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Pharmaceutical Biotechnology: A Focus on Industrial Application
by Adalberto Pessoa Jr., Michele Vitolo Paul Frederick LongPharmaceutical Biotechnology: A Focus on Industrial Application covers the development of new biopharmaceuticals as well as the improvement of those being produced. The main purpose is to provide background and concepts related to pharmaceutical biotechnology, together with an industrial perspective. This is a comprehensive text for undergraduates, graduates and academics in biochemistry, pharmacology and biopharmaceutics, as well as professionals working on the interdisciplinary field of pharmaceutical biotechnology. Written with educators in mind, this book provides teachers with background material to enhance their classes and offers students and other readers an easy-to-read text that examines the step-by-step stages of the development of new biopharmaceuticals. Features: Discusses specific points of great current relevance in relation to new processes as well as traditional processes Addresses the main unitary operations used in the biopharmaceutical industry such as upstream and downstream Includes chapters that allow a broad evaluation of the production process Dr. Adalberto Pessoa Jr. is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo and Visiting Senior Professor at King’s College London. He has experience in enzyme and fermentation technology and in the purification processes of biotechnological products such as liquid–liquid extraction, cross-flow filtration and chromatography of interest to the pharmaceutical and food industries. Dr. Michele Vitolo is Full Professor at the School of Pharmaceutical Sciences of the University of São Paulo. He has experience in enzyme technology, in immobilization techniques (aiming the reuse of the biocatalyst) and in the operation of membrane reactors for obtaining biotechnological products of interest to the pharmaceutical, chemical and food industries. Dr. Paul F. Long is Professor of Biotechnology at King's College London and Visiting International Research Professor at the University of São Paulo. He is a microbiologist by training and his research uses a combination of bioinformatics, laboratory and field studies to discover new medicines from nature, particularly from the marine environment.
Purification of Biotechnological Products: A Focus on Industrial Applications (ISSN)
by Pessoa Jr. Adalberto Beatriz Vahan Kilikian Paul LongThis outstanding text focuses on providing professionals and students working in the pharmaceutical and biotechnology field with the background necessary for developing of a product or process and with the necessary rigor required by federal regulatory agencies in the pharmaceutical industry. The material will enable teachers, lecturers and professors in biotechnology to prepare courses on basic concepts and applications for the purification of biotechnological products of industrial interest. These can be applied in practice, for example, with projects on purification development on an industrial scale or useful unit operations for the development of bioproducts of commercial interest.Features: Purification and development of new bioproducts and improvement of those being produced. Provides a background and concepts on the purification of biomolecules and with an industrial perspective. It allows professionals to understand the entire process of developing a biopharmaceutical or bio-food, from bench to industry in biotechnology; one of the fastest-growing sectors of the economy. It promotes the dissemination of information in a didactic way which is of paramount importance for interdisciplinary fields It enables the reader to follow step-by-step stages of the development of a new biopharmaceutical, and allows the optimization of existing processes.
The Physics of Baseball
by Robert K. AdairScads of interesting facts about baseball as well as the physical laws of the game.
The Physics of Baseball: Third Edition, Revised, Updated, and Expanded
by Robert K. AdairBlending scientific fact and sports trivia, Robert Adair examines what a baseball or player in motion does-and why. How fast can a batted ball go? What effect do stitch patterns have on wind resistance? How far does a curve ball break? Who reaches first base faster after a bunt, a right- or left-handed batter? The answers are often surprising—and always illuminating.This newly revised third edition considers recent developments in the science of sport such as the neurophysiology of batting, bat vibration, and the character of the "sweet spot." Faster pitchers, longer hitters, and enclosed stadiums also get a good, hard scientific look to determine their effects on the game.Filled with anecdotes about famous players and incidents, The Physics of Baseball provides fans with fascinating insights into America's favorite pastime.
Thomas Alva Edison: Inventing the Electric Age
by Gene AdairThomas Alva Edison revolutionized daily life as few people before or after him have done. The light bulb, the phonograph, the motion picture--through these and countless other technological marvels Edison left his mark on the modern world. Although he had little formal education, Edison showed a remarkable talent for practical science by the time he became a teenager. He was in his early twenties when he launched his inventing career in Boston (and later in New York City). In 1867, he established the world's first industrial research laboratory in Menlo Park, N. J. , and within six years, he and his assistants had developed a light-and-power system that amazed the world. Edison's inventions made him a millionaire, but money was always far less important to him than inventing itself. Even in his eighties, Edison stayed busy as he searched for a domestic source for rubber. When he died in 1931, the nation dimmed its lights in tribute.
Bone Adaptation: In Silico Approach (Frontiers of Biomechanics #2)
by Taiji Adachi Yoshitaka Kameo Ken-Ichi TsubotaThis book focuses on the systems biomechanics of bone remodeling that provide a multiscale platform for bone adaptation, spanning the cellular, tissue, and organ levels. The mathematical model explained in each section provides concrete examples of in silico approaches for bone adaptation. It will be immensely useful for readers interested in bone morphology and metabolism and will serve as an effective bridge connecting mechanics, cellular and molecular biology, and medical sciences. These in silico approaches towards exploring the mechanisms by which the functioning of dynamic living systems is established and maintained have potential for facilitating the efforts of graduate students and young researchers pioneering new frontiers of biomechanics.
Technological Progress, Income Distribution, and Unemployment: Theory and Empirics (SpringerBriefs in Economics)
by Hideyuki Adachi Kazuyuki Inagaki Tamotsu Nakamura Yasuyuki OsumiThis volume develops original methods of analyzing biased technological progress in the theory and empirics of economic growth and income distribution. Motivated by sharp increases in wage and income inequalities in the world since the beginning of the new century, many macroeconomists have begun to realize the importance of biased technological changes. However, the comprehensive explanations have not yet appeared. This volume analyzes the effects of factor-biased technological progress on growth and income distribution and shows that long-run trends of the capital-income ratio and capital share of income consistent with Piketty’s 2014 empirical results emerge. Incorporating the modified version of induced innovation theory into the standard neoclassical growth model, it also explains the long-run fluctuations of growth and income distribution consistent with the data shown in Piketty. Introducing a wage-setting function, the neoclassical growth model is modified to account for unemployment as well as to examine the dynamics of unemployment and the labor share of income under biased technological progress. Applying a new econometric method to Japanese industrial data, the authors test the key assumptions employed and important results derived in the theoretical part of this book.
Adult Crying: A Biopsychosocial Approach
by Ad J.J.M. Vingerhoets Randolph R. CorneliusCrying is a typical human expression of emotion. Surprisingly, until now little scientific attention has been devoted to this phenomenon. Many textbooks on emotion fail to pay attention to it, and in scientific journals there are hardly any contributions focusing on this behavior. In contrast, there is much interest from the lay public, allowing pseudo-scientists to formulate theories that have little or no scientific basis. Is there any evidence in support of statements that crying is healthy or that not crying may result in toxification? How do people react to the crying of others? Is crying important for the diagnosis of depression, and if so, how? This book aims to fill this gap in scientific literature. Crying is discussed from several perspectives and specific attention is given to methodological issues and assessment. Each chapter provides a review and a summary of the relevant scientific literature.
An Assessment of the Science Proposed for the Deep Underground Science and Engineering Laboratory(DUSEL)
by Ad Hoc Committee to Assess the Science Proposed for a Deep Underground Science Engineering LaboratoryAccording to the big bang theory, our Universe began in a state of unimaginably high energy and density, contained in a space of subatomic dimensions. At that time, unlike today, the fundamental forces of nature were presumably unified and the particles present were interacting at energies not attainable by present-day accelerators. Underground laboratories provide the conditions to investigate processes involving rare phenomena in matter and to detect the weak effects of highly elusive particles by replicating similar environments to those once harnessed during the earliest states of the Earth. These laboratories now appear to be the gateway to understanding the physics of the grand unification of the forces of nature. Built to shield extremely sensitive detectors from the noise of their surroundings and the signals associated with cosmic rays, underground facilities have been established during the last 30 years at a number of sites worldwide. To date, the United States' efforts to develop such facilities have been modest and consist primarily of small underground laboratories. However, the U. S. underground community has pushed for larger underground facilities on the scale of major laboratories in other countries. An Assessment of the Deep Underground Science and Engineering Laboratory (DUSEL) addresses this matter by evaluating the major physics questions and experiments that could be explored with the proposed DUSEL. Measuring the potential impact, this assessment also examines the broader effects of the DUSEL in regards to education and public outreach, and evaluates the need associated with developing U. S. programs similar to science programs in other regions of the world.
Assessment Of Mission Size Trade-offs For Nasa's Earth And Space Science Missions
by Ad Hoc Committee on the Assessment of Mission Size Trade-offs for Earth Space Science MissionsThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
Probability 1
by D. AczelFor thousands of years, it was the visionaries and writers who argued that we cannot be alone-that there is intellegent life in the universe. Now, with the discoveries of the Hubble Telescope, data emerging from Mars, and knowledge about life at the extremes, scientists are taking up where they left off. Amir Aczel, author of Fermat's Last Theorem, pulls together everyting science has discovered, and mixes in proabability theory, to argure the case for the existence of intelligent life beyond this planet. Probability 1 is an extraordinary tour de force in which the author draws on cosmology, math, and biology to tell the rollicking good story of scientists tackling important scientific questions that help answer this fundamental question. What is the probability of intelligent life in the universe? Read this book, and you'll be convinced, by the power of the argument and the excitement of the science.
Descartes's Secret Notebook: A True Tale of Mathematics, Mysticism , and the Quest to Understand the Universe
by Amir D. AczelRené Descartes (1596–1650) is one of the towering and central figures in Western philosophy and mathematics. His apothegm “Cogito, ergo sum” marked the birth of the mind-body problem, while his creation of so-called Cartesian coordinates have made our physical and intellectual conquest of physical space possible. But Descartes had a mysterious and mystical side, as well. Almost certainly a member of the occult brotherhood of the Rosicrucians, he kept a secret notebook, now lost, most of which was written in code. After Descartes’s death, Gottfried Leibniz, inventor of calculus and one of the greatest mathematicians in history, moved to Paris in search of this notebook—and eventually found it in the possession of Claude Clerselier, a friend of Descartes. Leibniz called on Clerselier and was allowed to copy only a couple of pages—which, though written in code, he amazingly deciphered there on the spot. Leibniz’s hastily scribbled notes are all we have today of Descartes’s notebook, which has disappeared. Why did Descartes keep a secret notebook, and what were its contents? The answers to these questions lead Amir Aczel and the reader on an exciting, swashbuckling journey, and offer a fascinating look at one of the great figures of Western culture.
Entanglement: The Greatest Mystery in Physics
by Amir D. AczelWhy packages separated by thousands of miles change together.
Finding Zero: A Mathematician's Odyssey to Uncover the Origins of Numbers
by Amir D. AczelThe invention of numerals is perhaps the greatest abstraction the human mind has ever created. Virtually everything in our lives is digital, numerical, or quantified. The story of how and where we got these numerals, which we so depend on, has for thousands of years been shrouded in mystery. Finding Zero is an adventure filled saga of Amir Aczel's lifelong obsession: to find the original sources of our numerals. Aczel has doggedly crisscrossed the ancient world, scouring dusty, moldy texts, cross examining so-called scholars who offered wildly differing sets of facts, and ultimately penetrating deep into a Cambodian jungle to find a definitive proof. Here, he takes the reader along for the ride. The history begins with the early Babylonian cuneiform numbers, followed by the later Greek and Roman letter numerals. Then Aczel asks the key question: where do the numbers we use today, the so-called Hindu-Arabic numerals, come from? It is this search that leads him to explore uncharted territory, to go on a grand quest into India, Thailand, Laos, Vietnam, and ultimately into the wilds of Cambodia. There he is blown away to find the earliest zero—the keystone of our entire system of numbers—on a crumbling, vine-covered wall of a seventh-century temple adorned with eaten-away erotic sculptures. While on this odyssey, Aczel meets a host of fascinating characters: academics in search of truth, jungle trekkers looking for adventure, surprisingly honest politicians, shameless smugglers, and treacherous archaeological thieves—who finally reveal where our numbers come from.
The Mystery of the Aleph
by Amir D. AczelThe history of infinity emphasizing the people who were interested in the concept. Stresses philosophical and religious importance of mathematical ideas throughout history. Fascinating even if math is not your strong suit.
Pendulum
by Amir D. AczelHe was neither a mathematician nor a trained physicist and yet Léon Foucault always knew that a mysterious force of nature was among us. Like Newton, Galileo, Copernicus, and others before him, Foucault sensed a dramatic relationship between the rotating skies above and the seemingly motionless ground beneath our feet. But it wasn't until 1851 -- in Paris, inside the Panthéon, and in the company of fellow amateur scientist Napoleon III -- that Foucault swung a pendulum and demonstrated an extraordinary truth about the world: that it turns on its axis. Pendulum is a fascinating journey through the mind and findings of one of the most important and lesser-known characters in the history of science. Through careful research and lively anecdotes, world-renowned author Amir D. Aczel reveals the astonishing range and breadth of Foucault's discoveries. For, in addition to offering the first unequivocal proof of Earth's rotation, Foucault gave us the modern electric compass and microscope, was a pioneer in photographic technology, and made remarkable deductions about color theory, heat waves, and the speed of light. At its heart, Pendulum is a story about the illustrious period in France during the Second Empire; the crucial triumph of science over religion; and, most compelling, the life of a struggling, self-made man whose pursuit of knowledge continues to inform our notions about the universe today.
Present at the Creation: Discovering the Higgs Boson
by Amir D. AczelThe Large Hadron Collider is the biggest, and by far the most powerful, machine ever built. A project of CERN, the European Organization for Nuclear Research, its audacious purpose is to re-create, in a 16.5-mile-long circular tunnel under the French-Swiss countryside, the immensely hot and dense conditions that existed some 13.7 billion years ago within the first trillionth of a second after the fiery birth of our universe. The collider is now crashing protons at record energy levels never created by scientists before, and it will reach even higher levels by 2013. Its superconducting magnets guide two beams of protons in opposite directions around the track. After accelerating the beams to 99.9999991 percent of the speed of light, it collides the protons head-on, annihilating them in a flash of energy sufficient--in accordance with Einstein's elegant statement of mass-energy equivalence, E=mc2--to coalesce into a shower of particles and phenomena that have not existed since the first moments of creation. Within the LHC's detectors, scientists hope to see empirical confirmation of key theories in physics and cosmology.In telling the story of what is perhaps the most anticipated experiment in the history of science, Amir D. Aczel takes us inside the control rooms at CERN at key moments when an international team of top researchers begins to discover whether this multibillion-euro investment will fulfill its spectacular promise. Through the eyes and words of the men and women who conceived and built CERN and the LHC--and with the same clarity and depth of knowledge he demonstrated in the bestselling Fermat's Last Theorem--Aczel enriches all of us with a firm grounding in the scientific concepts we will need to appreciate the discoveries that will almost certainly spring forth when the full power of this great machine is finally unleashed.Will the Higgs boson make its breathlessly awaited appearance, confirming at last the Standard Model of particles and their interactions that is among the great theoretical achievements of twentieth-century physics? Will the hidden dimensions posited by string theory be revealed? Will we at last identify the nature of the dark matter that makes up more than 90 percent of the cosmos? With Present at the Creation, written by one of today's finest popular interpreters of basic science, we can all follow the progress of an experiment that promises to greatly satisfy the curiosity of anyone who ever concurred with Einstein when he said, "I want to know God's thoughts--the rest is details."From the Hardcover edition.
A Strange Wilderness: The Lives of the Great Mathematicians
by Amir D. AczelThe international bestselling author of Fermat&’s Last Theorem explores the eccentric lives of history&’s foremost mathematicians. From Archimedes&’s eureka moment to Alexander Grothendieck&’s seclusion in the Pyrenees, bestselling author Amir Aczel selects the most compelling stories in the history of mathematics, creating a colorful narrative that explores the quirky personalities behind some of the most groundbreaking, influential, and enduring theorems. Alongside revolutionary innovations are incredible tales of duels, battlefield heroism, flamboyant arrogance, pranks, secret societies, imprisonment, feuds, and theft—as well as some costly errors of judgment that prove genius doesn&’t equal street smarts. Aczel&’s colorful and enlightening profiles offer readers a newfound appreciation for the tenacity, complexity, eccentricity, and brilliance of our greatest mathematicians.
Why Science Does Not Disprove God
by Amir D. AczelThe renowned science writer, mathematician, and bestselling author of Fermat's Last Theorem masterfully refutes the overreaching claims the "New Atheists," providing millions of educated believers with a clear, engaging explanation of what science really says, how there's still much space for the Divine in the universe, and why faith in both God and empirical science are not mutually exclusive.A highly publicized coterie of scientists and thinkers, including Richard Dawkins, the late Christopher Hitchens, and Lawrence Krauss, have vehemently contended that breakthroughs in modern science have disproven the existence of God, asserting that we must accept that the creation of the universe came out of nothing, that religion is evil, that evolution fully explains the dazzling complexity of life, and more. In this much-needed book, science journalist Amir Aczel profoundly disagrees and conclusively demonstrates that science has not, as yet, provided any definitive proof refuting the existence of God.Why Science Does Not Disprove God is his brilliant and incisive analyses of the theories and findings of such titans as Albert Einstein, Roger Penrose, Alan Guth, and Charles Darwin, all of whose major breakthroughs leave open the possibility— and even the strong likelihood—of a Creator. Bolstering his argument, Aczel lucidly discourses on arcane aspects of physics to reveal how quantum theory, the anthropic principle, the fine-tuned dance of protons and quarks, the existence of anti-matter and the theory of parallel universes, also fail to disprove God.
The Artist and the Mathematician
by Amir AczelNicolas Bourbaki, whose mathematical publications began to appear in the late 1930s and continued to be published through most of the twentieth century, was a direct product as well as a major force behind an important revolution that took place in the early decades of the twentieth century that completely changed Western culture. Pure mathematics, the area of Bourbaki's work, seems on the surface to be an abstract field of human study with no direct connection with the real world. In reality, however, it is closely intertwined with the general culture that surrounds it. Major developments in mathematics have often followed important trends in popular culture; developments in mathematics have acted as harbingers of change in the surrounding human culture. The seeds of change, the beginnings of the revolution that swept the Western world in the early decades of the twentieth century -- both in mathematics and in other areas -- were sown late in the previous century. This is the story both of Bourbaki and the world that created him in that time. It is the story of an elaborate intellectual joke -- because Bourbaki, one of the foremost mathematicians of his day -- never existed.
The Jesuit and the Skull
by Amir AczelFrom the New York Times bestselling author of Fermat's Last Theorem, "an extraordinary story"( Philadelphia Inquirer) of discovery, evolution, science, and faith. In 1929, French Jesuit priest Pierre Teilhard de Chardin was a part of a group of scientists that uncovered a skull that became known as Peking Man, a key evolutionary link that left Teilhard torn between science and his ancient faith, and would leave him ostracized by his beloved Catholic Church. His struggle is at the heart of The Jesuit and the Skull, which takes readers across continents and cultures in a fascinating exploration of one of the twentieth century's most important discoveries, and one of the world's most provocative pieces of evidence in the roiling debate between creationism and evolution.
Investigating Groundwater (IAH - International Contributions to Hydrogeology #29)
by Ian AcworthInvestigating Groundwater provides an integrated approach to the challenges associated with locating groundwater. Uniquely, the book provides a review of the wide range of techniques that can be deployed to investigate this important resource. Many of the practical examples given are based upon Australian experience but the methods have worldwide applicability. The book is published in colour and includes many original diagrams and photographs. Particular effort has been made to provide consistent terminology and SI units are used throughout the text. <P><P>Investigating Groundwater starts with an introduction to the historical significance of groundwater and gives an account of climate change. A description of the occurrence of groundwater in different rock types is then provided. A detailed account of surface water techniques is then followed by an account of the interconnections between surface water and groundwater. Four chapters describing groundwater hydraulics are then followed by four chapters describing the latest geophysical techniques. Once the best location of a borehole is determined using these techniques; chapters then describe appropriate drilling methods to use; provide a wide ranging review of geophysical logging, hydrochemical and isotopic techniques, before concluding with a detailed description of groundwater flow to a well. <P><P>Written for a worldwide audience of degree level geology/engineering practitioners, academics and students involved in groundwater resource investigation methods; Investigating Groundwater is essential reading for those involved in groundwater research. <P><P>Key Features: <li>Presents the theoretical background and a detailed description of the techniques used in the investigation of groundwater. <li>Describes the general occurrence of groundwater in different rock types; surface water hydrology and interconnected surface and groundwater systems. <li>Provides detailed descriptions of geophysical techniques (seismic, electrical, gravity and heat) and an account of available geophysical logging methods. <li>Reviews hydrochemical and isotope methods, followed by an account of drilling techniques. <li>Gives a detailed account of radial flow to a well, including appropriate modelling and pump-testing techniques and a consideration of non-linear flow. <P><P>Of interest to anyone involved in the development of groundwater resources, either for domestic supply, for agriculture or for mining.
Coulometric Electrode Array Detectors for HPLC
by I. N. Acworth M. Naoi H. Parvez S. ParvezThis sixth volume in the book series Progress in HPLC-HPCE examines the enhancement of high- performance liquid chromatography through the development of an advanced mode of electrochemical detection (ECD) --- the coulometric array detection --- from its initial, yet problematic, amperometric (thin-layer) design to the highly sensitive, selective and stable coulometric (flow-through) design. Unlike amperometric electrodes, the coulometric electrode is 100% efficient and measures signals from all of the analyte passing through it, which leads to improved sensitivity as well as unique selectivity. The coulometric electrode array offers the resolution of the photodiode array with the extreme sensitivity of an electrochemical detector.
Choices: Science Level Six
by AcsiYour sixth graders will acquire valuable skills through age-appropriate scientific inquiry while gaining a deeper appreciation of God's creation. This colorful hardcover text provides an engaging, hands-on, full-time instructional program. This science series was developed to guide students through investigating, observing and thinking about the world around them. Every chapter is designed to bring together the wonders of God's world and a Biblical worldview. The title of the series comes from the idea that God's design of creation was on purpose, and that theme is reflected throughout the lessons.
Principles of Plant Genetics and Breeding
by George AcquaahThe revised edition of the bestselling textbook, covering both classical and molecular plant breeding Principles of Plant Genetics and Breeding integrates theory and practice to provide an insightful examination of the fundamental principles and advanced techniques of modern plant breeding. Combining both classical and molecular tools, this comprehensive textbook describes the multidisciplinary strategies used to produce new varieties of crops and plants, particularly in response to the increasing demands to of growing populations. Illustrated chapters cover a wide range of topics, including plant reproductive systems, germplasm for breeding, molecular breeding, the common objectives of plant breeders, marketing and societal issues, and more. Now in its third edition, this essential textbook contains extensively revised content that reflects recent advances and current practices. Substantial updates have been made to its molecular genetics and breeding sections, including discussions of new breeding techniques such as zinc finger nuclease, oligonucleotide directed mutagenesis, RNA-dependent DNA methylation, reverse breeding, genome editing, and others. A new table enables efficient comparison of an expanded list of molecular markers, including Allozyme, RFLPs, RAPD, SSR, ISSR, DAMD, AFLP, SNPs and ESTs. Also, new and updated “Industry Highlights” sections provide examples of the practical application of plant breeding methods to real-world problems. This new edition: Organizes topics to reflect the stages of an actual breeding project Incorporates the most recent technologies in the field, such as CRSPR genome edition and grafting on GM stock Includes numerous illustrations and end-of-chapter self-assessment questions, key references, suggested readings, and links to relevant websites Features a companion website containing additional artwork and instructor resources Principles of Plant Genetics and Breeding offers researchers and professionals an invaluable resource and remains the ideal textbook for advanced undergraduates and graduates in plant science, particularly those studying plant breeding, biotechnology, and genetics.