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Molecular and Functional Models in Neuropsychiatry
by Jim J. HaganThe development of more effective treatments for neuropsychiatric disorders requires scientific progress on a broad front. Animal models have a vital role to play in advancing the field. When deployed in conjunction with detailed study of these diseases in man they bring the power to make controlled experimental interventions which allow the functional consequences of genetic variations and polymorphisms to be understood in terms of their cellular, systems and behavioural effects. Further, they provide a means by which complex cognitive and behavioural phenomena may be dissected and understood. Finally, they provide a bridge to understanding the effects of drugs on the functioning of the central nervous system, thereby improving our understanding of the actions of those drugs in man.
Molecularly Targeted Therapy for Childhood Cancer
by Peter J. Houghton Robert J. ArceciEach chapter will focus on the known molecular characteristics of specific childhood cancers, focusing on how the molecular 'drivers' can be exploited from a therapeutic standpoint with currently available targeted agents. Where applicable, integration of targeted therapies with conventional cytotoxic agents will be considered. This volume will provide a comprehensive summary of molecular characteristics of childhood cancers, and how the changes involved in transformation provide us with opportunities for developing relatively less toxic, but curative, therapies.
Molekulare Populationsgenetik: Theoretische Konzepte und empirische Evidenz
by Wolfgang Stephan Anja C. HörgerDas Buch behandelt die genetische Vielfalt von Populationen von Organismen. Es erläutert, wie genetische Vielfalt gemessen wird und wie aus diesen Daten die Mechanismen untersucht werden können, die die Variabilität auf der Genomebene und damit die Mikroevolution einer Population beeinflussen. Ziel dieses Buches ist es, das Wirken der natürlichen Selektion im Genom zu verstehen und vom Einfluss neutraler Evolutionskräfte (wie genetischer Drift, Mutation und Rekombination) unterscheiden zu lernen. Dazu werden die grundlegenden theoretischen Konzepte der Populationsgenetik eingeführt und anhand von zahlreichen Beispielen aus allen Organismengruppen (Menschen, Tieren, Pflanzen und Mikroorganismen) veranschaulicht. Um das Verständnis der theoretischen Ableitungen von Hypothesen und der darauf basierenden Datenanalysen zu überprüfen und weiter zu vertiefen, schließt jedes Kapitel mit Übungsaufgaben und Lösungen ab.
Molekulare Virologie
by Hermann Schätzl Susanne Modrow Uwe TruyenDieses bewährte Standardwerk vermittelt einen ausgewogenen Überblick über die bekannten humanpathogenen und tierpathogenen Viren, wie beispielsweise Papilloma- und Influenzaviren und wurde ergänzt um die eher neu aufgetretenen Viren, insbesondere Zikavirus, das neuartigen Coronavirus SARS-CoV-2 und das Schmallenberg-Virus, einem Bunyavirus, das Rinder, Schafe und Ziegen infiziert.Der erste Teil des Buches präsentiert die allgemeinen Prinzipien der Struktur, Vermehrung und Lebenszyklen von Viren und beschreibt die wichtigsten pathogenetischen und immunologischen Mechanismen viraler Erkrankungen. Auch die Diagnostik und Therapie sowie die Epidemiologie solcher Infektionen und das heutige Methodenrepertoire der Virologen werden hier vorgestellt.Der zweite, spezielle Teil führt systematisch durch die Vielfalt der human- und tierpathogenen Viren. Ausführlich dargestellt sind hier Morphologie, Genomorganisation, Proteinausstattung sowie Replikationsmechanismen der verschiedenen Virusfamilien. Für die jeweils wichtigsten Vertreter liefern die Autoren einen Überblick über die relevanten humanmedizinisch-klinischen beziehungsweise veterinärmedizinischen Aspekte. Auch seuchenrechtliche Fragen kommen hier zur Sprache.Das Lehrbuch dient seit vielen Jahren als bewährte Einführung in die molekular- und zellbiologischen Grundlagen der Virologie und ist unentbehrlich für Fachleute und Studierende. Die 4. Auflage wurde ergänzt mit den aktuellen Daten zu den jeweiligen Viren und bietet somit einen aktuellen Überblick zu den Replikationsstrategien und verbindet diese mit der Pathogenese der Erreger. Integriert wurden Virusspezies, die während der vergangenen Jahre neu aufgetreten sind und in vieler Hinsicht die öffentliche Diskussion beherrscht haben. Nicht zuletzt zählen hierzu die Infektionen des Menschen mit dem neuartigen Coronavirus SARS-CoV-2, dem Zikavirus, den tier- wie humanpathogenen Bornaviren sowie dem Schmallenberg-Virus, dessen Infektion bei Wiederkäuern schwere Fetopathien verursacht. Mit seiner klaren Gliederung und verständlichen Darstellung weist dieses systematisch angelegte Lehr- und Nachschlagewerk• Studierenden und Lehrenden in Biowissenschaften, Human- und Veterinärmedizin• Virologen, forschungsorientierten Klinikern, Tierärzten und Seuchenmedizinern sowie• Fachleuten in Mikrobiologie, Hygiene und Diagnostikden Weg durch die Vielfalt der virologischen Forschungsergebnisse.
Moles (Superpower Field Guide)
by Rachel PoliquinFunny and fact-filled, MOLES is another installment in the SUPERPOWER FIELD GUIDES series by author Rachel Poliquin, featuring full-color illustrations by Nicholas John Frith that will engage readers with witty narration and fun visual elements, inspiring readers to dig deep and see the world, both above and below ground, with new eyes. Meet Rosalie, a common mole. The first thing you need to know about Rosalie is that she is shaped like a potato. Not a new potato, all cute and round, but a plain old lumpy potato. She may be small. She may be spongy. But never underestimate a mole. I know what you’re thinking: moles are just squinty-eyed beasts that wreck your lawn. You’re right! Those squinty eyes and mounds of dirt are proof that moles have superpowers. There is absolutely nothing common about the common mole.
Molla e i saltasassi
by Rafael EstradaVi ho mai raccontato la storia di Molla? Molla era un bambino con il naso da topo, lo sguardo sognante e i capelli da porcospino. Credeva di poter fare qualunque cosa gli venisse in mente, tanto era buono ed innocente. —Mi piacerebbe saper saltare come i saltasassi —disse un giorno, quasi senza sapere perché, abbastanza forte da essere sentito da tutti. Sua madre, Balestra, sorrise come fanno le mamme; Elastico, suo padre, tossì come fanno i papà; e il nonno mosse il capo su e giù. Balestra conosceva più di chiunque altro la tendenza di Molla ad immaginare cose impossibili, e mentre gli pettinava gli indomabili capelli, con tutta la pazienza di una madre, gli chiese: —Che pazzia è questa di sognare di saltare, come se non avessimo i saltasassi? —Ma mamma, ti assicuro che non è una pazzia! Sono sicuro che con un po’ di esercizio ci si potrebbe riuscire. —Figlio mio, ti rendi conto che sarebbe come dire che annaffiandoti tutti i giorni, prima o poi comincerai a fare fiori e frutti? Molla la guardò di sghimbescio e arricciò il naso, sforzandosi di capire quello che sua madre voleva dirgli. Poi, con un sorriso, le rispose: —Tu lo sai che non è la stessa cosa, mamma… Nemmeno per un momento pensò di mettersi a discutere con suo figlio, perché sapeva quanto potesse essere ostinato. E così continuò a pettinarlo guardando verso la finestra, forse nella speranza che da lì potesse giungere qualche risposta. Poiché così non fu, si strinse nelle spalle rinunciando a domare sia Molla che i suoi ciuffi ribelli. —Coraggio, tesoro —gli disse, —fai colazione. Tutto questo succedeva durante una mattina soleggiata, quando l’inverno cominciava già ad accomiatarsi dalla Pietraia. L’erba si lasciava cadere ora da una parte, ora dall’altra, secondo il volere del vento.
Molluscan Faunas of the Gulf of Mexico: Endemism in North America’s Inland Sea
by Edward J. Petuch David P. BerschauerRecent biodiversity studies, reported here for the first time, have shown that the molluscan fauna of the Gulf of Mexico is far richer and more complex than previously thought. As a result of these new discoveries, the Gulf malacofauna is shown to contain large numbers of endemic species that reside within four separate biogeographical subdivisions of the larger Carolinian Molluscan Province: the Floridian, Suwannean, Texan, and Yucatanean Subprovinces. These four Gulf biotic components, with each supporting its own endemic fauna, are shown here to be separated by distinct ecological and oceanographic barriers. The resultant physical and genetic isolation has led to the evolution of spectacular sibling species radiations, many unknown and undescribed until now. Some of the most conspicuous and important of these are found in the gastropod families Fasciolariidae, Volutidae, Conidae, Muricidae, and Busyconidae, all of which are dominant predators in their respective benthonic ecosystems. The species within these ecologically important families, along with hundreds of endemic taxa in 50 other gastropod and bivalve families, are illustrated here in Molluscan Faunas of the Gulf of Mexico: Endemism in North America’s Inland Sea on 132 color plates and are discussed in detail in the individual chapters. Special attention is given to the mollusks of poorly studied and virtually unknown ecosystems such as those on the deep reefs off the Florida Keys and Dry Tortugas, the deep water coralline algal beds off western Florida, the Flower Garden Reefs off Texas, the petroleum seeps and brine pools of the Sigsbee Escarpment, the Campeche Bank Archipelago, and the deep water areas at the mouth of the Yucatan Channel.This new book is unlike previous taxonomic surveys of the Gulf of Mexico mollusks in that it highlights only the endemic species and genera and does not cover the large number of widespread Carolinian and Caribbean taxa that occur with them. In this aspect, the book is designed to be an augmentation to previous faunal surveys, adding hundreds more taxa that had been missed in these older surveys or were described after those earlier works had been published. The emphasis on endemic species and species complexes is meant to underscore the special nature of the Gulf of Mexico malacofauna, setting it aside from all others in the Tropical Western Atlantic Region.
Mollusk shells as bio-geo-archives
by Sandra Gordillo María Sol Bayer Gabriella Boretto Melisa CharóIn view of the wide range of disciplines involved in Quaternary research, this book offers a one-stop resource for the Quaternary research community, since it reviews the latest techniques and provides an approach to how mollusk shell remains are used in the reconstruction of marine environments in southern South America. Written by specialists in the field, this monograph sets the scene for multidisciplinary research involving taphonomy, paleoecology, paleobiography, morphometry, shell mineralogy analysis and sclerochronology performed on mollusk assemblages and/or selected taxa, and offers a consistent picture of spatial and temporal environmental and climatic changes.
Mollusks and Marine Environments of the Ten Thousand Islands
by Edward J. Petuch David P. BerschauerMollusks and Marine Environments of the Ten Thousand Islands provides the first comprehensive overview of the shells and habitats that are present in the last unexplored coastal area of southwestern Florida. The mysterious and primordial Ten Thousand Islands, where the rivers and marshlands of the Everglades empty into the Gulf of Mexico, house a number of remarkable marine ecosystems, many shown here in detail for the first time. Primary among these are unique worm shell “reef systems,” composed entirely of immense masses of vermetid gastropod mollusks. These previously unexplored and unstudied gastropod reefs, which are often many acres in size, are shown here to mimic coral reefs in their growth structure and represent the only large-scale molluscan reefs found anywhere on Earth. Living in association with the zonated gastropod reefs are a number of rare and unusual mollusks, some of which represent endemic species that are unique to the Ten Thousand Islands. These and many other southwestern Florida shells are illustrated throughout this book, along with detailed illustrations and descriptions of the marine and estuarine environments that dominate the archipelago and its adjacent lagoon systems.
Molly The Pony: A True Story
by Pam KasterMolly the pony waits. She waits in her stall. She waits during the storm. She waits for her owner to return. So begins the true story of a patient pony who is rescued from a south Louisiana barn after Hurricane Katrina and finds a new life on a farm with new animal friends. But Molly's tale of courage does not end here. When a dog on the farm attacks Molly, her front leg is badly injured. For a pony, a damaged leg is life threatening. To the amazement of veterinarians, though, Molly rises to her new challenge. She undergoes a rare surgery for horses: amputation of her front leg. Now fitted with a prosthetic limb, Molly relearns how to walk and embarks again on a new mission in life: making new people friends. This plucky pony's story of survival and friendship will win the hearts of readers young and old. All who have had to start over after displacement, abandonment, injury, or amputation will find a friend in Molly as they follow her story of bringing a smile to everyone she meets.
Molly Twinkletail Runs Away: Book 2 (Magic Animal Friends #2)
by Daisy MeadowsWelcome to a magical world where animals talk and play - just like you and me!Best friends Jess and Lily love all animals. But when they follow a mysterious golden cat into Friendship Forest - a place where animals live in tiny cottages and sip dandelion tea at the Toadstool Cafe - their summer holidays suddenly become much more magical!On their second adventure, Lily and Jess are invited to the Friendship Forest fair! But Grizelda the witch wants to spoil everyone's fun and her servants, the Boggits, trick little Molly Twinkletail into running away from the party. It's up to the girls to find her - but where in Friendship Forest would a tiny mouse hide?
Molly Twinkletail: Book 2 (Magic Animal Friends Early Reader #2)
by Daisy MeadowsThe much-loved series from the creator of Rainbow Magic - abridged for younger readers and illustrated in full colour!Welcome to a magical world where animals talk and play - just like you and me!Best friends Jess and Lily love all animals. But when they follow a mysterious golden cat into Friendship Forest - a place where animals live in tiny cottages and sip dandelion tea at the Toadstool Cafe - their animal friends suddenly become much more magical!On their second adventure, Lily and Jess are invited to the Friendship Forest fair! But Grizelda the witch wants to spoil everyone's fun and her servants, the Boggits, trick little Molly Twinkletail into running away from the party. It's up to the girls to find her - but where in Friendship Forest would a tiny mouse hide?
Molly and the Cat Café: A Novel (Cat Café)
by Melissa DaleyMelissa Daley's novel Molly and the Cat Cafe is a heartwarming story of determination and friendship.When two-year-old tabby, Molly, loses her beloved owner, her world falls apart. Re-homed with three cat-hating dogs, she decides to take matters into her own paws and embarks on a grueling journey to the nearest town. As Molly walks the cobbled streets of Stourton, she begins to lose all hope of finding a home… Until one day she is welcomed into the warmth by caring café owner, Debbie. Like Molly, Debbie is also an outsider and, with a daughter to care for, she is desperate to turn around the struggling café. But a local battle axe is on the warpath and she is determined to keep out newcomers, especially four-legged ones. It looks as if Debbie will have to choose between the café and Molly. Yet the solution to their problems may not be as far away as they think. Will Debbie and Molly be able to turn their fortunes around to launch the Cotswolds’ first Cat Café?
Molly's Story: A Dog's Purpose Puppy Tale (A Dog's Purpose Puppy Tales #Bk.1)
by W. Bruce CameronFrom W. Bruce Cameron, the author of the New York Times and USA Today bestselling novel A Dog's Purpose, now a major motion picture!Meet Molly—a very special dog with a very important purpose. An irresistible book for young middle grade readers adapted from A Dog's Journey, the sequel to the bestselling A Dog's Purpose—now a major motion picture!Molly knows that her purpose is to take care of her girl, C.J., but it won’t be easy. Neglected by her mother, Gloria, who won’t allow her to have a dog, C.J. is going through some tough times. Molly’s job is to stay hidden in C.J.’s room, cuddle up to her at night, and protect her from bad people. And no matter what Gloria does to separate them, nothing will keep Molly away from the girl that she loves.Adorable black-and-white illustrations by Richard Cowdrey bring Molly and her world to life. Also includes a discussion and activity guide that will help promote family and classroom discussions about Molly’s Story and the insights it provides about humankind’s best friends.At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Molly: The True Story of the Amazing Dog Who Rescues Cats
by Colin ButcherThe heartwarming true story of a man, his rescue dog, and how they became the UK’s most beloved pair of pet detectives.In 2003, veteran police officer Colin Butcher left the force to open the UKPD—United Kingdom Pet Detectives—the only British agency specializes in finding missing pets. When Colin first met Molly the Cocker Spaniel, she was young and inexperienced. But sensing that she had the makings of a valuable partner, he brought Molly on.Trained by top canine experts at Medical Detection Dogs, Molly became skilled at find missing cats—those beloved pets who are uniquely skilled at eluding humans. But the work is not always easy. Molly has faced hardships ranging from a near-fatal snakebite to the challenge of winning over Colin’s girlfriend, Sarah.Through it all, Colin and Molly developed an enduring love and affection. More than a working relationship, Molly is part of the family. In Molly, Colin recounts their remarkable story.
Molly: The True Story of the Dog Who Rescues Lost Cats
by Colin ButcherIn Colin Butcher and Joanne Lake's Molly: The True Story of the Dog Who Rescues Lost Cats, a rescue dog meets a retired police detective and they help find lost or stolen animals in this nonfiction middle grade adaptation...
Molt in Neotropical Birds: Life History and Aging Criteria (Studies in Avian Biology)
by Erik I. Johnson Jared D. WolfeMolt is an important avian life history event in which feathers are shed and replaced. The timing, duration, seasonality, extent and pattern of molt follows certain strategies and this book reviews and describes these strategies for nearly 190 species based on information gathered from a 30-year study of Central Amazonian birds. Most species accounts are illustrated with several color photos focusing on wing and tail feather molt, molt limits, and how to use these patterns to accurately age birds. Published in collaboration with and on behalf of the American Ornithological Society, this volume in the highly-regarded Studies in Avian Biology series is a rich source of life history information for ornithologists working on tropical birds.
Mom Hugs
by Michael JoostenThis funny and adorable board book featuring photographs of mama animals hugging their babies is the perfect Mother's Day gift!Open your arms to this funny and endearing photographic board book featuring a wide array of mama animals giving their adorable babies a cuddly embrace. With otters, polar bears, monkeys, kangaroos, and more, kids and parents alike will love discovering the amusing similarities between how humans and animals each hug the little ones they love. A perfect gift for Mother's Day . . . or any day.
Mom's Best Friend
by Sally Hobart AlexanderThis book explains the impact on the family of someone getting a successor dog guide, and also many of the tools that blind people use.
Mommies Are Amazing
by Meredith CostainIn this companion to Daddies Are Awesome, mommy cats and kittens take the spotlight, celebrating moms of all kinds.Loving and thoughtful, playful and daring, cuddly and caring—mommies are amazing. This gentle rhyming text celebrates the special bond between mother and child. Adorable mommy cat and kitten illustrations make this completely charming!
Mommies Say Shhh!
by Patricia PolaccoGoats say "Maa-Maa-Maa. " Birds say "Cheep-Cheep-Cheep. " Horses say "Neigh-Neigh-Neigh. " Rabbits say nothing at all! But when all of these animals get together and raise a honking, braying, neighing ruckus, what do mommies say? "Shhhhhh!" With the simplest of texts and a variety of fun animal noises, Patricia Polacco has created another read-aloud winner for the preschool crowd. .
Mommies are Amazing (Peppa Pig)
by ScholasticCelebrate all the mummies in the world of Peppa with this adorable board book!Peppa and George love Mummy Pig, and so do their friends! Join Peppa as she and her friends show their mummies how much they mean to them. This adorable and charming board book is perfect for sharing with parents, caregivers, or whomever you call "Mom"!
Mommy Calls Me Monkeypants
by J. D. Lester Hiroe NakataThis endearing book captures the sweetness and fun of mother and child interaction with a clever, funny text and illustrations that are right on the mark. J. D. Lester' s funny nicknames come to life with Hiroe Nakata's endearing, colorful artwork, resulting in a board book that is sweet, adorable, and fun--perfect for all new mommies and their babies to share.
Mommy Snuggles
by Anne Gutman Georg HallenslebenHow does a mother show her love? By bringing her baby everywhere! In this touching tribute to a mother's love, tigers, kangaroos, otters, penguins, and more keep their young close no matter where they go.
Mommy Snuggles
by Anne Gutman Georg HallenslebenHow does a mother show her love? By bringing her baby everywhere! In this touching tribute to a mother's love, tigers, kangaroos, otters, penguins, and more keep their young close no matter where they go.