- Table View
- List View
Molecular Imaging of Small Animals
by Habib ZaidiThis book examines the fundamental concepts of multimodality small-animal molecular imaging technologies and their numerous applications in biomedical research. Driven primarily by the widespread availability of various small-animal models of human diseases replicating accurately biological and biochemical processes in vivo, this is a relatively new yet rapidly expanding field that has excellent potential to become a powerful tool in biomedical research and drug development. In addition to being a powerful clinical tool, a number of imaging modalities including but not limited to CT, MRI, SPECT and PET are also used in small laboratory animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease and neurological disorders in living small animal models of disease. In vivo small-animal imaging is playing a pivotal role in the scientific research paradigm enabling to understand human molecular biology and pathophysiology using, for instance, genetically engineered mice with spontaneous diseases that closely mimic human diseases.
Gadd45 Stress Sensor Genes (Advances in Experimental Medicine and Biology #1360)
by M. Raza Zaidi Dan A. LiebermannThis second edition is fully updated throughout and covers the emerging evidence that indicates that the Gadd45 family of proteins plays a unique and critical role as sensors of stress, including genotoxic, physiological, and oncogenic stress. It sheds light on the complex cellular stress response, encompassing myriad molecular pathways with a plethora of regulators and effectors.The GADD45 stress response genes encode small (18 kd) nuclear/cytoplasmic proteins. These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. Despite marked similarities, Gadd45 genes are regulated differentially and exhibit functional diversity. Gadd45 proteins respond to physiological and oncogenic stress, and are implicated in cell cycle arrest, DNA demethylation and repair, apoptosis, cell survival, genomic stability, and inflammation. The purpose of this book is to provide a comprehensive overview of the unique global role that Gadd45 proteins play as stress sensors and the molecular pathways involved.
Ethics in Medicine
by Shabih H. ZaidiThis book both presents a succinct history of medical ethics and discusses a wide range of important ethical dilemmas in the provision of modern health care. A synopsis is provided of ethics through the ages and the role of ethics in the evolution of medicine. Principles and sources of medical ethics, as well as different religious and secular perspectives, are explained. Ethical concerns in relation to a variety of specific issues are then examined. These issues include, for example, human experimentation, stem cell research, assisted reproductive technologies, termination of pregnancy, rationing of health care, euthanasia, and quality of life issues. The author's many years of practicing medicine in different cultures and countries and his passion for theology works, philosophy, literature, poetry, history, and anthropology have informed and enriched the contents of this stimulating book.
Global Medical Education in Normal and Challenging Times (Advances in Science, Technology & Innovation)
by Shabih H. Zaidi Shahid Hassan Shoaleh Bigdeli Tabassum ZehraThis book is written by several medical educators from developed as well as developing countries based on decades of experience in teaching. The unique experience gained during the COVID-19 pandemic has added new dimensions to the traditional pedagogy, andragogy, and heutagogy, documented here. The salient topics include distance learning, virtual classrooms, virtual workshops on OSCEs, open book exams, micro-learning, micro-credentialing, blended or digitalized curriculum delivery, academic leadership, communication skills, professionalism, telemedicine, bioethics, cyber clinics, artificial intelligence, etc. This book is used as a text or reference book by physicians, teachers, scholars, students, and medical universities for teachers' training, capacity building, and guidance on fundamental pillars of cognitive domains of knowledge, skills, and attitude, as well as factual, conceptual, procedural, and metacognitive skills. It is also a source of guidance in faculty enhancement and toward continued quality improvement in medical education.
Vertigo: A Clinical Guide
by Shabih H. Zaidi Arun SinhaThis monograph on vertigo is based on the personal, hands-on, practical and clinical experience of managing vertigo in a large university-affiliated hospital. It covers all aspects of the subject, offering the latest information on epidemiology, aetiopathogenesis, diagnostics, the battery of vestibular and allied tests, treatment, rehabilitative management and ethical considerations. The neglected but substantial problem of paediatric vertigo is addressed, as are the many pathologies in the elderly population that can lead to disequilibrium and repeated falls. This book will prove of value to a range of practitioners, including family physicians, otologists, audiologists, vestibular scientists, neurologists, paediatricians, geriatricians, physiotherapists, rehabilitation therapists and general doctors, as well as medical and nursing students.
Teaching and Learning Methods in Medicine
by Shabih Zaidi Mona NasirThis book considers the evolution of medical education over the centuries, presents various theories and principles of learning (pedagogical and andragogical) and discusses different forms of medical curriculum and the strategies employed to develop them, citing examples from medical schools in developed and developing nations. Instructional methodologies and tools for assessment and evaluation are discussed at length and additional elements of modern medical teaching, such as writing skills, communication skills, evidence-based medicine, medical ethics, skill labs and webinars, are fully considered. In discussing these topics, the authors draw upon the personal experience that they have gained in learning, teaching and disseminating knowledge in many parts of the world over the past four decades. Medical Education in Modern Times will be of interest for medical students, doctors, teachers, nurses, paramedics and health and education planners.
Contemporary Challenges in Medical Education: From Theory to Practice
by Zareen Zaidi Eric I. Rosenberg Rebecca J. BeythWhile medical schools usually emphasize the teaching of advanced scientific fundamentals through a carefully planned, formal curriculum, few focus on the equally crucial “hidden curriculum” of professional attitudes, skills, and behaviors. This concise and practical guide helps educators effectively prepare students for seldom-taught issues that arise daily in the practice of clinical medicine. In this volume, experienced clinician-educators offer real-world examples of various pedagogical and clinical scenarios, providing evidence- and theory-based approaches to managing three areas of growth: professional development, professionalism, and teaching. Acknowledging human fallibility, the editors begin with a framework that institutions, educators, and learners can use to promote well-being, outlining strategies for mindfulness training, relaxation techniques, appreciative inquiry, narrative medicine, and positive psychology. They then apply these strategies to additional developmental topics like failure, burnout, and improving resilience, social identity formation, and graceful self-promotion. The editors move on to discuss power differentials. They suggest ways of combatting microaggressions faced by women and minorities, fostering a safe learning environment where learners feel comfortable advocating in the setting of ethical dilemmas, recognizing and avoiding student mistreatment, and encouraging humility. They close with implications for the classroom, explaining the benefits and pitfalls of electronic health records and social media, the positive and negative attributes of role models, how to comfortably navigate controversial topics like gun ownership and abortion, and teaching empathy. With helpful infographics and case studies, this volume is a valuable resource for frontline educators who wish to help learners navigate the transition from layperson to medical professional.
Treatment of Skin Diseases: A Practical Guide
by Zohra Zaidi Khalid Hussain Simi SudhakaranThis book summarises the key clinical features and their treatment across a range of skin diseases and describes the decision-making process when referring patients to specialists. It describes how treatment of the skin is often very different to other specialities, as both topical and systemic medications are used, and reviews the clinical signs, investigation and diagnostic approaches to skin diseases. Treatment of Skin Diseases: A Practical Guide principally aids primary care physicians, trainee dermatologists and dermatology nurse practitioners, but it is also a convenient management guide for allied health professionals, students and hospital-based physicians. A concise atlas of diagnostic photographs is included and incorporated with a simple set of common differentials to provide a useful reference for primary care readers and those training in dermatology. The book also contains information on the management of common skin problems, together providing a comprehensive introduction to the treatment of skin diseases. The treatment options for secondary and tertiary care are also included to provide a thorough picture of the spectrum of dermatologic therapeutics.
Dermatology in Clinical Practice
by Zohra Zaidi S. W LaniganThis book gives an insight into the common cutaneous disorders, discussing the treatment in detail, and giving a number of treatment options where required. More unusual diseases and syndromes are only mentioned where necessary. The first line physician's needs are kept in mind while writing each chapter, e.g. the chapter on cutaneous signs of systemic disease is described in more detail in comparison to other short books on dermatology, because physicians in the front line of patient management regularly deal with a vast number of medical problems. The book is designed to be short, clear and easy to read, with an emphasis on practical relevant information. It has been designed expressly to assist primary care physicians, residents and fellows in dermatology, and emergency medicine and other first line medical personnel.
3rd International Conference on Radiation Safety & Security in Healthcare Services: Proceedings of the Thirs, ICRSSHS, Dewan Budaya USM, Penang, Malaysia (Lecture Notes in Bioengineering)
by R. ZainonThis book presents the proceedings of the 3rd International Conference on Radiation Safety & Security in Healthcare Services. The conference was held at Universiti Sains Malaysia in Penang on 19th–20th August 2017.
Owning the Sun: A People's History of Monopoly Medicine from Aspirin to COVID-19 Vaccines
by Alexander ZaitchikFor readers of Bad Blood and Empire of Pain, an authoritative look at monopoly medicine from the dawn of patents through the race for COVID-19 vaccines and how the privatization of public science has prioritized profits over peopleOwning the Sun tells the story of one of the most contentious fights in human history: the legal right to produce lifesaving medicines. Medical science began as a discipline geared toward the betterment of all human life, but the merging of research with intellectual property and the rise of the pharmaceutical industry warped and eventually undermined its ethical foundations. Since World War II, federally funded research has facilitated most major medical breakthroughs, yet these drugs are often wholly controlled by price-gouging corporations with growing international ambitions. Why does the U.S. government fund the development of medical science in the name of the public only to relinquish exclusive rights to drug companies, and how does such a system impoverish us, weaken our responses to crises, and, as in the cases of AIDS and COVID-19, put the world at risk? Outlining how generations of public health and science advocates have attempted to hold the line against Big Pharma and their allies in government, Alexander Zaitchik&’s first-of-its-kind history documents the rise of privatized medicine in the United States and its subsequent globalization. From the controversial arrival of patent-wielding German drug firms in the late nineteenth century to present-day coordination between industry and philanthropic organizations—including the influential Bill & Melinda Gates Foundation—that stymie international efforts to vaccinate the world against COVID-19, Owning the Sun tells one of the most important and least understood histories of our time.
Veterinary Clinical Parasitology (7th edition)
by Anne M. Zajac Gary A. ConboyPeacocks can carry Ascaridia eggs while ducks and wild birds carry another ascarid genus. Mites can fool you because they are laterally compressed like fleas. Designed for desk reference but suitable for quick reviews and clinical practice, this guide focuses on morphologic identification of parasites in domestic animals, featuring accurate and cost-effective means of diagnosing parasitic infections. With over 400 color photographs and a layout ideal for field work, this covers the fecal examination for diagnosis, including collection, storage, shipment, exam procedures, use of the microscope, techniques for evaluation in grazing animals, identification of adult worms, and parasites of domestic animals. It also covers detection of protozoan and Helmith parasites in the urinary, reproductive and integumentary systems and in the eye, detection of parasites in the blood, diagnosis of arthropod parasites such as lice, fleas, flies, mites and ticks, and parasites of fish. Annotation ©2006 Book News, Inc. , Portland, OR (booknews. com)
Veterinary Clinical Parasitology
by Anne M. Zajac Gary A. Conboy Susan E. Little Mason V. ReichardNew edition of the market-leading benchtop reference on the diagnosis of internal and external parasites in animals, including expanded coverage of parasites of reptiles, birds, and other exotic species Veterinary Clinical Parasitology, 9th Edition, allows for a quick and accurate reference to internal and external parasites found in a wide variety of domestic animals and laboratory animal host species. Focusing on the tests and information most relevant to daily veterinary practice, this classic benchtop manual contains a wealth of high-quality images to assist readers in diagnosing parasitic disease and identifying and treating relevant parasites. Contributions by leading experts in veterinary pathobiology and parasitology cover fecal examination for the diagnosis of parasitism, detection of parasites in the blood, diagnosis of arthropod parasites, and more. The latest edition contains fully revised material throughout, including new and expanded information on immunodiagnostic and molecular diagnostic tests, additional parasite-specific material on the benefits and limitations of different test modalities, and increased coverage of reptiles, birds, and other exotic and laboratory animals. New sections include up-to-date information on anthelmintics, antiprotozoals, and other antiparasitic drugs, and challenging case studies that provide insights on situations where identification of parasites is especially difficult. Published under the auspices of the American Association of Veterinary Parasitologists (AAVP), this indispensable clinical manual: Describes accurate and cost-effective techniques for diagnosing parasitic infections in animals Presents clear and concise information on the distribution, life cycle, and significance of each parasite covered Contains hundreds of color clinical images to enable rapid picture-matching and aid in diagnosis Offers a spiral-bound format that allows the book to lie flat on the benchtop, ideal for regular use in daily practice Features revised content throughout, including new chapters and images, an improved format, an enhanced color scheme, and an updated companion website Veterinary Clinical Parasitology, 9th Edition is an essential resource for practicing veterinarians, veterinary technicians, diagnosticians, researchers, and students in need of a timely and efficient reference on morphologic identification of parasites in different animal species.
Embedding Culture and Quality for High Performing Organizations
by Norhayati Zakaria Flevy LasradoEmbedding Culture and Quality for High Performing Organizations (978-1-138-48338-5, K349105) Shelving Guide: The aim of this book is to bridge two different core disciplines: quality management and cross-cultural management, based on how multinational corporations work, and how culture determines individual practices and values. Understanding these previously separate fields is essential to keeping multinational cultures innovative and sustainable. The authors’ research blends corporate and cultural perspectives to promote quality management practices that build organizational excellence. Whereas most books currently on the market are based on corporate culture and quality management, this book uniquely considers cross-cultural impacts on organizational effectiveness and global human resource management. This book provides opportunities for business practitioners and researchers to learn practices that are effective in building sustainable organizational excellence. It offers a practice guide to building a quality management program that emphasizes culturally-diverse work environments, cross-cultural management, and organizational excellence.
Sustainable Technologies for the Management of Agricultural Wastes
by Zainul Akmar ZakariaThis book discusses modern technologies for utilizing various types of agricultural waste as a direct means of properly managing its abundance. It explores the potential of using waste materials obtained from the palm oil industry, used cooking oil, maize and tea plantations, as well as citrus-based plants for the production of useful, high-value materials such as pyroligenous acid and bio-oil (Chapter 1), ferulic acid (Chapter 4) and bio-control agents (Chapter 5-7, 9). It also includes case studies to further enhance readers’ understanding. This comprehensive volume is useful to anyone involved in agricultural waste management, green chemistry and agricultural biotechnology. It is also recommended as a reference work for all agriculture and biotechnology libraries.
The Foot Fix: 4 Weeks to Healthier, Happier Feet
by Yamuna ZakeThis book will empower you to get your feet functioning as they should do, without any medical intervention. Includes a 4-week plan of quick-and-easy exercises to get your feet back into shape, plus solutions for specific foot issues, from plantar fasciitis to fallen arches.This is a uniquely helpful and accessible guide to taking control of your own foot health by holistic heath innovator Yamuna Zake. We don't need doctors, orthotics or even surgery to relieve common foot problems, such as plantar fasciitis, bunions, neuromas, arthritis, hammertoes, and flat feet. By learning a correct gait that uses the entire foot to distribute weight, we can relieve and prevent common foot problems without any medical intervention. The book offers an easy-to-follow 4-week program of routines that take just 15 minutes a day during the program and allows readers to fix their feet and take ownership of their body. Each of the four weeks focuses on a different part of the foot: the heel, the arch, the ball and the toes. There are 3-4 exercises in each section and readers try them all and can choose to focus on those exercises in each section that they enjoy most. This programme is then supported with mindful foot practices to ensure bad habits don't return. Six common foot problems are also explored, including their causes (specific incorrect walking patterns) and ways of preventing and relieving them (exercises plus mindful practices). You won't find any medical concepts or terminology in this book, nor do you need to learn complicated foot anatomy. The whole program is based on what you already know: walking. You'll learn how to walk and stand correctly and to use every part of your feet as nature intended. That's all you need to do!
Psychiatric-Mental Health Nurse (PMH-BC) Certification Review
by Raymond ZakhariPsychiatric-Mental Health Nursing (PMH-BC™) Certification Review is designed to help you prepare for the American Nurses Credentialing Center (ANCC) board certification exam. This comprehensive study aid begins with an overview of the exam, scope and standards of practice, and fundamental theories. It examines topics such as therapeutic treatment and management, patient education, cultural competence, communication, health promotion, and crisis management. A wide range of psychiatric disorders, as organized in the DSM-5, are systematically reviewed in a templated approach that takes the reader through the nursing process step by step. <p><p>Each chapter covers everything you need to know to pass the exam and includes end-of-chapter questions to check your knowledge. The review concludes with a full-length practice test to get you ready for exam day. With over 300 practice questions, detailed review content and answer rationales, and access to ExamPrepConnect, this study aid empowers you with the tools and materials to study your way and the confidence to pass the first time, guaranteed! Know that you're ready. Know that you'll pass with Springer Publishing Exam Prep.
The Psychiatric-Mental Health Nurse Practitioner Certification Review Manual
by Raymond ZakhariThis review manual prepares students to successfully pass the ANCC Psychiatric-Mental Health Nurse Practitioner board certification examination. It encompasses all of the essential knowledge required, uses a succinct outline format that highlights critical detail, and systematically follows the test blueprint so that those taking the exam will be optimally prepared. The review manual begins with an overview of the certification examination, self-care, and test tips; the role of the psychiatric-mental health nurse practitioner, the scope of practice, and regulations; and the theoretical foundations of care. Other topics examined include the neuroanatomy and physiology of mental illness; psychopharmacology; physical assessment, diagnostic tests, and differential diagnosis. A wide range of psychiatric disorders, as organized in the DSM-5, are also reviewed. Each of the chapters includes learning objectives, easy-to-read outline format, and end-of-chapter review questions. The review manual concludes with a 150-question practice test. Key Features: - Reflects the latest ANCC test blueprint - Includes test-taking strategies and tips for preparing for the big day; scope of practice; and theoretical foundations of care - Covers a wide range of psychiatric disorders, as organized in the DSM-5 - Includes end-of-chapter review questions and rationales, PLUS a valuable 150-question practice test with rationales―more than 400 questions in total - Purchase includes access to the eBook for use on most mobile devices or computers
Alcohol and Cancer (Advances in Experimental Medicine and Biology #815)
by Samir Zakhari Vasilis Vasiliou Q. Max GuoThe World Health Organization has identified chronic alcohol consumption as one of the top ten risk factors for worldwide burden of disease. The International Agency for Research on Cancer has identified alcohol as carcinogenic to humans, including cancers of the upper aerodigestive tract, colon, liver and breast. Alcohol's actions may be direct e.g. effects on retinoic acid and one-carbon metabolism, or indirect, through metabolites such as acetaldehyde and reactive oxygen species or through various signaling pathways that influence cell cycle and apoptosis that may contribute to carcinogenesis. This report reviews the state of the art in alcohol-related cancer research in ten chapters.
Biological Basis of Alcohol-Induced Cancer (Advances in Experimental Medicine and Biology #815)
by Samir Zakhari Vasilis Vasiliou Helmut K. Seitz Jan B. HoekIn the recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated. This proceedings volume will contain chapters based upon the presentation of the 2nd International Conference on Alcohol and Cancer in Colorado, 2013. The various topics explore the affects of alcohol on: liver and breast cancer; cell signaling and cancer; stem cells; biomarkers and metabolomics; aerodigestive cancers; cancer and the immune system and more.
Neuroimaging of Traumatic Brain Injury
by Natalia Zakharova Valery Kornienko Alexander Potapov Igor ProninThe main purpose of this book is to present emerging neuroimaging data in order to define the role of primary and secondary structural and hemodynamic disturbances in different phases of traumatic brain injury (TBI) and to analyze the potential of diffusion tensor MRI, tractography and CT perfusion imaging in evaluating the dynamics of TBI. The authors present a new MRI classification of brain stem and hemispheric cortical/subcortical damage localization that is of significant prognostic value. New data are provided regarding the pathogenesis and dynamics of diffuse and focal brain injuries and qualitative and quantitative changes in the brain white matter tracts. It is shown that diffuse axonal injury can be considered a clinical model of multidimensional "split brain" with commissural, association and projection fiber disorders. The book will be of interest for neuroradiologists, neurosurgeons, neurologists and others with an interest in the subject.
Telemedicine for the Musculoskeletal Physical Exam: A Pocket Guide
by Mariam Zakhary Grant Cooper Joseph HerreraTelemedicine has ballooned in popularity and necessity in the COVID-19 world, and it has proved its worth. Even in the post-pandemic world, telemedicine will be here to stay, as it offers both patient and provider many advantages. However, physicians are often ill-equipped and lack sufficient training in how to conduct a physical examination remotely. Practical and timely, this book presents the current best practices for performing musculoskeletal examination remotely via telemedicine. It takes an anatomical approach, covering all joints and disorders commonly seen in the clinic, including preparation and general principles, the upper and lower extremities and the axial skeleton. For each region, the challenges and limitations of telemedicine are systematically highlighted and discussed, with techniques clearly described and illustrated. Concluding chapters present telemedicine procedures for both the functional assessment of a patient and evaluation and management of respiratory muscle dysfunction.Orthopedic and sports medicine practitioners, as well as general physicians, nurse practitioners, and physician assistants who treat patients with musculoskeletal disorders, will find this book highly engaging and enlightening.
Escrito sobre el cuerpo: Las bases de la Biomecánica Aplicada al Movimiento para vivir mejor
by Dra. Teresa ZalazarConocé el cuerpo a través de la Biomecánica Aplicada al Movimiento (BAM) y su propuesta de trabajo para aliviar dolores, respirar mejor, evitar lesiones y así lograr un destino más saludable, autónomo y consciente. A la sala de Biomecánica Aplicada al Movimiento (BAM) llegan personas con todo tipo de dolencias, que sufrieron accidentes, se lesionaron, atravesaron una enfermedad, tienen un dolor puntual o les duele todo el cuerpo, o simplemente buscan moverse un poco, respirar mejor y sentirse más aliviados. Este libro es para todos ellos o, como dice Teté -tal como llaman a la doctora Teresa Zalazar su infinidad de pacientes y alumnos-, "es para todas las personas que tienen un cuerpo". Todos tenemos un cuerpo, donde está inscripta la historia de cada uno. Este texto revelador y apasionante es una invitación a descubrir los secretos que esconde el cuerpo, a entender su anatomía y funcionamiento con explicaciones médicas precisas y sencillas, a destrabar las compensaciones instaladas en él, a realizar movimientos dirigidos para lograr mayor flexibilidad, a buscar la forma perfecta de cada uno y a permitir, también, que fluyan los recuerdos y las vivencias que se fueron alojando en él a lo largo de toda la vida.
Connected Medical Devices: Integrating Patient Care Data in Healthcare Systems (HIMSS Book Series)
by John ZaleskiThis book explores how medical device integration (MDI) supports quality patient care and better clinical outcomes by reducing clinical documentation transcription errors, improving data accuracy and density within clinical records and ensuring the complete capture of medical device information on patients. It begins with a comprehensive overview of the types of medical devices in use and the ways in which those devices interact, then examines factors such as interoperability standards, patient identification, clinical alerts and regulatory and security considerations.
Clinical Surveillance: The Actionable Benefits of Objective Medical Device Data for Critical Decision-Making (HIMSS Book Series)
by John R. ZaleskiFor more than a decade, the focus of information technology has been on capturing and sharing data from a patient within an all-encompassing record (a.k.a. the electronic health record, EHR), to promote improved longitudinal oversight in the care of the patient. There are both those who agree and those who disagree as to whether this goal has been met, but it is certainly evolving. A key element to improved patient care has been the automated capture of data from durable medical devices that are the source of (mostly) objective data, from imagery to time-series histories of vital signs and spot-assessments of patients. The capture and use of these data to support clinical workflows have been written about and thoroughly debated. Yet, the use of these data for clinical guidance has been the subject of various papers published in respected medical journals, but without a coherent focus on the general subject of the clinically actionable benefits of objective medical device data for clinical decision-making purposes. Hence, the uniqueness of this book is in providing a single point-of-capture for the targeted clinical benefits of medical device data--both electronic- health-record-based and real-time--for improved clinical decision-making at the point of care, and for the use of these data to address and assess specific types of clinical surveillance. Clinical Surveillance: The Actionable Benefits of Objective Medical Device Data for Crucial Decision-Making focuses on the use of objective, continuously collected medical device data for the purpose of identifying patient deterioration, with a primary focus on those data normally obtained from both the higher-acuity care settings in intensive care units and the lower-acuity settings of general care wards. It includes examples of conditions that demonstrate earlier signs of deterioration including systemic inflammatory response syndrome, opioid-induced respiratory depression, shock induced by systemic failure, and more. The book provides education on how to use these data, such as for clinical interventions, in order to identify examples of how to guide care using automated durable medical device data from higher- and lower-acuity care settings. The book also includes real-world examples of applications that are of high value to clinical end-users and health systems.