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Clinical Metabolomics Applications in Genetic Diseases
by Anas M. Abdel RahmanThis book helps readers discover the forefront of personalized medicine on clinical metabolomics and its applications in genetic diseases. This comprehensive guide offers a functional relationship map between cell components and genetic variations in various diseases, providing insights that can be applied to personalized medicine. The book covers the latest developments in metabolomics for health, with practical guidance for clinical experts looking to advance their laboratory techniques and career. The metabolomics profile is a powerful tool that has revolutionized our understanding of the relationship between genetics, clinical readouts, and disease outcomes. By integrating metabolomics with genomics and clinical phenotypes, the authors have developed diagnostic and prediction models that have vastly improved patient outcomes and deepened the understanding of disease mechanisms. This model has been successfully applied in various conditions, including inborn errors of metabolism, primary immunodeficiency, and endocrine disorders. However, integrating metabolomics with other omics datasets and clinical phenotypes requires careful study design, analytical tools, and data analysis and interpretation. This groundbreaking new book provides essential guidance for researchers, students, and professionals looking to leverage metabolomics in their own work, including biochemical and clinical geneticists, pharmacogenomics and pharmacometabolomics experts, pharmaceutics and diagnostic researchers, medical scientists, clinical dietitians, metabolic engineers, clinical chemists, and personalized medicine specialists.
Textbook of Medical Administration and Leadership
by Erwin Loh Paul W. LongThis textbook covers all general areas of knowledge required for a trainee, generalist medical administrator, and doctor undergoing training to be a medical administrator specialist. Chapters cover all the key topics on medical administration and leadership. Some of the key topics included are: health systems and policy, health law, private health and insurance, health disaster planning, population and public health, health information and technology, and health economics and financial management.Medical practitioners of today are part of huge changes in medical practice as continuing developments are happening in biomedical sciences and clinical practice with new health priorities, rising expectations among patients and the public, and changing societal attitudes. Consequently, basic knowledge and skills, while fundamentally important are not enough today on their own and doctors thus need to demonstrate leadership combined with sound management skills to drive the necessary changes required to meet the challenges head. This book serve as an invaluable resource for a wide spectrum of physicians including specialists, clinician managers and other health professionals, as well as non-clinical managers working in health. This is a gateway text for trainees in medical administration, specialist medical administrators, aspiring medical managers, health service managers, and heads of service and departments in various medical specialties.
Practical Guide to Hereditary Breast and Ovarian Cancer: Annual Meeting of the Japanese Organization of Hereditary Breast and Ovarian Cancer 2021
by Daisuke Aoki Seigo Nakamura Yoshio MikiThis book shares cutting-edge evidence on Hereditary Breast and Ovarian Cancer (HBOC) treatment, delivering facts on breast cancer, gynecologic oncology, and basic research to contribute to clinicians' practices. Each chapter presents the latest clinical techniques, basic experimental results, and the best-chosen research findings. The book is based on the works presented at the Japanese Organization of Hereditary Brest and Ovarian Cancer (JOHBOC) and a special chapter delivers a study based on the extensive data from the Japanese HBOC patients registered in the society's database, presenting novel evidence for further advancement in the field. The practice for HBOC has been rapidly increasing due to the clinical development of poly(ADP-ribose) polymerase inhibitors and the spread of companion diagnostics. In addition, the insurance coverage of a part of HBOC treatment raised social awareness in Japan, and the book illustrates not only clinical efforts but also issues related to the social system and the efforts of the association of related organizations. Hereditary Breast and Ovarian Cancer – Annual meeting of JOHBOC will be of interest to breast surgeons, obstetricians and gynecologists, pancreatic cancer surgeons, and urologists engaged in HBOC treatment through the implementation of companion diagnostics for PARP inhibitors administration. Also, physicians occupied in genetic medicine who perform genetic testing and medical staff practicing HBOC will find this book insightful. It is also for HBOC patients and their families, medical administrators in the social system of HBOC practice. Editors and authors hope to contribute to the equalization and widespread of HBOC practice and serve as a foundation for future advances in the disease's treatment and medical practice.
Novel Technologies in Biosystems, Biomedical & Drug Delivery
by Shrikaant Kulkarni A. K. Haghi Sonali ManwatkarThe book gives an insight into the theoretical background, conceptual understanding, latest developments, and applications in the field of pharmaceuticals in general and drug design, discovery, biosystems, and biomedical and drug delivery technologies in particular. Knowledge is drawn from various disciplines such as Chemistry, Biology, Material Science and Engineering, Statistics, Biomedicine, and Genetics . A host of applications like bio-imaging, novel biological agents, testing, characterization and validation of drugs, computer-based models in drug design, and application of statistical tools in data analysis, design, and development of drug delivery systems, and ecosystems are dealt with in detail. The said book undoubtedly confirms the requirements of the postgraduate students, research scholars, academicians, scientists, and researchers from the academia, pharmaceutical, biotechnology, and chemical engineering domain. The book covers a conceptual understanding of the exploration of drugs in tandem with intended uses, sound ecosystem development, and carriers for drug and supplement delivery.
Textbook of Traditional Chinese Medicine: Volume 1: Introduction, Examination, Etiologies and Pathogenesis and Differentiation of Syndromes
by Yong Huang Lifang ZhuThis book covers all the contents from theoretical basis to clinical practice comprehensively, which are under the guideline of classic inheritance and the essence of TCM. TCM is a comprehensive discipline. In this book, philosophical foundation, physiology and pathology, etiology, differentiation and diagnostics, and health-preservation of TCM, Chinese materia medica and prescription, acupuncture and moxibustion, characteristic therapies, and common clinical disease are systematically arranged.From Chapter 1-4, a clear picture of the philosophical foundation of TCM from yin-yang, five-element, qi, blood, body fluids and zang-fu viscera theory is presented. From Chapter 5-7 include etiology, pathogenesis, diagnostic and differentiation of syndromes. Chapter 8 is one of the most popular chapters with a topic of health-preservation. Chapter 9 mainly present clinical TCM therapies of common disease.This book is a useful textbook for graduate and undergraduate students inmedical schools, including MBBS (Bachelor of Medicine and Bachelor of Surgery) student.
Textbook of Traditional Chinese Medicine: Volume 2: Chinese Materia Medica, Prescription, Acupuncture and Moxibustion, Other Therapies and Common Diseases
by Yong Huang Lifang ZhuThis book covers all the contents from theoretical basis to clinical practice comprehensively, which are under the guideline of classic inheritance and the essence of TCM. TCM is a comprehensive discipline. In this book, philosophical foundation, physiology and pathology, etiology, differentiation and diagnostics, and health-preservation of TCM, Chinese materia medica and prescription, acupuncture and moxibustion, characteristic therapies, and common clinical disease are systematically arranged.Chapter 1 and Chapter 2 are about Chinese materia medica and prescription, presenting the tropism of natures, flavors and meridians, as well as commonly used prescription. Acupuncture and moxibustion therapy is the topic of Chapter 3, meridians and acupoints and acupuncture techniques are explained systematically and thoroughly. Chapter 4 is about some particular therapies such as massage, dietary therapy, qigong and Tai Chi. Chapter 5 mainly present clinical TCM therapies of common disease. And the last is appendix which provides supplementary materials as references.This book is a useful textbook for graduate and undergraduate students in medical schools, including MBBS (Bachelor of Medicine and Bachelor of Surgery) student.
Interpretation of Gastric Cancer Cases (Experts' Perspectives on Medical Advances)
by Jianqiang CaiThis book covers the diagnosis and treatment of various types of gastric cancer, and details the clinical process of gastric cancer treatment. Authors collects 37 clinical cases, which are typical gastric cancer cases with complicated disease or metastasis. In each case, the patient's gastroscopic results, abdominal CT images, pathological results and treatment process were analysed in detail. Combined with the expert's precise comments, the surgical treatment method and postoperative radiotherapy and chemotherapy and other treatment schemes of each case were clearly explained in an orderly manner.
Nanotechnology Based Delivery of Phytoconstituents and Cosmeceuticals
by Deep Pooja Hitesh KulhariThis book explores the role of nanotechnology in the delivery of natural phytoconstituents and cosmeceuticals. It presents polymeric nanocarriers, lipid-based nanocarriers, metal/metal oxide nanocarriers, protein nanocarriers, and dendrimers for the delivery of phytoconstituents. Further, it focuses on the usage of phytocompounds in various cosmeceutical products and nano delivery technologies used in the delivery of various cosmeceuticals. Finally, the book reviews the toxicity issues of nanoparticles in the delivery of phytoconstituents and cosmeceuticals and regulatory aspects for clinical applications of nano phytomedicines. This book is helpful for academicians and researchers working in pharmaceutical sciences, nano science, material science, plant science, and cosmetic science.
Vitellogenin in Fishes- Diversification, Biological Properties, and Future Perspectives
by Vaseeharan Baskaralingam Rapeepun VanichviriyakitThis book provides basic and advanced information on vitellogenin in fish. The proposed book discusses the history of vitellogenin, previtellogenesis, their diversification and classification in fishes, and tools for their identification and characterization. Further, their functional aspects in oogenesis and its regulatory mechanism, role as the immunocompetent molecule, and reproductive strategies are discussed. The book further examines vitellogenin as a hormone and biomarker, its related egg yolk proteins, and its mechanism on molecular cloning and induction. In addition, the book discusses its role in the disruption of the endocrine system in fish, its biological activities, its multivalent mechanism in marine and freshwater fishes, and its impact on the growth of ornamental fishes. Moreover, this book elaborates on the multiple vitellogenin genes, each with unique promoter regions and varying sensitivity to induction by estradiol, and multiple Vtg proteins themselves, with variable degrees of post-translational modification. As such, this book is helpful for researchers and students interested in the reproduction of fishes and reproductive biology.
Thyroid Disease in Pregnancy - A Guide to Clinical Management
by Haritha Sagili Jayaprakash Sahoo Swaramya ChandrasekaranThis book focuses on all aspects of thyroid disease in women during pregnancy, preconception and the postpartum period. Exceptional emphasis is provided on screening for thyroid dysfunction before and during pregnancy and interpretation of thyroid function tests in pregnancy. The chapters cover the topics on the role of Iodine, thyroid autoantibodies, hypothyroidism , thyrotoxicosis and thyroid nodules / cancer in pregnant women and postpartum thyroiditis with helpful illustrations and clear flow charts. This book serves as a resourceful guide for clinicians and medical practitioners in managing thyroid disease and related complications in women at different stages of pregnancy.
Diagnosis and Management of Primary Bone Tumors: Volume 2
by Won-Jong BahkThis book is the second in a two-volume set that offers comprehensive guidance on the diagnosis of bone tumors based on a modification of the WHO classification as well as management and follow-up. The emphasis throughout is on an integrated approach to diagnosis that highlights the role of clinical, radiologic, and pathologic correlation in reducing the possibility of diagnostic error. The diagnosis of bone tumors is difficult for a variety of reasons, including the numerous types of the tumors with variable subtypes, the protean radiologic manifestations and the variable pathologic findings case by case and even depending on the phase in each case, the presence of reactive changes to the tumor lesion, and overlapping findings between benign and malignant tumors. In addition, it is often more difficult by surgeon’s inadequate biopsy. The author’s aim is to offer the readers the best possible guidance in negotiating these difficulties. For each tumor types, a wide range of cases are presented, from the common to the very rare. Appearances on the full range of imaging studies are illustrated, including conventional radiographs, bone scans, CT scan, MRI, and even PET/CT scans in malignant cases. Attention is also drawn to the role of long-term follow-up radiographs in ensuring correct diagnosis and management. This book will be an ideal resource for all practitioners and researchers who involved in bone tumor diagnosis and also management. Volume 2 covers osteoclastic giant cell-rich tumors, hematopoietic tumors, notochordal tumors, cysts and cyst-like lesions, vascular and neurogenic tumors, and tumors of other mesenchymal cells.
Integrity, Transparency and Corruption in Healthcare & Research on Health, Volume II (Accounting, Finance, Sustainability, Governance & Fraud: Theory and Application)
by Kıymet Tunca ÇalıyurtThis book continues the discussion from Volume I on the risks organizations face in order to succeed with a special focus on the challenges brought on by the COVID-19 virus crisis. Taking on an interdisciplinary focus, the book brings together research from academics and practitioners from all over the world. Topics considered range from corruption in the health sector and COVID-19, eHealth efforts of countries during the pandemic, and fiscal policies and transparency in data sharing for effective management of the pandemic to a path forward to achieve health for all.
Calcium Phosphate Nanocoatings for Bone Regeneration (Tissue Repair and Reconstruction)
by Andy H. Choi Besim Ben-NissanThis book provides in-depth assessment on the latest clinical advances in multifunctional calcium phosphate nanocoatings and its influence on bone regeneration and early healing following implantation. A greater emphasis will be placed on the use of nanocomposite coatings to deliver biological materials such as mesenchymal stem cells, growth factors, bone morphogenetic and extracellular matrix proteins, and pharmaceutics such as simvastatin to improve and promote bone growth as well as reducing the timeframe needed for implant integration in both healthy and osteoporotic patients. The content of the book caters to clinical practitioners and researchers working in the field of biomaterials for bone regeneration.
Hip Arthroplasty: Current and Future Directions
by Mrinal SharmaThis book brings together the latest updates and current trends in arthroplasty of the hip covering the basics as well as complex and revision surgery. Eminent arthroplasty surgeons across the globe have contributed to the chapters and shared their clinical experiences. There are separate sections on primary hip arthroplasty, complex scenarios requiring hip replacement, and detailed management of related complications. It covers revision hip replacement in detail with the latest updates on surgical techniques and implants. There are separate sections on computer navigation and robotic-assisted hip replacement surgeries. A special section on implants and tribology has been added. The language of the book is easy-to-read, user friendly with pictorial representation of relevant surgical steps. Case-based discussions, surgical tips, and summary has been added in each chapter. The references given at the end of each chapter would be useful for those doing research. This book is an essential on-the-desk book for practicing orthopedic surgeons across the globe, beginners in arthroplasty surgery, postgraduate students of orthopedics, DNB students, and those interested in research.
Reliability Engineering Technology of Digital Diagnosis and Treatment Equipment
by Xiuqing Li Jun Gao Wen LiThis book focuses on the reliability engineering of medical devices, especially digital diagnosis and treatment equipment in China. It details the professional technologies and application methods of reliability design analysis, fault model analysis and reliability test of digital diagnosis and treatment equipment, to meet the needs of project undertakers of digital diagnosis and treatment equipment. From the three aspects: safety analysis and EMC design protection, material selection and control, and software engineering and quality, this book provides professional and technical ideas and methods of reliability for the quality problems prone to occur in the field of medical devices, as well as method guidance for readers. Meanwhile, it runs through the whole process of design, engineering, testing, production and management of all digital diagnosis and treatment equipment research and development enterprises and even product R & D enterprises in the field of medicaldevices. It is used as reading materials for personnel of testing institutions and evaluation institutions in medical devices.
Family Medicine OSCE: First Aid to Objective Structured Clinical Examination
by Shaima Lari Shammah Al Memari Dana Al MarzooqiIn this book, a clinician can experience the most typical medical subjects in a primary care setting, which is the highlight. The book brings knowledge and counseling skills into action as it takes you through various scenarios. In addition, it serves as a guide for passing the Objective Structured Clinical Examination, or "OSCE," by mirroring the Middle East and Arab World exam format in a structured fashion. With that, the book left behind distinctive traces that productively revealed its value and reputation.The book chapters provide a systematic approach to patient-centered medical problems, making it easier and handier for the students. The process covers in-depth history remarks, an organized set of physical examinations, and careful counseling tips.
Breast Oncoplasty and Reconstruction: Principles and Practice
by S. V. S. DeoThe book covers the concepts, techniques and strategies of oncoplastic breast surgery and reconstruction for breast cancer patients. It includes contemporary surgical procedures with step-by-step illustrations, pre-operative and post-operative considerations, pearls and pitfalls shared from the personal experiences and surgical practices of the individual authors. Experienced authors with diverse backgrounds and an in-depth understanding of the domains are involved in curating the content of the book. This book mainly focuses on practical tips and surgical techniques to reach a broad spectrum of surgeons practicing breast surgery from low and middle-income countries. It provides both the scientific basis and practical tips from experienced surgeons in the field. Breast cancer is an emerging major public health problem in low and middle-income countries. While the surgical approach to breast cancer has witnessed a major shift from mastectomy to breast conservation, oncoplasty and reconstruction in western countries, the field of breast surgery is still evolving in low and middle-income countries. Barriers to adopting newer surgical approaches include socio-cultural factors, disease-related factors, resource-related factors and availability of expertise. This book fills the gap and helps surgeons in low and middle-income countries in adapting contemporary breast surgical techniques into their day-to-day practice. This book will be relevant for surgical oncologists, breast and endocrine surgeons, general surgeons practicing breast surgery and plastic surgeons. Additionally, it will serve as a resource book for residents and fellows from general surgery, surgical oncology, breast surgery and plastic surgery streams.
Rights in Practice for People with a Learning Disability: Stories of Citizenship
by Liz Tilly Jan WalmsleyThis book aims to raise awareness about the possibility of achieving the goals of the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD), in order for all disabled people to enjoy the benefit of human rights. The stories of people who have been supported to enjoy their rights and their citizenship will enable readers to focus on how services and support can enable people with a learning disability to have their rights upheld, with an outcome of citizenship, independence and achievement. Despite the UNCRDP being in place since 2006, a significant number of learning disability service provider organisations and professionals in the UK are not aware of its existence. This book aims to bridge the gap between policy and practice to demonstrate the value of a human rights approach as the foundation for services and support for people with a learning disability.
Synbiotics in Human Health: Biology to Drug Delivery
by Kamal DuaThis reference book discusses the role of synbiotics in a wide range of disease states, including cardiovascular, reproductive, metabolic, neurodegenerative, gastrointestinal, thrombotic, skin, and inflammatory disorders. It reviews the functions of probiotics in the diagnosis, prevention, or treatment of various disease states. The book further covers improving the targeting efficiency of synbiotics through advanced drug delivery systems such as nanoparticles, microparticles, liposomes, microemulsion, solid lipid nanoparticles, and nano lipid carriers. The chapter addresses the implications of oral and topical delivery of synbiotics in different diseases and presents the safety assessment of synbiotics and clinical trials associated with synbiotics containing drug delivery systems for the treatment of diseases. The book also explores the synergistic welfare of synbiotics nutraceuticals in various conditions such as chronic respiratory diseases, gut health, and neurological functions and examines the toxicological profile, and regulatory aspects of nutraceutical supplements. As such, this book is a valuable resource for academics, research and industry professionals working in Pharmaceutical Sciences, Food Biotechnology, Immunology, and Health Sciences.
Case-based Atlas of Cardiac Imaging
by Sanjiv SharmaThis case-based atlas encompasses all aspects of imaging in congenital cardiac defects, cardiac masses, inflammatory and acquired heart diseases, cardiomyopathies and coronary-related pathologies. The chapters begin with a description of the imaging approach, followed by cases comprehensively covering the gamut of clinical scenarios that may be encountered in clinical practice. The atlas provides pertinent information about each discussed disease state, its imaging diagnosis and recent advances, including role of radiology in management, follow up and prognostication. Cases that may pose as imaging differentials accompany the index case, followed by a variety of companion cases illustrating the possible spectrum of abnormalities that the reader may be confronted with while dealing with the index case. It acts as a guide for the cardiovascular radiologist, physician, paediatrician, internist, cardiologist, cardiothoracic surgeon as well as radiology residents for inculcating an evidence-based approach for choosing the right imaging algorithm in the given clinical situation. The highly visual design of the atlas enables it to act as a quick and ready reference.
Diagnosis of Mycobacterium
by Amit Singh Divakar SharmaThis book covers all the aspects related to the laboratory diagnosis of Mycobacterium. Laboratory diagnosis includes microscopic to advance molecular diagnosis. Moreover, it deals with the methods used to detect antimycobacterial susceptibility tests and drug resistance. Chapters cover most potential methods and techniques from traditional to advanced future diagnostics for identifying tuberculosis, NTM, and latent TB infections. Also discussed the challenges and opportunities in the diagnostic science of infectious disease. This book offers assistance to students, postgraduate medical students, researchers, medical practitioners, postdoctoral fellows, microbiologists, nurses, and public health officers working in tuberculosis control programs to understand various modalities for diagnosis and drug-resistance tuberculosis.
Skeletal Dysplasias & Congenital Malformations
by Surender Singh YadavThis book presents significant clinical and radiological descriptions with photographic details of common and rare Skeletal Dysplasias and Congenital Malformations. It simplifies and classifies skeletal dysplasias and other orthopedic congenital anomalies with the help of a collection of complex cases.It contains 1195 images (404 Coloured). It also explains the simple and systematic approach to correct diagnosis and adequate management of such patients. All types of congenital anomalies of the musculoskeletal system are included, some of them treated.This book assists PG students in the Department of Orthopaedics, Paediatrics, and Radiology. It is also helpful as a ‘Reference Book’ for the concerned Medical teachers, Researchers, General Practitioners, and all others interested. The book will also benefit the parents of such children for correct diagnosis and required management.
Eel Science (Fisheries Science Series)
by Katsumi Tsukamoto Mari Kuroki Soichi WatanabeThis book is a compilation of eel research and fish migration studies for more than 40 years showing the research history and recent advances in eel studies. Dr. Katsumi Tsukamoto, the esteemed editor of this book, has been actively involved in eel research as one of the leading scientists in the world for a long time, and he and his team successfully collected the fertilized eggs and spawn-condition adult eels from the wild for the first time in the world. This book compiles the essentials of the scientific findings obtained by the editor and his colleagues and reviews the latest references of eel science. Knowledge and information in the book such as a spawning area survey, research on artificial production of glass eels, the discovery of a new species, etc. will attract the reader’s interest, as these are written based on the authors’ experiences. Readers can obtain a comprehensive understanding of eels from various aspects of eel science including the cultural and socio-economic importance of eels and valuable scientific information using state-of-the-art approaches. The book also endeavors to contribute to the conservation of eel species, some of which have been classified as endangered by the IUCN and to promoting harmonious coexistence between humans and nature.
Fungi Bioactive Metabolites: Integration of Pharmaceutical Applications
by Sunil Kumar Deshmukh Jacqueline Aparecida Takahashi Sanjai SaxenaThis book presents the exploration and exploitation of various bioactive metabolites obtained from fungi isolated from diverse habitats for pharmaceutical applications. Various fungal sources have been brought under one umbrella ranging from endophytes, marine fungi, endolichenic fungi to fungi existing in the extremophilic conditions like desert and Antarctica and Artic environment. The book tries to cover maximally the range of the pharmaceutical applications wherein these bioactive agents from fungi have been exploited or are in the clinical pipelines and primarily include antibacterial, antifungal, antibiofilm, anticancer, antioxidant, autoimmunological, anti-inflammatory, and anti-thrombotic diseases. The book further emphasizes on the novel strategies to screen or enhance secondary metabolite production. Some other topics includes peptides, nonpeptides drugs, pigments, and enhancement of production of Echinocandin and Kojic acid. The role of bioinformatics in drug discovery and biotransformations have also been discussed. This book is going to be a comprehensive treatise and a valuable source for mycologists, biotechnologists, microbiologists, biotechnologists, and undertaking research in pharmaceutical sector as well as academia in setting up their research aspirations for using fungi in the process of drug discovery and development.
Modern Taxonomy of Bacteria and Archaea: New Methods, Technology and Advances
by Wen-Jun Li Jian-Yu Jiao Nimaichand Salam Manik Prabhu Narsing RaoThis book introduces the current approaches in prokaryotic taxonomy and streamlines the advanced techniques for use in prokaryotic systematics. While highlighting the key differences in the taxonomy of cultured and not-yet-cultured bacteria and archaea, it presents the genomic technology involved in microbial systematics that serves as comprehensive guidelines for isolating and identifying bacteria. Microbial systematics is a fundamentally important discipline area for microbiologists and those seeking to understand Earth’s biodiversity. As bacterial taxonomy is critical in microbial ecology and clinical microbiology works, the correct identification of microbes is crucial. However, the microbial collection existing and described as cultured species so far are either based on the taxonomic pattern that existed during its time of first cultivation. With evolving technology, many microbes were found to be wrongly classified. Therefore, it is essential to keep in contact withthe developing technology and methods for the correct placement of cultured bacteria and their identification. This book is an excellent guideline for adequately identifying, classifying, and describing novel taxa of bacteria and archaea.