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Acquired Mitochondropathy – A New Paradigm in Western Medicine explaining Chronic Diseases
by Enno FreyeThe book on Acquired Mitochondropathy offers a new perspective on the understanding and the treatment of chronic ailments. Addressing a new paradigm deemed necessary, since in one of every four adults in the western world chronic ailments are on the rise. Resulting from energy dysfunction of cellular organelles, the mitochondria, the most of the common symptoms the physician faces during medical consultation are presented. An increasing focus on chronic disabilities presents difficulties for the busy practitioner, since patients typically describe a complex pattern of discomfort, disability, and distress, with pain affecting physical, social, and psychological functioning, which have to be put in the proper perspective. Since clinicians must efficiently condense widely varied symptomatic descriptions into characteristic patterns to permit accurate diagnosis and implement effective treatment, this book serves as a useful educational resource for the healthcare provider.
Across the Bridge: Understanding the Origin of the Vertebrates
by Henry Gee“Addresses an important topic for biologists and zoologists about vertebrates’ place in the ‘grand scheme’ . . . genuinely witty and charming . . . magnificent.” —Neil J. Gostling, University of SouthamptonOur understanding of vertebrate origins and the backbone of human history evolves with each new fossil find and DNA map. Many species have now had their genomes sequenced, and molecular techniques allow genetic inspection of even non-model organisms. But as longtime Nature editor Henry Gee argues in Across the Bridge, despite these giant strides and our deepening understanding of how vertebrates fit into the tree of life, the morphological chasm between vertebrates and invertebrates remains vast and enigmatic.As Gee shows, even as scientific advances have falsified a variety of theories linking these groups, the extant relatives of vertebrates are too few for effective genetic analysis. Moreover, the more we learn about the species that do remain—from sea-squirts to starfish—the clearer it becomes that they are too far evolved along their own courses to be of much use in reconstructing what the latest invertebrate ancestors of vertebrates looked like. Fossils present yet further problems of interpretation. Tracing both the fast-changing science that has helped illuminate the intricacies of vertebrate evolution as well as the limits of that science, Across the Bridge helps us to see how far the field has come in crossing the invertebrate-to-vertebrate divide—and how far we still have to go.“A beautiful ode to some of the least appreciated animals . . . guides the reader joyfully through deuterostomes—weaving disparate elements of embryology, paleontology, and morphology into an unprecedented and accessible narrative.” —Jakob Vinther, University of Bristol
Across the Pond
by Joy McCulloughFrom the author of A Field Guide to Getting Lost comes a heartwarming story about new beginnings, burgeoning friendships, and finding your flock.Callie can&’t wait for her new life to start. After a major friendship breakup in San Diego, moving overseas to Scotland gives her the perfect chance to reinvent herself. On top of that, she&’s going to live in a real-life castle! But as romantic as life in a castle sounds, the reality is a little less comfortable: it&’s run-down, freezing, and crawling with critters. Plus, starting off on the wrong foot with the gardener&’s granddaughter doesn&’t help her nerves about making new friends. So she comes up with the perfect solution: she&’ll be homeschooled. Her parents agree, on one condition: she has to participate in a social activity. Inspired by a journal that she finds hidden in her bedroom, Callie decides to join a birding club. Sure, it sounds unusual, but at least it&’s not sports or performing. But when she clashes with the club leader, she risks losing a set of friends all over again. Will she ever be able to find her flock and make this strange new place feel like home?
Across the Stream
by Mirra GinsburgA hen and her chicks -- with the help of a duck and her ducklings -- find a way to put their bad dreams behind them!
Act of Valor: True Blue K-9 Unit (True Blue K-9 Unit #4)
by Dana MentinkShe saw something she shouldn’t have…A True Blue K-9 Unit storyWhen airline employee Violet Griffin encounters several suspicious passengers, she’s thrust into the crosshairs of a drug smuggling operation. NYPD officer Zach Jameson and his drug detection beagle, Eddie, can tell this is no small-time threat. Someone’s gunning for Violet, and after recently losing his brother, Zach refuses to lose her, too…especially now that she’s gone from friend to the woman he’s falling for.
Acting Out #14
by Laurie Halse AndersonAn all-new book in acclaimed author Laurie Halse Anderson's series for younger readers! Zoe is back in Ambler after living with her mom in Los Angeles, and she doesn't know what to feel about it. It's fun to be back with the Vet Volunteers, but Zoe misses her mom, who is filming a movie in Canada. Meanwhile, there seems to be a rash of animals being poisoned by antifreeze across the town, and Zoe fears that David's new adopted cat, Rover, might be one of them. So the gang works to raise awareness about antifreeze poisoning, and Zoe's mom has a special surprise in store for everyone.
Active Landscape Photography: Diverse Practices (Active Landscape Photography)
by Anne C GodfreyDiverse Practices, the third book in the Active Landscape Photography series, presents a set of unique photographic examples for site-specific investigations of landscape places. Contributed by authors across academia, practice and photography, each chapter serves as a rigorous discussion about photographic methods for the landscape and their underlying concepts. Chapters also serve as unique case studies about specific projects, places and landscape issues. Project sites include the Miller Garden, Olana, XX Miller Prize and the Philando Castile Peace Garden. Landscape places discussed include the archeological landscapes of North Peru, watery littoral zones, the remote White Pass in Alaska, Sau Paulo and New York City’s Chinatown. Photographic image-making approaches include the use of lidar, repeat photography, collage, mapping, remote image capture, portraiture, image mining of internet sources, visual impact assessment, cameraless photography, transect walking and interviewing. These diverse practices demonstrate how photography, when utilized through a set of specific critical methods, becomes a rich process for investigating the landscape. Exploring this concept in relationship to specific contemporary sties and landscape issues reveals the intricacy and subtlety that exists when photography is used actively. Practitioners, academics, students and researchers will be inspired by the underlying concepts of these examples and come away with a better understanding about how to create their own rigorous photographic practices.
Actual Size
by Steve JenkinsHow big is a crocodile? What about a tiger, or the world's largest spider? Can you imagine a tongue that is two feet long or an eye that's bigger than your head? Sometimes facts and figures don't tell the whole story. Sometimes you need to see things for yourself--at their actual size.
Actualistic Taphonomy in South America (Topics in Geobiology #48)
by Sergio Martínez Alejandra Rojas Fernanda CabreraHighlighting the latest research on Actualistic Taphonomy (AT), this book presents the outcomes of a meeting that took place in Montevideo, Uruguay, in October 2017. Its respective chapters offer valuable insights into South American archaeology, invertebrate and vertebrate fauna, and flora. In recent years, there has been a surge of new research on AT, as evidenced by numerous papers, talks, theses, etc. However, there are still very few AT books or even dedicated journal articles. Reflecting the discipline’s newfound maturity, this book, written by South American authors, offers a unique resource for academics and students of Paleontology, Geology, and Biology around the world.
Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms
by Denson G. FujikawaThe purpose of this book is to present clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death. The spectrum of clinically relevant pathologically induced excitotoxic neuronal death includes cerebral ischemia, traumatic brain injury, cerebral hypoglycemia, and status epilepticus. By investigating mechanisms, potential neuroprotective strategies can be identified that may have future clinical application.
Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms
by Denson G. FujikawaAn overview of the biochemical mechanisms that produce acute nerve cell death in the brain. Covers injuries and disorders including stroke, brain and spinal cord trauma, hypoglycemic coma, and prolonged epileptic seizures. All of these lead to high concentrations of calcium in nerve cells which, in turn, causes degradation of cytoplasmic proteins, cleavage of nuclear DNA, and eventually cell death. The Second Edition contains 11 thoroughly updated chapters and 3 additional chapters that did not appear in the previous edition.
Ada Magnífica y las mascotas desaparecidas (Los Preguntones #Volumen 5)
by Andrea BeatyUna serie original de Netflix, ganadora de un Emmy como Serie Animada Preescolar. ¡Un nuevo libro para esta serie que acompaña a la serie Los Preguntones! Esta serie de no ficción para los pequeños que empiezan a leer es ilustrada a todo color y basada en la nueva serie de Netflix ¡Ada Twist, científica! /Ada Twist, Scientist! Blue River Creek tiene un problema: ¡hay un ladrón de mascotas suelto! O al menos, Sofía e Iggy están convencidas de que lo hay, cuando sus mascotas desaparecen. Pero como científica, Ada sabe que es importante no sacar conclusiones precipitadas y en vez, tomar en cuenta los hechos reales. ¿Cómo descubrirán lo que realmente sucedió con las mascotas del pueblo? ¡Usando el método científico, por supuesto! ¡Formando una hipótesis, recopilando datos y haciendo la experimentación, los preguntones deberán encontrar los animales perdidos antes de que desaparezcan aún más mascotas! Basada en la serie bestseller y en el nuevo exitoso programa de Netflix, ¡esta nueva serie de no ficción es perfecta para los jóvenes científicos del mañana!
Adams and Stashak's Lameness in Horses
by Gary M. BaxterProvides a fully updated Seventh Edition of the classic gold-standard reference on equine lameness This new edition of the go-to resource for equine lameness features updates throughout and more in-depth information on objective lameness assessment, sports medicine, rehabilitation, treatment options, and advanced imaging. With contributions from the world’s leading authorities on the subject, the book covers functional anatomy, examination, imaging, lameness of the distal limb, proximal limb, and axial skeleton, principles of musculoskeletal disease, therapies, occupation-related conditions, lameness in young horses, and farriery. More than 1,700 images support the text, making it an exhaustive reference for all aspects of lameness in horses. Now in its seventh edition, Adams and Stashak’s Lameness in Horses continues to be the definitive resource on equine lameness for veterinary specialists, practitioners, interns, residents, and students alike. The book is supplemented with a companion website offering a plethora of “how-to” videos demonstrating lameness examination and select perineural and intrasynovial anesthesia techniques. Offers a fully revised new edition of the classic text on equine lameness Includes more extensive information on objective lameness assessment, sports medicine, rehabilitation, treatment options and advanced imaging Features over 1,700 images to illustrate the concepts described Written by internationally renowned experts in the field Includes access to a companion website with "how-to" videos Adams and Stashak’s Lameness in Horses is a must-have reference for any practicing large animal and equine veterinarian, equine veterinary specialist, or veterinary student dealing with lameness in the horse.
Adam's Task: Calling Animals by Name
by Karen Joy Fowler Donald Mccaig Vicki HearneA groundbreaking meditation on our human-animal relationships and the moral code that binds it.Adam's Task, Vicki Hearne's innovative masterpiece on animal training, brings our perennial discussion of the human-animal bond to a whole new metaphysical level. Based on studies of literary criticism, philosophy, and extensive hands-on experience in training, Hearne asserts, in boldly anthropomorphic terms, that animals (at least those that interact more with humans) are far more intelligent than we assume. In fact, they are capable of developing an understanding of "the good," a moral code that influences their motives and actions.Drawing on an eclectic range of influences-Nietzsche, T. S. Eliot, Disney animal trainer William Koehler, and Genesis from the Bible, among others-Hearne writes in contemplative, exploratory, and brilliant prose as she interweaves personal anecdotes with philosophy. Hearne develops an entirely new system of animal training that contradicts modern animal behavioral research and that, as her examples show, is astonishingly effective.Widely praised, highly influential, and now with a new foreword by New York Times bestselling author Karen Joy Fowler, Adam's Task will make every trainer, animal psychologist, and animal-lover stop, think, and question.
Adam's Task
by Vicki Hearne Donald MccaigIn it Vicki Hearne asserts that animals that interact with humans are more intelligent than we assume. In fact, they are capable of developing an understanding of "the good," a moral code that influences their motives and actions. Hearne's thorough studies led her to adopt a new system of animal training that contradicts modern animal behavioral research, but-as her examples show-is astonishingly effective. Hearne's theories will make every trainer, animal psychologist, and animal-lover stop, think, and question.
Addie Ant Goes on an Adventure (Addie Ant's Garden Friends Ser.)
by Maren Morris Karina ArgowAcclaimed singer-songwriter Maren Morris and former schoolteacher Karina Argow have together written their picture-book debut, Addie Ant Goes on an Adventure. This delightful story of one little ant’s journey for independence while realizing when to ask for help, is set against the backdrop of a vast and abundant garden inhabited by some very helpful insect friends.Addie Ant travels from one garden bed to another on her first solo adventure. As she forges her own path, she gets lost along the way and finds help from her trusted garden pals, Lewis Ladybug, Beatrix Butterfly, and Cleo Cricket, in finding her way back home. A celebration of friendship, this sweet book is a collaboration by renowned, musical artist Maren Morris and former schoolteacher and close friend Karina Argow. Artist Kelly Anne Dalton brings the delightfully written characters to life with colorful and charming illustrations. Join Addie Ant in a vast and magical garden adventure full of insect friends, growing vegetables, blooming flowers, and the inspiring abundance of nature.
Adeline Porcupine (Tiny Tales)
by Charles GhignaAlthough Adeline Porcupine looks prickly on the outside, she is one of the most lovable characters around. She loves spending time with her friends. In fact, it's her favorite thing to do. From going to magic shows to playing games, Adeline makes every adventure memorable.
Adelita's Amazing Journey
by Elizabeth Armstrong HallAdelita, a loggerhead sea turtle, was the first ocean-going animal to be tracked with a satellite transmitter. How would she find her way?
Adeno-Associated Virus: Methods and Protocols (Methods in Molecular Biology #807)
by Richard O. Snyder Philippe MoullierToday, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of backgrounds to have an understanding -- or at least an appreciation of -- the regulatory environment and constraints that affect vector design, manufacturing, pre-clinical testing, and clinical use, with an emphasis on patient protection. In Adeno-Associated Virus: Methods and Protocols, experts from the United States and Europe have contributed current knowledge of this multi-dimensional field relating to the biology of AAV, rAAV vector design, vector manufacturing and product testing, performance of rAAV vectors in major organs, rAAV-related immunological issues, design of animal and clinical studies, and clinical experience. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Adeno-Associated Virus: Methods and Protocols provides a complete and comprehensive understanding of this multi-disciplinary and rapidly progressing field.
Adenosine: A Key Link between Metabolism and Brain Activity
by Susan Masino Detlev BoisonHomeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system - including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.
Adhesive Interactions of Mussel Foot Proteins (Springer Theses)
by Jing YuWater and moisture undermine strong adhesion to polar surfaces. Marine mussels, however, achieve durable underwater adhesion using a suite of proteins that are peculiar in having high levels of 3, 4-dihydroxyphenylalanine (Dopa). Mussel adhesion has inspired numerous studies on developing the next generation of wet adhesives. This thesis presents recent progress in understanding the basic surface and intermolecular interactions employed by mussels to achieve strong and durable wet adhesion. The surface forces apparatus (SFA) and various other techniques were applied to measure the interactions between mussel foot protein-3 fast (Mfp-3 fast) and the model substrate, mica, as well as the interactions between various mussel adhesive proteins The results in this thesis show that Dopa plays an essential role in mussel adhesion and that mussels delicately control the interfacial redox environment to achieve strong and durable Dopa mediated adhesion. The interplay between Dopa and hydrophobic interactions is also evident in mussel adhesion.
Adiestra en positivo: Guía completa para educar a tu perro desde cero
by Enric RodríguezLa guía imprescindible para educar a tu perro desde el respeto con Enric en positivo, el canal de adiestramiento canino más visto de España. Si quieres adiestrar a tu perro, o corregir problemas de comportamiento sin tener que acudir a métodos basados en el miedo y en el dolor, ¡esta es tu guía! En Adiestra en positivo encontrarás nociones básicas sobre psicología canina, consejos para evitar malas conductas, y trucos y habilidades para enseñarles desde el cariño. Enric Rodríguez, titulado en adiestramiento canino desde hace más de veinte años y creador del canal de YouTube sobre adiestramiento más visto de España, apuesta por técnicas no violentas que te serán de utilidad para entender y mejorar el comportamiento de tu perro, pero, sobre todo, para educarlo y enriquecer vuestra conexión como un miembro más de la familia.
Adiestramiento canino
by Pílula DigitalEste Manual fue desarrollado luego de largos años de estudio y cuidado de perros en las más diversas áreas, desde cachorros hasta perros adultos y ancianos. Com mais de 10 anos de experiência no cuidado de perros, este Manual surgió para ayudar a novos padres de perros y para "salvar" a quien ya intentó de todo para educar a seu mejor amigo, pero sin éxito. Las técnicas de entrenamiento aquí presentadas ya han foram repetidamente aplicadas y están 100% aprobadas por todos los que las han utilizado. Luego de leer y aplicar este Manual, su mascota amiga será un compañero muy educado y preparado para cumplir sus órdenes. Enseñe buenos modales y elimine los malos comportamientos. Tener la posibilidad de realizar un entrenamiento completo en casa es maravilloso, y yo hice esto pensando en usted. Es plenamente posible tener un perro entrenado, que cumpla sus órdenes sin necesidad de gastar en adiestradores. Recuerde: la clave del éxito está en su conexión con su perro, persistencia y consistencia en el entrenamiento. ¡Le deseo éxito y aquí estamos para lo que precise!
Adiós: Cómo afrontar la partida de nuestros mejores amigos
by Valeria SchapiraEstas páginas son un material imprescindible para quienes comparten o han compartido su vida con un animal de compañía. Sea que esté sano, enfermo o ya haya partido, este libro es una guía práctica para acompañar ese proceso. Valeria Schapira relata de manera íntima, sincera y cercana su relación con Joy, el perro con quien convive desde hace diez años y a quien considera su gran maestro. La longevidad del animal y, en consecuencia, la idea de su finitud fue tal vez lo que la motivó a escribir este libro. Adiós. Cómo afrontar la partida de nuestros mejores amigos es un manual, una "cajita de herramientas", en palabras de la propia autora. Una guía con respuestas a cuestiones prácticas -como qué hacer cuando el animal se enferma, qué tipos de terapias podrían mejorar su calidad de vida, cómo hablar con los niños de la muerte, cómo superar su ausencia- y una ayuda para aquellos que atraviesan momentos similares. En definitiva, una caricia al alma para quienes aman a los animales y saben que ellos son el espejo en el cual todos los seres humanos deberíamos mirarnos para, al fin, evolucionar.
Adopt Me!: An Original Novel (Adopt Me!)
by Kiel PhegleyBased on the fan-favorite game Adopt Me! comes this action-packed original middle grade novel featuring charming illustrations throughout. Now available in a lower-priced hardcover edition!Sophia Lee and her best friend, Kat, live on Adoption Island, a paradise filled with pets, customizable homes, and endless adventures. But their world is turned upside down when they discover that the entire island's beloved pets are starting to go missing.As panic spreads across the island, Sophia, Kat, Pinky, Jumper, Finn, and a legendary Queen Bee named Matilda must embark on a quest to uncover the truth. Their journey leads them to encounter everything from a self-proclaimed king to a talking book with cryptic clues and the island's most popular party host.When the friends stumble upon a hidden camp where the missing pets are held captive, the story takes a shocking twist that will ultimately test Sophia and Kat's friendship. Sophia must stand up for what's right, even if it means risking everything. Will Sophia and Kat save the pets and restore peace to Adoption Island?Perfect for fans of action-packed adventures and the fan-favorite online game, this book includes illustrations throughout!