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Adsorption and Phase Behaviour in Nanochannels and Nanotubes
by Lawrence J. Dunne George ManosChannels of nanotubular dimensions exist in a variety of materials (examples are carbon nanotubes and the nanotubular channels of zeolites and zeotypes) and show promise for numerous applications due to their unique properties. One of their most important properties is their capacity to adsorb molecules and these may exist in a variety of phases. "Adsorption and Phase Behaviour in Nanochannels and Nanotubes" provides an excellent review of recent and current work on adsorption on nanometerials. It is an impressive collection of papers dealing with the adsorption and phase behaviour in nanoporous materials from both experimental and theoretical perspectives. "Adsorption and Phase Behaviour in Nanochannels and Nanotubes" focuses on carbon nanotubes as well as zeolites and related materials.
Adsorption and Diffusion in Nanoporous Materials
by Rolando Roque-MalherbeOffering a materials science point of view, the author covers the theory and practice of adsorption and diffusion applied to gases in microporous crystalline, mesoporous ordered, and micro/mesoporous amorphous materials. Examples used include microporous and mesoporous molecular sieves, amorphous silica, and alumina and active carbons, akaganeites, prussian blue analogues, metal organic frameworks and covalent organic frameworks. The use of single component adsorption, diffusion in the characterization of the adsorbent surface, pore volume, pore size distribution, and the study of the parameters characterizing single component transport processes in porous materials are detailed.
Adsorption, Aggregation and Structure Formation in Systems of Charged Particles: From Colloidal to Supracolloidal Assembly (Springer Theses)
by Bhuvnesh BhartiThis thesis presents studies on the interaction of soft materials like surfactants and proteins with hard silica nanomaterials. Due to its interdisciplinary nature it combines concepts from the fields of physical chemistry, nanoscience and materials science, yielding to fundamental insights into the structure-directing forces operating at the nano-scale. It is shown that the morphology of surfactant micellar aggregates adsorbed at the surface of nanoparticles and inside tubular nanopores can be tuned on demand by the co-adsorption of a surface modifier. The interaction of globular proteins with silica nanoparticles is dominated by electrostatic interactions and can be controlled by pH and ionic strength, while the bridging of nanoparticles by adsorbed protein molecules leads to large-scale hybrid aggregates of protein with the nanoparticles. Concepts emerging from the role of electrostatic interactions in the hetero-aggregation of nanoparticles with protein molecules are used for the co-assembly of charged microbeads into linear clusters and chains of controllable length.
AdS3/CFT2 and Holographic Entanglement Entropy (Springer Theses)
by Jie-qiang WuThis book focuses on AdS3/CFT2, addressing different aspects of this correspondence in field theory and in gravity, including entanglement entropy, higher genus partition function, and conformal block. Holographic entanglement entropy is an important area in holographic and quantum information, which implies a deep relation between geometry and quantum entanglement. In this book, the authors use holographic entanglement entropy as a tool to investigate AdS3/CFT2. They study the entanglement entropy at high temperature in field theory and in holographics, and show that the results match each other in classical and one-loop order. In the AdS3/CFT2 system, they examine in detail the correspondence, exploring the higher genus partition function, entanglement entropy in a general system and conformal block, and they find good correspondence in field theory and gravity. The result strongly supports AdS3/CFT2 correspondence. In addition, they develop several important techniques in 2d CFT and 3d gravity, which also offer inspiration for other fields.
AdS/CFT Duality User Guide (Lecture Notes in Physics #903)
by Makoto NatsuumeThis book describes applications of the AdS/CFT duality to the "real world. " The AdS/CFT duality is an idea that originated from string theory and is a powerful tool for analyzing strongly-coupled gauge theories using classical gravitational theories. In recent years, it has been shown that one prediction of AdS/CFT is indeed close to the experimental result of the real quark-gluon plasma. Since then, the AdS/CFT duality has been applied to various fields of physics; examples are QCD, nuclear physics, condensed-matter physics, and nonequilibrium physics. The aim of this book is to provide background materials such as string theory, black holes, nuclear physics, condensed-matter physics, and nonequilibrium physics as well as key applications of the AdS/CFT duality in a single volume. The emphasis throughout the book is on a pedagogical and intuitive approach focusing on the underlying physical concepts. It also includes step-by-step computations for important results, which are useful for beginners. This book will be a valuable reference work for graduate students and researchers in particle physics, general relativity, nuclear physics, nonequilibrium physics, and condensed-matter physics.
Adrenocortical Carcinoma: Basic Science and Clinical Concepts
by Gary D. Hammer Tobias ElseWe anticipate the book to be a definitive text on the subject that explores all aspects of the study of adrenal cancer and the treatment of patients with the disease. Chapters will cover epidemiology, pathogenesis, genetics, cancer stem cells, historic and emerging therapies, mouse models of adrenal cancer, new developments in tumor profiling, worldwide collaborative groups and tumor registries together with resources for the practitioner and community of adrenal cancer scientists. We do not wish this book to compete with the other larger books in the Endocrine and Endocrine Surgery literature. In addition, it is not expected to cover benign adrenal diseases that have been covered in detail in other venues. We envision this book to be a very specialized and exhaustive text on basic, translational and clinical aspects of adrenal cancer.
The Adrenal Medulla 1986-1988 (CRC Press Revivals)
by Stephen W. CarmichaelThis volume provides a complete review of all the articles which have appeared in the literature since 1986 that pertain to the adrenal medulla and adrenal chromaffin. Over 1700 articles are reviewed, organized, and summarized. Topics covered include the transplantation of medulla into the brain, stimulus-secretion coupling, neuropeptides, enzymes of catecholamine biosynthesis, growth factors, neural regulation and clinical considerations, including imaging and tumors. This book will provide interesting reading for neurobiologists, cell biologists, pathologists, diagnostic radiologists, and advanced biology students.
ADP-ribosylation and NAD+ Utilizing Enzymes: Methods and Protocols (Methods in Molecular Biology #1813)
by Paul ChangThis volume focuses on mono-ADP-ribosylation and enzymes that use NAD+ including Sirtuins, PARPs, and bacterial and eukaryotic ADP-ribosyltransferases. The chapters in this book are organized into eight parts, and offer detailed descriptions of key protocols used to study topics such as in vitro techniques for ADP-ribosylation substrate identification; biochemical and biophysical assays of PAR-WWE domain interactions; monitoring expression and enzyme activity of ecto-ARTCs; HPLC-based enzymes assays for Sirtuins; and identifying target RNAs of PARPs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, ADP-ribosylation and NAD+ Utilizing Enzymes: Methods and Protocols is a valuable resource for anyone interested in this developing and expanding field.
Adoptive Cellular Immunotherapy of Cancer
by H. C. StevensonThis volume presents the most complicated and powerful cancer biotherapies developed. It provides an overview of human immune system function and the mechanisms by which adoptive cellular immunotherapies (ACI) harnesses the activity. The volume provides a vision on the developments in ACI.
Adoption of LMS in Higher Educational Institutions of the Middle East (Advances in Science, Technology & Innovation)
by Rashid A. Khan Hassan Qudrat-UllahThis book discusses the adoption of learning management systems (LMS) in higher education institutions. It presents influential predictors that may impact instructors’ behavioral intention to adopt learning management systems in the context of Arab culture, as well as a unique model of technology acceptance that draws on and combines previous technology adoption models (i.e., a modified unified theory of acceptance and use of technology model – UTAUT2). Moreover, this study extends the UTAUT2 model by including Hofstede’s (1980) cultural dimensions, and technology awareness as the moderators of the model. It also describes the explanatory technique approach used to collect quantitative data from the instructors at higher education institutions in Saudi Arabia and were analyzed with structural equation modeling using SPSS/Amos software. The findings revealed that facilitating conditions were the strongest predictor of behavioral intention to adopt an LMS, followed by performance expectancy and hedonic motivation, technology awareness, and cultural dimensions exerted a moderating influence on instructors’ behavioral intention to use LMS in their teaching. By including new constructs, this becomes the first study of its kind exploring instructors’ use of LMS in Higher Educational Institutions of Saudi Arabia and other countries of the Middle East. It offers practical insights for a broad range of researchers and professionals at higher education institutions and serves as a reference guide for designers of learning management systems (e.g., blackboard systems), policymakers, and the Ministry of Education staff.
The Adoptee's Guide to DNA Testing: How to Use Genetic Genealogy to Discover Your Long-Lost Family
by Tamar WeinbergReconnect with your roots! Adoptees, foundlings, and others with unknown parentage face unique challenges in researching their ancestors. Enter this book: a comprehensive guide to adoption genealogy that has the resources you need to find your family through genetic testing. Inside, you'll find:Strategies for connecting your genealogy to previous genealogistsDetailed guides for using DNA tests and tools, plus how to analyze your test results and apply them to researchReal-life success stories that put the book's techniques into practice and inspire you to seek your own discoveries
Adolescents and Adults with Learning Disabilities and ADHD
by Noël GreggMost of the literature on learning disabilities and attention-deficit/hyperactivity disorder (ADHD) focuses on the needs of elementary school-age children, but older students with these conditions also require significant support. Comprehensive and authoritative, this book helps educators and clinicians navigate the maze of laws, policies, and scientific research relating to diagnostic and intervention decision making for adolescents and adults. Leading expert No\u00ebl Gregg provides clear guidance on how to conduct and document evidence-based assessments and select appropriate instructional and testing accommodations. Featuring helpful case vignettes, decision-making flowcharts, and coverage of the latest assistive technologies, the book gives special attention to supporting students during the crucial transition from high school to higher education or vocational settings.
Adolescence
by Laurence SteinbergCutting-edge science, personalized for today’s students. <p><p> As a well-respected researcher, Laurence Steinberg connects current research with real-world application, helping students see the similarities and differences in adolescent development across different social, economic, and cultural backgrounds. <p><p> Through an integrated, personalized digital learning program, students gain the insight they need to study smarter, stay focused, and improve their performance.
ADN. EL DETECTOR DE MENTIRAS (EBOOK)
by Viviana Bernath"A través de la investigación de casos reales, Viviana Bernath aborda, con autoridad y sencillez, un tema crucial de nuestro tiempo: el de las implicaciones psicosociales derivadas del acceso a la información genética. Expresión de un hondo humanismo, su enfoque interesará tanto al lector profano como al especialista sensible a las relaciones entre su quehacer y la comunidad. Al igual que todas las revoluciones del conocimiento que lo precedieron -la de Aristóteles, la de Galileo, la de Newton, la de Darwin, la de Freud, la de Einstein- el descubrimiento del ADN sitúa la existencia humana en un nuevo marco histórico tan cautivante como polémico. Consciente de las consecuencias éticas, subjetivas e interdisciplinarias que entraña el acceso a la información genética, la autora rehúye las racionalizaciones fáciles y cualquier triunfalismo tecnocrático para internarse, con lucidez y cautela, en el territorio brumoso e insoslayable del sentido del conocimiento. ADN. El detector de mentiras es un libro apasionante, rico en testimonios y abierto a esa pluralidad de perspectivas que exige la comprensión cabal del complejísimo asunto que se tiene entre manos. Con él, Viviana Bernath, investigadora de creciente prestigio profesional, se revela como una de nuestras mejores divulgadoras científicas." Santiago Kovadloff
ADN. El detector de mentiras: Infidelidad, adopción, herencia, diagnóstico de enfermedades, reproducción asist
by Viviana BernathA través de la investigación de casos reales, la autora reflexionaacerca de las implicaciones psicosociales derivadas del acceso a lainformación genética. Cómo el ADN revolucionó temas como el diagnósticode enfermedades, la infidelidad, la fertilización asistida, entre otros. «Expresión de un hondo humanismo, su enfoque interesará tantoal lector profano como al especialista sensible a las relaciones entresu quehacer y la comunidad. Al igual que todas las revoluciones delconocimiento que lo precedieron -la de Aristóteles, la de Galileo, la deNewton, la de Darwin, la de Freud, la de Einstein- el descubrimiento delADN sitúa la existencia humana en un nuevo marco histórico tancautivante como polémico.Consciente de las consecuencias éticas, subjetivas e interdisciplinariasque entraña el acceso a la información genética, la autora rehúye lasracionalizaciones fáciles y cualquier triunfalismo tecnocrático parainternarse, con lucidez y cautela, en el territorio brumoso einsoslayable del sentido del conocimiento."ADN. El detector de mentiras" es un libro apasionante, rico entestimonios y abierto a esa pluralidad de perspectivas que exige lacomprensión cabal del complejísimo asunto que se tiene entre manos. Conél, Viviana Bernath, investigadora de creciente prestigio profesional,se revela como una de nuestras mejores divulgadoras científicas».Santiago Kovadloff
Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Springer Theses)
by Wenfei JinIn this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.
Admissions: Life as a Brain Surgeon
by Henry MarshThe International Bestseller"Consistently entertaining...Honesty is abundantly apparent here--a quality as rare and commendable in elite surgeons as one suspects it is in memoirists." —The Guardian"Disarmingly frank storytelling...his reflections on death and dying equal those in Atul Gawande's excellent Being Mortal." —The EconomistHenry Marsh has spent a lifetime operating on the surgical frontline. There have been exhilarating highs and devastating lows, but his love for the practice of neurosurgery has never wavered. Following the publication of his celebrated New York Times bestseller Do No Harm, Marsh retired from his full-time job in England to work pro bono in Ukraine and Nepal. In Admissions he describes the difficulties of working in these troubled, impoverished countries and the further insights it has given him into the practice of medicine. Marsh also faces up to the burden of responsibility that can come with trying to reduce human suffering. Unearthing memories of his early days as a medical student, and the experiences that shaped him as a young surgeon, he explores the difficulties of a profession that deals in probabilities rather than certainties, and where the overwhelming urge to prolong life can come at a tragic cost for patients and those who love them.Reflecting on what forty years of handling the human brain has taught him, Marsh finds a different purpose in life as he approaches the end of his professional career and a fresh understanding of what matters to us all in the end.
Admissible Consensus and Consensualization for Singular Multi-agent Systems (Engineering Applications of Computational Methods #11)
by Jianxiang Xi Le Wang Xiaogang Yang Jiuan Gao Ruitao LuThis book explores admissible consensus analysis and design problems concerning singular multi-agent systems, addressing various impact factors including time delays, external disturbances, switching topologies, protocol states, topology structures, and performance constraint. It also discusses the state-space decomposition method, a key technique that can decompose the motions of singular multi-agent systems into two parts: the relative motion and the whole motion. The relative motion is independent of the whole motion. Further, it describes the admissible consensus analysis and determination of the design criteria for different impact factors using the Lyapunov method, the linear matrix inequality tool, and the generalized Riccati equation method. This book is a valuable reference resource for graduate students of control theory and engineering and researchers in the field of multi-agent systems.
Admirable Evasions
by Theodore DalrympleIn Admirable Evasions, Theodore Dalrymple explains why human self-understanding has not been bettered by the false promises of the different schools of psychological thought. Most psychological explanations of human behavior are not only ludicrously inadequate oversimplifications, argues Dalrymple, they are socially harmful in that they allow those who believe in them to evade personal responsibility for their actions and to put the blame on a multitude of scapegoats: on their childhood, their genes, their neurochemistry, even on evolutionary pressures.Dalrymple reveals how the fashionable schools of psychoanalysis, behaviorism, modern neuroscience, and evolutionary psychology all prevent the kind of honest self-examination that is necessary to the formation of human character. Instead, they promote self-obsession without self-examination, and the gross overuse of medicines that affect the mind.Admirable Evasions also considers metaphysical objections to the assumptions of psychology, and suggests that literature is a far more illuminating window into the human condition than psychology could ever hope to be.
ADME Processes in Pharmaceutical Sciences: Dosage, Design, and Pharmacotherapy
by Alan Talevi Pablo A. QuirogaAbsorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. Whereas primarily oriented to Pharmacy students and graduates, it can also be useful for scientist from different fields elated to pharmaceutics and pharmacology. (e.g., material scientists, material engineers, medicinal chemists, physicians) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and related biological background.Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies are included as teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, in silico and in vitro prediction of ADME properties, or chronopharmacokinetic. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and is written with experts on the correspondent topic, including industrial scientists and academics from USA and UK.Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations. ADME Processes and Pharmaceutical Sciences is written as a core textbook for courses on pharmaceutical sciences: pharmacology, pharmacokinetics,drug delivery, biopharmaceutics, drug design and medicinal chemistry courses.
The ADME Encyclopedia: A Comprehensive Guide on Biopharmacy and Pharmacokinetics
by Alan TaleviThe ADME Encyclopedia covers pharmacokinetic phenomena (Absorption, Distribution, Metabolism and Excretion processes) and their relationship with the design of pharmaceutical carriers and the success of drug therapies. It covers both basic and advanced knowledge, serving as introductory material for students of biomedical careers and also as reference, updated material for graduates and professionals working in any field related to pharmaceutical sciences (medicine, pharmaceutical technology, materials science, medicinal chemistry). Structured as alphabetically ordered entries with cross-references, the Encyclopedia not only provides basic knowledge on ADME processes, but also detailed entries on some advanced subjects such as drug transporters, last generation pharmaceutical carriers, pharmacogenomics, personalized medicine, bioequivalence studies, biowaivers, biopharmaceuticals, gene delivery, pharmacometrics, pharmacokinetic drug interactions or in silico and in vitro assessment of ADME properties
ADME-Enabling Technologies in Drug Design and Development
by Donglu Zhang Sekhar SurapaneniA comprehensive guide to cutting-edge tools in ADME research The last decade has seen tremendous progress in the development of analytical techniques such as mass spectrometry and molecular biology tools, resulting in important advances in drug discovery, particularly in the area of absorption, distribution, metabolism, and excretion (ADME). ADME-Enabling Technologies in Drug Design and Development focuses on the current state of the art in the field, presenting a comprehensive review of the latest tools for generating ADME data in drug discovery. It examines the broadest possible range of available technologies, giving readers the information they need to choose the right tool for a given application, a key requisite for obtaining favorable results in a timely fashion for regulatory filings. With over thirty contributed chapters by an international team of experts, the book provides: A thorough examination of current tools, covering both electronic/mechanical technologies and biologically based ones Coverage of applications for each technology, including key parameters, optimal conditions for intended results, protocols, and case studies Detailed discussion of emerging tools and techniques, from stem cells and genetically modified animal models to imaging technologies Numerous figures and diagrams throughout the text Scientists and researchers in drug metabolism, pharmacology, medicinal chemistry, pharmaceutics, toxicology, and bioanalytical science will find ADME-Enabling Technologies in Drug Design and Development an invaluable guide to the entire drug development process, from discovery to regulatory issues.
ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development
by Honghui Zhou Frank-Peter TheilWith an emphasis on the fundamental and practical aspects of ADME for therapeutic proteins, this book helps readers strategize, plan and implement translational research for biologic drugs. • Details cutting-edge ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs• Combines theoretical with practical aspects of ADME in biologic drug discovery and development and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned perspective • Includes case studies about leveraging ADME to improve biologics drug development for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines• Presents regulatory expectations and industry perspectives for developing biologic drugs in USA, EU, and Japan• Provides mechanistic insight into biodistribution and target-driven pharmacokinetics in important sites of action such as tumors and the brain
Adjuvants and Agrochemicals: Volume 2: Recent Development, Application, and Bibliography of Agro-Adjuvants
by Paul N. ChowStudies of Adjuvants involve many scientific fields from basic research of the chemistry, through investigations into physiological effects and environmental impact, to mixture formulation and field use. These important areas are illustrated in these two volumes, which are contributions from the First International Symposium on Adjuvants for Agrochemicals, held in Brandon, Manitoba on August 5 to 7, 1986. A total of 200 participants from 19 countries met to discuss their common interest in adjuvant science, technology, and application. It is the editors hope that these volumes will stimulate interest in and promote a better understanding of the chemical, physiological, and agronomic aspects of adjuvants as they relate agrochemicals. In addition, the revisedAdjuvants for Agrochemicals: A Selected Bibliography of World Literature in the English Language will be a valuable resource for agricultural researchers and other users. We hope that adjuvant research will lead to even safer, more efficient, and more economical use of chemicals in agriculture and forestry.
Adjuvants and Agrochemicals: Volume 1: Mode Of Action and Physiological Activity
by Paul N. ChowStudies of Adjuvants involve many scientific fields from basic research of the chemistry, through investigations into physiological effects and environmental impact, to mixture formulation and field use. These important areas are illustrated in these two volumes, which are contributions from the First International Symposium on Adjuvants for Agrochemicals, held in Brandon, Manitoba on August 5 to 7, 1986. A total of 200 participants from 19 countries met to discuss their common interest in adjuvant science, technology, and application. It is the editors hope that these volumes will stimulate interest in and promote a better understanding of the chemical, physiological, and agronomic aspects of adjuvants as they relate agrochemicals. In addition, the revisedAdjuvants for Agrochemicals: A Selected Bibliography of World Literature in the English Language will be a valuable resource for agricultural researchers and other users. We hope that adjuvant research will lead to even safer, more efficient, and more economical use of chemicals in agriculture and forestry.