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Fundamentals of Clinical Data Science
by Pieter Kubben Michel Dumontier Andre DekkerThis open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.
Fundamentals of Clinical Data Science
by Pieter Kubben Michel Dumontier Andre DekkerThis open access book comprehensively covers the fundamentals of clinical data science, focusing on data collection, modelling and clinical applications. Topics covered in the first section on data collection include: data sources, data at scale (big data), data stewardship (FAIR data) and related privacy concerns. Aspects of predictive modelling using techniques such as classification, regression or clustering, and prediction model validation will be covered in the second section. The third section covers aspects of (mobile) clinical decision support systems, operational excellence and value-based healthcare. Fundamentals of Clinical Data Science is an essential resource for healthcare professionals and IT consultants intending to develop and refine their skills in personalized medicine, using solutions based on large datasets from electronic health records or telemonitoring programmes. The book’s promise is “no math, no code”and will explain the topics in a style that is optimized for a healthcare audience.
Fundamentals of Clinical Psychopharmacology
by Peter Whelan Peter Lydyard Michael FangerThis book provides up-to-date, evidence-based and unbiased information about psychopharmacology. It spans the range of the discipline, from mode of action and side effects of drugs to meta-analyses of clinical trials. This latest edition is fully updated and provides the key facts about currently used psychotropic drugs, set in the context of the neuroscience of the disorders they treat. It also includes a new chapter on the principles of psychiatric prescribing. Key references are provided at the end of each chapter along with suggestions for further reading.
The Fundamentals of Clinical Research: A Universal Guide for Implementing Good Clinical Practice
by P. Michael Dubinsky Karen A. HenryThis book focuses on the practical application of good clinical practice (GCP) fundamentals and provides insight into roles and responsibilities included in planning, executing, and analyzing clinical trials. The authors describe the design of quality into clinical trial planning and the application of regulatory, scientific, administrative, business, and ethical considerations. Describes the design of quality into the clinical trial planning Has end-of-chapter questions and answers to check learning and comprehension Includes charts that visually summarize the content and allow readers to cross-reference details in relevant chapters Offers a companion website containing supplemental training resources
Fundamentals of Clinical Trials
by Lawrence M. Friedman Curt D. Furberg David L. DemetsThis is the fourth edition of a very successful textbook on clinical trials methodology, written by three recognized experts who have long and extensive experience in all areas of clinical trials. Most chapters have been revised considerably from the third edition. A chapter on ethics has been added and topics such as noninferiority and adaptive designs now receive considerable discussion. There is much new material on adverse events, adherence, data monitoring, and issues in analysis. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials from a variety of medical disciplines to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan, and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology.
Fundamentals of Clinical Trials
by Lawrence M. Friedman Curt D. Furberg David L. DeMets David M. Reboussin Christopher B. GrangerThis is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials.This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals.The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives.Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful.
Fundamentals of Clinical Trials
by Christopher B. Granger David M. Reboussin David L. Demets Curt D. Furberg Lawrence M. FriedmanThis is the fifth edition of a very successful textbook on clinical trials methodology, written by recognized leaders who have long and extensive experience in all areas of clinical trials. The three authors of the first four editions have been joined by two others who add great expertise. Most chapters have been revised considerably from the fourth edition. A chapter on regulatory issues has been included and the chapter on data monitoring has been split into two and expanded. Many contemporary clinical trial examples have been added. There is much new material on adverse events, adherence, issues in analysis, electronic data, data sharing and international trials. This book is intended for the clinical researcher who is interested in designing a clinical trial and developing a protocol. It is also of value to researchers and practitioners who must critically evaluate the literature of published clinical trials and assess the merits of each trial and the implications for the care and treatment of patients. The authors use numerous examples of published clinical trials to illustrate the fundamentals. The text is organized sequentially from defining the question to trial closeout. One chapter is devoted to each of the critical areas to aid the clinical trial researcher. These areas include pre-specifying the scientific questions to be tested and appropriate outcome measures, determining the organizational structure, estimating an adequate sample size, specifying the randomization procedure, implementing the intervention and visit schedules for participant evaluation, establishing an interim data and safety monitoring plan, detailing the final analysis plan and reporting the trial results according to the pre-specified objectives. Although a basic introductory statistics course is helpful in maximizing the benefit of this book, a researcher or practitioner with limited statistical background would still find most if not all the chapters understandable and helpful. While the technical material has been kept to a minimum, the statistician may still find the principles and fundamentals presented in this text useful. This book has been successfully used for teaching courses in clinical trial methodology.
Fundamentals of Complementary, Alternative, and Integrative Medicine
by Marc S. MicozziFoundations of Complementary/Alternative Medicine in Health Care, Fundamental Sciences, Mind-Body Medicine, Bodywork and Manual Therapies, Western Electromagnetic, Natural, Nutritional, and Plant-Based Therapies, Traditional World Medical Systems Part 1: East and Southeast Asia, Part 2: Middle Asia, Part 3: Africa, Americas, and the Pacific.
Fundamentals of Craniofacial Growth
by Andrew D. Dixon David A.N. Hoyte Olli RonningThis book brings together in one volume selected important topics in craniofacial growth. Topics include: principles of skeletal growth; osteogenesis and its control; formation of the cranial base and craniofacial joints; prenatal development of the facial skeleton; growth of the mandible, nasomaxillary complex, orbit, cranial base, ear capsule, and cranial vault; bone remodeling; muscles; soft tissues; and blood vessels.Fundamentals of Craniofacial Growth contains detailed illustrations and extensive reference lists. Independently authored chapters provide comprehensive reviews encompassing both contemporary and historical perspectives. In addition to medicine and dentistry, contributors provide expertise from such diverse backgrounds as anatomy, biology, biomathematics, embryology, orthodontics, physical anthropology, and plastic and reconstructive surgery.
Fundamentals of Craniofacial Malformations: Vol. 1, Disease and Diagnostics
by Ulrich MeyerThis is the first volume in an interdisciplinary three-book series covering the full range of biological, clinical, and surgical aspects in the evaluation, diagnosis, and treatment of patients with craniofacial malformations. This volume opens by considering general topics such as developmental biology and disease classification and then examines in depth the biological basis of the various malformations, including craniosynostoses, cleft-lip and palate with complex orofacial clefts, branchio-oculo-facial syndromes, rare syndromes, soft tissue malformations, and dysgnathia. Psychological aspects, including psychological evaluation methods and therapies and quality of life issues, are then addressed. Finally, all relevant clinical, radiological, and genetic investigations are described and important diagnostic issues are explored. Featuring numerous high-quality illustrations, the book will be of high value for all clinicians, researchers, and postgraduate students who deal with these malformations. The accompanying two volumes describe treatment principles and present in an atlas manner all relevant surgical techniques in detail. The content of this multivolume set, written by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this medical field.
Fundamentals of Craniofacial Malformations: Vol. 2, Treatment Principles
by Ulrich MeyerThis is the second volume in an interdisciplinary three-book series covering the full range of biological, clinical, and surgical aspects in the evaluation, diagnosis, and treatment of patients with craniofacial malformations. In this volume, readers will find detailed discussion of the treatment principles for craniosynostoses, orofacial clefts, branchio-oculo-facial syndromes, soft tissue malformations, dysgnathia and rare syndromes. In addition to description of important facets of treatment and the treatment planning process, guidance is offered on diagnosis and disease classification. Featuring numerous high-quality illustrations, the book will be of value for all clinicians and trainees who are involved in the management of patients with these malformations. The accompanying two volumes discuss the biological basis of disease, psychological aspects, and diagnostic issues and present surgical techniques with the aid of accompanying surgical videos.
Fundamentals of Critical Care: A Textbook for Nursing and Healthcare Students (Fundamentals)
by Ian Peate Barry HillFundamentals of Critical Care Fundamentals of Critical Care A Textbook for Nursing and Healthcare Students In Fundamentals of Critical Care, a team of clinicians and health educators deliver an accessible, timely, and evidence-based introduction to the role of nurses and healthcare practitioners in critical care. The book explores fundamental concepts in critical care and their implications for practice. Each chapter outlines essential knowledge necessary to understand key concepts and includes high quality, full-colour artwork to enhance learning and recall. Readers are also provided with clinical scenarios, practice questions, and red and orange flags to indicate physiological and psychological alerts respectively. Covering a range of common and specialised disease processes and treatments requiring critical care, the book provides: A thorough introduction to the critical care unit, including philosophies of care, ways of working, humanisation, and outreach Comprehensive exploration of organisational influences, including political, local, national, and international influences Practical discussion of legal, ethical, and professional issues, as well as evidence-based approaches to critical care In-depth examination of nursing care assessment tools, nursing communication, cognition, pharmacology, and more Perfect for nursing students and trainee nursing associates, Fundamentals of Critical Care: A Textbook for Nursing and Healthcare Students will also earn a place in the libraries of healthcare students in physiotherapy, paramedicine, medicine, and those returning to practice. All content reviewed by students for students. If you would like to be one of our student reviewers, go to www.reviewnursingbooks.com to find out more. To receive automatic updates on Wiley books and journals, join our email list. Sign up today at www.wiley.com/email
Fundamentals of Digital Imaging in Medicine
by Roger BourneIn general, image processing texts are intended for students of engineering and computer science, and there is little written at all on the specific requirements of medical image processing. Students of medical radiation science (Diagnostic radiography, Nuclear medicine, Radiation therapy) usually have minimal mathematical and computer science training and find the available texts incomprehensible. A text that explains the principles of image processing in minimally-mathematical language is needed for these students. Contrary to the claims of some textbook authors, the vast majority of technologists that process images do not need to understand the mathematics involved, but would nevertheless benefit from a thorough understanding of the general process.
Fundamentals of Drug Delivery
by Heather A E BensonA comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.
Fundamentals of Drug Development
by Jeffrey S. BarrettFundamentals of DRUG DEVELOPMENT Enables readers to understand the process of pharmaceutical research, its regulatory basis, and how it fits into the global healthcare environment This book discusses how to conduct pharmaceutical research and the context for how the industry fits into global healthcare. Holistically, the well-qualified author helps readers and students of drug development appreciate the time and expense of the process. Specifically, the work identifies the emerging trends shaping the future of drug development, along with important related topics like generic drugs, data sharing, and collaboration. To aid in seamless reader comprehension, the book includes a glossary of terms and a self-assessment quiz for each chapter at the end. PowerPoint slides are also available as an online ancillary for adopting professors. Sample topics covered in the book include: Drug development and its phases Decision-making processes, drug development milestones, and compound progression metrics The various disciplines involved along with an assessment of the complexity and risks associated across the stages of development Differences in the nature and scope of development programs due to the therapeutic area of interest Associated costs and resources required Graduate students and professors teaching courses in drug development, drug discovery, pharmaceuticals, medicinal chemistry, and drug synthesis will be able to use this book as a complete resource for understanding all the complexities and nuances involved in the drug development process.
Fundamentals of Environmental Assessment
by Glenn W. Suter IIBased on the "go to" book in the field of ecological risk assessment, this shorter, principles-based, updated textbook is essential for students and new practitioners who want to understand the purposes of environmental assessments and how to achieve them. It includes environmental risks to humans as well as nonhuman populations and ecosystems, and most types of environmental assessments. Drawing upon the author’s extensive experience in the field, first as a senior research staff member in the Environmental Sciences Division at Oak Ridge Laboratory and then as science advisor in the United States Environmental Protection Agency’s National Center for Environmental Assessment, the book explains fundamental principles and basic techniques and illustrates them with example applications which carry through multiple chapters and make this book a practical and hands-on guide. Both the content and the style are inviting and approachable to different levels of students. Features Integrates human health and ecological assessments. Includes epidemiological, risk, causal, impact, and outcome assessments. Focuses on fundamental principles that are applicable in all nations and legal contexts. Employs an engaging style and draws on the author’s practical experience. Explains fundamental concepts in short chapters, making it perfect for beginners in the field. Explains the challenges and rewards of a career in environmental assessment. This book is a practical guide for senior and graduate students in environmental sciences and management, as well as new practitioners of assessment who want to understand the purposes of environmental assessments and how to achieve them.
Fundamentals Of Epidemiology And Biostatistics: Combining the Basics
by Ray M. MerrillThis book will familiarize students with basic principles of epidemiology and biostatistics. Designed for use in a single course, it will clarify the distinction and complementary roles of epidemiology and biostatistics in a range of settings, and train students on the complementary roles epidemiology and biostatistics play in carrying out selected activities in the health professions.
Fundamentals of Evidence-Based Health Care and Translational Science
by Francesco ChiappelliComparative effectiveness research - the conduct and synthesis of systematic research in order to compare the benefits and harms of alternative treatment options - is of critical importance in enabling informed health care decisions to be made. This user-friendly, practical handbook examines in depth how best to perform such comparative effectiveness research. A wide range of topics and methods are discussed, including research synthesis, sampling analysis, assessment of evidence design, systematic evaluation of statistical analysis, and meta-analysis. The discussion extends well beyond the fundamentals by encompassing "complex" systematic reviews, "cumulative" meta-analyses, and logic-based versus utility-based decision making. Health care providers, researchers, instructors, and students will all find this to be an invaluable reference on the compelling current issues and important analytical tools in comparative effectiveness research.
Fundamentals of Evidence Based Medicine
by Kameshwar PrasadThis is a basic book on evidence-based medicine (EBM). It starts with an introduction to the topic. It outlines the relationship between EBM and research and quality of care. Then It goes on to cover the most commonly used modules of EBM, i.e. therapy, diagnosis, prognosis and meta-analysis. Each module starts with an introduction to fundamental concepts, and description of the related research process, and then follows the critical appraisal of related type of research artcle. At the end, it covers the different systems of grading of level of evidence and strength of recommendations. The book also has three examples of critical appraisal on diagnosis, therapy, and meta-analysis.
Fundamentals Of Fire Fighter Skills: Evidence-based Practices
by National Fire Protection AssociationEach new print copy of Fundamentals of Fire Fighter Skills also includes Navigate 2 Advantage Access that unlocks a complete eBook, Study Center, homework and Assessment Center, and a dashboard that reports actionable data. Experience Navigate 2 today at www.jblnavigate.com/2. The National Fire Protection Association (NFPA) and the International Association of Fire Chiefs (IAFC) are pleased to bring you the third edition of Fundamentals of Fire Fighter Skills, the next step in the evolution of Fire Fighter I and Fire Fighter II training. With superior teaching and learning tools, the first and second editions of Fundamentals of Fire Fighter Skills set a new benchmark in fire fighter training. Now the NFPA, IAFC, and Jones & Bartlett Learning are proud to raise the bar for the fire service again. Comprehensive Content The third edition covers the entire spectrum of the 2013 Edition of NFPA 1001: Standard for Fire Fighter Professional Qualifications, as well as the requirements for Operations level responders in the 2013 Edition of NFPA 472: Standard for Competence of Responders to Hazardous Materials/Weapons of Mass Destruction Incidents. From fire suppression to hazardous materials to emergency medical care, this one volume covers all of Fire Fighter I and Fire Fighter II training requirements. The training program also includes coverage of the UL/NIST research studies and experiments on fire behavior and techniques for ventilation, fire suppression, and search and rescue as a result of the changes in modern building construction and furnishing materials. As a result of these changes, today's fires release energy faster, reach flashover potential sooner, may reach higher temperatures, and are much more likely to become ventilation-limited than building fires of even a few years ago. Tools for Success * Quickly identify Fire Fighter II content and skill drills through clear visual roadmaps. * Rapidly access content through clear and concise Knowledge and Skill Objectives with page references, as well as NFPA 1001 and 472 correlations. * Encourage critical thinking skills. Fire Fighter I and Fire Fighter II case studies offer students a genuine context for applying the knowledge presented in the chapter.
Fundamentals of Frontline Surgery
by Mansoor KhanFundamentals of Frontline Surgery is an easy to read text, written by world class faculty, that provides clinicians with succinct and didactic information about what to do in high intensity, resource limited situations.With global conflicts and humanitarian emergencies on the rise, there has been a dramatic uptake in the number of volunteers for both military and humanitarian operations. This manual aids best practice and fast decision making in the field.
Fundamentals of General Surgery
by Francesco Palazzo Michael J PucciThis book provides a comprehensive guide to the surgical skills required during general surgery. General Concepts are covered with descriptions of basic terminology, the logic behind specific approaches, limitations of specific skills, technical and practical considerations, and safety of using specific approaches and skills. More advanced topics including gastro-intestinal anastomosis, exploring a patient after a major trauma, and managing crisis situations are also discussed, as well as current controversies and future directions within general surgery.Fundamentals of General Surgery is relevant to trainees in general surgery and its subspecialties, and aims to give them an easy to access resource that contains real life examples, iconography, and recommended further reading.
Fundamentals of Hand Therapy: Clinical Reasoning and Treatment Guidelines for Common Diagnoses of the Upper Extremity (2nd Edition)
by Cynthia CooperPerfect for hand therapy specialists, hand therapy students, and any other professional who encounters clients with upper extremity issues, Fundamentals of Hand Therapy, 2nd Edition contains everything you need to make sound therapy decisions. Coverage includes hand anatomy, the evaluation process, and diagnosis-specific information. Expert tips, treatment guidelines, and case studies round out this comprehensive text designed to help you think critically about each client’s individual needs. <p><p> "Overall, a very clear readable style is adopted throughout, with theory supported by various anecdotal case studies. Excellent use is made of illustrations, and many chapters contain the helpful addition of ‘clinical pearls’ or ‘tips from the field’, which are an attempt to make transparent the links between theory and practice. In conclusion, this is an excellent core text for reference purposes." Reviewed by: British Journal of Occupational Therapy Date: Aug 2014 <p> Clinical Pearls and Precautions highlight relevant information learned by the experienced author and contributors that you can apply to clinical practice.<br> Case examples included in the diagnoses chapters in Part Three demonstrate the use of clinical reasoning and a humanistic approach in treating the client.<br> Diagnosis-specific information in the final section of the book is well-organized to give you quick access to the information you need.<br> Special features sections such as Questions to Discuss with the Physician, What to Say to Clients, Tips from the Field, and more help readers find their own clinical voices.<br> Online sample exercises give you a pool to pull from during professional practice.<br> NEW! Chapters on yoga and pilates provide guidance into new ways to treat upper extremity problems.<br> NEW! Chapter on wound care gives you a thorough foundation on how wounds impact therapeutic outcomes.<br> NEW! Chapter on orthotics has been added to cover basic splinting patterns.<br> NEW! Online resources help assess your understanding and retention of the material
Fundamentals Of Health Care Administration
by Shelley SafianThis foundational text introduces future health care administrators to the full scope of responsibilities associated with these crucial positions. Fundamentals of Health Care Administration prepares students for comprehensive education on the health care industry, and helps them build the strong critical thinking and analysis skills they will need as administrators. Its broad coverage includes finance, human resources, risk assessment, crisis management, compliance, internal and external audits, quality assessment/control, performance improvement, legal and ethical concerns, and more. The first chapter includes a bulleted list of required knowledge and skills from an actual health care administrator’s job description. The remaining chapters tie directly to that job description. Each chapter illustrates key concepts with relevant examples, including short selections from authoritative government documents. Complex concepts are organized into bulleted lists or steps, making them easier to understand and use. Extensive chapter review includes multiple choice, matching, short answer, and true/false questions.
Fundamentals of Health Care Financial Management
by Steven BergerIn this thoroughly revised and updated third edition of Fundamentals of Health Care Financial Management, consultant and educator Steven Berger offers a practical step-by-step approach to understanding the fundamental theories and relationships guiding financial decisions in health care organization. Set in a fictional mid-sized hospital, the book is written in diary form, taking the reader into the inner workings of the finance executive's office. This introduction to the most-used tools and techniques of health care financial management includes health care accounting and financial statements; managing cash, billings and collections; making major capital investments; determining cost and using cost information in decision-making; budgeting and performance measurement; and pricing. As in the previous editions, this book introduces key practical concepts in fundamental areas of financial management.