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Glial-Neuronal Signaling in Neuroendocrine Systems (Masterclass in Neuroendocrinology #11)
by Jeffrey G. Tasker Jaideep S. Bains Julie A. ChowenThis volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.
Glial Physiology and Pathophysiology
by Alexei Verkhratsky Arthur Morgan ButtGlial Physiology and Pathophysiology provides a comprehensive, advanced text on the biology and pathology of glial cells.Coverae includes:the morphology and interrelationships between glial cells and neurones in different parts of the nervous systemsthe cellular physiology of the different kinds of glial cellsthe mechanisms of intra- and inter-cellular signalling in glial networksthe mechanisms of glial-neuronal communicationsthe role of glial cells in synaptic plasticity, neuronal survival and development of nervous systemthe cellular and molecular mechanisms of metabolic neuronal-glial interactionsthe role of glia in nervous system pathology, including pathology of glial cells and associated diseases - for example, multiple sclerosis, Alzheimer's, Alexander disease and Parkinson'sNeuroglia oversee the birth and development of neurones, the establishment of interneuronal connections (the 'connectome'), the maintenance and removal of these inter-neuronal connections, writing of the nervous system components, adult neurogenesis, the energetics of nervous tissue, metabolism of neurotransmitters, regulation of ion composition of the interstitial space and many, many more homeostatic functions. This book primes the reader towards the notion that nervous tissue is not divided into more important and less important cells. The nervous tissue functions because of the coherent and concerted action of many different cell types, each contributing to an ultimate output. This reaches its zenith in humans, with the creation of thoughts, underlying acquisition of knowledge, its analysis and synthesis, and contemplating the Universe and our place in it.An up-to-date and fully referenced text on the most numerous cells in the human brainDetailed coverage of the morphology and interrelationships between glial cells and neurones in different parts of the nervous systemDescribes the role og glial cells in neuropathologyFocus boxes highlight key points and summarise important factsCompanion website with downloadable figures and slides
Glioblastoma: Methods and Protocols (Methods in Molecular Biology #1741)
by Dimitris G. PlacantonakisThis volume details cutting-edge protocols on the characterization of the genome, epigenome, proteome, metabolome and single-cell transcriptome of tumors and tumor-derived cultures. Chapters focus on subpopulations of cells with stem-like properties, laser capture microdissection, and modeling human glioma with human embryonic stem cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Glioblastoma: Methods and Protocols aims to support researchers seeking new and refined protocols to better decrypt this tumor.
Glioblastoma:
by Swapan K. RayGlioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.
The Gliocentric Brain: Phenotype Plasticity of the Damaged Brain
by Wolfgang WalzThe brain is the body’s most vulnerable organ due to the defined roles of neurons within circuits. Neurons are vastly outnumbered by microglia, astrocytes, oligodendrocytes, macrophages, cells of the blood brain barrier and invading immune cells. These cells display different grades of reactivities and interactions. They integrate their responses and not only change phenotypes but can also completely reprogram after damage to protect the neuronal complexity. The interactions of these satellite cells in the healthy brain are described as well as their roles in all major brain diseases. Special emphasis is put on immune system – brain interactions and regenerative and repair processes. The gliotic response is compared with the reactions to injuries of the skin and other organs. A final chapter addresses the definition of a cell type. It concludes that cell types can no longer be regarded as defined entities over the body’s lifetime but are prone to phenotype plasticity and even complete reprograming.
Glioma Cell Biology
by Aleksi Sedo Rolf MentleinGliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology.
Glioma Imaging: Physiologic, Metabolic, and Molecular Approaches
by Whitney B. PopeThis book covers physiologic, metabolic and molecular imaging for gliomas. Gliomas are the most common primary brain tumors. Imaging is critical for glioma management because of its ability to noninvasively define the anatomic location and extent of disease. While conventional MRI is used to guide current treatments, multiple studies suggest molecular features of gliomas may be identified with noninvasive imaging, including physiologic MRI and amino acid positron emission tomography (PET). These advanced imaging techniques have the promise to help elucidate underlying tumor biology and provide important information that could be integrated into routine clinical practice. The text outlines current clinical practice including common scenarios in which imaging interpretation impacts patient management. Gaps in knowledge and potential areas of advancement based on the application of more experimental imaging techniques will be discussed. In reviewing this book, readers will learn: current standard imaging methodologies used in clinical practice for patients undergoing treatment for glioma and the implications of emerging treatment modalities including immunotherapythe theoretical basis for advanced imaging techniques including diffusion and perfusion MRI, MR spectroscopy, CEST and amino acid PET the relationship between imaging and molecular/genomic glioma features incorporated in the WHO 2016 classification update and the potential application of machine learningabout the recently adopted and FDA approved standard brain tumor protocol for multicenter drug trialsof the gaps in knowledge that impede optimal patient management and the cutting edge imaging techniques that could address these deficits
Glioma Signaling
by Jolanta BarańskaGlioma Signaling is a text reference on cellular signaling processes focused on the mechanism of nucleotide receptors activation by exogenic nucleotides and the formation of complex signaling cascades, including cytoplasmic transcription factors, induced by growth factors, cytokines and cannabinoids. The book provides a framework explaining how signal transduction elements may modulate glioma cytoskeleton structure, cytoplasmic calcium concentration changes, cellular growth, progression and invasion, as well as presents perspective concerning potential targets for glioma therapy.
Glioma Signaling (Advances in Experimental Medicine and Biology #1202)
by Jolanta BarańskaGliomas, developing in the brain from the transformed glial cells, are a very special kind of tumor, extremely refractory to conventional treatments. Therefore, for the development of new antitumor strategies, a better understanding of molecular mechanisms responsible for their biology, growth and invasion is still needed. This book is a reference on cellular signaling processes regulating gliomas physiology and invasiveness. The work is focused on the mechanism of nucleotide receptor activation by exogenous nucleotides and formation of complex signaling cascades induced by growth factors, cytokines and cannabinoids. The second edition of the book enriched in new chapters provides a framework explaining how signal transduction elements may modulate numerous genetic and epigenetic alterations, describes the role of local microenvironment in cellular growth, progression and invasion and, in the light of extensive new results, presents perspectives concerning potential targets for gliomas therapy.
Glissonean Pedicles Approach in Minimally Invasive Liver Surgery
by Benedetto Ielpo Edoardo Rosso Alessandro AnselmoAim of this book is to present the main minimally invasive approaches to the Glissonean pedicles. This kind of technique for hepatectomy has been gaining interest in recent years and may represent the ideal method to achieve anatomical liver resections. Currently the most performed procedure for liver surgery is still the classic intrafascial approach in which, after entering the Glissonean sheath, the portal triad elements are singularly dissected and isolated. However, this is a quite challenging technique to pursue in a minimally invasive setting. Nowadays the laparoscopic and robotic approach for liver resections are increasing worldwide and the intra or extra hepatic Glissonean approach, in which the portal triad elements are dissected and isolated “en bloc” without entering the Glissonean sheath, can facilitate the surgical technique. Furthermore this strategy allows better identification of the ischemic area and could decrease blood loss during dissection, as the liver inflow is kept under control. This book includes a step-by-step description of each pedicle isolation and section, with original laparoscopic and robotic pictures and videos. HPB surgeons who are interested in this technique may find these pages, written in cooperation with some of the most prominent worldwide experts, to be highly informative and valuable.
Global Applications of Culturally Competent Health Care: Guidelines for Practice
by Larry Purnell Dula Pacquiao Marilyn “Marty” DouglasThis book is unique in its global approach to applying the Guidelines for Culturally Competent Nursing Practice that were recently endorsed by the International Council of Nurses (ICN) and distributed to all of its 130 national nursing associations. The purpose of this book is to illustrate how these guidelines can be put into clinical practice and to show how practitioners from different countries with diverse populations can implement them. The first chapter provides the conceptual basis for Culturally Competent Health Care and describes how the guidelines were developed. Each of the next 10 sections presents a chapter describing a specific guideline followed by three or four chapters with detailed case studies to illustrate how the guideline was implemented in a particular cultural setting. All case studies follow a similar format and are written by international authors with clinical expertise and work experience in the culture being presented. This book will be useful for advanced practice nurses, healthcare students, clinicians, administrators, educators, researchers, and those who provide community health or population-based care.
Global Approach in Safety Testing
by Joseph J Degeorge Jan Willem van der LaanThis volume will consider one of ICH's major categories, Safety i.e. topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but even after ICH6 no explanations have been given during a formal Congress about the background of the ICH Guidance documents. Even more important than what has been written, might have been those thoughts of the experts that are not included in the Guidance documents. Why has the guideline been written as it is written, and why have some aspects been deleted. These and other related questions are the contents of this book, written by experts who were involved in the ICH process. Furthermore, the chapters will contain discussions on the "lessons learnt" and "future developments".
Global Bioethics: The Impact of the UNESCO International Bioethics Committee
by Alireza Bagheri Jonathan D. Moreno Stefano SempliciThe UNESCO International Bioethics Committee is an international body that sets standards in the field of bioethics. This collection represents the contributions of the IBC to global bioethics. The IBC is a body of 36 independent experts that follows progress in the life sciences and its applications in order to ensure respect for human dignity and freedom. Currently, some of the topics of the IBC contributions have been discussed in the bioethics literature, mostly journal articles. However, this is a unique contribution by the scholars who developed these universal declarations and reports. The contributors have not only provided a scholarly up to date discussion of their research topics, but as members of the IBC they have also discussed specific practical challenges in the development of such international documents. This book will be suited to academics within bioethics, health care policy and international law.
Global Bioethics: Building on the Leopold Legacy
by Van Rensselaer PotterThis book on Bioethics discusses regarding the Leopold legacy, human survival, dilemmas in ecological Bioethics, two kinds of bioethics, dilemmas in medical bioethics, the control of human fertility and global bioethics defined. Appendix includes the Leopold heritage and a bioethical creed for individuals.
The Global Biopolitics of the IUD: How Science Constructs Contraceptive Users and Women's Bodies (Inside Technology)
by Chikako TakeshitaThe biography of a multifaceted technological object, the IUD, illuminates how political contexts shaped contraceptive development, marketing, use, and users. The intrauterine device (IUD) is used by 150 million women around the world. It is the second most prevalent method of female fertility control in the global South and the third most prevalent in the global North. Over its five decades of use, the IUD has been viewed both as a means for women's reproductive autonomy and as coercive tool of state-imposed population control, as a convenient form of birth control on a par with the pill and as a threat to women's health. In this book, Chikako Takeshita investigates the development, marketing, and use of the IUD since the 1960s. She offers a biography of a multifaceted technological object through a feminist science studies lens, tracing the transformations of the scientific discourse around it over time and across different geographies. Takeshita describes how developers of the IUD adapted to different social interests in their research and how changing assumptions about race, class, and female sexuality often guided scientific inquiries. The IUD, she argues, became a “politically versatile technology,” adaptable to both feminist and nonfeminist reproductive politics because of researchers' attempts to maintain the device's suitability for women in both the developing and the developed world. Takeshita traces the evolution of scientists' concerns—from contraceptive efficacy and product safety to the politics of abortion—and describes the most recent, hormone-releasing, menstruation-suppressing iteration of the IUD. Examining fifty years of IUD development and use, Takeshita finds a microcosm of the global political economy of women's bodies, health, and sexuality in the history of this contraceptive device.
The Global Biopolitics of the IUD
by Chikako TakeshitaThe intrauterine device (IUD) is used by 150 million women around the world. It is the second most prevalent method of female fertility control in the global South and the third most prevalent in the global North. Over its five decades of use, the IUD has been viewed both as a means for women's reproductive autonomy and as coercive tool of state-imposed population control, as a convenient form of birth control on a par with the pill and as a threat to women's health. In this book, Chikako Takeshita investigates the development, marketing, and use of the IUD since the 1960s. She offers a biography of a multifaceted technological object through a feminist science studies lens, tracing the transformations of the scientific discourse around it over time and across different geographies. Takeshita describes how developers of the IUD adapted to different social interests in their research and how changing assumptions about race, class, and female sexuality often guided scientific inquiries. The IUD, she argues, became a "politically versatile technology," adaptable to both feminist and nonfeminist reproductive politics because of researchers' attempts to maintain the device's suitability for women in both the developing and the developed world. Takeshita traces the evolution of scientists' concerns, from contraceptive efficacy and product safety to the politics of abortion and describes the most recent, hormone-releasing, menstruation-suppressing iteration of the IUD. Examining fifty years of IUD development and use, Takeshita finds a microcosm of the global political economy of women's bodies, health, and sexuality in the history of this contraceptive device.
The Global Body Market
by Michele GoodwinThe dark side of body part trading operates in a dynamic fashion, full of mystery, intrigue, and ambition. On the one hand, black and gray markets are illegal, but also pioneering and inventive; and although this type of criminal activity requires a level of dexterity and innovation, the point should not be lost that these markets thrive and flourish, sometimes in view of law. On the other hand, altruistic body part procurement is mired by low participation, which encourages black market transactions. Thousands of sick patients die each year without the hope of receiving an organ or bone marrow donation through the altruistic procurement system, so they turn to the dark side. This book offers a frank conversation about altruism in the global body market. It exposes how researchers exploit their patients' ignorance to harvest tissue samples, blood, and other biologics without consent for research and patent development. The book chronicles exploitation in the name of altruism, including the nonconsensual use of children in dangerous clinical trials, and analyzes social and legal commitments to the value of altruism - offering an important critique of the vulnerability of altruism to corruption, coercion, pressure, and other negative externalities.
Global Cardiac Surgery Capacity Development in Low and Middle Income Countries (Sustainable Development Goals Series)
by Jacques KpodonuThis book provides a focused resource on how cardiac surgery capacity can be developed and how it assists in the sustainable development and strengthening of associated health systems. Background is provided on the extent of the problems that are experienced in many nations with suggestions for how suitable frameworks can be developed to improve cardiac healthcare provision. Relevant aspects of governance, financial modelling and disease surveillance are all covered. Guidance is also given on how to found and nurture cardiac surgery curriculum and residency programs. Global Cardiac Surgery Capacity Development in Low and Middle Income Countries provides a practically applicable resource on how to treat cardiac patients with limited resources. It identifies the key challenges and presents strategies on how these can be managed, therefore making it a critical tool for those involved in this field.
Global Catastrophic Biological Risks (Current Topics in Microbiology and Immunology #424)
by Thomas V. Inglesby Amesh A. AdaljaThis volume focuses on Global Catastrophic Biological Risks (GCBRs), a special class of infectious disease outbreaks or pandemics in which the combined capacity of the world’s private and government resources becomes severely strained. These events, of which the 1918 influenza pandemic is emblematic, cause severe disruptions in the normal functioning of the world, exact heavy tolls in terms of morbidity and mortality, and lead to major economic losses. GCBRs can be caused by any type of microorganism, and myriad contextual factors can influence their impact. Additionally, there are cascading questions that arise in connection with GCBR prediction, preparation, and response. This book gathers contributions from thought leaders who discuss the multi-faceted approaches needed in order to address this problem. From understanding the special characteristics of various microbes to financing challenges, the volume provides an essential primer on a neglected but highly relevant topic. Physicians, scientists, policymakers, public health practitioners and anyone with an interest in the field of pandemics, emerging infectious disease, biosecurity, and global health security will find it a valuable and insightful resource.
Global Challenges for a Sustainable Society: EURECA-PRO The European University for Responsible Consumption and Production (Springer Proceedings in Earth and Environmental Sciences)
by José Alberto Benítez-Andrades Paula García-Llamas Ángela Taboada Laura Estévez-Mauriz Roberto BaeloEURECA-PRO is the global educational core hub and interdisciplinary research and innovation leader in qualitative environmental and social framework development for responsible consumption and production.Through its novel approach, on the one hand, it holistically contributes to the highly topical issue of Sustainable Consumption and Production under the umbrella of Sustainable Development Goal 12, and on the other hand it effectively contributes to the development of the European Higher Education Area complimentary to Sustainable Development Goal 4.In this book readers will find the discussion results among professionals, academics and scientists on responsible consumption and production, regarding the latest advances to achieve a sustainable society. This book contents 5 chapters focused on: Smart and healthy societies, Recycling, reused and longer lasting products, fresh air, clean water, healthy soil and biodiversity, cleaner energy and cutting-edge clean technological innovation, and industry 4.0.This book also intends to show the current and future challenges, and innovative solutions considering the technological, humanistic, educational, economic, social and environmental dimensions of sustainability
Global Child Health: A Toolkit To Address Health Disparities (Springerbriefs In Public Health)
by Krishnan Subrahmanian Padma SwamyThis timely resource brings child health to the forefront of global health and the crucial goal of universal equity of care. Its resource-based framework offers contemporary perspective on factors driving child health disparities, specific vulnerabilities of underserved children, and ways readers can become effective advocates for children. The book critiques current child health policy worldwide, examining both policies that are helping to alleviate and are contributing to further inequities. And the authors provide an extensive toolkit to aid professionals in multidimensional screening for child, newborn, maternal, and post-natal health as well as socioeconomic determinants of health. Included in the coverage:· What is global health? · The current state of global child health and disparities · Global health disparities in high-resource settings · Pathologies disproportionally affecting the underserved · Policy and advocacy framework · Navigating the domestic resources (an advocate’s well child check) Global Child Health will find a ready audience among child health providers (physicians, advanced practice providers, nursing staff, social workers, allied healthcare providers, public health professionals), medical educators (medical schools, departments of pediatrics, schools of public health, nursing schools and programs, schools of allied health), and child health policymakers (staff at USAID, Health and Human Services, health services researchers in child and global health policy, health advocacy-related nonprofit organizations).
The Global Circulation of Chinese Materia Medica, 1700–1949: A Microhistory of the Caterpillar Fungus (Medicine and Biomedical Sciences in Modern History)
by Di LuThis book explores the dissemination of knowledge around Chinese medicinal substances from the eighteenth to twentieth centuries in a global context. The author presents a microhistory of the caterpillar fungus, a natural, medicinal substance initially used by Tibetans no later than the fifteenth century and later assimilated into Chinese materia medica from the eighteenth century onwards. Tracing the transmission of the caterpillar fungus from China to France, Britain, Russia and Japan, the book investigates the tensions that existed between prevailing Chinese knowledge and new European ideas about the caterpillar fungus. Emerging in eighteenth and nineteenth-century Europe, these ideas eventually reached communities of scientists, physicians and other intellectuals in Japan and China. Seeking to examine why the caterpillar fungus engaged the attention of so many scientific communities across the globe, the author offers a transnational perspective on the making of modern European natural history and Chinese materia medica.
Global Cleft Care in Low-Resource Settings
by David W. LowCleft lip and palate represents the most common congenital facial anomaly. Congenital anomalies are one of the top 10 causes of disability and suffering in many low and middle income countries (LMICs.) Further, an estimated 30% of the global burden of disease is treated primarily through surgery, and among surgical conditions, treating clefts conveys disproportionately large benefit relative to cost because suffering can be halted at a young age and deliver a lifetime of health. Over the last 50 years, cleft care has advanced in low-resource settings through international surgical missions and the efforts of sparse local providers. While exciting anecdotes of impact abound from these efforts, recent studies have identified a complication rate that often exceeds 50% and there is concern about the sustainability of foreign volunteer missions.This book serves as a thorough resource for providing medical and surgical care of cleft lip and palate deformities in low-resource settings, geared to the context of those settings. The content is consensus-based and evidence-based, with emphasis on treatment that is appropriate to a low-resource context and how this differs from that in higher-resource environments. It is authored by recognized cleft experts in close partnership with providers who practice in low-resource settings. It is heavily pictorially based through illustrative figures, photos and diagrams, to be facile for those who speak English as a second language. Following the introduction, Complete Cleft Care in Low-Resource Settings has six main sections: patient workup, surgical treatment, comprehensive care, educational innovation, care delivery models, and finally a series of illustrative case studies. Uniquely, the book’s breadth encompasses cleft care comprehensively, but does so through a practical “how to” format with many “from the field” examples of what has worked.
Global Climate Change and Environmental Policy: Agriculture Perspectives
by V. Venkatramanan Shachi Shah Ram PrasadGlobal climate change threatens human existence through its potential impact on agriculture and the environment. Agriculture is climate-sensitive, and climate variability and climate change have net negative impact on it. Additionally, the agricultural landscape is affected by monoculture and agro-biodiversity loss, soil fertility depletion and soil loss, competition from biofuel production, crop yield plateaus and invasive species. Nevertheless, the global agricultural production system has to meet the food demands from the growing human population, which is set to exceed 10 billion by 2050. This book discusses the impacts of climate change on agriculture, animal husbandry and rural livelihoods. Further, since agriculture, forestry and other land-use sectors contribute about 10–12 gigatonnes of CO2-equivalent per year, it argues that agricultural policy must dovetail adaptation and mitigation strategies to reduce greenhouse gases emissions. This calls for a reformative and disruptive agricultural strategy like climate-smart agriculture, which can operate at all spatio-temporal scales with few modifications. The book also redefines sustainable agriculture through the lens of climate-smart agriculture in the context of the sustainability of Earth's life- support system and inter- and intra-generational equity. The climate-smart agriculture approach is gaining currency thanks to its inherent positive potential, and its goal to establish an agricultural system which includes "climate-smart food systems", "climate-proof farms", and "climate-smart soils". Climate-smart agriculture provides a pathway to achieve sustainable development goals which focus on poverty reduction, food security, and environmental health.
Global Climate Change and Human Health: From Science to Practice
by Jay Lemery Kim Knowlton Cecilia SorensonLearn more about the impact of global warming and climate change on human health and disease The Second Edition of Global Climate Change and Human Health delivers an accessible and comprehensive exploration of the rapidly accelerating and increasingly ubiquitous effects of climate change and global warming on human health and disease. The distinguished and accomplished authors discuss the health impacts of the economic, climatological, and geopolitical effects of global warming. You’ll learn about: The effect of extreme weather events on public health and the effects of changing meteorological conditions on human health How changes in hydrology impact the spread of waterborne disease and noninfectious waterborne threats Adaptation to, and the mitigation and governance of, climate change, including international perspectives on climate change adaptation Perfect for students of public health, medicine, nursing, and pharmacy, Global Climate Change and Human Health, Second Edition is an invaluable resource for anyone with an interest in the intersection of climate and human health and disease.