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Pharmaceutical Experimental Design (Drugs and the Pharmaceutical Sciences)
by Gareth A. Lewis Didier Mathieu Roger Phan-Tan-LuuThis useful reference describes the statistical planning and design of pharmaceutical experiments, covering all stages in the development process-including preformulation, formulation, process study and optimization, scale-up, and robust process and formulation development.Shows how to overcome pharmaceutical, technological, and economic constraint
Pharmaceutical Statistics: Practical and Clinical Applications, Fifth Edition (Drugs and the Pharmaceutical Sciences)
by Sanford Bolton Charles BonThrough the use of practical examples and solutions, Pharmaceutical Statistics: Practical and Clinical Applications, Fifth Edition provides the most complete and comprehensive guide to the various statistical applications and research issues in the pharmaceutical industry, particularly in clinical trials and bioequivalence studies.
Pharmaceutical Statistics: MBSW 39, Muncie, Indiana, USA, May 16-18, 2016 (Springer Proceedings in Mathematics & Statistics #218)
by Ray Liu Yi TsongThis book presents the proceedings of the 39th annual Midwest Biopharmaceutical Statistics Workshop (MBSW), held in Muncie, Indiana on May 16–18, 2016. It consists of selected peer- reviewed and revised papers on topics ranging from statistical applications in drug discovery and CMC to biomarkers, clinical trials, and statistical programming. All contributions feature original research, and together they cover the full spectrum of pharmaceutical R&D – with a special focus on emergent topics such as biosimilarity, bioequivalence, clinical trial design, and subgroup identification.Founded in 1978, the MBSW has provided a forum for statisticians to share knowledge, research, and applications on key statistical topics in pharmaceutical R&D for almost forty years, with the 2016 conference theme being “The Power and 3 I’s of Statistics: Innovation, Impact and Integrity.” The papers gathered here will be of interest to all researchers whose work involves the quantitative aspects of pharmaceutical research and development, including pharmaceutical statisticians who want to keep up-to-date with the latest trends, as well as academic statistics researchers looking for areas of application.
Pharmacokinetics and Toxicokinetics
by Mehdi BoroujerdiPharmacokinetics and Toxicokinetics provides an overview of pharmacokinetics and toxicokinetics in a comprehensible, interrelated, and applied manner. It integrates the principles held in common by both fields through a logical and systematic approach. The book presents mathematical descriptions of physiological processes employed in different appr
Pharmacokinetics: Basics to Applications
by Biswajit MukherjeeThis textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.
The Pharmacy Technician Workbook and Certification Review (Basic Pharmacy and Pharmacology)
by American Pharmacy AssociationThis workbook was developed to correspond with the textbook, The Pharmacy Technician, Sixth Edition, by Perspective Press. For pharmacy technician students, it is a valuable tool for success. It provides a useful format for memorizing important information and checking knowledge. Hundreds of key concepts and terms are carefully explained, and there are over 1,000 exercises and problems for self testing. Answers are included at the back of the book "In the Workplace" sections provide sample job-related documents and skills checklists. The sixth edition includes additional skills checklists as well as "In the Workplace Activities" that provide practical, active-learning applications of the concepts discussed in The Pharmacy Technician. Working out these exercises and activities successfully will help you to succeed in your training.
Phase Analysis of Sound Fields: A System-Theoretical Approach
by Mikio TohyamaThis book deals with the phase properties in the context such as sound fields in rooms from a perspective of transfer functions for sound paths. Phase analysis, i.e., investigations of zeros of transfer functions, is a qualitative or system theoretic approach to sound fields rather than the wave-theoretic power spectral analysis. The examination of phase responses offers new insights into sound fields and yields results that the standard power spectral analysis cannot provide. This book presents experimental data and numerical examples based on the mathematical formulations. It shows the mathematical formulations of acoustics and communication systems for engineers and physicists to get familiar with the basics of science. Chapters 1–5 provide the theoretical basis on the system theoretic approach to sound fields where Chapters 1 and 2 are introductions to discrete acoustic systems, Chapters 3–5 summarize wave equations, geometrical and random theories of room acoustics, and Chapters 6–10 develop details of transfer functions in sound.
Phase Field Theory in Materials Physics: The Hodograph Equation
by Peter GalenkoThis book deals with the use of the hodograph equation in phase transformations in condensed matter, especially, for crystallization and solidification processes. The main focus of the book is the interpretation of the phase-field equations for isotropic and anisotropic interfaces based on the advanced Gibbs–Thomson and Herring conditions, respectively. Beginning with the basic ideas behind the extended irreversible thermodynamics, the kinetic phase-field model for slow and arbitrarily fast phase transformations is derived where the unified hodograph equation follows from:• the sharp interface limit of the diffuse interface or• the traveling wave solution of the propagating phase field.Under the example of solute trapping and disorder trapping effects, comparing theoretical results with molecular dynamics simulations, and with the analysis of experimental data, the concrete workability of the developed hodograph equation is demonstrated for widest range of driving force in phase transformations.
Phase II Clinical Development of New Drugs
by Naitee Ting Ding-Geng Chen Shuyen Ho Joseph C. CappelleriThis book focuses on how to appropriately plan and develop a Phase II program, and how to design Phase II clinical trials and analyze their data. It provides a comprehensive overview of the entire drug development process and highlights key questions that need to be addressed for the successful execution of Phase II, so as to increase its success in Phase III and for drug approval. Lastly it warns project team members of the common potential pitfalls and offers tips on how to avoid them.
Phase Space Dynamics in Plasma Based Wakefield Acceleration (Springer Theses)
by Xinlu XuThis book explores several key issues in beam phase space dynamics in plasma-based wakefield accelerators. It reveals the phase space dynamics of ionization-based injection methods by identifying two key phase mixing processes. Subsequently, the book proposes a two-color laser ionization injection scheme for generating high-quality beams, and assesses it using particle-in-cell (PIC) simulations. To eliminate emittance growth when the beam propagates between plasma accelerators and traditional accelerator components, a method using longitudinally tailored plasma structures as phase space matching components is proposed. Based on the aspects above, a preliminary design study on X-ray free-electron lasers driven by plasma accelerators is presented. Lastly, an important type of numerical noise—the numerical Cherenkov instabilities in particle-in-cell codes—is systematically studied.
Phase Transformation in Metals: Mathematics, Theory, and Practice
by Nestor PerezThis new edition retains its class-tested explanation of the physics of phase transformation and associated constraints from a metallurgical/materials science point of view, and adds an enhanced treatment of the underlying theoretical concepts with greater clarification. The new edition continues its examination of crystallography, mass transport by diffusion, thermodynamics, heat transfer and related temperature gradients, thermal deformation, and even fracture mechanics. The work presented emphasizes solidification and related analytical models based on heat transfer. This corresponds with the most fundamental physical event of continuous evolution of latent heat of fusion for directional or non-directional liquid-to-solid phase transformation at a specific interface with a certain geometrical shape, such as planar or curved front. Dr. Perez introduces mathematical and engineering approximation schemes for describing the phase transformation, mainly during solidification of pure metals and alloys. Giving clear definitions and explanations of theoretical concepts and full detail of derivation of formulae, this interdisciplinary volume is ideal for graduate and upper-level undergraduate students in applied science, and professionals in the metal making and surface reconstruction industries.
Phase Transition Dynamics
by Tian Ma Shouhong WangThis book is an introduction to a comprehensive and unified dynamic transition theory for dissipative systems and to applications of the theory to a range of problems in the nonlinear sciences. The main objectives of this book are to introduce a general principle of dynamic transitions for dissipative systems, to establish a systematic dynamic transition theory, and to explore the physical implications of applications of the theory to a range of problems in the nonlinear sciences. The basic philosophy of the theory is to search for a complete set of transition states, and the general principle states that dynamic transitions of all dissipative systems can be classified into three categories: continuous, catastrophic and random. The audience for this book includes advanced graduate students and researchers in mathematics and physics as well as in other related fields.
Phase Transition Dynamics
by Tian Ma Shouhong WangThis book is an introduction to a comprehensive and unified dynamic transition theory for dissipative systems and to applications of the theory to a range of problems in the nonlinear sciences. The main objectives of this book are to introduce a general principle of dynamic transitions for dissipative systems, to establish a systematic dynamic transition theory, and to explore the physical implications of applications of the theory to a range of problems in the nonlinear sciences. The basic philosophy of the theory is to search for a complete set of transition states, and the general principle states that dynamic transitions of all dissipative systems can be classified into three categories: continuous, catastrophic and random. The audience for this book includes advanced graduate students and researchers in mathematics and physics as well as in other related fields.This second edition introduces a unified theory for topological phase transitions, provides a first-principle approach to statistical and quantum physics, and offers a microscopic mechanism of quantum condensates (Bose-Einstein condensation, superfluidity, and superconductivity). Reviews of first edition: “The goals of this interesting book are to derive a general principle of dynamic transitions for dissipative systems and to establish a systematic dynamic transition theory for a wide range of problems in the nonlinear sciences. … The intended audience for this book includes students and researchers working on nonlinear problems in physics, meteorology, oceanography, biology, chemistry, and the social sciences.” (Carlo Bianca, Mathematical Reviews, December, 2014) “This is a clearly written book on numerous types of phase transitions taken in a broad sense when a dynamical dissipative system transforms from one physical state into another. … The book is a very useful literature not only for the professionals in the field of dynamic systems and phase transitions but also for graduate students due to its interdisciplinary coverage and state-of-the-art level.” (Vladimir Čadež, zbMATH, Vol. 1285, 2014)
Phase Transitions (Primers in Complex Systems #3)
by Ricard SoléPhase transitions--changes between different states of organization in a complex system--have long helped to explain physics concepts, such as why water freezes into a solid or boils to become a gas. How might phase transitions shed light on important problems in biological and ecological complex systems? Exploring the origins and implications of sudden changes in nature and society, Phase Transitions examines different dynamical behaviors in a broad range of complex systems. Using a compelling set of examples, from gene networks and ant colonies to human language and the degradation of diverse ecosystems, the book illustrates the power of simple models to reveal how phase transitions occur. Introductory chapters provide the critical concepts and the simplest mathematical techniques required to study phase transitions. In a series of example-driven chapters, Ricard Solé shows how such concepts and techniques can be applied to the analysis and prediction of complex system behavior, including the origins of life, viral replication, epidemics, language evolution, and the emergence and breakdown of societies. Written at an undergraduate mathematical level, this book provides the essential theoretical tools and foundations required to develop basic models to explain collective phase transitions for a wide variety of ecosystems.
Phase Transitions in Materials
by Brent FultzOffering a fresh viewpoint on phase changes and the thermodynamics of materials, this textbook covers the thermodynamics and kinetics of the most important phase transitions in materials science, spanning classical metallurgy through to nanoscience and quantum phase transitions. Clear, concise and complete explanations rigorously address transitions from the atomic scale up, providing the quantitative concepts, analytical tools and methods needed to understand modern research in materials science. Topics are grouped according to complexity, ensuring that students have a solid grounding in core topics before they begin to tackle more advanced material, and are accompanied by numerous end-of-chapter problems. With explanations firmly rooted in the context of modern advances in electronic structure and statistical mechanics, and developed from classroom teaching, this book is the ideal companion for graduate students and researchers in materials science, condensed matter physics, solid state science, and physical chemistry.
Phase Type Distributions, Volume 2: Theory and Application
by András Horváth Miklós TelekPhase type distributions are widely applicable modeling and statistical tools for non-negative random quantities. They are built on Markov chains, which provide a simple, intuitive stochastic interpretation for their use. Phase Type Distribution starts from the Markov chain-based definition of phase type distributions and presents many interesting properties, which follow from the basic definition. As a general family of non-negative distributions with nice analytical properties, phase type distributions can be used for approximating experimental distributions by fitting or by moments matching; and, for discrete event simulation of real word systems with stochastic timing, such as production systems, service operations, communication networks, etc. This book summarizes the up-to-date fitting, matching and simulation methods, and presents the limits of flexibility of phase type distributions of a given order. Additionally, this book lists numerical examples that support the intuitive understanding of the analytical descriptions and software tools that handle phase type distributions.
Phenological Research
by Irene L. Hudson Marie R. KeatleyAs climate change continues to dominate the international environmental agenda, phenology - the study of the timing of recurring biological events - has received increasing research attention, leading to an emerging consensus that phenology can be viewed as an 'early warning system' for climate change impact. A multidisciplinary science involving many branches of ecology, geography and remote sensing, phenology to date has lacked a coherent methodological text. This new synthesis, including contributions from many of the world's leading phenologists, therefore fills a critical gap in the current biological literature. Providing critiques of current methods, as well as detailing novel and emerging methodologies, the book, with its extensive suite of references, provides readers with an understanding of both the theoretical basis and the potential applications required to adopt and adapt new analytical and design methods. An invaluable source book for researchers and students in ecology and climate change science, the book also provides a useful reference for practitioners in a range of sectors, including human health, fisheries, forestry, agriculture and natural resource management.
A Phenomenological Mathematical Modelling Framework for the Degradation of Bioresorbable Composites (Springer Theses)
by Ismael Moreno-GomezThis book presents a generalised computational model for the degradation of resorbable composites, using analytic expressions to represent the interwoven phenomena present during degradation. It then combines this modelling framework with a comprehensive database of quantitative degradation data mined from existing literature and from novel experiments, to provide new insights into the interrelated factors controlling degradation. Resorbable composites made of biodegradable polyesters and calcium-based ceramics have significant therapeutic potential as tissue engineering scaffolds, as temporary implants and as drug-loaded matrices for controlled release. However, their degradation is complex and the rate of resorption depends on multiple connected factors such as the shape and size of the device, polymer chemistry and molecular weight, particle phase, size, volume fraction, distribution and pH-dependent dissolution properties. Understanding and ultimately predicting the degradation of resorbable composites is of central importance if we are to fully unlock the promise of these materials.
Phenomenological Structure for the Large Deviation Principle in Time-Series Statistics
by Takahiro NemotoThis thesis describes a method to control rare events in non-equilibrium systems by applying physical forces to those systems but without relying on numerical simulation techniques, such as copying rare events. In order to study this method, the book draws on the mathematical structure of equilibrium statistical mechanics, which connects large deviation functions with experimentally measureable thermodynamic functions. Referring to this specific structure as the "phenomenological structure for the large deviation principle", the author subsequently extends it to time-series statistics that can be used to describe non-equilibrium physics. The book features pedagogical explanations and also shows many open problems to which the proposed method can be applied only to a limited extent. Beyond highlighting these challenging problems as a point of departure, it especially offers an effective means of description for rare events, which could become the next paradigm of non-equilibrium statistical mechanics.
Phenomenology and Mathematics
by Mirja HartimoDuring Edmund Husserl's lifetime, modern logic and mathematics rapidly developed toward their current outlook and Husserl's writings can be fruitfully compared and contrasted with both 19th century figures (Boole, Schröder, Weierstrass) as well as the 20th century characters (Heyting, Zermelo, Gödel). Besides the more historical studies, the internal ones on Husserl alone and the external ones attempting to clarify his role in the more general context of the developing mathematics and logic, Husserl's phenomenology offers also a systematically rich but little researched area of investigation. This volume aims to establish the starting point for the development, evaluation and appraisal of the phenomenology of mathematics. It gathers the contributions of the main scholars of this emerging field into one publication for the first time. Combining both historical and systematic studies from various angles, the volume charts answers to the question "What kind of philosophy of mathematics is phenomenology?"
The Philosophers and Mathematics: Festschrift for Roshdi Rashed (Logic, Epistemology, and the Unity of Science #43)
by Hassan TahiriThis book explores the unique relationship between two different approaches to understand the nature of knowledge, reality, and existence. It collects essays that examine the distinctive historical relationship between mathematics and philosophy. Readers learn what key philosophers throughout the ages thought about mathematics. This includes both thinkers who recognized the relevance of mathematics to their own work as well as those who chose to completely ignore its many achievements.The essays offer insight into the role that mathematics played in the formation of each included philosopher’s doctrine as well as the impact its remarkable expansion had on the philosophical systems each erected. Conversely, the authors also highlight the ways that philosophy contributed to the growth and transformation of mathematics. Throughout, significant historical examples help to illustrate these points in a vivid way. Mathematics has often been a favored interlocutor of philosophers and a major source of inspiration. This book is the outcome of an international conference held in honor of Roshdi Rashed, a renowned historian of mathematics. It provides researchers, students, and interested readers with remarkable insights into the history of an important relationship throughout the ages.
Philosophical and Methodological Debates in Public Health
by Jordi Vallverdú Angel Puyol Anna EstanyThis interdisciplinary volume gathers selected, refereed contributions on various aspects of public health from several disciplines and research fields, including the philosophy of science, epidemiology, statistics and ethics. The contributions were originally presented at the 1st Barcelona conference of “Philosophy of Public Health” (5th – 7th May 2016). This book is intended for researchers interested in public health and the contemporary debates surrounding it.
A Philosophical Essay on Probabilities
by Marquis De LaplaceThis classic introduces the concepts and uses of probability theory. It demonstrates, without the use of higher mathematics, the application of probability to games of chance, physics, reliability of witnesses, astronomy, insurance, democratic government, and many other areas. It also shows how scientists can express complex ideas in simple terms.
A Philosophical Guide to Chance
by Toby HandfieldIt is a commonplace that scientific inquiry makes extensive use of probabilities, many of which seem to be objective chances, describing features of reality that are independent of our minds. Such chances appear to have a number of paradoxical or puzzling features: they appear to be mind-independent facts, but they are intimately connected with rational psychology; they display a temporal asymmetry, but they are supposed to be grounded in physical laws that are time-symmetric; and chances are used to explain and predict frequencies of events, although they cannot be reduced to those frequencies. This book offers an accessible and non-technical introduction to these and other puzzles. Toby Handfield engages with traditional metaphysics and philosophy of science, drawing upon recent work in the foundations of quantum mechanics and thermodynamics to provide a novel account of objective probability that is empirically informed without requiring specialist scientific knowledge.
Philosophical Introduction to Set Theory (Dover Books on Mathematics)
by Stephen PollardThe primary mechanism for ideological and theoretical unification in modern mathematics, set theory forms an essential element of any comprehensive treatment of the philosophy of mathematics. This unique approach to set theory offers a technically informed discussion that covers a variety of philosophical issues. Rather than focusing on intuitionist and constructive alternatives to the Cantorian/Zermelian tradition, the author examines the two most important aspects of the current philosophy of mathematics, mathematical structuralism and mathematical applications of plural reference and plural quantification.Clearly written and frequently cited in the mathematical literature, this book is geared toward advanced undergraduates and graduate students of mathematics with some aptitude for mathematical reasoning and prior exposure to symbolic logic. Suitable as a source of supplementary readings in a course on set theory, it also functions as a primary text in a course on the philosophy of mathematics.