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Statistical Methods in Biology: Design and Analysis of Experiments and Regression
by A. Mead S.J. Welham S.A. Gezan S.J. ClarkWritten in simple language with relevant examples, this illustrative introductory book presents best practices in experimental design and simple data analysis. Taking a practical and intuitive approach, it only uses mathematical formulae to formalize the methods where necessary and appropriate. The text features extended discussions of examples that include real data sets arising from research. The authors analyze data in detail to illustrate the use of basic formulae for simple examples while using the GenStat statistical package for more complex examples. Each chapter offers instructions on how to obtain the example analyses in GenStat and R.
Statistical Methods in Biomarker and Early Clinical Development
by Liang Fang Cheng SuThis contributed volume offers a much-needed overview of the statistical methods in early clinical drug and biomarker development. Chapters are written by expert statisticians with extensive experience in the pharmaceutical industry and regulatory agencies. Because of this, the data presented is often accompanied by real world case studies, which will help make examples more tangible for readers. The many applications of statistics in drug development are covered in detail, making this volume a must-have reference.Biomarker development and early clinical development are the two critical areas on which the book focuses. By having the two sections of the book dedicated to each of these topics, readers will have a more complete understanding of how applying statistical methods to early drug development can help identify the right drug for the right patient at the right dose. Also presented are exciting applications of machine learning and statistical modeling, along with innovative methods and state-of-the-art advances, making this a timely and practical resource.This volume is ideal for statisticians, researchers, and professionals interested in pharmaceutical research and development. Readers should be familiar with the fundamentals of statistics and clinical trials.
Statistical Methods in Customer Relationship Management
by V. Kumar J. Andrew PetersenStatistical Methods in Customer Relationship Management focuses on the quantitative and modeling aspects of customer management strategies that lead to future firm profitability, with emphasis on developing an understanding of Customer Relationship Management (CRM) models as the guiding concept for profitable customer management. To understand and explore the functioning of CRM models, this book traces the management strategies throughout a customer's tenure with a firm. Furthermore, the book explores in detail CRM models for customer acquisition, customer retention, customer acquisition and retention, customer churn, and customer win back.Statistical Methods in Customer Relationship Management:Provides an overview of a CRM system, introducing key concepts and metrics needed to understand and implement these models.Focuses on five CRM models: customer acquisition, customer retention, customer churn, and customer win back with supporting case studies.Explores each model in detail, from investigating the need for CRM models to looking at the future of the models.Presents models and concepts that span across the introductory, advanced, and specialist levels.Academics and practitioners involved in the area of CRM as well as instructors of applied statistics and quantitative marketing courses will benefit from this book.
Statistical Methods in Diagnostic Medicine
by Xiao-Hua Zhou Nancy A. Obuchowski Donna K. McclishA new edition of the cutting-edge guide to diagnostic tests in medical research In recent years, a considerable amount of research has focused on evolving methods for designing and analyzing diagnostic accuracy studies. Statistical Methods in Diagnostic Medicine, Second Edition continues to provide a comprehensive approach to the topic, guiding readers through the necessary practices for understanding these studies and generalizing the results to patient populations. Following a basic introduction to measuring test accuracy and study design, the authors successfully define various measures of diagnostic accuracy, describe strategies for designing diagnostic accuracy studies, and present key statistical methods for estimating and comparing test accuracy. Topics new to the Second Edition include: Methods for tests designed to detect and locate lesions Recommendations for covariate-adjustment Methods for estimating and comparing predictive values and sample size calculations Correcting techniques for verification and imperfect standard biases Sample size calculation for multiple reader studies when pilot data are available Updated meta-analysis methods, now incorporating random effects Three case studies thoroughly showcase some of the questions and statistical issues that arise in diagnostic medicine, with all associated data provided in detailed appendices. A related web site features Fortran, SAS®, and R software packages so that readers can conduct their own analyses. Statistical Methods in Diagnostic Medicine, Second Edition is an excellent supplement for biostatistics courses at the graduate level. It also serves as a valuable reference for clinicians and researchers working in the fields of medicine, epidemiology, and biostatistics.
Statistical Methods in Drug Combination Studies (Chapman & Hall/CRC Biostatistics Series #69)
by Wei Zhao Harry YangThe growing interest in using combination drugs to treat various complex diseases has spawned the development of many novel statistical methodologies. The theoretical development, coupled with advances in statistical computing, makes it possible to apply these emerging statistical methods in in vitro and in vivo drug combination assessments. Howeve
Statistical Methods in Epilepsy (Chapman & Hall/CRC Interdisciplinary Statistics)
by Sharon Chiang Vikram R. Rao Marina VannucciEpilepsy research promises new treatments and insights into brain function, but statistics and machine learning are paramount for extracting meaning from data and enabling discovery. Statistical Methods in Epilepsy provides a comprehensive introduction to statistical methods used in epilepsy research. Written in a clear, accessible style by leading authorities, this textbook demystifies introductory and advanced statistical methods, providing a practical roadmap that will be invaluable for learners and experts alike.Topics include a primer on version control and coding, pre-processing of imaging and electrophysiological data, hypothesis testing, generalized linear models, survival analysis, network analysis, time-series analysis, spectral analysis, spatial statistics, unsupervised and supervised learning, natural language processing, prospective trial design, pharmacokinetic and pharmacodynamic modeling, and randomized clinical trials.Features: Provides a comprehensive introduction to statistical methods employed in epilepsy research Divided into four parts: Basic Processing Methods for Data Analysis; Statistical Models for Epilepsy Data Types; Machine Learning Methods; and Clinical Studies Covers methodological and practical aspects, as well as worked-out examples with R and Python code provided in the online supplement Includes contributions by experts in the field The handbook targets clinicians, graduate students, medical students, and researchers who seek to conduct quantitative epilepsy research. The topics covered extend broadly to quantitative research in other neurological specialties and provide a valuable reference for the field of neurology.
Statistical Methods in Health Disparity Research (Chapman & Hall/CRC Biostatistics Series)
by J. Sunil RaoA health disparity refers to a higher burden of illness, injury, disability, or mortality experienced by one group relative to others attributable to multiple factors including socioeconomic status, environmental factors, insufficient access to health care, individual risk factors, and behaviors and inequalities in education. These disparities may be due to many factors including age, income, and race. Statistical Methods in Health Disparity Research will focus on their estimation, ranging from classical approaches including the quantification of a disparity, to more formal modeling, to modern approaches involving more flexible computational approaches. Features:• Presents an overview of methods and applications of health disparity estimation• First book to synthesize research in this field in a unified statistical framework• Covers classical approaches, and builds to more modern computational techniques• Includes many worked examples and case studies using real data• Discusses available software for estimation The book is designed primarily for researchers and graduate students in biostatistics, data science, and computer science. It will also be useful to many quantitative modelers in genetics, biology, sociology, and epidemiology.
Statistical Methods in Healthcare
by Frederick Faltin Ron Kenett Fabrizio RuggeriIn recent years the number of innovative medicinal products and devices submitted and approved by regulatory bodies has declined dramatically. The medical product development process is no longer able to keep pace with increasing technologies, science and innovations and the goal is to develop new scientific and technical tools and to make product development processes more efficient and effective. Statistical Methods in Healthcare focuses on the application of statistical methodologies to evaluate promising alternatives and to optimize the performance and demonstrate the effectiveness of those that warrant pursuit is critical to success. Statistical methods used in planning, delivering and monitoring health care, as well as selected statistical aspects of the development and/or production of pharmaceuticals and medical devices are also addressed.With a focus on finding solutions to these challenges, this book:Provides a comprehensive, in-depth treatment of statistical methods in healthcare, along with a reference source for practitioners and specialists in health care and drug development.Offers a broad coverage of standards and established methods through leading edge techniques.Uses an integrated, case-study based approach, with focus on applications.Looks at the use of analytical and monitoring schemes to evaluate therapeutic performance.Features the application of modern quality management systems to clinical practice, and to pharmaceutical development and production processes.Addresses the use of modern Statistical methods such as Adaptive Design, Seamless Design, Data Mining, Bayesian networks and Bootstrapping that can be applied to support the challenging new vision.Practitioners in healthcare-related professions, ranging from clinical trials to care delivery to medical device design, as well as statistical researchers in the field, will benefit from this book.
Statistical Methods in Human Genetics (Indian Statistical Institute Series)
by Indranil Mukhopadhyay Partha Pratim MajumderThis book provides an overview of statistical concepts and basic methodology for the study of genetics of human traits and diseases. It attempts to provide a step-by-step description of problem identification, study design, methodology of data collection, data exploration, data summarization and visualization, and more advanced analytical methods for inferring genetic underpinnings of human phenotypes. The book provides codes in R programming language for implementation of most of the statistical methods described, which will enable practitioners to perform analysis of data on their own, without having to mold the data to fit the requirements of commercial statistical packages. Useful to anyone engaged in studies to understand and manage good health, the book is a useful guide for sustainable development of humankind. Primarily intended for practicing biologists especially those who carry out quantitative biological research, in particular, human geneticists, the book is also helpful in classroom teaching.
Statistical Methods in Hydrology and Hydroclimatology (Springer Transactions in Civil and Environmental Engineering)
by Rajib MaityThis book focuses on the application of statistical methods in the field of hydrology and hydroclimatology. Among the latest theories being used in these fields, the book introduces the theory of copulas and its applications in this context. The purpose is to develop an understanding and illustrate the usefulness of the statistical techniques with detailed theory and numerous worked out examples. Apart from this, MATLAB-based codes and solutions of some worked out examples are also provided to assist the readers to handle real life data. This book presents a comprehensive knowledge of statistical techniques combining the basics of probability and the current advances in stochastic hydrology. Besides serving as a textbook for graduate courses on stochastic modeling in hydrology and related disciplines, the book offers valuable resources for researchers and professionals involved in the field of hydrology and climatology.
Statistical Methods in Medical Research
by Peter Armitage Geoffrey Berry J. N. MatthewsThe explanation and implementation of statistical methods for the medical researcher or statistician remains an integral part of modern medical research. This book explains the use of experimental and analytical biostatistics systems. Its accessible style allows it to be used by the non-mathematician as a fundamental component of successful research. Since the third edition, there have been many developments in statistical techniques. The fourth edition provides the medical statistician with an accessible guide to these techniques and to reflect the extent of their usage in medical research. The new edition takes a much more comprehensive approach to its subject. There has been a radical reorganization of the text to improve the continuity and cohesion of the presentation and to extend the scope by covering many new ideas now being introduced into the analysis of medical research data. The authors have tried to maintain the modest level of mathematical exposition that characterized the earlier editions, essentially confining the mathematics to the statement of algebraic formulae rather than pursuing mathematical proofs. Received the Highly Commended Certificate in the Public Health Category of the 2002 BMA Books Competition.
Statistical Methods in Medical Research
by Charan Singh RayatThis book covers all aspects of statistical methods in detail with applications. It presents solutions to the needs of post-graduate medical students, doctors and basic medical scientists for statistical evaluation of data. In present era, dependency on softwares for statistical analysis is eroding the basic understanding of the statistical methods and their applications. As a result, there are very few basic medical scientists capable of analyzing their research data due to lack of knowledge and ability. This book has been written in systematic way supported by figures and tables for basic understanding of various terms, definitions, formulae and applications of statistical methods with solved examples and graphic presentation of data to create interest in this mathematical science.
Statistical Methods in Molecular Biology
by Madhu Mazumdar Heather L. Epps Xi Kathy Zhou Heejung BangWhile there is a wide selection of 'by experts, for experts' books in statistics and molecular biology, there is a distinct need for a book that presents the basic principles of proper statistical analyses and progresses to more advanced statistical methods in response to rapidly developing technologies and methodologies in the field of molecular biology. Statistical Methods in Molecular Biology strives to fill that gap by covering basic and intermediate statistics that are useful for classical molecular biology settings and advanced statistical techniques that can be used to help solve problems commonly encountered in modern molecular biology studies, such as supervised and unsupervised learning, hidden Markov models, methods for manipulation and analysis of high-throughput microarray and proteomic data, and methods for the synthesis of the available evidences. This detailed volume offers molecular biologists a book in a progressive style where basic statistical methods are introduced and gradually elevated to an intermediate level, while providing statisticians knowledge of various biological data generated from the field of molecular biology, the types of questions of interest to molecular biologists, and the state-of-the-art statistical approaches to analyzing the data. As a volume in the highly successful Methods in Molecular BiologyTM series, this work provides the kind of meticulous descriptions and implementation advice for diverse topics that are crucial for getting optimal results. Comprehensive but convenient, Statistical Methods in Molecular Biology will aid students, scientists, and researchers along the pathway from beginning strategies to a deeper understanding of these vital systems of data analysis and interpretation within one concise volume.
Statistical Methods in Psychiatry and Related Fields: Longitudinal, Clustered, and Other Repeated Measures Data (Chapman & Hall/CRC Interdisciplinary Statistics)
by Ralitza GueorguievaData collected in psychiatry and related fields are complex because outcomes are rarely directly observed, there are multiple correlated repeated measures within individuals, there is natural heterogeneity in treatment responses and in other characteristics in the populations. Simple statistical methods do not work well with such data. More advanced statistical methods capture the data complexity better, but are difficult to apply appropriately and correctly by investigators who do not have advanced training in statistics. This book presents, at a non-technical level, several approaches for the analysis of correlated data: mixed models for continuous and categorical outcomes, nonparametric methods for repeated measures and growth mixture models for heterogeneous trajectories over time. Separate chapters are devoted to techniques for multiple comparison correction, analysis in the presence of missing data, adjustment for covariates, assessment of mediator and moderator effects, study design and sample size considerations. The focus is on the assumptions of each method, applicability and interpretation rather than on technical details. Features Provides an overview of intermediate to advanced statistical methods applied to psychiatry. Takes a non-technical approach with mathematical details kept to a minimum. Includes lots of detailed examples from published studies in psychiatry and related fields. Software programs, data sets and output are available on a supplementary website. The intended audience are applied researchers with minimal knowledge of statistics, although the book could also benefit collaborating statisticians. The book, together with the online materials, is a valuable resource aimed at promoting the use of appropriate statistical methods for the analysis of repeated measures data. Ralitza Gueorguieva is a Senior Research Scientist at the Department of Biostatistics, Yale School of Public Health. She has more than 20 years experience in statistical methodology development and collaborations with psychiatrists and other researchers, and is the author of over 130 peer-reviewed publications.
Statistical Methods in Spatial Epidemiology
by Andrew B. LawsonSpatial epidemiology is the description and analysis of the geographical distribution of disease. It is more important now than ever, with modern threats such as bio-terrorism making such analysis even more complex. This second edition of Statistical Methods in Spatial Epidemiology is updated and expanded to offer a complete coverage of the analysis and application of spatial statistical methods. The book is divided into two main sections: Part 1 introduces basic definitions and terminology, along with map construction and some basic models. This is expanded upon in Part II by applying this knowledge to the fundamental problems within spatial epidemiology, such as disease mapping, ecological analysis, disease clustering, bio-terrorism, space-time analysis, surveillance and infectious disease modelling. Provides a comprehensive overview of the main statistical methods used in spatial epidemiology.Updated to include a new emphasis on bio-terrorism and disease surveillance.Emphasizes the importance of space-time modelling and outlines the practical application of the method.Discusses the wide range of software available for analyzing spatial data, including WinBUGS, SaTScan and R, and features an accompanying website hosting related software.Contains numerous data sets, each representing a different approach to the analysis, and provides an insight into various modelling techniques.This text is primarily aimed at medical statisticians, researchers and practitioners from public health and epidemiology. It is also suitable for postgraduate students of statistics and epidemiology, as well professionals working in government agencies.
Statistical Methods of Quality Assurance
by Hans-Joachim. Mittag Horst RinneThis comprehensive textbook is a basic reference which should be recommended to students and teachers in engineering, technology and management as well as to the whole community of professionals already working in quality-related areas.The book aims to be a step-by-step introduction to statistical quality assurance. It has been specifically designed for self-study and includes over 100 fully solved exercises and worked examples. In addition to traditional quality control procedures the book also presents very carefully elaborated results of recent research in order to encourage their adoption into practice.
Statistical Methods Using SPSS
by Gabriel Otieno OkelloStatistical Methods Using SPSS provides a practical approach for better understanding of the advanced statistical concepts that are applied in business, economics, epidemiology, public health, agriculture and other areas of data analytics. Advanced statistical methods or advanced statistical techniques for analyzing data arise because of the complex nature of data sets that cannot be analyzed using the basic or the usual and common analytical techniques. This book describes more advanced statistical methods, offering a modern approach by introducing the advanced statistical concepts, before showing the application of these concepts in real-world examples with the application of SPSS statistical software.This book is useful in explaining advanced statistical analysis techniques to postgraduate students, doctoral students and researchers. It is also a useful reference for students and researchers who require further guidance in advanced data analysis and is designed for those with basic statistical knowledge. Exercises are also included at the end of each chapter to aid in the understanding of the statistical analysis techniques explained in the book.Key features: there are many topics on advanced statistical techniques, a provision of theoretical statistical concepts, there is a step-by-step guide for the different statistical analysis techniques being done using SPSS, there are variety of data set examples to help explain the different statistical concepts, and there is a practical applications of the statistical concepts in SPSS.
Statistical Methods with Applications to Demography and Life Insurance
by Estate V. KhmaladzeSuitable for statisticians, mathematicians, actuaries, and students interested in the problems of insurance and analysis of lifetimes, Statistical Methods with Applications to Demography and Life Insurance presents contemporary statistical techniques for analyzing life distributions and life insurance problems. It not only contains traditional material but also incorporates new problems and techniques not discussed in existing actuarial literature.The book mainly focuses on the analysis of an individual life and describes statistical methods based on empirical and related processes. Coverage ranges from analyzing the tails of distributions of lifetimes to modeling population dynamics with migrations. To help readers understand the technical points, the text covers topics such as the Stieltjes, Wiener, and Ito integrals. It also introduces other themes of interest in demography, including mixtures of distributions, analysis of longevity and extreme value theory, and the age structure of a population. In addition, the author discusses net premiums for various insurance policies.Mathematical statements are carefully and clearly formulated and proved while avoiding excessive technicalities as much as possible. The book illustrates how these statements help solve numerous statistical problems. It also includes more than 70 exercises.
Statistical Misconceptions: Classic Edition (Psychology Press And Routledge Classic Editions Ser.)
by Schuyler HuckBrief and inexpensive, this engaging book helps readers identify and then discard 52 misconceptions about data and statistical summaries. The focus is on major concepts contained in typical undergraduate and graduate courses in statistics, research methods, or quantitative analysis. Fun interactive Internet exercises that further promote undoing the misconceptions are found on the book's website. The author’s accessible discussion of each misconception has five parts: The Misconception - a brief description of the misunderstanding Evidence that the Misconception Exists – examples and claimed prevalence Why the Misconception is Dangerous – consequence of having the misunderstanding Undoing the Misconception - how to think correctly about the concept Internet Assignment - an interactive activity to help readers gain a firm grasp of the statistical concept and overcome the misconception. The book's statistical misconceptions are grouped into 12 chapters that match the topics typically taught in introductory/intermediate courses. However, each of the 52 discussions is self-contained, thus allowing the misconceptions to be covered in any order without confusing the reader. Organized and presented in this manner, the book is an ideal supplement for any standard textbook. Statistical Misconceptions is appropriate for courses taught in a variety of disciplines including psychology, medicine, education, nursing, business, and the social sciences. The book also will benefit independent researchers interested in undoing their statistical misconceptions.
Statistical Misconceptions: Classic Edition (Psychology Press & Routledge Classic Editions)
by Schuyler W. HuckThis engaging book helps readers identify and then discard 52 misconceptions about data and statistical summaries. The focus is on major concepts contained in typical undergraduate and graduate courses in statistics, research methods, or quantitative analysis. Interactive Internet exercises that further promote undoing the misconceptions are found on the book's website. The author’s accessible discussion of each misconception has five parts: The Misconception - a brief description of the misunderstanding Evidence that the Misconception Exists – examples and claimed prevalence Why the Misconception is Dangerous – consequence of having the misunderstanding Undoing the Misconception - how to think correctly about the concept Internet Assignment - an interactive activity to help readers gain a firm grasp of the statistical concept and overcome the misconception. The book's statistical misconceptions are grouped into 12 chapters that match the topics typically taught in introductory/intermediate courses. However, each of the 52 discussions is self-contained, thus allowing the misconceptions to be covered in any order without confusing the reader. Organized and presented in this manner, the book is an ideal supplement for any standard textbook. An ideal supplement for undergraduate and graduate courses in statistics, research methods, or quantitative analysis taught in psychology, education, business, nursing, medicine, and the social sciences. The book also appeals to independent researchers interested in undoing their statistical misconceptions.
Statistical Modeling and Computation
by Dirk P. Kroese Joshua C.C. ChanThis textbook on statistical modeling and statistical inference will assist advanced undergraduate and graduate students. Statistical Modeling and Computation provides a unique introduction to modern Statistics from both classical and Bayesian perspectives. It also offers an integrated treatment of Mathematical Statistics and modern statistical computation, emphasizing statistical modeling, computational techniques, and applications. Each of the three parts will cover topics essential to university courses. Part I covers the fundamentals of probability theory. In Part II, the authors introduce a wide variety of classical models that include, among others, linear regression and ANOVA models. In Part III, the authors address the statistical analysis and computation of various advanced models, such as generalized linear, state-space and Gaussian models. Particular attention is paid to fast Monte Carlo techniques for Bayesian inference on these models. Throughout the book the authors include a large number of illustrative examples and solved problems. The book also features a section with solutions, an appendix that serves as a MATLAB primer, and a mathematical supplement.
Statistical Modeling and Inference for Social Science
by Sean GailmardWritten specifically for graduate students and practitioners beginning social science research, Statistical Modeling and Inference for Social Science covers the essential statistical tools, models and theories that make up the social scientist's toolkit. Assuming no prior knowledge of statistics, this textbook introduces students to probability theory, statistical inference and statistical modeling, and emphasizes the connection between statistical procedures and social science theory. Sean Gailmard develops core statistical theory as a set of tools to model and assess relationships between variables - the primary aim of social scientists - and demonstrates the ways in which social scientists express and test substantive theoretical arguments in various models. Chapter exercises guide students in applying concepts to data, extending their grasp of core theoretical concepts. Students gain the ability to create, read and critique statistical applications in their fields of interest.
Statistical Modeling and Machine Learning for Molecular Biology (Chapman & Hall/CRC Computational Biology Series)
by Alan MosesMolecular biologists are performing increasingly large and complicated experiments, but often have little background in data analysis. The book is devoted to teaching the statistical and computational techniques molecular biologists need to analyze their data. It explains the big-picture concepts in data analysis using a wide variety of real-world molecular biological examples such as eQTLs, ortholog identification, motif finding, inference of population structure, protein fold prediction and many more. The book takes a pragmatic approach, focusing on techniques that are based on elegant mathematics yet are the simplest to explain to scientists with little background in computers and statistics.
Statistical Modeling and Simulation for Experimental Design and Machine Learning Applications: Selected Contributions from SimStat 2019 and Invited Papers (Contributions to Statistics)
by Jürgen Pilz Viatcheslav B. Melas Arne BathkeThis volume presents a selection of articles on statistical modeling and simulation, with a focus on different aspects of statistical estimation and testing problems, the design of experiments, reliability and queueing theory, inventory analysis, and the interplay between statistical inference, machine learning methods and related applications. The refereed contributions originate from the 10th International Workshop on Simulation and Statistics, SimStat 2019, which was held in Salzburg, Austria, September 2–6, 2019, and were either presented at the conference or developed afterwards, relating closely to the topics of the workshop. The book is intended for statisticians and Ph.D. students who seek current developments and applications in the field.
Statistical Modeling for Biological Systems: In Memory of Andrei Yakovlev
by David Oakes Anthony Almudevar Jack HallThis book commemorates the scientific contributions of distinguished statistician, Andrei Yakovlev. It reflects upon Dr. Yakovlev’s many research interests including stochastic modeling and the analysis of micro-array data, and throughout the book it emphasizes applications of the theory in biology, medicine and public health. The contributions to this volume are divided into two parts. Part A consists of original research articles, which can be roughly grouped into four thematic areas: (i) branching processes, especially as models for cell kinetics, (ii) multiple testing issues as they arise in the analysis of biologic data, (iii) applications of mathematical models and of new inferential techniques in epidemiology, and (iv) contributions to statistical methodology, with an emphasis on the modeling and analysis of survival time data. Part B consists of methodological research reported as a short communication, ending with some personal reflections on research fields associated with Andrei and on his approach to science. The Appendix contains an abbreviated vitae and a list of Andrei’s publications, complete as far as we know. The contributions in this book are written by Dr. Yakovlev’s collaborators and notable statisticians including former presidents of the Institute of Mathematical Statistics and of the Statistics Section of the AAAS. Dr. Yakovlev’s research appeared in four books and almost 200 scientific papers, in mathematics, statistics, biomathematics and biology journals. Ultimately this book offers a tribute to Dr. Yakovlev’s work and recognizes the legacy of his contributions in the biostatistics community.