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Functional Genomics and Evolution of Photosynthetic Systems
by Robert Burnap Wim VermaasNew possibilities have been brought about by the stunning number of genomic sequences becoming available for photosynthetic organisms. This new world of whole genome sequence data spans the phyla from photosynthetic microbes to algae to higher plants. These whole genome projects are intrinsically interesting, but also inform the variety of other molecular sequence databases including the recent 'meta-genomic' sequencing efforts that analyze entire communities of organisms. As impressive as they are, are obviously only the beginning of the effort to decipher the biological meaning encoded within them. This book aims to highlight progress in this direction. This book aims toward a genome-level understanding of the structure, function, and evolution of photosynthetic systems and the advantages accrued from the availability of phyletically diverse sets of gene sequences for the major components of the photosynthetic apparatus. While not meant to be fully comprehensive in terms of the topics covered, it does provide detailed views of specific cases and thereby illustrates important new directions that are being taken in this fast-moving field--a field that involves the integration of bioinformatics, molecular biology, physiology, and ecology.
Functional Glycomics
by Jianjun LiThe study of functional glycomics requires the continuous development of rapid and sensitive methods for the identification of glycan structures and integration to structure-function relationships. In Functional Glycomics: Methods and Protocols, a panel of world-renowned experts provide new developments and emerging glycomics techniques in the form of detailed protocols exploring the fundamental challenges and most cutting-edge novel applications. Written in the highly successful Methods in Molecular BiologyTM series format, chapters in this volume present brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes sections, highlighting key tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Functional Glycomics: Methods and Protocols serves as an ideal reference for scientists working in biochemistry, molecular biology, cell biology, immunology, microbiology, and virology and a guide to appropriate techniques and the design of achievable research plans in this vital field.
Functional Hydrogels in Drug Delivery: Key Features and Future Perspectives
by Umile Gianfranco Spizzirri Giuseppe CirilloThe book deals with the synthesis and characterization of hydrogels specifically used as drug delivery systems. Each chapter includes the most recent updates about the different starting materials employed and the improvement of their physicochemical and biological properties to synthetize high performing carriers for specific uses.
Functional Illness of the Head and Neck
by Brian W. Blakley Joan E. BlakleyThis book uniquely discusses an approach to illnesses for which the causes are unknown. It fills the gaps in the literature by relaying research on functional illness, identifying and assessing various options, and indicating some decision-making suggestions that should help clinicians and patients think about therapy. Special considerations for functional illness include “probability” explanations based on the experience of others, serious consideration of the severity of symptoms before treatments are applied, and balancing the risks, costs, and consequences of treatment; including the patient’s thoughts and attitudes is critical for success in treating functional illness. Unique and comprehensive, Functional Illness is an invaluable reference for medical physicians of all specialties who wish to understand better and identify functional illness symptoms.
Functional Imaging and Modeling of the Heart
by Hans Van Assen Peter Bovendeerd Tammo DelhaasThis book constitutes the refereed proceedings of the 8th International Conference on Functional Imaging and Modeling of the Heart, held in Maastricht, The Netherlands, in June 2015. The 54 revised full papers were carefully reviewed and selected from 72 submissions. The focus of the papers is on following topics: function; imaging; models of mechanics; and models of electrophysiology.
Functional Imaging in Movement Disorders (Routledge Revivals)
by W. R. MartinFirst published in 1990, this indispensable volume brings together authoritative, up-to-date, critical accounts of the present status of positron emission tomography (PET) in the study of movement disorders both in terms of the basic science relevant to PET and the clinical science related to the study of specific disease processes. For better understanding, it includes a review of the basic principles of PET and tracer kinetics. It also reviews clinical studies concerning Parkinson's and Huntington's disease, as well as some of the less common movement disorders such as progressive supranuclear palsy, olivopontocerebellar atrophy, and dystonia. Throughout the text, it emphasizes PET as a tool for the quantitative measurement of meaningful biochemical and physiological processes. This state-of-the-art work provides a perspective concerning the degree to which PET studies have advanced knowledge and the future role anticipated for PET. All clinical and basic researchers interested in functional imaging with PET and movement disorders will find this book an absolute must.
Functional Imaging in Oncology
by Santiago E. Rossi L. Celso Hygino Da Cruz Jr. Joan C. Vilanova Antonio LunaIn the new era of functional and molecular imaging, both currently available imaging biomarkers and biomarkers under development are expected to lead to major changes in the management of oncological patients. This well-illustrated two-volume book is a practical manual on the various imaging techniques capable of delivering functional information on cancer, including preclinical and clinical imaging techniques, based on US, CT, MRI, PET and hybrid modalities. This first volume explains the biophysical basis for these functional imaging techniques and describes the techniques themselves. Detailed information is provided on the imaging of cancer hallmarks, including angiogenesis, tumor metabolism, and hypoxia. The techniques and their roles are then discussed individually, covering the full range of modalities in clinical use as well as new molecular and functional techniques. The value of a multiparametric approach is also carefully considered.
Functional Informatics in Drug Discovery (Drug Discovery Ser. #Vol. 9)
by Sergey IlyinIntegrating various technologies with informational systems provides vast improvements to the overall research and development that occur in the biopharmaceutical industry. One of the first books to explore this area, Functional Informatics in Drug Discovery examines all aspects of technology integration and information flow in a biopharmaceutical
Functional Limb Salvage: The Multidisciplinary Team Approach
by Christopher E. Attinger John S. SteinbergTaking a truly interdisciplinary approach to the topic, Functional Limb Salvage is a ready reference for all clinicians and surgeons treating this patient population, including plastic, vascular, orthopedic and podiatric surgeons and their support staff. The content of this text is focused on defining and expanding upon the importance and, more specifically, the intricacies of the multidisciplinary team approach. Although this is often touched upon or cited as an integral aspect of care, there are only sparse descriptions of the interplay of multiple team members in concert with the care of this challenging patient population. This comprehensive text opens with definitions, demographics, epidemiology, pathophysiology and etiology of the limb salvage patient population, whether due to infection, ischemia or deformity. The multidisciplinary team itself is then outlined, from the who, when and where of the intervention to the role of the individual clinicians themselves; from vascular and plastic surgeons to podiatric and orthopedic surgeons, multiple medical specialties, and with thorough attention to the integral support staff of NPs, PAs and many others. History and assessment are then discussed as a prelude to both conservative and surgical treatments, including wound healing optimization, orthotics and prosthetics, skin grafting, amputation, bioengineered tissue and more. A final chapter on innovation and landmark publications rounds out the presentation.
Functional Magnetic Resonance Imaging Processing
by Xingfeng LiWith strong numerical and computational focus, this book serves as an essential resource on the methods for functional neuroimaging analysis, diffusion weighted image analysis, and longitudinal VBM analysis. It includes four MRI image modalities analysis methods. The first covers the PWI methods, which is the basis for understanding cerebral flow in human brain. The second part, the book's core, covers fMRI methods in three specific domains: first level analysis, second level analysis, and effective connectivity study. The third part covers the analysis of Diffusion weighted image, i. e. DTI, QBI and DSI image analysis. Finally, the book covers (longitudinal) VBM methods and its application to Alzheimer's disease study.
Functional Mapping of the Cerebral Cortex
by Richard W. ByrneThis book provides up-to-date, practical information on functional mapping in order to assist neurosurgeons responsible for safely removing lesions in and around eloquent cortex - one of the greatest challenges in neurosurgery. The roles of pre- and intraoperative mapping techniques are clearly explained, highlighting the advantages and limitations of each tool available to the neurosurgeon. The inclusion of treatment algorithms for applications in specific clinical circumstances ensures that the book will serve as a clear guide to this most complex of neurosurgical problems. To further assist the reader, instructive clinical case examples, accompanied by intraoperative photos and other illustrative material, help to explain the applications of functional mapping of eloquent cortex in different pathologies. Practitioners will find the book to be a ready guide to navigation of the practical decisions commonly faced when operating in eloquent cortex.
Functional Mitral and Tricuspid Regurgitation
by Kok Meng John ChanThis book covers in detail all aspects of functional mitral and tricuspid regurgitation, from its pathophysiology and natural history, to its assessment, medical and surgical treatment, and long term results. Functional Mitral and Tricuspid Regurgitation encompasses information and knowledge from a diverse background including cardiology, cardiac surgery and basic science. This is necessary for a full understanding of the subject in order to optimally manage patients with this condition.
Functional Movement Disorder: An Interdisciplinary Case-Based Approach (Current Clinical Neurology)
by Kathrin LaFaver Carine W. Maurer Timothy R. Nicholson David L. PerezThis book is a practical manual for clinical practitioners seeking to take an interdisciplinary and multidisciplinary approach to the diagnosis and management of functional movement disorder (FMD). It discusses case vignettes, reviews the diagnostic approach, provides an update on available treatments, highlights clinical pearls and details references for further reading.Organized into three parts, the book begins with a framework for conceptualizing FMD - including its historical context, the biopsychosocial model and an integrated neurologic-psychiatric perspective towards overcoming mind-body dualism. Part II then provides a comprehensive overview of different FMD presentations including tremor, dystonia, gait disorders, and limb weakness, as well as common non-motor issues such as pain and cognitive symptoms. The book concludes with chapters on updated practices in delivering the diagnosis, working with patients and care partners to achieve shared understanding of a complex condition, as well as an overview of evidence-based and evolving treatments. Supplemented with high-quality patient videos, Functional Movement Disorder is written for practicing neurologists, psychiatrists, psychologists, allied mental health professionals, and rehabilitation experts with an interest in learning more about diagnosis and management of FMD.
Functional Nanomaterials for Regenerative Tissue Medicines (Emerging Materials and Technologies)
by Mariappan RajanThis book covers nanomaterials in tissue engineering for regenerative therapies of heart, skin, eye, skeletal muscle, and the nervous system. The book emphasizes fundamental design concepts and emerging forms of nanomaterials in soft- and hard-tissue engineering. FEATURES Fills a gap in the literature related to the application of nanomaterials in hard- and soft-tissue regeneration, repair, and restructure Discusses a variety of applications, including cardiac, kidney, liver, bone, wound healing, artificial organs, and dental Presents advantages and limitations of various nanomaterials alongside future challenges Functional Nanomaterials for Regenerative Tissue Medicines is essential for academics and industry professionals working in tissue engineering, biomedicine, biopharmaceuticals, and nanotechnology. It is primarily intended for materials researchers (to develop the platforms related to tissue regeneration) as well as clinicians (to learn and apply nanomaterials in their practice) and industrial scientists (to develop commercial blood substitute products).
Functional Neuroimaging: A Clinical Approach
by Andrei HolodnyThe first text designed specifically with clinical practitioners in mind, Functional Neuroimaging demonstrates the clinical application and utilization of functional neuroradiology for early diagnosis, neurological decision-making, and assessing response to cancer therapy. Edited by the Founding President of American Society of Functional Neuroradi
Functional Neuroimaging in Exercise and Sport Sciences
by Charles H. Hillman Henning Boecker Lukas Scheef Heiko K. StrüderRegular physical exercise is associated with substantial health benefits. Recent evidence not only holds for cardiovascular effects promoting "physical health", but also for the central nervous system believed to promote "brain health". Moderate physical exercise has been found to improve learning, memory, and attentional processing, with recent research indicating that neuroprotective mechanisms and associated plasticity in brain structure and function also benefit. Physical exercise is also known to induce a range of acute or sustained psychophysiological effects, among these mood elevation, stress reduction, anxiolysis, and hypoalgesia. Today, modern functional neuroimaging techniques afford direct measurement of the acute and chronic relation of physical exercise on the human brain, as well as the correlation of the derived physiological in vivo signals with behavioral outcomes recorded during and after exercise. A wide range of imaging techniques have been applied to human exercise research, ranging from electroencephalography (EEG), magnetoencephalography (MEG), near infrared spectroscopy (NIRS), magnetic resonance imaging (MRI) to positron emission tomography (PET). All of these imaging methods provide distinct information, and they differ considerably in terms of spatial and temporal resolution, availability, cost, and associated risks. However, from a "multimodal imaging" perspective, neuroimaging provides an unprecedented potential to unravel the neurobiology of human exercise, covering a wide spectrum ranging from structural plasticity in gray and white matter, network dynamics, global and regional perfusion, evoked neuronal responses to the quantification of neurotransmitter release. The aim of this book is to provide the current state of the human neuroimaging literature in the emerging field of the neurobiological exercise sciences and to outline future applications and directions of research.
Functional Neuroimaging in Whiplash Injury: New Approaches
by Andreas OtteThis book, now in its second, completely revised and updated edition, offers a critical approach to the challenging interpretation of the latest research data obtained using functional neuroimaging in whiplash injury. Such a comprehensive guide to recent and current international research in the field is more necessary than ever, given that the confusion regarding the condition and the medicolegal discussions surrounding it have increased further despite the publication of much literature on the subject. In recent decades especially the functional imaging methods – such as single-photon emission tomography, positron emission tomography, functional MRI, and hybrid techniques – have demonstrated a variety of significant brain alterations. Functional Neuroimaging in Whiplash Injury - New Approaches covers all aspects, including the imaging tools themselves, the various methods of image analysis, different atlas systems, and diagnostic and clinical aspects. The book will help physicians, patients and their relatives and friends, and others to understand this condition as a disease.
Functional Neuroimaging in Whiplash Injury: New Approaches
by Andreas OtteThis book, now in its third, completely revised and updated edition, offers a critical approach to the challenging interpretation of the latest research data obtained using functional neuroimaging in whiplash injury. Such a comprehensive guide to recent and current international research in the field is more necessary than ever, given that the confusion regarding the condition and the medicolegal discussions surrounding it have increased further despite the publication of much literature on the subject. In recent decades especially the functional imaging methods – such as single-photon emission tomography, positron emission tomography, functional MRI, and hybrid techniques – have demonstrated a variety of significant brain alterations. Functional Neuroimaging in Whiplash Injury - New Approaches covers all aspects, including the imaging tools themselves and the various methods of image analysis. Details on biomechanics, including the finite element method and facts on historical whiplash experiments and crash tests have now been added to this new edition. The book will continue to help physicians, patients and their relatives and friends, and others to understand this condition as a disease.
Functional Neuroradiology: Principles and Clinical Applications
by Scott H. Faro Feroze B. MohamedThis new edition fully updates and expands Faro and Mohamed’s Functional Neuroradiology, a gold standard, comprehensive introduction to the state-of-the-art functional imaging in neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 12 major sections, including: Diffusion and Perfusion Imaging, Magnetic Resonance Spectroscopy and Chemical Exchange Saturation Transfer Imaging, Multi-Modality Functional Neuroradiology, BOLD Functional MRI, Diffusion Tensor Imaging, Presurgical Brain Tumor Mapping, Emerging neuroimaging techniques, Functional Spine and Hydrocephalus imaging, and Neuroanatomical Gray and White matter Brain Atlases. This second edition is fully updated throughout and includes more than 15 new chapters on topics such as: Brain tumor Radiogenomics, CNS Tumor Surveillance and Functional MR Perfusion Imaging, CNS Machine Learning, Focused Ultrasound therapy, TBI Sports Related Injury, and CNS Lymphatic system. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.
Functional Neuroradiology
by Feroze B. Mohamed Scott H. Faro John T. Ulmer Meng LawFunctional Neuroradiology: Principles and Clinical Applications, is a follow-up to Faro and Mohamed's groundbreaking work, Functional (BOLD)MRI: Basic Principles and Clinical Applications. This new 49 chapter textbook is comprehensive and offers a complete introduction to the state-of-the-art functional imaging in Neuroradiology, including the physical principles and clinical applications of Diffusion, Perfusion, Permeability, MR spectroscopy, Positron Emission Tomography, BOLD fMRI and Diffusion Tensor Imaging. With chapters written by internationally distinguished neuroradiologists, neurologists, psychiatrists, cognitive neuroscientists, and physicists, Functional Neuroradiology is divided into 9 major sections, including: Physical principles of all key functional techniques, Lesion characterization using Diffusion, Perfusion, Permeability, MR spectroscopy, and Positron Emission Tomography, an overview of BOLD fMRI physical principles and key concepts, including scanning methodologies, experimental research design, data analysis, and functional connectivity, Eloquent Cortex and White matter localization using BOLD fMRI and Diffusion Tensor Imaging, Clinical applications of BOLD fMRI in Neurosurgery, Neurology, Psychiatry, Neuropsychology, and Neuropharmacology, Multi-modality functional Neuroradiology, Beyond Proton Imaging, Functional spine and CSF imaging, a full-color Neuroanatomical Brain atlas of eloquent cortex and key white matter tracts and BOLD fMRI paradigms. By offering readers a complete overview of functional imaging modalities and techniques currently used in patient diagnosis and management, as well as emerging technology, Functional Neuroradiology is a vital information source for physicians and cognitive neuroscientists involved in daily practice and research.
Functional Nucleic Acid Based Biosensors for Food Safety Detection
by Yunbo LuoThis book highlights the development of a functional nucleic acid based biosensor detection method in the context of food safety. Although there have been major advances in food processing technology in both developed and developing countries, food safety assurance systems are generally becoming more stringent, in response to growing (both real and perceived) food safety problems. These problems are due in part to foodborne microorganisms, heavy metals, and small chemical molecules (biological toxins, pesticide residues, and veterinary drug residues), etc. In addition, the nucleic acid biomarkers (DNA methylation, microRNA, and circRNA) induced by these risk factors are also closely related to food safety. Accordingly, this book offers a brief guide to targets and strategies in functional nucleic acid based biosensors for food safety detection. Divided into several chapters that focus on various respective targets, it will be a valuable resource for students and researchers in the fields of biosensor detection, food science etc.
Functional Ophthalmic Disorders
by Robert Enzenauer William Morris Thomas O'Donnell Jill MontreyThis is a practical manual for diagnostic testing, focusing on the historical and contemporary research on functional disorders in general, and functional visual disorders in particular. Functional Ophthalmic Disorders: Ocular Malingering and Visual Hysteria is a how-to manual that is written for the practicing ophthalmologist and optometrist, complete with color photos that allow the reader to see pictures of select diseases. In addition to the photos, videos are provided online to illustrate the various tests and possible results conducted on a mock patient to assist in the differential diagnosis. Written and edited by leaders in the field, some of the topics covered include history of functional disorders, ophthalmologic examination in malingering and techniques and tests for functional and simulated defects.
Functional Performance in Older Adults (Third Edition)
by Bette R. Bonder Vanina Dal Bello-Haas Marilyn B. Wagner Bette Bonder Vanina Bello-Haas"The contributors represent diverse disciplines, however their messages create a coherent, integrated work of universal interest and application. I highly recommend the use of this text for allied health students who are studying geriatric rehabilitation and for clinicians who wish to renew their knowledge. "--Carole Knight, MEd, OTR/L, Occupational Therapy in Health Care Journal, Volume 16, Number 2/3 February 2003, review of the 2nd Edition. The ideal resource for rehabilitation professionals who are working with or preparing to work with older adults! It describes the normal aging process, illustrates how health and social factors can impede an aging person's abilities, and demonstrates how to develop mechanisms for maximizing the well-being of older adults.
Functional Respiratory Disorders
by Ran D AnbarMany patients with pulmonary complaints fail to improve despite physicians' best efforts. Sometimes, we ascribe this failure to lack of adherence with therapy, or to the severity of the condition. What we often fail to appreciate, however, is that sometimes the lack of improvement can be explained by the patients' psychological states. The first section of Functional Respiratory Disorders: When Respiratory Symptoms Do Not Respond to Pulmonary Treatment will help clinicians recognize functional respiratory symptoms that can arise as a result of both organic and psychological causes. The second section of this book provides detailed discussions of such disorders, links to video examples of laryngoscopic evaluation of patients with vocal cord issues, case studies and quizzes. Examples and exercises that should strengthen the clinician's confidence in identifying and treating these functional conditions are also provided. Finally, the third section of the book will help the clinician differentiate the patients for whom referral to a mental health provider is mandatory from those for whom other approaches may be useful. For the latter group, the book teaches clinicians to empower themselves by learning how to incorporate various therapies for functional disorders into their practice, including biofeedback, breathing techniques, basic cognitive behavioral therapy techniques, and hypnosis. Links are provided to instructive video examples of biofeedback, hypnosis, and speech therapy. Practical strategies for obtaining training in these modalities are provided in the appendix. Functional Respiratory Disorders: When Respiratory Symptoms Do Not Respond to Pulmonary Treatment is an important new book that will help clinicians consider the possible impact of functional contributions to the clinical presentation of every patient with respiratory symptoms and identified respiratory disease.
The Functional Role of Critical Dynamics in Neural Systems (Springer Series on Bio- and Neurosystems #11)
by Nergis Tomen J. Michael Herrmann Udo ErnstThis book offers a timely overview of theories and methods developed by an authoritative group of researchers to understand the link between criticality and brain functioning. Cortical information processing in particular and brain function in general rely heavily on the collective dynamics of neurons and networks distributed over many brain areas. A key concept for characterizing and understanding brain dynamics is the idea that networks operate near a critical state, which offers several potential benefits for computation and information processing. However, there is still a large gap between research on criticality and understanding brain function. For example, cortical networks are not homogeneous but highly structured, they are not in a state of spontaneous activation but strongly driven by changing external stimuli, and they process information with respect to behavioral goals. So far the questions relating to how critical dynamics may support computation in this complex setting, and whether they can outperform other information processing schemes remain open. Based on the workshop “Dynamical Network States, Criticality and Cortical Function", held in March 2017 at the Hanse Institute for Advanced Studies (HWK) in Delmenhorst, Germany, the book provides readers with extensive information on these topics, as well as tools and ideas to answer the above-mentioned questions. It is meant for physicists, computational and systems neuroscientists, and biologists.