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Advances in Pharmaceutical Product Development
by Keerti Jain Awesh K. YadavThis book discusses the stages involved in pharmaceutical product development including the importance, requirement, and effect of each stage and process. It also covers prototype development for pharmaceutical formulations, scale-up studies, optimization, testing, packaging, and commercialization of different dosage forms for pharmaceutical products like tablets, suspensions, emulsions, coating, inhalational products, sterile products, and herbal formulations. The book also presents advancements in tablet production and tablet coating, including materials, material handling, granulation and granulation technologies, process automation, processing problems in tablet production and troubleshooting, advances in equipment for coating and coating materials. Further, the chapter explores the advances in the formulation and development of aerosols, nebulizers, inhalers, metered Dose Inhalers (MDI), and dry powder Inhalers (DPIs). Towards the end, the book examines the challenges, formulation development, testing, stability, and regulatory guidelines in the development of herbal formulations. This book provides a valuable source of information for the researcher, scientists, students, and people working in the area mainly focused on the challenges in pharmaceutical product development.
Advances in Pharmacokinetics and Pharmacodynamics (AAPS Introductions in the Pharmaceutical Sciences #9)
by Panos MacherasThis book provides a concise overview of recent advances in Pharmacokinetics (PK) and Pharmacodynamics (PD). The pharmacokinetics section covers the state of the art in Physiologically Based Pharmacokinetic (PBPK) modeling (Chapter 1) as well as the assessment of food effect on drug absorption using PBPK modeling (Chapter 2). Chapters 3 and 4 describe the recent development of Physiologically Based Finite Time Pharmacokinetic (PBFTPK) models and their applications to pharmacokinetic data. The pharmacodynamics section focuses on PK/PD modeling. Chapter 5 provides an overview of PK/PD modeling and simulation in clinical practice and studies. Chapter 6 deals with the subject/physiology variability issue encountered in PK/PD studies, while Chapter 7 reviews the influence of clinical pharmacology in the modernization of drug development and regulation. This book is an essential reference for pharmaceutical scientists.
Advances in Physical Ergonomics & Human Factors: Proceedings of the AHFE 2018 International Conference on Physical Ergonomics & Human Factors, July 21-25, 2018, Loews Sapphire Falls Resort at Universal Studios, Orlando, Florida, USA (Advances in Intelligent Systems and Computing #789)
by Ravindra S. Goonetilleke Waldemar KarwowskiThis book reports on the state of the art in physical ergonomics and addresses the design of products, processes, services, and work systems to ensure they are productive, safe, and enjoyable for people to use. The human body’s responses to physical and physiological work demands, strain injuries from repetition, vibration, force, and posture are the most common types of issues examined, along with their design implications. The book explores a wide range of topics in physical ergonomics, including the consequences of repetitive motion, materials handling, workplace safety, the usability of portable devices, design, working postures, and the work environment. Mastering physical ergonomics and safety engineering concepts is fundamental to creating products and systems that people can safely and conveniently use, as well as avoiding stresses and minimizing the risk of accidents. Based on the AHFE 2018 Conference on Physical Ergonomics and Human Factors, held on July 21–25, 2018, in Orlando, Florida, USA, this book provides readers with a comprehensive perspective on the current challenges in physical ergonomics, which is a critical aspect in the design of any human-centered technological system, and for factors influencing human performance.
Advances in Physical, Social & Occupational Ergonomics: Proceedings of the AHFE 2021 Virtual Conferences on Physical Ergonomics and Human Factors, Social & Occupational Ergonomics, and Cross-Cultural Decision Making, July 25-29, 2021, USA (Lecture Notes in Networks and Systems #273)
by Ravindra S. Goonetilleke Shuping Xiong Henrijs Kalkis Zenija Roja Waldemar Karwowski Atsuo MurataThis book reports on cutting-edge findings and developments in physical, social and occupational ergonomics. It covers a broad spectrum of studies and evaluation procedures concerning physical and mental workload, work posture and ergonomic risk. Further, it reports on significant advances in the design of services and systems, including those addressing special populations, for purposes such as health, safety and education, and discusses solutions for a better and safer integration of humans, automated systems and digital technologies. The book also analyzes the impact of culture on people’s cognition and behavior, providing readers with timely insights into theories on cross-cultural decision-making, and their diverse applications for a number of purposes in businesses and societies. Based on the AHFE 2021 conferences on Physical Ergonomics and Human Factors, Social & Occupational Ergonomics, and Cross-Cultural Decision Making, held virtually on 25–29 July, 2021, from USA, it provides readers with a comprehensive overview of the current challenges in physical, social and occupational ergonomics, including those imposed by technological developments, highlights key connections between them, and puts forward optimization strategies for sociotechnical systems, including their organizational structures, policies and processes.
Advances in Physiological Computing (Human–Computer Interaction Series)
by Stephen H. Fairclough Kiel GilleadeThis edited collection will provide an overview of the field of physiological computing, i. e. the use of physiological signals as input for computer control. It will cover a breadth of current research, from brain-computer interfaces to telemedicine.
Advances in Planning and Operation of Relief Supply Chain in Major Public Health Emergency
by Jiazhen Huo Jianjun Zhang Axel Werwatz Guanwei HuangWith Operations Research and System Dynamics as research tools, this book discusses the theme of emergency supplies in Major Public Health Emergency (MPHE) scenarios. The subject includes a series of new issues: critical criteria matching supply with demand for emergency supplies in MPHE, emergency medical materials reserve mode, dynamic optimization of emergency logistics, dynamic optimization of allocating multi-period and multi-category emergency supplies, etc. This book is suitable for university teachers, undergraduate and graduate students, and researchers in fields of logistics and supply chain management as well as emergency management. The most important features of this book include: Firstly, to achieve fairness and accuracy of material distribution during the epidemic, this book constructs a material shortage adjustment function. Secondly, from the comprehensive perspective of cross-regional coordination, multi-organization coordination and multiperiod coordination, the operation optimization models of emergency material supply in major epidemic situation are constructed. Additionally, the comparative analysis and empirical research of the practices in China and Germany also reflects the novelty and benefit of the book.
Advances in Plastination Techniques
by Nicolás E. OttonePlastination is currently considered one of the most innovative forms of conservation of complete bodies, sections and organs, both human and animal, for use in undergraduate and postgraduate teaching, as well as morphological research. In this sense, to develop the various plastination techniques, specific equipment and specialized training of academics are required, who have the ability to carry out the diversity of protocols that exist, depending on the anatomical material to be preserved. The decomposition of organic matter is a vital process in nature, but it is also an impediment to morphological studies and research. This is particularly important in biological specimens that shrink considerably when exposed to normal atmospheric conditions. For this reason, it has always been a constantly pursued objective for anatomists. Plastination, in this regard, is a true alternative in the conservation of perishable biological tissues (complete bodies, complete organs such as brains, livers, lungs, kidneys, hearts, muscles, joint preparations, cuts in sections of complete corpses) - or from isolated regions, etc.) reaching a dry and imperishable state through the use of different polymers and special plastics, ensuring that the organs, limbs and entire bodies do not lose their texture and apparently normal disposition. This original book describes in detail and in an updated way the plastination techniques for the conservation of human and animal biological material, demonstrating the applications in teaching and research of anatomy, morphological sciences and health sciences. The didactic chapters present the history and the fundamentals of plastination techniques (steps, equipment, supplies, material, temperature), as well as its clinical, surgical and research applications. The work also features biosafety issues and provides Ethical Considerations in Plastination. Advances in Plastination Techniques is intended for a cross-section of academics, technicians and advanced students from all areas of Health Sciences - including Physicians and Dentists - and Veterinary Sciences.
Advances in Polymer Sciences and Technology: Select Papers from APA 2017 (Materials Horizons: From Nature to Nanomaterials)
by Bhuvanesh Gupta Anup K. Ghosh Atsushi Suzuki Sunita RattanThis book presents select papers presented at the annual meeting of the Asian Polymer Association. The chapters in this volume document and report on a wide range of significant recent results for various applications, as well as scientific developments in the areas of polymer science and engineering. The chapters include original research from all areas of polymer science and technology with a focus on the manufacture, processing, analysis and application of long chain polymer molecules. This book will be of interest to researchers in academia and industry alike.
Advances in Precision Nutrition, Personalization and Healthy Aging
by Alexander G. HaslbergerThis book provides an overview on current trends and developments in precision nutrition and personalized health preservation, focussing on a field which is undergoing rapid change. Today, personalized strategies contrast generally accepted guidelines for specified groups and improved health and disease markers are shifting health care toward preventive strategies. At the same time, advances in food additives, nutraceuticals, functional, and medical foods are breaking down the traditional domains of health-related disciplines. This book aims to provide an overview on these processes, discusses arising problems, and provides an outlook on the future of personalized health care and the role of precision nutrition. It covers preliminary thoughts on what has been achieved and focusses on developments in the area of metabolic diseases, aging, and neurology. The book is intended as a primer in the field of precision nutrition and is aimed at researchers, clinicians, and students in health-related disciplines, who would like to get insights into current trends and developments in this area
Advances in Pregnancy-Related Protein Research Functional and Clinical Applications
by Gabor N. Than H. Bohn Denes G. SzaboAdvances in Pregnancy-Related Protein Research describes the most significant advances in pregnancy-related protein research that have occurred over the last 25 years. The fetal, pregnancy, placental, and endometrial proteins discussed are classified by their origin and biological activity. The structure and function of newly discovered pregnancy protein families are examined in detail. Physiological values of various pregnancy and placental proteins are presented, and the pathophysiological significance of diagnostic and therapeutic data is addressed. Advances in Pregnancy-Related Protein Research will be a useful reference for obstetricians, oncologists, immunologists, reproduction specialists, oncodevelopmental biologists, gynecologists, and other researchers interested in the subject.
Advances in Processing Technologies for Bio-based Nanosystems in Food (Contemporary Food Engineering #1)
by António A. Vicente Óscar L. Ramos Ricardo N. Pereira Miguel A. Cerqueira José A. TeixeiraNanotechnology can be used to address challenges faced by the food and bioprocessing industries for developing and implementing improved or novel systems that can produce safer, nutritious, healthier, sustainable, and environmental-friendly food products. This book overviews the most recent advances made on the field of nanoscience and nanotechnology that significantly influenced the food industry. Advances in Processing Technologies for Bio-Based Nanosystems in Food provides a multidisciplinary review of the complex mechanisms involved in the research, development, production and legislation of food containing nanostructures systems. Features: Presents the most recent advances made in the field of nanoscience and nanotechnology as applied to the food industry Discusses innovative approaches and processing technologies Shows how nanotechnology can be used to produce safer, nutritious, healthier, sustainable and environmental-friendly food products Covers the complex mechanisms involved in the research, development, production and legislation of food containing nanostructures Selected examples of nanotechnology applications in food industry are shown, focusing on advanced aspects of food packaging, processing and preservation; followed by one contribution that presents the potential commercialization and the main challenges for scale-up. Comprised of 15 chapters, this book provides much-needed and up-to-date information on the use of emergent technologies in bio-based nanosystems for foods, and serves as an ideal reference for scientists, regulators, industrialists, and consumers that conduct research and development in the food processing industry.
Advances In Protein Chemistry And Structural Biology: Inflammation in Neuropsychiatric Disorders Volume 88
by Rossen DonevPublished continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.
Advances in Psoriasis: A Multisystemic Guide
by Jeffrey M. Weinberg Mark LebwohlIt has become increasingly clear that psoriatic disease, both of the skin and joints, can be a significant diagnostic and therapeutic challenge for the physician and a debilitating illness for the patient. Genetic and immunologic advances have increased our understanding of the pathophysiology of psoriasis and psoriatic arthritis and there is a need for practically oriented evidence based references to describe the management options open to clinicians. The speed at which developments are occurring in the field also necessitates a novel approach to keeping up with these changes in practice and the need is for a reference that that be updated regularly as the subject requires. Psoriasis is an incredibly fast-moving discipline within dermatology. Guidelines, treatment options and management all change at incredible speed. There is a requirement to provide a comprehensive reference resource to provide practical, user friendly information for the dermatology profession to aid in the decision-making process. Psoriasis is a graphical subdiscipline of medicine and therefore this will have copious illustrations. As a fast moving discipline the emphasis must be on annual updates to ensure that readers are kept up to date on the important areas of development.
Advances in Psoriasis: A Multisystemic Guide
by Jeffrey M. Weinberg Mark LebwohlThis extensively revised second edition provides an up-to-date and highly informative textbook on psoriasis. The understanding of the mechanisms behind the disease and the available treatment options have continued to develop rapidly in recent times, with this vital resource covering the latest in these management options, including targeted T-cell therapy, the use of immunomodulators, systemic therapies, and ultraviolet and laser therapy. In addition, it provides a detailed overview of the pathophysiology, comorbidities, epidemiology and triggers of the disease. Advances in Psoriasis: A Multisystemic Guide extensively details the scientific basis and practice management of psoriasis. It is therefore a vital resource for practicing and trainee dermatologists looking to develop their clinical knowledge of how to manage and treat these patients.
Advances in Psychiatry
by Afzal Javed Kostas N. FountoulakisThis book will be the newest edition on the series ‘advances in psychiatry’. The previous 3 volumes can be found online at http://www.wpanet.org/detail.php?section_id=10&content_id=660 . They were highly successful in covering a broad area of psychiatry from different perspectives and angles and by reflecting both specialized but also international and global approaches. This series have guaranteed quality therefore can be used by different scientific groups for teaching and learning and also as a means for fast dissemination of advanced research and transformation of research findings into the everyday clinical practice. There is already a body of readers anticipating the next volume.
Advances in Psychopharmacology: Improving Treatment Response
by Mark S. GoldThe book focuses on the prediction and optimization of pharmacological treatment of psychiatric patients. Topics covered include the importance of accurate psychiatric diagnosis, medical problems which can mimic psychiatric illness, and the interface between psychiatric illness and opiate addiction and alcoholism. Current literature on predicting responses to antidepressants, lithium, antipsychotics and antianxiety agents is summarized. This practical guide also offers details on the state-of-the-art uses of blood levels in psychiatric practice for each class of drugs as well as other useful information in tables, graphs and flow charts.
Advances in Pulmonary Drug Delivery
by PHILIP CHI LIP KWOK AND HAK-KIM CHANThe respiratory tract has been used to deliver biologically active chemicals into the human body for centuries. However, the lungs are complex in their anatomy and physiology, which poses challenges to drug delivery. Inhaled formulations are generally more sophisticated than those for oral and parenteral administration. Pulmonary drug development is therefore a highly specialized area because of its many unique issues and challenges. Rapid progress is being made and offers novel solutions to existing treatment problems. Advances in Pulmonary Drug Delivery highlights the latest developments in this field.
Advances in Pulmonary Medicine: Research and Innovations (Advances in Experimental Medicine and Biology #1160)
by Mieczyslaw PokorskiThis book discusses a wide range of investigations and practice-oriented advances in pulmonary medicine and critical care. Pulmonary diseases are a major cause of hospitalization and mortality, affecting millions of people worldwide. Addressing a range of topics, including chronic obstructive pulmonary disease, sleep apnea, and lung cancer, the book offers insights into the disease mechanisms and risk factors, along with practical aspects concerning the maintenance of quality of life, adherence to therapy, and palliative treatment and care. Further, it explores diagnostic and treatment approaches to respiratory dysfunction and respiratory failure, highlighting the beneficial effects of good sleep quality in chronic pulmonary conditions and lung transplant patients. The book also presents novel experimental research on the cellular voltage-gated sodium channels in the mechanism of pathological cough, which is particularly relevant for future targeted antitussive therapy. Lastly, it addresses the epidemiological aspects of pulmonary infections. As such, this book is a valuable resource for medical scholars, clinicians, family physicians, and other professionals seeking to improve the management of respiratory diseases.
Advances in QSAR Modeling: Applications in Pharmaceutical, Chemical, Food, Agricultural and Environmental Sciences (Challenges and Advances in Computational Chemistry and Physics #24)
by Kunal RoyThe book covers theoretical background and methodology as well as all current applications of Quantitative Structure-Activity Relationships (QSAR). Written by an international group of recognized researchers, this edited volume discusses applications of QSAR in multiple disciplines such as chemistry, pharmacy, environmental and agricultural sciences addressing data gaps and modern regulatory requirements. Additionally, the applications of QSAR in food science and nanoscience have been included - two areas which have only recently been able to exploit this versatile tool. This timely addition to the series is aimed at graduate students, academics and industrial scientists interested in the latest advances and applications of QSAR.
Advances in Radiation Oncology (Cancer Treatment and Research #172)
by Jeffrey Y. C. Wong Timothy E. Schultheiss Eric H. RadanyThis book concisely reviews important advances in radiation oncology, providing practicing radiation oncologists with a fundamental understanding of each topic and an appreciation of its significance for the future of radiation oncology. It explores in detail the impact of newer imaging modalities, such as multiparametric magnetic resonance imaging (MRI) and positron emission tomography (PET) using fluorodeoxyglucose (FDG) and other novel agents, which deliver improved visualization of the physiologic and phenotypic features of a given cancer, helping oncologists to provide more targeted radiotherapy and assess the response. Due consideration is also given to how advanced technologies for radiation therapy delivery have created new treatment options for patients with localized and metastatic disease, highlighting the increasingly important role of image-guided radiotherapy in treating systemic and oligometastatic disease. Further topics include the potential value of radiotherapy in enhancing immunotherapy thanks to the broader immune-stimulatory effects, how cancer stem cells and the tumor microenvironment influence response, and the application of mathematical and systems biology methods to radiotherapy.
Advances in Radiation Oncology in Lung Cancer (Medical Radiology)
by Branislav JeremićThis is the third, completely updated edition of a comprehensive book in which many of the world’s leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings in lung cancer and other intrathoracic malignancies. Lung cancer remains the major cancer killer in both sexes worldwide. It is so despite significant progress in recent decades in both diagnostic and treatment approaches. New biological and technological advances in this field are now faster incorporated in the overall decision-making process and are bringing fast and substantial improvements in both survivals and quality of life of lung cancer patients. Optimized patient-oriented approaches are reality of the third decade of this millennium and thoracic oncologists strive towards nothing but seamlessly delivering it in a continuous battle with lung cancer. The first three sections of the work cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer as well as other intrathoracic malignancies are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including stereotactic radiotherapy, and particle therapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer. This concise yet comprehensive book is an invaluable resource for radiation oncologists.
Advances in Radiation Oncology in Lung Cancer (Medical Radiology)
by Branislav JeremicThis is the second, completely updated edition of a comprehensive book in which many of the world's leading lung cancer specialists discuss the recent advances in the radiation oncology of lung cancer and reflect on the latest research findings. The first three sections cover the basic science of lung cancer, clinical investigations, including histology and staging, and a wide range of fundamental treatment considerations. Current treatment strategies for small cell and non-small cell lung cancer are then explained and evaluated in detail, with due attention to novel approaches that promise further improvements in outcome. The various types of treatment-related toxicity are discussed, and quality of life studies and prognostic factors are also considered. After evaluating the latest technological and biological advances, including IMRT, IMAT, cyber knife treatment, and tomotherapy, the book concludes by thorough consideration of specific aspects of clinical research in lung cancer.
Advances in Rapid Sex-Steroid Action: New Challenges and New Chances in Breast and Prostate Cancers
by Antimo Migliaccio Gabriella CastoriaBreast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.
Advances in Respiratory Cancerogenesis (Advances in Experimental Medicine and Biology #911)
by Mieczyslaw PokorskiLung cancer is the leading cause of mortality worldwide, with a low survival rate. Carcinogenesis generally requires a constellation of entwined steps, involving both innate cellular and environmental factors. This book shares the updated knowledge on the origin and development of cancer through genotypic changes which upset the physiological balance between cell proliferation, differentiation, growth control, and apoptosis. The emphasis is put on the role of microRNA proteins involved in the cellular processes above outlined. Cognitive changes, related to dysregulated cellular mechanisms in cancer cells, as yet unchartered area of research, also are tackled. A better understanding of the molecular and cellular biology of lung cancer is the key source of breakthroughs in the diagnosis and prognosis, and finding more effective therapies that target specific mutations. The book provides a source of current facts and trends in clinical research and practice. It will be of interest to clinicians, researchers, and other medical professionals.
Advances in Revision Total Knee Arthroplasty
by E. Carlos Rodríguez-MerchánThis book offers a comprehensive guide to revision total knee arthroplasty, a complex surgical procedure with increasing numbers due to the aging world's population. Covering both septic and aseptic prosthetic failure, it presents an updated overview of available surgical techniques – from one or two-stage revision for periprosthetic joint infection to robot-assisted total joint arthroplasty. Moreover, the authors explore the current role and future potentialities of artificial intelligence. This volume offers the reader state-of-the-art information aiming to illuminate contentious topics in the field.