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Inflammatory Dermatopathology
by Jenny Cotton Steven D. BillingsInflammatory Dermatopathology: A Pathologist's Survival Guide provides expert guidance for the reader to develop a systematic approach to the diagnosis of inflammatory disorders of the skin. It covers the most common and clinically important inflammatory disorders of the skin through an image-rich easy to read format. Each section includes practical tips to help navigate the differential diagnosis. Microscopic features are listed as bullet points to enhance readability. Examples of diagnostic comments that practicing pathologists can utilize in their own reports are also provided. Demonstrating a global understanding of inflammatory dermatoses in a quick and efficient manner, Inflammatory Dermatopathology: A Pathologist's Survival Guide will both guide the reader in how to approach inflammatory dermatoses, as well as provide a tool that will help with the writing of surgical pathology reports.
Inflammatory Dermatoses: The Basics
by Bruce R. Smoller Kim M. HiattInflammatory Dermatoses: The Basics will serve as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The reader will be able to focus upon a single histologic observation, i.e., inflammatory conditions without epidermal changes, and use this as a starting point from which to build a differential diagnosis based upon pattern recognition. As each entity is addressed, there will be a concise discussion of the basic clinical findings and epidemiologic associations. This will be followed by a histologic description, highlighting areas that serve to discriminate between the entity under discussion and similar ones. Any immunologic studies that might augment the diagnostic sensitivity or specificity will be discussed. The chapters are thematically based and consist of essential bullet points arranged in organized outlines allowing for easy access and direct comparison between entities. The salient histologic features are depicted with abundant high quality, full-color photomicrographs placed immediately adjacent to the appropriate histologic bullet points. This volume will serve as an effective and efficient handbook for the student of dermatopathology, and as a practical bench reference for the practicing diagnostician who desires rapid access to criteria that are useful in differentiating histologically similar entities. The elaborate pictorial documentation will also enable the book to serve as an atlas of the commonest dermatologic disorders.
Inflammatory Diseases of Blood Vessels
by Carol A. Langford Jorg J. Goronzy Gary S. Hoffman Cornelia M. WeyandIn recent years, considerable progress has been made in understanding the vasculitic diseases, largely due to the introduction of effective treatments for diseases that were once uniformly fatal, the conduct of structured clinical studies, and advances in immunology and molecular biology. Despite these achievements, the vasculitic diseases continue to be associated with morbidity and mortality from chronic organ damage, relapses, and the side effects of treatment. Investigations into the mechanisms of vascular inflammation may lead to a better comprehension of the pathogenesis of vasculitic diseases and to treatment that is more effective and less toxic. These areas of promising research, together with current knowledge about the vasculitic diseases, are extensively examined in this new edition, which is designed to provide a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease.
Inflammatory Diseases of the Brain
by Stefan HähnelThis second, updated edition of Inflammatory Diseases of the Brain provides a comprehensive overview of the field from a neuroradiological point of view. In order to ensure a standardized approach throughout, each disease-oriented chapter is again subdivided into three principal sections: epidemiology, clinical presentation, and therapy; imaging; and differential diagnosis. A separate chapter addresses technical and methodological issues and imaging protocols. An important focus of the book is the current role of advanced MR imaging techniques, such as diffusion and perfusion MRI and MR spectroscopy, in the differentiation of inflammatory and other brain diseases. All of the authors are recognized experts, and the numerous high-quality and informative illustrations include some not contained in the first edition. This book will be of great value not only to neuroradiologists but also to neurologists, neuropediatricians, and general radiologists.
Inflammatory Disorders
by Mieczyslaw PokorskiThe mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.
Inflammatory Disorders of the Nervous System
by Alireza Minagar J. Steven AlexanderA cutting-edge review of the fundamental biological principles underlying the more common inflammatory disorders of the nervous system. The authors provide extensive updates on the latest findings concerning the mechanisms of inflammation and introduce such new concepts and methodologies as "endothelial and leukocyte microparticles" and "gene microarray technology" to help explain important links between the central nervous system (CNS) and general inflammatory processes. Among the diseases examined from an inflammatory perspective are multiple sclerosis, acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, CNS vasculitis, neuropsychiatric systemic lupus erythematosis, Alzheimer's disease, and Parkinson's disease. The role of the immune system in neuroinflammation is also explored in such disorders as neurosarcoidois, HIV-Associated dementia, and HTLV-associated neurological disorders.
Inflammatory Mechanisms in Allergic Diseases (Clinical Allergy And Immunology Ser. #Vol. 16)
by Burton Zweiman Lawrence B. SchwartzContains patterns of allergic reactivity for disorders such as asthma, atopic dermatitis, urticaria, and anaphylaxis. Written by leading experts in the field, Inflammatory Mechanisms in Allergic Diseases covers non-anaphylactic drug disorders; synthesis and formation of IgE antibodies; new treatments using allergenic peptides, immunostimulatory oligonucleotides, and pharmacogenomics;recent advances targeting effector mechanisms; hypersensitivity reactions to drugs and more! With over 3100 references, tables, drawings, and micrographs, Inflammatory Mechanisms in Allergic Diseases is an essential reference for allergists, pulmonologists, immunologists, dermatologists, ophthalmologists, otolaryngologists, internists, pediatricians, family practitioners, and medical students in these disciplines.
Inflammatory Mechanisms in Asthma
by Stephen T. Holgate William W. BusseThis timely volume brings together the latest basic and clinical insights on the cellular and mediator mechanisms involved in the induction and persistence of airway dysfunction of asthma by over 90 experts in the field-paving the way for developing novel and more effective antiinflammatory therapeutic agents and strategies. Furnishing a comprehensive and up-to-date view of the expanding and interrelated components underlying asthma pathogenesis, Inflammatory Mechanisms in Asthma describes how evidence on airway inflammation is obtained with invasive and noninvasive procedures, such as bronchoalveolar lavage and sputum analysis reviews the complex interactions of inflammatory cells that contribute to chronic inflammation and bronchial hyperreactivity, including eosinophils, basophils, neutrophils, fibroblasts, epithelial cells, and macrophages considers mast cells, cytokines, neural factors, leukotrienes, kinins, and other mediators that regulate the development, establishment, or resolution of asthma exacerbations presents new information suggesting that airway changes in asthma can lead to remodeling or airway fibrosis and more! Enhanced with over 4700 references, tables, drawings, and photographs, this compelling investigation into the pathophysiology of asthma is an indispensable resource for pulmonologists, physiologists, immunologists, allergists, epidemiologists, biochemists, molecular biologists, and graduate and medical school students in these disciplines.
Inflammatory Mechanisms in Mediating Hearing Loss
by Vickram Ramkumar Leonard P. RybakCommon forms of preventable hearing loss are drug and noise-induced hearing loss which are believed to be produced by a similar mechanism. The generation of reactive oxygen species appears to be a common mechanism mediating hearing loss produced by these different sources. As such, a number of laboratories have focused their research towards identifying the sources of ROS production in the cochlea following administration of chemotherapeutic agents or noise exposure. This led to the identification of ROS generating enzymes, such as xanthine oxidases, nitric oxide synthase, and NADPH oxidases which are activated and/or induced during the development of hearing loss. A consequence of these findings was the implementation of antioxidants in preclinical studies for the treatment of hearing loss. These antioxidants have provided different levels of protection in animal and human studies, but none of these have been approved by the US Food and Drug Administration for the treatment of hearing loss. More recently, it was shown that noise-induced hearing loss was associated with recruitment of inflammatory cells and mediators in the cochlea. This finding would suggest that noise could produce injury to the cochlea which stimulates local and/or circulating inflammatory cells. A similar finding was observed in the cochlea following administration of the anticancer drug, cisplatin. In addition, our laboratory and others have provided a plausible mechanism by which noise or chemotherapeutic agents could stimulate the inflammatory response. Surprisingly, this mechanism involves ROS activation of transcription factors linked to inflammatory processes in the cochlea. These studies have led to the use of anti-inflammatory agents for the treatment of hearing loss. Preliminary studies targeting inflammatory cytokines appear especially promising in preclinical studies. A primary goal of this project is to describe our current understanding of the oxidant hypothesis of noise and drug-induced hearing loss and show how this relates to cochlear inflammation. Several different aspects of the cochlear inflammatory process will be discussed in detail, ranging from the sources of inflammatory cells, chemokines, inflammatory cytokines, and cochlea resident immune cells. Molecular pathways leading to activation of the local inflammatory process will be highlighted and treatment options will be discussed. The relevance of certain clinically used anti-inflammatory interventions, such as trans-typmanic steroids will also be discussed. Furthermore, we will examine recent patents focusing on the use of anti-inflammatory agents for the treatment of drug and noise-induced hearing loss.
The Inflammatory Myopathies
by Lawrence J. KagenThis book presents a comprehensive review of the inflammatory myopathies, including dermatomyositis, polymyositis, and inclusion body myositis. Representing the most up-to-date knowledge on this family of diseases, The Inflammatory Myopathies covers clinical presentation, methods of diagnosis, ongoing assessment of clinical course, treatment, and the latest information on pathogenesis. Physical, laboratory, imaging, and serological findings are discussed in the context of chronic disease, complications, and co-morbidities. The role and mechanism of inflammatory response is also explored with reference to emerging humoral and cellular targets for therapeutic intervention. The Inflammatory Myopathies is the gold-standard in the field and a must have resource for rheumatologists, neurologists and all healthcare professionals who treat afflicted patients.
Inflammatory Pathways in Diabetes
by Michael PugiaThis book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease, and identifies new diagnostic immunological methods that offer potential companion diagnostics for diabetic diseases. New methods in proteomics, mass spectroscopy, immunological assay design, measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways. Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases. The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance, metabolic syndrome, nephritis and other diabetic inflammatory conditions, and is the first to describe the impact of novel adipokines, protease inhibitors and complement markers. By presenting new methodologies for biomarker discovery, it provides a valuable resource for researchers studying clinical diagnosis, drug development, bio-analytical chemistry, proteomics and biochemistry. It is also useful for those conducting clinical and biological studies for targeted drug development. The methodologies and approaches can be applied to other markers, and the information will be helpful in the preparation of research grant applications.
Inflammatory Response in Cardiovascular Surgery
by Edmo Atique Gabriel Sthefano Atique GabrielIn recent years, The impact of the inflammatory response in cardiovascular surgery has been a focus of much attention within the field of cardiac surgery. Despite that, scientific research on the topic is still lacking in the health science literature. To develop the bank of information available to all involved in the field, the Editors of this book have assembled a group of leading experts to investigate the most current and exciting topics related to inflammation and cardiovascular surgery. As such Inflammatory Response in Cardiovascular Surgery is vital reading for all involved in the management of cardiovascular surgical patients, such as cardiovascular and transplant surgeons, anesthesiologists, intensive care physicians, cardiovascular and vascular fellows, and researchers.
The Influence of Chemistry on New Foods and Traditional Products
by Giampiero Barbieri Caterina Barone Arpan Bhagat Giorgia Caruso Zachary Ryan Conley Salvatore ParisiThis Brief concerns the influence of chemistry in the modern food and beverages industry. The world of traditional foods has been soundlessly but increasingly interconnected with the chemical industry in the last century. Different areas are considered in a multidisciplinary approach: - the production of chemical additives and of non-food components needed in the food industry (e. g. packaging materials) - the regulatory perspective of the whole food production chain - commercialization of food commodities - the problem of food safety from the viewpoint of official auditors with medical or veterinarian competencies - new and emerging risks related to food packaging materials - the assessment of the authenticity of edible products. This Brief includes different viewpoints, ranging from the management of allergens and food additives in the food plant to the complex matter of the formulation of traditional products with the consequent production of "alternative" versions of the same food.
The Influence of Global Environmental Change on Infectious Disease Dynamics: Workshop Summary
by Eileen R. ChoffnesThe twentieth century witnessed an era of unprecedented, large-scale, anthropogenic changes to the natural environment. Understanding how environmental factors directly and indirectly affect the emergence and spread of infectious disease has assumed global importance for life on this planet. While the causal links between environmental change and disease emergence are complex, progress in understanding these links, as well as how their impacts may vary across space and time, will require transdisciplinary, transnational, collaborative research. This research may draw upon the expertise, tools, and approaches from a variety of disciplines. Such research may inform improvements in global readiness and capacity for surveillance, detection, and response to emerging microbial threats to plant, animal, and human health. "The Influence of Global Environmental Change on Infectious Disease Dynamics" is the summary of a workshop hosted by the Institute of Medicine Forum on Microbial Threats in September 2013 to explore the scientific and policy implications of the impacts of global environmental change on infectious disease emergence, establishment, and spread. This report examines the observed and potential influence of environmental factors, acting both individually and in synergy, on infectious disease dynamics. The report considers a range of approaches to improve global readiness and capacity for surveillance, detection, and response to emerging microbial threats to plant, animal, and human health in the face of ongoing global environmental change.
Influence of Microplastics on Environmental and Human Health: Key Considerations and Future Perspectives
by Yvonne LangMicroplastics have received increased attention in the research world over the last ten years. A number of significant publications by the World Health Organisation, European Union, SAPEA, and GESAMP have highlighted this growing environmental and health emergency. This book provides an accessible introduction to the microplastic problem and details its potential impact both on nature and human health. Filled with the latest developments in the field, it attempts to address the gaps in our knowledge of microplastics and will also propose additional areas of research and impact to be considered to resolve this crisis. It will be of interest to researchers and academics working in the areas of microplastic pollution, microplastic detection, and the impact of microplastics on environmental and human health. It will also be of use to undergraduate students of environmental programmes, analytical programmes, and public health programmes. Key Features: Chapters describe the impact of our reliance on plastics in certain sectors and how they relate to microplastic pollution Investigates emerging solutions to the microplastic pollution Presents a multi-disciplinary perspective, covering topics such as analytical techniques, quantitative techniques, environmental monitoring, and human health monitoring
Influence of Pregnancy Weight on Maternal and Child Health: WORKSHOP REPORT
by National Research Council Institute of Medicine of the National AcademiesThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
Influential Leadership: Change Your Behavior, Change Your Organization, Change Health Care (ACHE Management)
by Michael FrisinaLeaders make things happen. Influential leaders go a step further by making a positive difference in organizations and in the lives of people who both serve and are served by the organization. Influential leaders perform at a higher level, are more productive, and achieve greater results than other leaders with similar circumstances and resources. Influential Leadership reveals: How good people skills—trust and accountability, not processes—can strengthen the organization’s pursuit of performance excellence How leaders and staff will change their behavior when they understand how it affects the outcome of their work, the lives of those around them, and the organization’s performance How self-aware, influential leaders are in a better position to collaborate and connect with others and to lead the organization to success “Dr. Frisina’s words get right to the heart of what sets apart truly great leaders, and are a road map for the journey.” —Lynn B. Wythe, RN, MSN, CNOR, director of nursing, Palmetto Health Baptist, Columbia, South Carolina “The author exhibits a passion for leadership excellence. . . . This book is a must for everyone entering into a leadership position, from the front-line manager to the CEO.” —Philip K. Beauchamp, LFACHE, president and CEO (ret.), Morton Plant Mease Healthcare, Inc., Clearwater, Florida “Chock full of examples and self-assessment tools. . . . The powerful takeaways from each section form an agenda for leading transformational change.” —Laura Avakian, leadership consultant, author, and past president of the American Society for Healthcare Human Resources Administration “Dr. Frisina leverages a lifetime of observations and hard-earned wisdom to give us a handful of guiding principles to make us all better leaders in our professional and personal lives.” —William R. Berry, MD, MPH, FACS, research associate, Department of Health Policy and Management, Harvard School of Public Health
Influenza: The Hundred Year Hunt to Cure the Deadliest Disease in History
by Jeremy BrownOn the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure? <P><P>While influenza is now often thought of as a common and mild disease, it still kills over 30,000 people in the US each year. Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. <P><P>In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come. Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. \ <P><P>Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts. <P><P>Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.
Influenza: Advances in Diagnosis and Management (Respiratory Disease Series: Diagnostic Tools and Disease Managements)
by Jiro FujitaThis book explores the latest research and practical data on the clinical management of influenza. Starting with the definition, epidemiology and pathogenesis, the first part reviews the basic science of the influenza virus and infection. The next three parts then discusses the diagnosis, complications and management, providing practical data and insights that are useful in day-to-day patient care. The last part focuses on the trending topics, including a new drug, oral baloxavir marboxil, which was introduced in Japan in 2018 and is the first polymerase inhibitor to be licensed for the treatment of uncomplicated influenza. In Japan, since the medical insurance system is well-established, patients receive medical examinations quickly after the onset of influenza viral infection, making it easy to implement early diagnostic tools and early treatment. Providing practical data and insights, Influenza - Advances in Diagnosis and Management is a useful resource for clinicians, residents and trainees around the globe.
Influenza and Public Health: Learning from Past Pandemics (The\earthscan Science In Society Ser.)
by Jennifer Gunn Tamara Giles-Vernick Susan CraddockMajor influenza pandemics pose a constant threat. As evidenced by recent H5N1 avian flu and novel H1N1, influenza outbreaks can come in close succession, yet differ in their transmission and impact. With accelerated levels of commercial and population mobility, new forms of flu virus can also spread across the globe with unprecedented speed. Responding quickly and adequately to each outbreak becomes imperative on the part of governments and global public health organizations, but the difficulties of doing so are legion. One tool for pandemic planning is analysis of responses to past pandemics that provide insight into productive ways forward. This book investigates past influenza pandemics in light of today's, so as to afford critical insights into possible transmission patterns, experiences, mistakes, and interventions. It explores several pandemics over the past century, from the infamous 1918 Spanish Influenza, the avian flu epidemic of 2003, and the novel H1N1 pandemic of 2009, to lesser-known outbreaks such as the 1889-90 influenza pandemic and the Hong Kong Flu of 1968. Contributors to the volume examine cases from a wide range of disciplines, including history, sociology, epidemiology, virology, geography, and public health, identifying patterns that cut across pandemics in order to guide contemporary responses to infectious outbreaks.
Influenza and Respiratory Care
by Mieczyslaw PokorskiRespiratory infections constitute a major public health concern. The goal of this book is to share knowledge on the best advances in influenza and influenza-like viral infections, and new molecular-based diagnostic methods that discern the antigenic shift providing viruses the ability to constantly evolve and elude the host immune response. Co-infections, co-morbidities, persistently meager anti-flu vaccination coverage, and infection complications are dealt with. The chapters also further insight into such topics as the effect of sex hormones, and socioeconomic and anthropometric measures, on respiratory and immune functions underlying the severity of asthma and respiratory allergy. Psychological functioning in respiratory disorders, taking into account quality of life, illness acceptance, and depressive symptoms is also reviewed as it is all too often underestimated by healthcare providers. The book is intended for clinicians, researchers, students, and all other actors in health-related issues.
The Influenza Pandemic of 1918–1919: A Brief History With Documents
by Susan K. KentThe influenza pandemic of 1918-19 appeared suddenly at the end of the First World War and with explosive impact took the lives of at least 30 million people worldwide. Spreading rapidly across the globe, it defied all previous understandings of the disease, striking the youngest and healthiest individuals most acutely and confounding the doctors and governments who struggled to contain it. In this volume, Susan Kingsley Kent presents an overview of the disease, detailing its symptoms, tracking its spread, and offering insights into the medical community's understanding of and reaction to the pandemic. <P><P> Documents from period newspapers, medical journals, and government publications, as well as letters, journal entries, memoirs, and novels written by survivors and medical staff, provide a variety of perspectives from six continents and illuminate the impact of the pandemic — from the lives of children orphaned by the flu to colonial rebellions for which the pandemic served as a major catalyst. Document headnotes, maps and illustrations, a chronology, questions for consideration, a selected bibliography, and an index enrich students' understanding.
Influenza Pathogenesis and Control - Volume II
by Richard W. Compans Michael B. A. OldstoneThis two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection. . Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
Influenza Vaccines for the Future
by Giuseppe Del Giudice Rino RappuoliThe emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.
Influenza Virus
by Gabriele Neumann Yoshihiro KawaokaReports of influenza-like illnesses date back to the Middle Ages, and outbreaks of influenza likely afflicted humans long before that. Over the last half century, influenza virus research has led to the development of two classes of antivirals - ion channel and neuraminidase inhibitors. Recently, a method of the artificial generation of an influenza virus was established. This system has been instrumental in the development of novel influenza vaccines and in the understanding of viral pathogenicity and the functions of viral proteins. Influenza Virus: Methods and Protocols summarizes the current techniques that have made this progress possible, ranging from protocols for virus isolation, growth, and subtyping to procedures for the efficient generation of any influenza virus. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Influenza Virus: Methods and Protocols seeks to serve both professionals and novices with the techniques used in numerous laboratories around the world that are, thus, the building blocks that underpin almost all influenza virus research.