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Appointment Planning in Outpatient Clinics and Diagnostic Facilities (SpringerBriefs in Health Care Management and Economics)
by Maartje E. ZonderlandAppointment Planning in Outpatient Clinics and Diagnostic Facilities provides a concise overview of the medical and mathematical aspects of appointment planning in healthcare. This SpringerBrief specifically focuses on outpatient clinics and diagnostic facilities. It begins by introducing the topic from a medical perspective, discussing the kinds of clinics and facilities that are out there, while exploring the appointment systems they use and the problems they face. Next, the mathematical aspects of appointment planning are examined, including Markov decision modelling, queueing theory, etc. Subsequently the book addresses implementation issues that may arise, whether they be technical, medical or cultural. Finally Appointment Planning in Outpatient Clinics and Diagnostic Facilities provides an outlook on the appointment systems of the future and what they will require as a consequence of current and future developments in the medical sector.
Handbook of Healthcare Logistics: Bridging the Gap between Theory and Practice (International Series in Operations Research & Management Science #302)
by Maartje E. Zonderland Richard J. Boucherie Erwin W. Hans Nikky KortbeekThis book presents healthcare logistics solutions that have been successfully implemented at a variety of healthcare facilities. In each case, a major challenge is presented, along with the solution approach and implementation steps, followed by the impact on hospital operations. Problems encountered when implementing the results in practice are also discussed.Much of the work presented is drawn from the experiences of members of the Center for Healthcare Operations Improvement and Research (CHOIR) at Twente, along with the CHOIR spin-off company, Rhythm.
Nipple Sparing Mastectomy: Minimally Invasive Video-Assisted Technique
by Sandro Zonta Adele Sgarella Alberta FerrariThis book describes in detail three different techniques for minimally invasive video-assisted breast surgery: nipple-sparing mastectomy with a hand-held external retractor, with a single-port device, and with robotic assistance. All three techniques can be employed for radical treatment of breast cancer or for risk reduction surgery, and the last two are brand new. The techniques are clearly explained with the aid of numerous high-quality illustrations. All surgical stages are covered in detail, and helpful information is provided on key aspects of surgical anatomy, diagnostic workup, instrumentation, and postoperative management. Nipple Sparing Mastectomy is the first manual to cover these techniques, which are likely to become standard in the field of oncological breast surgery. It will be invaluable for breast surgeons who are skilled in nipple-sparing mastectomy and oncoplastic techniques or are working in breast units that offer genetic counseling to high-risk patients.
Natural Orifice Translumenal Endoscopic Surgery
by Ricardo Zorron Anthony N. Kalloo Facs, Hon Jses Jacques Marescaux Hon Frcs, Facs, Hon Jses Jacques FrcsAre you interested in using NOTES to treat your patients? Do you need a multimedia tool to guide you through all aspects of clinical management? Just as laparoscopic surgery revolutionized surgical practice in the 1980's and 90's, offering genuine competition to traditional open surgery, Natural Orifice Translumenal Endoscopic Surgery (NOTES) presents a genuinely different alternative for surgeons and patients alike as we move forward in the 21st century. Advantages over laparoscopic surgery include lower anesthesia requirements, faster recovery and shorter hospital stays, avoidance of transabdominal wound infections, less immunosuppression, better postoperative pulmonary and diaphragmatic function and of course, the potential for "scarless" abdominal surgery. Combining high-level text with a superb companion website, Natural Orifice Translumenal Endoscopic Surgery (NOTES): Textbook and Video-Atlas provides you with a hands-on, in-depth and practical multimedia tool on this exciting breakthrough, to consult either on the ward or in surgery. Highlights include: Full coverage of the fundamentals of NOTES, its current clinical applications and techniques, and future perspectives Over 50 outstanding videos illustrating NOTES being performed by the experts Full-color throughout and superbly illustrated with over 250 figures Edited by global leaders and pioneers in the field, who have recruited a world-class contributor team As well being a valuable text for gastroenterologists, GI surgeons and general surgeons, Natural Orifice Translumenal Endoscopic Surgery (NOTES): Textbook and Video-Atlas will also appeal to urologists, urologic surgeons, gynecologists, gynecologic surgeons, thoracic and ENT surgeons.
Real-World Evidence in a Patient-Centric Digital Era (Chapman & Hall/CRC Biostatistics Series)
by Kelly H Zou Lobna A. Salem Amrit RayReal-world evidence is defined as evidence generated from real-world data outside randomized controlled trials. As scientific discoveries and methodologies continue to advance, real-world data and their companion technologies offer powerful new tools for evidence generation. Real-World Evidence in a Patient-Centric Digital Era provides perspectives, examples, and insights on the innovative application of real-world evidence to meet patient needs and improve healthcare, with a focus on the pharmaceutical industry. This book presents an overview of key analytical issues and best practices. Special attention is paid to the development, methodologies, and other salient features of the statistical and data science techniques that are customarily used to generate real-world evidence. It provides a review of key topics and emerging trends in cutting-edge data science and health innovation. Features: Provides an overview of statistical and analytic methodologies in real-world evidence to generate insights on healthcare, with a special focus on the pharmaceutical industry Examines timely topics of high relevance to industry such as bioethical considerations, regulatory standards, and compliance requirements Highlights emerging and current trends, and provides guidelines for best practices Illustrates methods through examples and use-case studies to demonstrate impact Provides guidance on software choices and digital applications for successful analytics Real-World Evidence in a Patient-Centric Digital Era will be a vital reference for medical researchers, health technology innovators, data scientists, epidemiologists, population health analysts, health economists, outcomes researchers, policymakers, and analysts in the healthcare industry.
Anti-Cancer N-Heterocyclic Carbene Complexes of Gold: Thiol “Switch-on” Fluorescent Probes, Thioredoxin Reductase Inhibitors and Endoplasmic Reticulum Targeting Agents (Springer Theses)
by Taotao ZouThis thesis focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin. These metal complexes contain N-heterocyclic carbene (NHC) ligands which are able to form strong M-C(NHC) bonds, conferring high stability and favorable lipophilicity, reactivity and binding specificity of metal complexes on biomolecules. The author demonstrates significant advances made in anti-cancer gold(III), gold(I) and platinum(II) complexes. Detailed chemical synthesis, in vitro and/or in vivo anti-cancer activities are clearly presented including: (i) a class of Au(III) complexes containing a highly fluorescent N^N^N ligand and NHC ligand that simultaneously act as fluorescent thiol "switch-on" probes and anti-cancer agents; (ii) a dinuclear gold(I) complex with a mixed diphosphine and bis(NHC) ligand displaying favorable stability and showing significant inhibition of tumor growth in two independent mice models with no observable side effects; and (iii) a panel of stable luminescent cyclometalated platinum(II) complexes exhibiting high specificity to localize to the endoplasmic reticulum (ER) domain, inducing ER stress and cell apoptosis. These works highlight the clinical potential that gold and platinum complexes offer for cancer treatment.
Prions and Diseases
by Wen-Quan Zou Pierluigi GambettiTransmissible spongiform encephalopathies (TSE), known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. Modern studies, including the protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In the second edition of Prions and Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date discussion of these unique infectious pathogens and their associated diseases. The book provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the full range of animal and human prion diseases. As a result, the book contains by far the most authoritative views about the past, present, and future of prions and prion diseases. The new second edition covers such important emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.
Prions and Diseases: Volume 1, Physiology and Pathophysiology
by Wen-Quan Zou Pierluigi GambettiVolume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer's disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.
Pathogenesis and Treatment of Acne and Rosacea
by Christos C. Zouboulis Andreas D. Katsambas Albert M. KligmanThis book, written by experts from across the world, provides comprehensive coverage of acne and rosacea, focusing in particular on pathogenesis and treatment but also considering clinical aspects, prognostic factors, and impacts on quality of life. Both standard knowledge and important, clinically relevant insights that have emerged over the past decade are presented with the goal of assisting the reader in understanding these diseases and improving treatment outcome. It is explained how high-level research has recently given rise to a variety of new concepts in etiology and treatment, and emerging trends are also discussed. The book is in a reader-friendly format that highlights core messages with a very practical and clinical focus. Pathogenesis and Treatment of Acne and Rosacea will be an indispensable reference for all physicians who care for patients with acne or rosacea and for scientists working in the field.
Medical Arabic
by Abderrahman Zouhir Abdulqadir AbdulkarimMedical Arabic is a valuable resource for students interested in learning medical Arabic at ACTFL level Advanced Low. Effective communication is essential in health care, and communication is most effective when both parties share a common language, therefore resulting in a comfortable relationship between health care provider and patient. This textbook is intended for those with prior knowledge of Arabic language and grammar. It is designed to provide students with the linguistic and cultural competencies and medical Arabic terminology necessary to communicate in medical settings such as a hospital, clinic, or a community health care facility. Students will be able to ask questions in Arabic and provide answers in common medical situations, conduct patient interviews, and understand a wider variety of possible responses from patients. The book provides clear explanations of medical vocabulary and concepts as they occur in the reading materials to encourage active interaction with the text. The book’s drills are designed as either in-class exercises or homework. The answer key for the book exercises is also provided as a downloadable e-resource. Written by dynamic authors who taught Arabic as a foreign language for several years and reviewed by physicians and professionals in the field, the book is an essential guide for students in medical school, biology, and other science majors. Students will find Medical Arabic more than merely a textbook but rather a pathway to enhance their communication skills effectively.
Life and Learning of Digital Teens: Adolescents and digital technology in the Czech Republic (Young People and Learning Processes in School and Everyday Life #6)
by Jiří Zounek Libor Juhaňák Klára ZáleskáThis book describes and explains how digital technologies enter adolescents’ everyday life and learning in different contexts and environments. The book is based on research conducted in recent years in the Czech Republic, the results of which are set within a broad theoretical and international framework.The authors consider the theoretical and methodological anchoring of the topic, describing various approaches in an effort to comprehensively describe and understand the learning process of today’s pupils. They focus on ways to explore learning in the digital era, domestication of digital technology in families, and parents' approaches to digital technology. Attention is paid to adolescents’ competences and autonomy in the use of digital technologies, as well as their views on technology in their lives and learning. The authors summarize the most important results of the research, but also consider the options of empirical research and their own experience with the research of such a complex concept.
A Concise Guide To Intraoperative Monitoring
by George Zouridakis Andrew PapanicolaouCovering both the applications and the related theory, A Concise Guide to Intraoperative Monitoring provides a general but comprehensive introduction to IOM. Unlike existing texts that typically report the results of specific studies, this book presents comprehensive coverage of the entire procedure, as well as the specific protocols used in hospital practice, examples of typical recordings, possible problems, and recommended solutions. At the end of each chapter the author poses several questions for review. These questions help technologists and medical residents in their preparation for the board exams. Taken together, these features make the book an ideal reference or training manual. <p><p> A Concise Guide to Intraoperative Monitoring begins by discussing the basic principles underlying the generation of bioelectrical signals. It then describes the electronic equipment and the various electrophysiological procedures involved in IOM. From this foundation, the book gradually advances to more specific topics, such as surgical procedures, neuronal structures at risk, the optimum combinations of tests to administer, and the proper interpretation of test results. The material also provides you with a background on general anesthesia and analyzes the effects of various drugs on electrophysiological recordings. A Concise Guide to Intraoperative Monitoring also discusses the proper placement of stimulation and recording electrodes, as well as intervention strategies and equipment troubleshooting.
Optical Guided-wave Chemical and Biosensors I
by Mohammed Zourob Akhlesh LakhtakiaFor the first time, distinguished scientists from key institutions worldwide provide a comprehensive approach to optical sensing techniques employing the phenomenon of guided wave propagation for chemical and biosensors. This includes both state-of the-art fundamentals and innovative applications of these techniques. The authors present a deep analysis of their particular subjects in a way to address the needs of novice researchers such as graduate students and post-doctoral scholars as well as of established researchers seeking new avenues. Researchers and practitioners who need a solid foundation or reference will find this work invaluable. This first of two volumes contains eight chapters covering planar waveguides for sensing, as well as sensing techniques based on plasmonic waveguides.
Biological Microarrays: Methods and Protocols (Methods in Molecular Biology #671)
by Mohammed Zourob Kahp-Yang Suh Ali KhademhosseiniRecent developments in microarray technology have changed the landscape of biology and biomedical research, and they have revolutionized RNA and DNA research. In Biological Microarrays: Methods and Protocols, expert researchers explore exciting new developments in the field, providing a comprehensive approach to biological microarrays that conveys not only the state-of-the-art fundamentals, but also includes applications of the most innovative methods. Chapters address both the application of biological microarrays, including DNA/RNA, apatmer, proteins, tissues, oligonucleotides, carbohydrates, biomaterials, cells, bacteria, and virus microarrays, and also explore the different techniques used for generating microarray platforms. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and revolutionary, Biological Microarrays: Methods and Protocols serves as a primary source for academics, practitioners, and professionals in related fields, including biologists, biotechnologists, biochemists, analytical chemists, and biomedical, physical, and microsystems engineers, to name a few, appealing to all of those interested in the present and future state of biological microarray research.
JIMD Reports - Case and Research Reports, 2012/4 (JIMD Reports #9)
by Johannes Zschocke Garry Brown Eva Morava Verena Peters K Michael GibsonJIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
JIMD Reports - Case and Research Reports, Volume 13
by Johannes Zschocke K. Michael Gibson Garry Brown Eva Morava Verena PetersJIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
JIMD Reports, Volume 41: Focus Issue: Adults And Metabolism (Jimd Reports #41)
by Johannes Zschocke Eva Morava Verena Peters Matthias Baumgartner Marc Patterson Shamima RahmanJIMD Reports publishes case and short research reports in the area of inherited metabolic disorders. Case reports highlight some unusual or previously unrecorded feature relevant to the disorder, or serve as an important reminder of clinical or biochemical features of a Mendelian disorder.
Basiswissen Humangenetik (Springer-lehrbuch)
by Johannes Zschocke Christian SchaafMediziner sind häufig mit Fragen der Humangenetik konfrontiert, ob bei Kindern mit Trisomie 21 oder Mukoviszidose-Patienten. In dem Band werden die Grundlagen der Genetik dargestellt – in Verbindung mit praktischen Fragestellungen: Welche Krankheitsbilder gibt es? Wie werden welche Organe beeinflusst? Darüber hinaus werden spezielle klinische Probleme sowie der Umgang mit Patienten und mit Daten erörtert. Das Lehrbuch ist eine Hilfe für Mediziner, wenn sie Patientengespräche führen, Risiken abwägen und ethische Grundsätze im Blick behalten wollen.
Klinische Elektroenzephalographie
by Stephan Zschocke Hans-Christian HansenDie Autoren beschreiben in dem Band die physiologischen und pathophysiologischen Grundlagen der Elektroenzephalographie (EEG) und machen die Technologie Schritt für Schritt verständlich: Behandelt werden die EEG-Potenziale in ihren verschiedenen Formen sowie der Einsatz der EEG in der Intensivmedizin. Das Werk hilft Ärzten, brauchbare Kurven zu gewinnen, Befunde zu verstehen und zu interpretieren, aber auch Fehler zu vermeiden. Die 3., aktualisierte und überarbeitete Auflage enthält ein neues Kapitel über die EEG in der Neuropädiatrie.
Function and Control of the Spx-Family of Proteins Within the Bacterial Stress Response
by Peter ZuberThis SpringerBrief on Spx reviews the investigations that led to the discovery of Spx and its orthologs and ties together the results of various studies that have explored the function and control of spx in Gram-positive organisms. Spx of Bacillus subtilis has been extensively studied, but very little has been published about it. This book incorporates a number of studies that have been conducted in other Gram positive bacteria, which examined the role of Spx orthologs in stress response, bacterial development and virulence. The book contains an overview that will introduce the protein and its orthologous forms, its association with RNA polymerase, the species of Gram-positive bacteria in which it is found, and the conditions in which it is abundant and active. Spx is a member of a large group of proteins belonging to the ArsC/Spx protein family, so the review touches upon the bioinformatic support for the protein family composition and its meaning with regard to protein structure/function.
Urticaria and Angioedema
by Torsten Zuberbier Clive Grattan Marcus MaurerUrticaria is one of the most common diseases encountered in dermatology. The fleeting nature of wheals often makes a first diagnosis by both patients and physicians seem easy. The disease itself is of a highly complex nature, with a variety of clinical manifestations ranging from pinpoint sized wheals to extensive angioedema. Further complexities include the diversity of possible eliciting and aggravating factors, the many different clinical subtypes and the therapeutic responsiveness.This second, extensively revised edition includes the indications listed in the most recent international guidelines, provides a practical, comprehensive review of all clinical aspects and causes, and addresses the diagnosis and therapy of different types of urticaria. Specific chapters are devoted to classification, aetiopathogenesis, patient reported outcomes, acute urticaria, chronic urticaria and its comorbidities, angioedema without weals, inducible urticarias, special populations including children, treatment with antihistamines and omalizumab, other interventions and looking ahead to new therapies. This new edition is a must read for dermatologists, allergists, pediatricians and practitioners of all disciplines who want their patients to benefit from cutting-edge diagnostics and treatments.
Corneal Surgery: Essential Techniques
by Bruno Zuberbuhler David Gartry David Spokes Stephen TuftThis book is an informative and comprehensive guide to the essential techniques currently employed in corneal surgery. It focuses in particular on two principal areas: the treatment of corneal disorders by means of different forms of corneal transplantation and the use of the Excimer laser to treat refractive disorders. In order to facilitate learning and later deployment of the techniques a multimedia approach is used. Surgical steps are described clearly within the book and can then be observed in detail on the accompanying high-quality DVD. A further feature is the inclusion of a chapter devoted to wet lab training, which presents practical preparatory exercises. This book will be of special value as a handy reference for ophthalmologists who are just embarking upon their surgical training. However, it will also be informative for trained eye surgeons, who will be able to compare their own practice with the presented procedures and to assimilate the latest techniques.
Cleaning Up: How Hospital Outsourcing Is Hurting Workers and Endangering Patients (The Culture and Politics of Health Care Work)
by Dan ZuberiTo cut costs and maximize profits, hospitals in the United States and many other countries are outsourcing such tasks as cleaning and food preparation to private contractors. In Cleaning Up, the first book to examine this transformation in the healthcare industry, Dan Zuberi looks at the consequences of outsourcing from two perspectives: its impact on patient safety and its role in increasing socioeconomic inequality. Drawing on years of field research in Vancouver, Canada as well as data from hospitals in the U. S. and Europe, he argues that outsourcing has been disastrous for the cleanliness of hospitals-leading to an increased risk of hospital-acquired infections, a leading cause of severe illness and death-as well as for the effective delivery of other hospital services and the workers themselves. Zuberi's interviews with the low-wage workers who keep hospitals running uncover claims of exposure to near-constant risk of injury and illness. Many report serious concerns about the quality of the work due to understaffing, high turnover, poor training and experience, inadequate cleaning supplies, and on-the-job injuries. Zuberi also presents policy recommendations for improving patient safety by reducing the risk of hospital-acquired infection and ameliorating the work conditions and quality of life of hospital support workers. He makes the case that hospital outsourcing exemplifies the trend towards low-road service-sector jobs that threatens to undermine society's social health, as well as the physical health and well-being of patients in health care settings globally.
Ancient Medicine: From Mesopotamia to Rome
by Laura M. ZucconiThis book by Laura Zucconi is an accessible introductory text to the practice and theory of medicine in the ancient world. In contrast to other works that focus heavily on Greece and Rome, Zucconi&’s Ancient Medicine covers a broader geographical and chronological range. The world of medicine in antiquity consisted of a lot more than Hippocrates and Galen.Zucconi applies historical and anthropological methods to examine the medical cultures of not only Mesopotamia, Egypt, Greece, and Rome but also the Levant, the Anatolian Peninsula, and the Iranian Plateau. Devoting special attention to the fundamental relationship between medicine and theology, Zucconi&’s one-volume introduction brings the physicians, patients, procedures, medicines, and ideas of the past to light.
Ancient Medicine: From Mesopotamia to Rome
by Laura M. ZucconiThis book by Laura Zucconi is an accessible introductory text to the practice and theory of medicine in the ancient world. In contrast to other works that focus heavily on Greece and Rome, Zucconi&’s Ancient Medicine covers a broader geographical and chronological range. The world of medicine in antiquity consisted of a lot more than Hippocrates and Galen.Zucconi applies historical and anthropological methods to examine the medical cultures of not only Mesopotamia, Egypt, Greece, and Rome but also the Levant, the Anatolian Peninsula, and the Iranian Plateau. Devoting special attention to the fundamental relationship between medicine and theology, Zucconi&’s one-volume introduction brings the physicians, patients, procedures, medicines, and ideas of the past to light.