibility into how these products have performed and are likely to perform in patients. The costs continue to rise not only in healthcare expenditures, but also in death and disability. The IMD Spiderweb is presented as a prime lesson in the challenges in healthcare affordability and outcomes that occur throughout the entire healthcare industry. It is also put forward as an opportunity. The story behind how these challenges arose and continue to be deepened by the current healthcare ecosystem also provides a foundation for solutions.
Implants and Oral Rehabilitation of the Atrophic Maxilla: Advanced Techniques and Technologies
by Marco RinaldiThis book covers the most suitable techniques for the rehabilitation of patients experiencing tooth loss, trauma or other situations resulting in bone atrophy. The book discusses current technologies, from diagnosis to treatment and surgery, applied to atrophic jaws using innovative tools and new PSI (patient specific implant) approaches. Oral Rehabilitation of the Atrophic Maxilla and the selection of the best treatment options for patients is one of the most difficult tasks facing the profession today. Readers will be able to solve complex problems and evaluate all available applications for patient management. Zygomatic implants, reconstructive surgery with bone grafts, post-oncologicasl and post traumatic reconstructions as well as dynamic navigation and robot assisted dental surgery are covered. The book is written by recognized experts and leaders in the field, and includes simpler techniques within the reach of many implantologists and more complex techniques that require specific surgical skills. It is relevant for, implanologist, periodontists, oral and maxillofacial surgeon, prosthodontists and every clinician treating maxillary atrophy.
Implementatie: Effectieve verbetering van de patiëntenzorg
by Richard Grol Michel WensingDit boek helpt zorgverleners, leidinggevenden, staffunctionarissen, beleidsmakers en onderzoekers om patiëntenzorg op een effectieve manier te verbeteren. Het geeft een praktische, stapsgewijze aanpak voor de implementatie van innovaties in de gezondheidszorg, die rekening houdt met de weerbarstigheid van de praktijk.In Implementatie ligt de nadruk op het verbeteren van het handelen van artsen, verpleegkundigen, paramedici, andere zorgverleners, en de teams waarin zij werken. De patiënt staat hierbij centraal. De uitgave geeft een toegankelijk overzicht van het wetenschappelijk onderzoek op het gebied van implementatie. Het beantwoordt bijvoorbeeld de vraag hoe het komt dat veel waardevolle inzichten, hulpmiddelen, programma’s en best practices de weg naar de praktijk niet vinden. En andersom hoe het kan dat er soms werkwijzen gebruikt worden waarvan is aangetoond dat ze geen meerwaarde hebben voor patiënten of burgers. Hierbij wordt nadruk gelegd op de rol van contextfactoren bij verbetering en implementatie. De vele concrete voorbeelden van verandertrajecten in Nederland en daarbuiten vullen dit overzicht aan.Implementatie in de zorg mag zich verheugen in een groeiende belangstelling van wetenschap en praktijk. Deze achtste editie bevat daarom veel nieuwe ontwikkelingen en actuele voorbeelden. Het boek is compacter geschreven en een aantal hoofdstukken is grondig herzien. Het resultaat is een omvattend, actueel en praktisch toepasbaar overzicht van de kennis op het gebied van verbetering van de patiëntenzorg.
Implementierungsstrategien im Gesundheitswesen: Die 50 wichtigsten Implementierungs-Frameworks in der Praxis - eine Literaturrecherche
by Florian O. StummerDie Herausforderungen des 21. Jahrhunderts für das Gesundheitswesen verlangen nach neuen und innovativen Lösungen. Meist ist jedoch die Implementierung eben dieser neuen Prozesse die größte Herausforderung für Unternehmen und Gesundheitseinrichtungen. Sei es die Einführung einer neuen Technologie oder die Etablierung eines neuen Departments - nachweislich scheitern etwa 70 Prozent aller Projekte innerhalb von 36 Monaten. In einer immer schneller werdenden, transdisziplinären Wirtschaftswelt ist es von entscheidender Bedeutung, über die richtigen Implementierungs-Instrumente zu verfügen, um langfristige strategische Veränderungen nachhaltig umsetzen zu können.Das vorliegende Kompendium gibt Ihnen die wichtigsten Implementierungs-Frameworks an die Hand, um auf die Fragestellungen ihrer Organisation effiziente Lösungsprozesse für die Zukunft entwickeln zu können. Die Auswahl erfolgte auf Basis einer wissenschaftlichen Literaturrecherche. Mit zahlreichen Best-Practice-Beispielen aus der Gesundheitsbranche.
Implementing the Mediterranean Diet: Nutrition in Practice and Public Health
by Richard HoffmanImplementing the Mediterranean Diet Implementing the Mediterranean Diet: Nutrition in Practice and Public Health situates this &‘gold standard&’ of diets within the wider food environment by bridging the gap between the evidence-based health benefits of the Mediterranean diet and its implementation. The text explores the many approaches that can be used by health professionals to help consumers adopt this healthy eating pattern, as well as the barriers encountered with implementing this diet at home and in the wider environment. It also considers sustainable food and farming practices, and national food strategies. A one-stop resource for food and health professionals, this seminal text demonstrates the full range of benefits that the Mediterranean diet can bring to society. This ground-breaking book: Gives an in-depth review of the effectiveness of the Mediterranean diet in disease prevention and the management of chronic diseases Contextualises the diet within the food environment, showing why the whole dietary pattern and minimizing the consumption of highly processed foods are both so important Shows how to implement the Mediterranean diet, motivating and guiding consumers to make the transition Addresses the practical and behavioural barriers to food choice in terms of taste, cost, variety, convenience and animal welfare concerns Implementing the Mediterranean Diet is a must-have resource for advanced undergraduate and postgraduate students in the food sciences, and for healthcare professionals such as dietitians, nutritionists, GPs, and health workers, especially those working in non-Mediterranean, high-income countries.
Imposter Doctors: Patients at Risk
by Rebekah BernardWhen you experience a medical emergency, you expect to be treated by a licensed physician with expertise in your condition. What happens when you look up from your hospital gurney to find that the doctor has been replaced by a non-physician practitioner w
Improving Online Presentations: A Guide for Healthcare Professionals
by Cemal Cingi Nuray Bayar Muluk Can Cemal CingiThis books offers a detailed overview of the key skills needed to make impactful online presentations. The book opens with a chapter on communication in healthcare, before discussing the advantages and disadvantages of the online versus live presentations. The following chapters discuss the technology used and the organization of the contents to be delivered, before analyzing the audience. The volume then reviews all the verbal and non-verbal techniques and presents the common mistakes and the tips to avoid them. A final chapter deals with challenging situations. Written by two professors and medicine and a communication specialist, the book is intended for healthcare professionals at all levels, It will be also a valuable resource for scientists and researchers willing to deliver effective and engaging virtual presentations.
Improving Person-Centered Innovation of Nursing Care: Leadership for Change
by Barbara SassenThis English edition helps students and nursing professionals give each patient their unique position in healthcare delivery. The book provides tools to connect key topics and innovations in healthcare, developing a complete perspective on patient/person-centred care. It provides a comprehensive picture of important and recent insights on health and care. At its core, nurses provide care with a focus on the patient as a person. This person-centred care engages each patient's needs, preferences and expectations when providing integrated care.In this volume, care starts from the patient's point of view rather than from the role and function of the healthcare professional. The author relates themes such as relational care delivery, shared decision-making and empowerment to key concepts such as patient- and family-centred care, integrated care, patient-centred leadership(styles), quality of care and value-based healthcare.This book briefly and powerfully integrates these themes and describes them from a patient and client perspective, underpinned by the scientific literature on them. The themes are linked in a flowchart, starting from illness and working towards health, extending health even if people have a (physicalor mental) health problem. The purpose of this book is to offer a professional view of person-centred care. It stresses the importance of shared-decision making and leadership in promoting health in the care-setting. As such, it will be essential for any healthcare professional.
Impulse: The Science of Sex and Desire
by Jon E. Grant Samuel R. ChamberlainSex is everywhere in modern society, yet it remains taboo. We all have questions about sex that are too uncomfortable to ask – how do we get reliable answers? In this go-to guide Drs Grant and Chamberlain use their clinical expertise to answer the questions you wish you could ask about sex. Questions like: Is my sex drive or sex behavior normal? Can someone have too much sex? Or too little? How has Internet dating and pornography changed sex? This go-to guide will help you understand common sexual issues, know when to worry (or not) about different sexual behaviors, and learn how our sex lives adapt to changing technology or in times of crisis. It also provides step-by-step advice for dealing with a range of sexual issues, and practical strategies for strengthening relationships.
In Utero Pediatrics: Research & Practice
by Kun SunThis book is to provide readers with an overview of in utero Pediatrics, an interdisciplinary medicine focusing on sequential and comprehensive care for fetuses and children who have functional and/or structural disorders originated from in utero. It covers congenital disorders in cardiology, neurosurgery, urology, general surgery, endocrine genetics, and other related topics. Each chapter starts with the basic theory, illustrates clinical practices on certain congenital disorders, and summaries recent research and advances in the field. Written by experts with wealthy experiences, this case-based book will be a valuable reference for pediatricians and perinatologists, as well as those who are interested in this field.
In Vitro Diagnostic Industry in China
by Haibo Song Lizhong DaiThis book systematically describes the achievements and current situation of in vitro diagnostic (IVD) industry in China. It consists of twelve parts, including the overview on the IVD industry in China in 2021, hot technologies and products of IVD industry, academic, technological and product development in the field of IVD, such as biochemical diagnosis, immune-diagnosis, point-of-care testing, molecular diagnosis, blood and body fluid diagnosis, microbial detection, laboratory assembly line, etc.In this second edition, the new contents added include the development of new coronavirus molecular diagnostic products, flight mass spectrometry, tandem mass spectrometry, tumor markers, ELISA immune reagents, autoimmune diagnostics, concomitant diagnosis, fecal and intestinal microecology detection, pathological diagnosis, raw materials for in vitro diagnostic reagents, standard substances and quality controls for in vitro diagnostic reagents, etc., making the content of the whole book more novel and rich.This book is compiled by an editorial committee composed of well-known entrepreneurs, experts and professors in IVD industry in China. It is a reference book for practitioners of IVD industry, medical laboratory and medical staffs all over the world.
In the Blood: How Two Outsiders Solved a Centuries-Old Medical Mystery and Took On the US Army
by Charles BarberThe "high-stakes" true story of how an absent-minded inventor and a down-on-his-luck salesman joined forces to create a once‑in‑a‑generation lifesaving product: "Suspenseful storytelling helps us see and feel the struggle and frustration, the sweat and tears . . . Inspiring&” (Robert Kolker, #1 New York Times bestselling author of Hidden Valley Road). At the 1993 Battle of Mogadishu, dramatized by the popular film Black Hawk Down, the majority of soldiers who died were killed instantly or bled to death before they could reach an operating table. This tragedy reinforced the need for a revolutionary treatment that could transform trauma medicine. So, when Frank Hursey and Bart Gullong—who had no medical or military experience—discovered that a cheap, crushed rock called zeolite had blood‑clotting properties, they brought it to the military's attention. The Marines and the Navy adopted the resulting product, QuikClot, immediately. The Army, however, resisted. It had two products of its own being developed to prevent excessive bleeds, one of which had already cost tens of millions of dollars. The other, "Factor Seven," had a more dangerous complication: its side effects could be deadly. Unwilling to let its efforts end in failure—and led by the highly influential surgeon Colonel John Holcomb—the Army set out to smear QuikClot&’s reputation. Over the course of six years, Hursey and Gullong engaged in an epic struggle with Holcomb for recognition. Ultimately, a whistle‑blower inside the Army challenged the Army&’s embrace of Factor Seven, which resulted in a massive lawsuit led by the U.S. Department of Justice. The lawsuit focused further attention on the financial ties between the pharmaceutical company that produced Factor Seven and Holcomb&’s research institute. By withholding QuikClot—which later became the medical miracle of the Iraq War—and in the use of Factor Seven with its known, life-threatening risks of heart attacks and strokes, the lives of countless soldiers were imperiled. Using deep reportage and riveting prose, In the Blood recounts this little‑known David‑and‑Goliath story of corruption, greed, and power within the military—and the devastating consequences of unchecked institutional arrogance.
In the Company of Grace: A Veterinarian's Memoir of Trauma and Healing
by Jody LulichThe son of a Black mother and white father overcomes family trauma to find the courage of compassion in veterinary practice Rising to accept a prestigious award, Jody Lulich wondered what to say. Explain how he&’d been attracted to veterinary medicine? Describe how caring for helpless, voiceless animals in his own shame and pain provided a lifeline, a chance to heal himself as well? Lulich tells his story in In the Company of Grace, a memoir about finding courage in compassion and strength in healing—and power in finally confronting the darkness of his youth.Lulich&’s white father and Black mother met at a civil rights rally, but love was no defense against their personal demons. His mother&’s suicide, in his presence when he was nine years old, and his sometimes brutal father&’s subsequent withdrawal set Lulich on a course from the South Side of Chicago to the Tuskegee School of Veterinary Medicine in Alabama to an endowed chair at the University of Minnesota, forever searching for the approval and affection that success could not deliver. Though shadowed by troubling secrets, his memoir also features scenes of surprising light and promise—of the neighbors who take him in, a brother&’s unlikely effort to save Christmas, his mother&’s memories of the family&’s charmed early days, bright moments (and many curious details) of veterinary practice. Most consequentially, at Tuskegee Lulich rents a room in the home of a seventy-five-year-old Black woman named Grace, whose wholehearted adoption of him—and her own stories of the Jim Crow era—finally gives him a sense of belonging and possibility.Completing his book amid the furor over George Floyd&’s murder, Lulich reflects on all the ways that race has shaped his life. In the Company of Grace is a moving testament to the power of compassion in the face of seemingly overwhelming circumstances.
In-Flight Medical Emergencies: A Practical Guide to Preparedness and Response
by William J. Brady Jose V. NableThis book functions as a practical guide for health care professionals encountering medical emergencies during a commercial flight. A second edition to its successful predecessor, this text covers the most common emergencies encountered during flight, both general medical emergencies and those specifically tied to the effects of flying, including cardiac, respiratory, and neurological issues. Medicolegal issues are considered in depth for both United States domestic and international flights, as there is potential legal risk involved in giving medical assistance on a flight. This new edition includes expanded and updated original chapters revised based on available new research material. Additional chapters examine how to handle disruptive passengers experiencing acute behavioral issues during flight, emerging infectious diseases. This issue is particularly relevant due to COVID-19, specifically concerning the anxiety and readjustment challenges of resuming everyday travel. This edition includes a new chapter recounting the history of the handling of in-flight medical events. In-Flight Medical Emergencies, 2nd ed functions as an essential resource for physicians and all healthcare professionals who travel regularly.
Incentives and Disincentives in Organ Donation: A Multicultural Study among Beijing, Chicago, Tehran and Hong Kong (Philosophy and Medicine #133)
by Ruiping FanThis book provides the first systematic study on three types of incentives for organ donation. It covers extensive research conducted in four culturally different societies: Hong Kong, mainland China, Iran and the United States, and shows on the basis of the research that a new model of incentives can be constructed to enhance organ donation in contemporary societies. The book focuses on three types of incentives: honorary incentives, commonly adopted in the United States and other Western countries by offering things such as a thank-you card and a memorial park for donors to encourage donations motivated by pure altruism; compensationalist incentives, adopted in the Islamic Republic of Iran to encourage donation by providing monetary compensation to unrelated living donors for appreciating their altruistic contribution of donation; and familist incentives, implemented in Israel and mainland China to provide priority to organ transplantation to donors and/or their family members. The book demonstrates that a new model of incentives must go beyond offering only one type of incentives and should rather include different types of incentives that are practically effective, politically legitimate and ethically justifiable for particular societies. This implies that suitable incentive measures may vary from society to society to optimize organ donation. This book provides a clear reference for both the scholars and practitioners in the field of organ transplantation, as well as for general readers interested in bioethics and health care policy.
Incidental Findings of the Nervous System
by Ahmet Tuncay Turgut Mehmet Turgut Fuyou Guo Sanjay BehariWritten and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of the incidental findings of the nervous system, with emphasis on asymptomatic brain and spinal lesions that have the potential to cause illness. It includes very informative chapters, organized into four main groups: first, incidental findings of the brain and cranium, including intracranial, intraventricular and skull base lesions, infarcts and calcification; secondly, incidental findings of the spine and spinal cord, including spinal cord tumors, syringomyelia, arteriovenous malformations and craniovertebral junction anomalies; thirdly, incidental findings of the spinal nerves and peripheral nerves, including tumors of the plexi and peripheral nerves; and fourthly, other lesions, including acquired incidental lesions of the brain and spine as well as the medicolegal and psychiatric aspects related to these lesions. The uniqueness of this compilation lies in the fact that several abnormalities exist in the nervous system that have the potential to cause life threatening illness; yet because they are asymptomatic and incidental, this leads to major management dilemmas related to whether or not to surgically the lesion. The proponents of an early surgical management subscribe to the philosophy that getting rid of an entity earlier on when it is asymptomatic, leads to an early cure and obviates any risk of it becoming aggressive and incurable later on; those opting for a ‘wait and watch’ policy subscribe to the view that no intervention (as well as subjecting the patient to the risk of surgery) is mandated until the lesion becomes symptomatic. This may subject a person to a lifetime of anxiety related to how that lesion is going to evolve, when in all likelihood, the subject may remain asymptomatic throughout his/her life. The psychological aspects of the patient who is extremely disturbed by the presence of this incidental lesion; and, who cannot adjust to the reality that the treating doctor actually does not have a well-defined plan for it, are issues that are adequately addressed with clinical illustrations and examples. This comprehensive reference book will be an ideal source for neuroscientists at all levels, from graduate students to researchers in specific disciplines studying this region, including neurosurgeons, neurologists, neuroradiologists, neuropathologists and psychiatrists, who seek both basic and more advanced information regarding the incidental findings of the nervous system.
Inclusion Bodies: Methods and Protocols (Methods in Molecular Biology #2617)
by Julian Kopp Oliver SpadiutThis detailed volume presents a series of protocols dealing with different aspects of inclusion body (IB) processing, from cloning procedures to purification of refolded product. Commencing with chapters on upstream processing, looking into different expression strategies for IB production, the book continues with downstream applications, highlighting early protein purification and subsequent analytics, as well as success stories of IB-based processes. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Inclusion Bodies: Methods and Protocols serves as an ideal resource for facilitating diverse aspects of IB processing.
Inconceivable Iran: To Reproduce or Not to Reproduce? (Fertility, Reproduction and Sexuality: Social and Cultural Perspectives #50)
by Soraya TremayneCelebrating the 50th volume of the landmark Fertility, Reproduction and Sexuality series, this book offers a much-needed analysis of shifting reproductive policies and practices in the Islamic Republic of Iran, a society that is usually represented as either “revolutionary” or “oppressive.” Instead, Tremayne reflects on more than four decades of research arguing that changing reproductive behaviors on the part of ordinary Iranians must always be viewed against the backdrop of core cultural values and traditions, which are often reinforced, instead of radically altered, by new reproductive technologies, juridical opinions, and state policies.