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Extrusion Bioprinting of Scaffolds for Tissue Engineering Applications
by Daniel X. ChenThis book introduces readers to the theory and practice of extrusion bio-printing of scaffolds for tissue engineering applications. The author emphasizes the fundamentals and practical applications of extrusion bio-printing to scaffold fabrication, in a manner particularly suitable for those who wish to master the subject matter and apply it to real tissue engineering applications. Readers will learn to design, fabricate, and characterize tissue scaffolds to be created by means of extrusion bio-printing technology.
Grundlagen der Datenanalyse mit R
by Daniel WollschlägerDieses Buch liefert eine anwendungsorientierte Einführung in die Grundlagen der Datenauswertung mit dem freien Statistikpaket R. Es behandelt deskriptive Auswertungen ebenso wie inferenzstatistische Analysen. Neben den geläufigsten univariaten Verfahren berücksichtigt es nonparametrische sowie ausgewählte multivariate Methoden. Zudem deckt es die vielfältigen Möglichkeiten ab, Diagramme zu erstellen und Daten mit anderen Programmen auszutauschen. Die statistischen Verfahren werden an Beispielen erläutert und an vielen Stellen mit Diagrammen illustriert. Hinzu kommen manuelle Kontrollrechnungen, um die Ergebnisse von R Schritt für Schritt nachvollziehbar zu machen. Das Buch richtet sich an alle, die R kennenlernen und in konkreten Aufgabenstellungen einsetzen möchten, ohne bereits über Vorerfahrungen mit befehlsgesteuerten Programmen oder Programmiersprachen zu verfügen.
Grundlagen der Datenanalyse mit R: Eine anwendungsorientierte Einführung (Statistik und ihre Anwendungen)
by Daniel WollschlägerDieses Buch liefert eine anwendungsorientierte Einführung in die Datenauswertung mit der freien Statistikumgebung R. Es behandelt deskriptive Auswertungen ebenso umfassend wie inferenzstatistische Analysen. Neben klassischen univariaten Verfahren berücksichtigt das Buch nonparametrische Tests, Resampling-Methoden und multivariate Statistik. Zudem deckt es die vielfältigen Möglichkeiten ab, Daten aufzubereiten und Diagramme zu erstellen. Die statistischen Verfahren werden anhand von Beispielen erläutert und an vielen Stellen mit Diagrammen illustriert. Das Buch richtet sich an alle, die R kennenlernen und in konkreten Aufgabenstellungen einsetzen möchten, ohne bereits über Vorerfahrungen mit befehlsgesteuerten Programmen oder Programmiersprachen zu verfügen. Für die fünfte Auflage wurde das Buch vollständig aktualisiert: Es bezieht sich nun auf die Version 4.0.0 von R, auch die Auswahl und Darstellung verwendeter Zusatzpakete wurde der dynamischen Entwicklung angepasst. Außerdem wurde insbesondere der Abschnitt zur Datenaufbereitung überarbeitet: Zur stärkeren Ausrichtung auf Data-Science-Anwendungen stellt er nun ausführlich das Paket dplyr vor, enthält eine erweiterte Darstellung von R-Markdown-Dokumenten und bespricht Hinweise zur Reproduzierbarkeit von Auswertungen.
Grundlagen der Datenanalyse mit R: Eine anwendungsorientierte Einführung (Statistik und ihre Anwendungen)
by Daniel WollschlägerDieses Buch liefert eine anwendungsorientierte Einführung in die Datenauswertung mit der freien Statistikumgebung R. Es behandelt deskriptive Auswertungen ebenso umfassend wie inferenzstatistische Analysen. Neben klassischen univariaten Verfahren berücksichtigt das Buch nonparametrische Tests, Resampling-Methoden und multivariate Statistik. Zudem deckt es die vielfältigen Möglichkeiten ab, Daten aufzubereiten und Diagramme zu erstellen. Die statistischen Verfahren werden anhand von Beispielen erläutert und an vielen Stellen mit Diagrammen illustriert.Das Buch richtet sich an alle, die R kennenlernen und in konkreten Aufgabenstellungen einsetzen möchten, ohne bereits über Vorerfahrungen mit befehlsgesteuerten Programmen oder Programmiersprachen zu verfügen. In die vierte Auflage sind sowohl die Neuerungen von R 3.3.2 als auch jüngere Entwicklungen bei den Zusatzpaketen eingeflossen. Gleichzeitig wurde der Text überarbeitet und um ein eigenes Kapitel zu Diagrammen mit ggplot2 erweitert. Der Text behandelt nun auch allgemeine numerische Methoden wie Nullstellensuche, numerische Integration und Ableitung sowie numerische Optimierung.
R kompakt: Der schnelle Einstieg in die Datenanalyse
by Daniel WollschlägerDieses Buch bietet eine kompakte Einführung in die Datenauswertung mit der freien Statistikumgebung R. Ziel ist es dabei, einen Überblick über die Funktionalität von R zu liefern und einen schnellen Einstieg in die deskriptive Datenauswertung sowie in die Umsetzung der wichtigsten statistischen Tests zu ermöglichen. Zudem deckt das Buch die vielfältigen Möglichkeiten ab, Diagramme zu erstellen, Daten mit anderen Programmen auszutauschen und R durch Zusatzpakete zu erweitern. Das Buch ist damit für Leser geeignet, die R kennenlernen und rasch in konkreten Aufgabenstellungen einsetzen möchten.Für die 3. Auflage wurde das Buch grundlegend überarbeitet und auf Neuerungen der R Version 4.1.0 sowie der aktuellen Landschaft der Zusatzpakete abgestimmt. Mit einer stärkeren Ausrichtung auf Data Science Anwendungen stellt das Buch nun ausführlich die Pakete dplyr zur Datenaufbereitung und ggplot2 für Diagramme vor. Darüber hinaus enthält das Buch eine Darstellung von dynamischen R Markdown Dokumenten zur Unterstützung reproduzierbarer Auswertungen.
Drug Control and International Law (Routledge Research in International Law)
by Daniel WisehartThis book provides for an extensive legal analysis of the international drug control system in light of the growing challenges and criticism that this system faces. In the current debate on global drug policy, the central pillars of the international drug control system – the UN Drug Conventions as well as its institutions – are portrayed as outdated, suppressive and seen as an obstacle to necessary changes. The book’s objective is to provide an in-depth and positivist insight into drug control’s present legal framework and thus provide for a better understanding of the normative assumptions upon which drug control is currently based. This is attained by clarifying the objectives of the international drug control system and the premises by which these objectives are to be achieved. The objective of the current global framework of international drug control is the limitation of drugs to medical and scientific purposes. The meaning of this objective and its concrete implications for States’ parties as well as its problems from the perspective of other regimes of international law, most notably international human rights law, are extensively analysed. Additionally, the book focuses on how the international drug control system attempts to reach the objective of confining drugs to medical and scientific purposes, i.e. by setting up a universal system that exercises a rigid control on drug supply. The consequences of this heavy focus on the reduction of drug supply are outlined, and the book concludes by making suggestions on how the international drug control system could be reformed in the near future in order to better meet the existing challenges. The analysis occurs from a general international law perspective. It aims to map the international drug control system within a wider context of international law and to understand whether the problems that the international drug control system faces are exemplary for the difficulties that institutionalized systems of global scope face in the twenty-first century.
Health Technology Assessment
by Daniel WidrigDas Buch befasst sich mit den weltweit laufenden Bemühungen, Health Technology Assessment (HTA) im Gesundheitswesen zu etablieren. Der Autor stellt die historische Entwicklung von HTA dar und präsentiert eine sorgfältige Definition des Begriffes. Dazu gehört eine kritische Auseinandersetzung mit den Grundprinzipien von HTA sowie der damit verknüpften rechtlichen Aspekte. Neben Aufbau und Unterarten von HTAs wird zudem ein Lösungsansatz vorgestellt, um HTA-Arten klar voneinander abzugrenzen. Ein Grossteil der Arbeit umfasst eine zugängliche Einführung in die an HTA beteiligten Disziplinen. Zudem werden ausgewählte nationale und internationale HTA-Agenturen porträtiert. Überlegungen zur ,,Best-Practice" und ein dreistufiger Lösungsansatz zur Implementation von HTA runden das Werk ab. Es ist das erste Werk, dass sich in so ganzheitlicher Weise mit der Thematik auseinandersetzt.
Advances in Vagal Afferent Neurobiology (Frontiers in Neuroscience)
by Bradley J. Undem Daniel WeinreichTaking a comprehensive approach in which all aspects of the vagal afferent system are considered, this extensive text reviews the development, neurochemistry, anatomy, biophysics, pharmacology, and physiology of the vagal afferent nerves. The authors present experimental techniques used to investigate the development, morphology, electrophysiology and reflex function of the vagal afferent nerves, and include state-of-the-art reviews of vagal afferent neurobiology by some of the world's leading experts in these fields.
Health Technology Assessment, Courts and the Right to Healthcare
by Daniel Wei WangBoth developing and developed countries face an increasing mismatch between what patients expect to receive from healthcare and what the public healthcare systems can afford to provide. Where there has been a growing recognition of the entitlement to receive healthcare, the frustrated expectations with regards to the level of provision has led to lawsuits challenging the denial of funding for health treatments by public health systems. This book analyses the impact of courts and litigation on the way health systems set priorities and make rationing decisions. In particular, it focuses on how the judicial protection of the right to healthcare can impact the institutionalization, functioning and centrality of Health Technology Assessment (HTA) for decisions about the funding of treatment. Based on the case study of three jurisdictions – Brazil, Colombia, and England – it shows that courts can be a key driver for the institutionalization of HTA. These case studies show the paradoxes of judicial control, which can promote accountability and impair it, demand administrative competence and undermine bureaucratic capacities. The case studies offer a nuanced and evidence-informed understanding of these paradoxes in the context of health care by showing how the judicial control of priority-setting decisions in health care can be used to require and control an explicit scheme for health technology assessment, but can also limit and circumvent it. It will be essential for those researching Medical Law and Healthcare Policy, Human Rights Law, and Social Rights.
Reducing Gun Violence in America: Informing Policy with Evidence and Analysis
by Daniel W. Webster and Jon S. VernickOutstanding Academic Title, Choice MagazineThe staggering toll of gun violence—which claims 31,000 U.S. lives each year—is an urgent public health issue that demands an effective evidence-based policy response.The Johns Hopkins University convened more than 20 of the world's leading experts on gun violence and policy to summarize relevant research and recommend policies that are both constitutional and have broad public support. Collected for the first time in one volume, this reliable, empirical research and legal analysis will help lawmakers, opinion leaders, and concerned citizens identify policy changes to address mass shootings, along with the less-publicized gun violence that takes an average of 80 lives every day.Selected recommendations include:• Background checks: Establish a universal background check system for all persons purchasing a firearm from any seller. • High-risk individuals: Expand the set of conditions that disqualify an individual from legally purchasing a firearm. • Mental health: Focus federal restrictions on gun purchases by persons with serious mental illness on the dangerousness of the individual.• Trafficking and dealer licensing: Appoint a permanent director to ATF and provide the agency with the authority to develop a range of sanctions for gun dealers who violate gun sales or other laws. • Personalized guns: Provide financial incentives to states to mandate childproof or personalized guns. • Assault weapons and high-capacity magazines: Ban the future sale of assault weapons and the future sale and possession of large-capacity ammunition magazines.• Research funds: Provide adequate federal funds to the Centers for Disease Control and Prevention, National Institutes of Health, and National Institute of Justice for research into the causes and solutions of gun violence.The book includes an analysis of the constitutionality of many recommended policies and data from a national public opinion poll that reflects support among the majority of Americans—including gun owners—for stronger gun policies.
The Cancer Recovery Eating Plan: The Right Foods to Help Fuel Your Recovery
by Daniel W. NixonDr. Nixon, editor-in-chief of the journal Cancer Prevention, cuts through the hype to explain the latest scientific findings on food and cancer. He presents individualized eating plans according to the type of cancer and offers a three-month plan to benefit the person with cancer. Over 100 recipes help put the plan into action.From the Trade Paperback edition.
Clinical Maxillary Sinus Elevation Surgery
by Daniel W. KaoMaxillary sinus elevation, followed by placement of a wide variety of grafting materials, has been the generally accepted surgical protocol for the development of bone in the sinus cavity. Over the years, various techniques have been proposed for maxillary sinus elevation, which differ in surgical approach, bone graft materials, and advanced technology application for hard tissue and soft tissue management.Dr. Kao and a team of experts begin by discussing anatomy, radiographic image applications and limitations, and then provide step-by-step clinical procedures for the lateral window technique, including piezosurgery, and the trans-alveolar methods, including balloon and controlled hydostatic sinus elevation. Also included are chapters on post-operative care and complication management.
Artificial Intelligence for Improved Patient Outcomes: Principles for Moving Forward with Rigorous Science
by Daniel W. ByrneArtificial Intelligence for Improved Patient Outcomes provides new, relevant, and practical information on what AI can do in healthcare and how to assess whether AI is improving health outcomes. With clear insights and a balanced approach, this innovative book offers a one-stop guide on how to design and lead pragmatic real-world AI studies that yield rigorous scientific evidence—all in a manner that is safe and ethical. Daniel Byrne, Director of Artificial Intelligence Research at AVAIL (the Advanced Vanderbilt Artificial Intelligence Laboratory) and author of landmark pragmatic studies published in leading medical journals, shares four decades of experience as a biostatistician and AI researcher. Building on his first book, Publishing Your Medical Research, the author gives the reader the competitive advantage in creating reproducible AI research that will be accepted in prestigious high-impact medical journals.
Manual of Normative Measurements in Head and Neck Imaging
by Daniel Thomas GinatThis text is a comprehensive reference guide for normative measurements of anatomic structures in the head and neck, including lymph nodes, temporal bone, skull base, craniocervical junction, orbit, tonsillar tissues, thyroid, and salivary glands. The aim is to assist in the accurate interpretation of imaging studies of this region, where the size of different structures is of high importance for the differentiation of normal and abnormal anatomy, taking into account patient age and gender. The book includes illustrated examples of the proper measurement techniques. Furthermore, examples of pathology with abnormal measurements are included for comparison. The Manual of Normative Measurements in Head and Neck Imaging will serve as a valuable asset for radiologists and clinicians who are involved in the evaluation of patients with head and neck disorders.
Neuroradiological Imaging of Skin Diseases and Related Conditions
by Daniel Thomas GinatThis unique book, written by acknowledged experts, provides a comprehensive review of the wide spectrum of skin diseases that may affect the head and neck region and central nervous system. The clearly written, informative text is accompanied by abundant examples of radiological imaging and corresponding vivid clinical photographs. Coverage includes congenital skin lesions, neurocutaneous syndromes, benign and malignant skin tumors, vascular malformations and lesions, trauma, infectious and inflammatory processes, and post-treatment appearances. The book will be an invaluable clinical resource for both neuroradiologists and dermatologists. Patients with skin diseases often undergo neuroradiological imaging, and it is therefore important for neuroradiologists to be familiar with the various types of dermatological conditions and their imaging appearances.
Born On a Blue Day
by Daniel Tammet'I was born on 31 January 1979 - a Wednesday. I know it was a Wednesday, because the date is blue in my mind and Wednesdays are always blue, like the number nine or the sound of loud voices arguing.' Like the character Hoffman portrayed, he can perform extraordinary maths in his head, sees numbers as shapes, colours, textures and motions, and can learn to speak a language fluently from scratch in three days. He also has a compulsive need for order and routine. He eats exactly 45 grams of porridge for breakfast and cannot leave the house without counting the number of items of clothing he's wearing. If he gets stressed or unhappy he closes his eyes and counts. But in some ways Daniel is not all like the Rain Man. He is virtually unique amongst people who have severe autisitic disorders in being capable of living a fully-functioning, independent life. It is this incredible self-awareness and ability to communicate what it feels like to live in a totally extraordinary way that makes BORN ON A BLUE DAY so powerful.
Born On a Blue Day: Inside The Extraordinary Mind Of An Autistic Savant
by Daniel Tammet'I was born on 31 January 1979 - a Wednesday. I know it was a Wednesday, because the date is blue in my mind and Wednesdays are always blue, like the number nine or the sound of loud voices arguing.' Like the character Hoffman portrayed, he can perform extraordinary maths in his head, sees numbers as shapes, colours, textures and motions, and can learn to speak a language fluently from scratch in three days. He also has a compulsive need for order and routine. He eats exactly 45 grams of porridge for breakfast and cannot leave the house without counting the number of items of clothing he's wearing. If he gets stressed or unhappy he closes his eyes and counts. But in some ways Daniel is not all like the Rain Man. He is virtually unique amongst people who have severe autisitic disorders in being capable of living a fully-functioning, independent life. It is this incredible self-awareness and ability to communicate what it feels like to live in a totally extraordinary way that makes BORN ON A BLUE DAY so powerful.
Clinical Trials
by Daniel StevenIt started as a simple enough case for Dylan Ice, ambitious African-American attorney at a prestigious St. Louis law firm. Hospitalized patient Nicole Girard was mentally unfit, so her parents wanted guardianship in order to make decisions on her behalf. Dylan easily wins the case, but then Nicole disappears, leaving him with many unanswered questions. Dylan knows he should leave it alone, but as he delves into the mysterious case, he becomes caught in a labyrinth of corruption, conspiracy, and violence in the medical world.
Final Remedy
by Daniel StevenDr. Karen Moore confronts a multimillion-dollar malpractice suit and ugly accusations of racism when a patient dies of an apparent drug overdose, and her only ally is prosecuting attorney Elliot Roth. When a black man dies of an apparent overdose, everyone on the ER staff assumes he's the latest victim of D.C.'s drug epidemic--until he's identified. Now, under ugly accusations of racism, attending physician Dr. Karen Moore has become the target of a multimillion-dollar malpractice suit that could destroy her entire future.
Management of Post-Mortem Pregnancy: Legal and Philosophical Aspects
by Daniel SperlingRecent advances in medical technology have provided healthcare staff with the possibility of maintaining the life of a brain-dead pregnant woman on life-support in order to achieve successful delivery of the foetus. Management of Post-Mortem Pregnancy examines the legal and ethical difficulties surrounding such post-mortem management. Offering practical guidance based on a combined analysis of similar situations that affect pregnant women's lifestyle and physical condition and of the legal framework of pregnancy clauses in advance directive legislation, the volume considers pregnant women's obligations towards their foetuses. It discusses the main moral, legal, psychological, religious, spiritual and physical aspects of the question on the interests of dead people, as well as the jurisprudential question of the foetus' interests. The book will be a valuable guide for all those involved with the decision-making process of such tragic cases. It will also be of wider use to anyone with an interest in legal, ethical and bio-medical issues.
Monkey Mind: A Memoir of Anxiety
by Daniel SmithAnxiety once paralyzed Daniel Smith over a roast beef sandwich, convincing him that a choice between ketchup and barbeque sauce was as dire as that between life and death. It has caused him to chew his cuticles until they bled, wear sweat pads in his armpits, and confess his sexual problems to his psychotherapist mother. It has dogged his days, threatened his sanity, and ruined his relationships. <P><P>In Monkey Mind, Smith articulates what it is like to live with anxiety, defanging the disease with humor, traveling through its demonic layers, and evocatively expressing its self-destructive absurdities and painful internal coherence. With honesty and wit, he exposes anxiety as a pudgy, weak-willed wizard behind a curtain of dread and tames what has always seemed to him, and to the tens of millions of others who suffer from anxiety, a terrible affliction.
Medical Necessity: Health Care Access and the Politics of Decision Making
by Daniel SkinnerHow the politics of &“medical necessity&” complicates American health care The definition of medical necessity has morphed over the years, from a singular physician&’s determination to a complex and dynamic political contest involving patients, medical companies, insurance companies, and government agencies. In this book, Daniel Skinner constructs a comprehensive understanding of the politics of defining this concept, arguing that sustained political engagement with medical necessity is essential to developing a health care system that meets basic public health objectives.From medical marijuana to mental health to reproductive politics, the concept of medical necessity underscores many of the most divisive and contentious debates in American health care. Skinner&’s close reading of medical necessity&’s production illuminates the divides between perceptions of medical need as well as how the gatekeeper concept of medical necessity tends to frame medical objectives. He questions the wisdom of continuing to use medical necessity when thinking critically about vexing health care challenges, exploring the possibility that contracts, rights, and technology may resolve the contentious politics of medical necessity.Skinner ultimately contends that a major shift is needed, one in which health care administrators, doctors, and patients admit that medical necessity is, at its base, a contestable political concept.
Nur rasten und rosten?: Leistungsfähigkeit älterer Menschen in Geschichte und Gegenwart
by Daniel SchäferAktiv, gesund und vor allem produktiv im Alter? Seit mittlerweile 40 Jahren fordern Wissenschaft und Politik ein Umdenken: Alte Menschen sollen selbstständig und leistungsfähig bleiben, statt sich zurückzuziehen und abzubauen. Doch was ist dran an diesen Ideen, und sind sie wirklich so neu? Daniel Schäfer nimmt Sie mit auf einen ausgedehnten Streifzug durch die Kultur- und Wissensgeschichte mit vielen Gedankenanstößen für die Gegenwart. Sie erfahren, was Medizin, Psychologie und andere Forschungsbereiche derzeit über Stärken und Schwächen beim körperlichen, mentalen und sexuellen Altern wissen. Und was Menschen in früheren Epochen über diese Themen gedacht haben. Das zeigt uns: Einseitig positive und negative Altersbilder wirken auch noch heute nach. Doch jenseits dieser Stereotypen gibt es viele unterschiedliche Möglichkeiten, aber auch Grenzen, im Alter für andere und auch für sich selbst tätig zu sein.
Target Organ Toxicity in Marine and Freshwater Teleosts: Organs (New Perspectives: Toxicology and the Environment)
by Daniel Schlenk, William H. BensonAddressing the numerous gaps in current information, Target Organ Toxicology in Marine and Freshwater Teleosts is an essential resource for researchers and professionals in aquatic toxicology and environmental risk assessment. All the chapters are written by researchers who are internationally recognised for their work in mechanistic aspects of aquatic toxicology. Each chapter focuses on a specific target organ or physiological system and describes how various agents disrupt the normal physiological system and processes. This volume is devoted to specific organs with coverage of the gill, kidney, skin, liver and gut. The companion volume, Systems, provides coverage of toxic effects in the central nervous, immune, neurobehavioural and reproductive systems as well as describing general mechanisms of toxicity.
Spectral Techniques In Proteomics
by Daniel S. SemFacilitating the innovation, development, and application of new spectroscopic methods in proteomics, Spectral Techniques in Proteomics provides a broad overview of the spectroscopic toolbox that can be used, either with proteome or sub-proteome mixtures or with individual/purified proteins studied in parallel. It gives a modest overview of