- Table View
- List View
In Search of Sexual Health: Diagnosing and Treating Syphilis in Hot Springs, Arkansas, 1890–1940
by Elliott BowenHow did beliefs about syphilis shape the kinds of treatment people with this disease received? The story of how a town in the Ozark hinterlands played a key role in determining standards of medical care around syphilis.During the late 1800s and early 1900s, the central Arkansas city of Hot Springs enjoyed a reputation as one of the United States' premier health resorts. Throughout this period, the vast majority of Americans who traveled there did so because they had (or thought they had) syphilis—a disease whose incidence was said to be dramatically on the rise all across the country. Boasting an impressive medical infrastructure that included private clinics, a military hospital, and a venereal disease clinic operated by the United States Public Health Service, Hot Springs extended a variety of treatment options. Until the antibiotic revolution of the 1940s, Hot Springs occupied a central position in the country's struggle with sexually transmitted disease.Drawing upon health-seekers' firsthand accounts, clinical case files, and the writings of the city's privately practicing specialists, In Search of Sexual Health examines the era's "venereal peril" from the standpoint of medical practice. How, Elliott Bowen asks, did people with VD understand their illnesses, and what therapeutic strategies did they employ? Highlighting the unique role that resident doctors, visiting patients, and local residents played in shaping Hot Springs' response to syphilis, Bowen argues that syphilis's status as a stigmatized disease of "others" (namely prostitutes, immigrants, and African Americans) had a direct impact on the kinds of treatment patients received, and translated into very different outcomes for the city's diverse clientele—which included men as well as women, blacks as well as whites, and the poor as well as the rich.Whereas much of the existing scholarship on the history of sexually transmitted diseases privileges the actions of medical elites and federal authorities, this study reveals Hot Springs, a remote and fairly obscure town, as a local node with a significant national impact on American medicine and public health. Providing a richer, more complex understanding of a critical chapter in the history of sexually transmitted diseases, In Search of Sexual Health will prove valuable to historians of medicine, public health, and the environment, in addition to scholars of race, gender, sexuality.
In Search of the Good
by Daniel CallahanDaniel Callahan helped invent the field of bioethics more than forty years ago when he decided to use his training in philosophy to grapple with ethical problems in biology and medicine. Disenchanted with academic philosophy because of its analytical bent and distance from the concerns of real life, Callahan found the ethical issues raised by the rapid medical advances of the 1960s--which included the birth control pill, heart transplants, and new capacities to keep very sick people alive--to be philosophical questions with immediate real-world relevance. In this memoir, Callahan describes his part in the founding of bioethics and traces his thinking on critical issues including embryonic stem cell research, market-driven health care, and medical rationing. He identifies the major challenges facing bioethics today and ruminates on its future. Callahan writes about founding the Hastings Center--the first bioethics research institution--with the author and psychiatrist Willard Gaylin in 1969, and recounts the challenges of running a think tank while keeping up a prolific flow of influential books and articles. Editor of the famous liberal Catholic magazine Commonweal in the 1960s, Callahan describes his now-secular approach to issues of illness and mortality. He questions the idea of endless medical "progress" and interventionist end-of-life care that seems to blur the boundary between living and dying. It is the role of bioethics, he argues, to be a loyal dissenter in the onward march of medical progress. The most important challenge for bioethics now is to help rethink the very goals of medicine.
In Search of the Good: A Life in Bioethics (Basic Bioethics)
by Daniel CallahanOne of the founding fathers of bioethics describes the development of the field and his thinking on some of the crucial issues of our time. Daniel Callahan helped invent the field of bioethics more than forty years ago when he decided to use his training in philosophy to grapple with ethical problems in biology and medicine. Disenchanted with academic philosophy because of its analytical bent and distance from the concerns of real life, Callahan found the ethical issues raised by the rapid medical advances of the 1960s—which included the birth control pill, heart transplants, and new capacities to keep very sick people alive—to be philosophical questions with immediate real-world relevance. In this memoir, Callahan describes his part in the founding of bioethics and traces his thinking on critical issues including embryonic stem cell research, market-driven health care, and medical rationing. He identifies the major challenges facing bioethics today and ruminates on its future.Callahan writes about founding the Hastings Center—the first bioethics research institution—with the author and psychiatrist Willard Gaylin in 1969, and recounts the challenges of running a think tank while keeping up a prolific flow of influential books and articles. Editor of the famous liberal Catholic magazine Commonweal in the 1960s, Callahan describes his now-secular approach to issues of illness and mortality. He questions the idea of endless medical “progress” and interventionist end-of-life care that seems to blur the boundary between living and dying. It is the role of bioethics, he argues, to be a loyal dissenter in the onward march of medical progress. The most important challenge for bioethics now is to help rethink the very goals of medicine.
In Shock: My Journey from Death to Recovery and the Redemptive Power of Hope
by Rana AwdishA riveting first-hand account of a physician who's suddenly a dying patient and her revelation of the horribly misguided standard of care in the medical worldDr. Rana Awdish never imagined that an emergency trip to the hospital would result in hemorrhaging nearly all of her blood volume and losing her unborn first child. But after her first visit, Dr. Awdish spent months fighting for her life, enduring consecutive major surgeries and experiencing multiple overlapping organ failures. At each step of the recovery process, Awdish was faced with something even more unexpected: repeated cavalier behavior from her fellow physicians—indifference following human loss, disregard for anguish and suffering, and an exacting emotional distance. Hauntingly perceptive and beautifully written, In Shock allows the reader to transform alongside Awidsh and watch what she discovers in our carefully-cultivated, yet often misguided, standard of care. Awdish comes to understand the fatal flaws in her profession and in her own past actions as a physician while achieving, through unflinching presence, a crystalline vision of a new and better possibility for us all. As Dr. Awdish finds herself up against the same self-protective partitions she was trained to construct as a medical student and physician, she artfully illuminates the dysfunction of disconnection. Shatteringly personal, and yet wholly universal, she offers a brave road map for anyone navigating illness while presenting physicians with a new paradigm and rationale for embracing the emotional bond between doctor and patient.
In Sickness and In Health
by Richard K. ThomasThe increasing importance of sickness and disability data across health-related disciplines is the focus of this concise but comprehensive resource. It reviews the basics of morbidity at the population level by defining core concepts, analyzing why morbidity has overtaken mortality as central to demographic study, and surveying ways these data are generated, accessed, and measured. Subsequent chapters demonstrate how this knowledge can be used to better understand--and potentially solve--critical public health issues, benefitting not only populations served, but also areas such as health services planning, resource allocation, and health policy-setting. To make this material useful to the most readers, this reference: Explains why and how morbidity data are categorized by health professionals and other data users. Examines various methods of identifying and measuring morbidity data. Identifies demographic and non-demographic factors associated with morbidity. Describes and evaluates sources of U. S. morbidity data. Reviews the current state of morbidity in the U. S. , and what it means for healthcare and society in general. Suggests future uses of morbidity data in reducing health disparities and improving population health. In Sickness and In Health is uniquely relevant to demographers and demography students, public health professionals, and epidemiologists. Its presentation of concepts and applications makes the book a valuable classroom text and a useful guide for those addressing challenges facing U. S. healthcare.
In Sight: My Life in Science and Health Innovation
by Julia LevyIn Sight is a memoir about how a love of science and discovery drove Julia Levy, a celebrated scholar and biotech CEO, to work her way through gender bias in order to achieve academic and professional recognition. Her story traces the unconventional invention of a breakthrough drug treatment from its development from laboratory research to its application as a medical treatment for vision loss. Told from a female perspective, In Sight is a unique and personal story covering Levy’s early years as a refugee, her university training in the UK and her appointment as professor at the University of British Columbia. Years spent as an academic led the author to unexpected exposure to the biotechnology industry and a chance meeting with colleagues that led to the formation of a lucrative biotechnology company, known today as QLT Inc. The bulk of the book covers the years spent building the company, and Levy’s surprising transition from chief scientific officer to CEO. In Sight is an honest description of the trials of drug development, the tensions inherent in the commercialization of health innovations, and the truly remarkable hurdles faced by women in the scientific community.
In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future
by Brian S. HilbushLearn how AI and data science are upending the worlds of biology and medicine In Silico Dreams: How Artificial Intelligence and Biotechnology Will Create the Medicines of the Future delivers an illuminating and fresh perspective on the convergence of two powerful technologies: AI and biotech. Accomplished genomics expert, executive, and author Brian Hilbush offers readers a brilliant exploration of the most current work of pioneering tech giants and biotechnology startups who have already started disrupting healthcare. The book provides an in-depth understanding of the sources of innovation that are driving the shift in the pharmaceutical industry away from serendipitous therapeutic discovery and toward engineered medicines and curative therapies. In this fascinating book, you'll discover: An overview of the rise of data science methods and the paradigm shift in biology that led to the in silico revolution An outline of the fundamental breakthroughs in AI and deep learning and their applications across medicine A compelling argument for the notion that AI and biotechnology tools will rapidly accelerate the development of therapeutics A summary of innovative breakthroughs in biotechnology with a focus on gene editing and cell reprogramming technologies for therapeutic development A guide to the startup landscape in AI in medicine, revealing where investments are poised to shape the innovation base for the pharmaceutical industry Perfect for anyone with an interest in scientific topics and technology, In Silico Dreams also belongs on the bookshelves of decision-makers in a wide range of industries, including healthcare, technology, venture capital, and government.
In Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications
by Claudio N. CavasottoIn Silico Drug Discovery and Design: Theory, Methods, Challenges, and Applications provides a comprehensive, unified, and in-depth overview of the current methodological strategies in computer-aided drug discovery and design. Its main aims are to introduce the theoretical framework and algorithms, discuss the range of validity, strengths and limita
In Silico Methods for Predicting Drug Toxicity
by Emilio BenfenatiThis detailed volume explores in silico methods forpharmaceutical toxicity by combiningthe theoretical advanced research with the practical application of the tools. Beginning with a section covering sophisticated models addressing the bindingto receptors, pharmacokinetics and adsorption, metabolism, distribution, andexcretion, the book continues with chapters delving into models for specifictoxicological and ecotoxicological endpoints, as well as broad views of themain initiatives and new perspectives which will very likely improve our way ofmodelling pharmaceuticals. Written for the highly successful Methods in Molecular Biology series,chapters include the kind of detailed implementation advice that is key forachieving successful research results. Authoritative and practical, In Silico Methods for Predicting DrugToxicity offers the advantage of incorporating data and knowledge fromdifferent fields, such as chemistry, biology, -omics, and pharmacology, toachieve goals in this vital area of research.
In Silico Methods for Predicting Drug Toxicity (Methods in Molecular Biology #2425)
by Emilio BenfenatiThis fully updated book explores all-new and revised protocols involving the use of in silico models, particularly with regard to pharmaceuticals. Divided into five sections, the volume covers the modeling of pharmaceuticals in the body, toxicity data for modeling purposes, in silico models for multiple endpoints, a number of platforms for evaluating pharmaceuticals, as well as an exploration of challenges, both scientific and sociological. Written for the highly successful Methods in Molecular Biology series, chapters include the kind of detail and implementation advice necessary for successful results. Authoritative and comprehensive, In Silico Methods for Predicting Drug Toxicity, Second Edition aims to guide the reader through the correct procedures needed to harness in silico models, a field which now touches a wide variety of research specialties.
In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols (Methods in Pharmacology and Toxicology)
by Kunal RoyThis essential volume explores a variety of tools and protocols of structure-based (homology modeling, molecular docking, molecular dynamics, protein-protein interaction network) and ligand-based (pharmacophore mapping, quantitative structure-activity relationships or QSARs) drug design for ranking and prioritization of candidate molecules in search of effective treatment strategy against coronaviruses. Beginning with an introductory section that discusses coronavirus interactions with humanity and COVID-19 in particular, the book then continues with sections on tools and methodologies, literature reports and case studies, as well as online tools and databases that can be used for computational anti-coronavirus drug research. Written for the Methods in Pharmacology and Toxicology series, chapters include the kind of practical detail and implementation advice that ensures high quality results in the lab. Comprehensive and timely, In Silico Modeling of Drugs Against Coronaviruses: Computational Tools and Protocols is an ideal reference for researchers working on the development of novel anti-coronavirus drugs for SARS-CoV-2 and for coronaviruses that will likely appear in the future.
In Silico Models for Drug Discovery
by Sandhya KortagereInfectious diseases caused by viruses, parasites, bacteria, and fungi are the number one cause of death worldwide. Although new technologies have improved diagnosis of infectious diseases, the efficacy of all known current anti-infective agents is threatened by the spread of drug-resistant forms of the pathogens. Hence, there remains an urgent need to develop anti-infective agents that target drug-resistant pathogens. In Silico Models for Drug Discovery presents a comprehensive look at the role in silico models play in understanding infectious diseases and in developing novel therapeutics to treat them. Written by leading experts in the field, chapters cover topics such as techniques to derive novel antimicrobial targets, methods of interpreting polypharmacology-based drug target networks, and molecular dynamics techniques used to compute binding energies of drugs to their target proteins, to name a few. Written in the successful Methods in Molecular BiologyTM series or in review article format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, In Silico Models for Drug Discovery seeks to serve both professionals and novices involved in the study and treatment of infectious diseases.
In Silico Technologies in Drug Target Identification and Validation (Drug Discovery Series)
by Scott Markel Darryl LeónThe pharmaceutical industry relies on numerous well-designed experiments involving high-throughput techniques and in silico approaches to analyze potential drug targets. These in silico methods are often predictive, yielding faster and less expensive analyses than traditional in vivo or in vitro procedures. In Silico Technologies in Drug Target Ide
In Silico Tools for Gene Discovery
by Marcus Hinchcliffe Bing YuAs functional genomics has become one of the major focuses in molecular biology, the need for more sophisticated tools to assist in the identification of the functionality of undefined genes and the correlation of DNA variants with a particular phenotype has increased greatly. In Silico Tools for Gene Discovery collects many common and useful in silico tools available today. The volume begins by investigating locus mapping information on linkage analysis, association mapping, integrative analysis, and exome analysis as well as tools for DNA marker selection, in silico PCR, and statistical analysis. It continues with a section on gene discovery from a defined locus, including gene prioritization, knowledge tracking, and data mining, and concludes with several useful in silico tools presented for the functional characterization of genes, which include DNA sequencing analysis, variant characterization, as well as RNA and protein analysis. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, step-by-step, readily reproducible protocols, and vital notes on troubleshooting and avoiding known pitfalls. Resourceful and easy to follow, In Silico Tools for Gene Discovery seeks to facilitate scientists with further key research on locus mapping, to accelerate gene identification, and to help ascertain the functionality of DNA variation.
In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems (Methods in Pharmacology and Toxicology)
by Thomas-Benjamin Seiler Markus BrinkmannThis detailed volume examines the complex study of the assessment of in situ bioavailability and toxicity of organic chemicals in aquatic systems with a toolbox of reliable techniques. Beginning with a section on approaches for chemical analytical and bioanalytical techniques in bioavailability research, the book continues with methods to monitor effects in situ and conduct bioassays to assess the effects of complex environmental samples. It concludes with descriptions of various computational models. Written for the Methods in Pharmacology and Toxicology series, chapters feature the kind of expert implementation advice that leads to greater success in the field. Authoritative and versatile, In Situ Bioavailability and Toxicity of Organic Chemicals in Aquatic Systems serves as an ideal guide to aid in tackling the challenge of analyzing and understanding chemical pollution in aquatic systems.
In Situ Hybridization Protocols
by K. H. ChooThirty-one detailed, practical chapters many by the originators themselves present easy-to-follow protocols of in situ hybridization techniques for mapping DNA sequences onto chromosomes, quantitation/localization of RNA in tissues, and detection of virus nucleic acids. The methods serve molecular biologists in most areas of basic and applied research, and in every sort of organism ranging from viruses to Drosophila to humans. The expert contributors provide step-by-step instructions for the preparation of probes for DNA, teleomeric repeats, cDNA sequences, small synthetic oligomers, whole cosmids, mega-size YACs, and chromosome-specific paints from somatic cell hybrids and flow-sorted chromosomes. They also present radioactive and nonradioactive probe labeling procedures with the use of nick translation, random priming, multicolor labeling, PRINS labeling of DNA and RNA, and PCR in situ hybridization. Color illustrations enhance the text. Troubleshooting tips, alternative ways of doing things, and informative explanations of why certain steps are done -- aids not usually found in standard journal recipes -- guarantee a significant difference in the outcome of experiments.
In The Blood
by Don DonaldsonSurviving leukemia, Dr. Holly Fisher is ready to have a child using eggs that were saved before she underwent the fertility-killing treatment. To her horror, she learns her eggs have been stolen from the fertility clinic, taken by a man posing as her lawyer. Holly vows to track the man down, never realizing her attempts will put her in the middle of a medical nightmare.
In This Together: My Story
by Ann RomneyNew York Times Bestseller: Ann Romney’s “breezy and frank” memoir of her MS diagnosis and her husband’s unwavering support through the struggle (The Washington Post).A lot of people talk about a transformation that happens when life throws you a curve ball, and the big one in my life was my MS diagnosis. . . . In sharing my story, I want to give others hope as I’ve been given hope on this journey.—Ann RomneyWhen Mitt and Ann Romney met in their late teens, a great American love story began. And their life together would be blessed: five healthy sons, financial security, and a home filled with joy. Then, in 1998, Ann was diagnosed with multiple sclerosis.She couldn’t believe it was real; the disease had no cure at that time—and it still doesn’t. Mitt told her that day that they would tackle the diagnosis as a team: They were in it together. “If you have to be in a wheelchair,” he told her, “I’ll be right there to push it.” And Ann thought, “But I’ll be the one in the wheelchair.”A caregiver and helper her whole life, she’d crossed a terrible invisible line. Instead of caring for her family, she was now the patient. Ann and Mitt would go on to face the most frightening and humbling experience of their lives.From reflections on her early life, her marriage, and her diagnosis and recovery to the sources of her faith and the stories of others who overcame adversity and inspired her to keep going, In This Together is a brave and deeply honest portrait of a family facing an unexpected blow, often in the most public of circumstances.
In Time and with Love
by Marilyn SegalWritten in a jargon-free, parent-friendly style, this generously illustrated book is filled with advice on such topics as nursing, feeding, dressing, interacting with siblings, discipline, and social skills development of handicapped children. Includes a section on games and activities that encourage motor and language skills, and advice on play and care for toddlers and older children.
In Two Minds: Stories of murder, justice and recovery from a forensic psychiatrist
by Dr Sohom Das'thought provoking'Gwen AdsheadShocking, eye-opening and grimly fascinating, these are the true stories, patients and cases that have characterised a career spent treating mentally disordered offenders.As a forensic psychiatrist, it's Dr Das's job to treat and rehabilitate what the tabloids might call the 'criminally insane', many of whom assault, rob, rape, and even kill. His work takes him to high-security prisons and securely locked hospital wards across the country, as well as inside courtrooms, giving evidence as an expert witness.From the young woman who smothered her two-year-old nephew in a flash of psychosis, to the teenager who set his house on fire with his mother locked inside, Dr Das must delve into the minds of these violent offenders to elicit their symptoms of mental illness, understand their actions and prevent future atrocities.In this honest, revealing and at times humorous memoir, Dr Das shares stories from his fifteen years as a psychiatric doctor working with this dangerous clientele, detailing some of his most extreme, heart-breaking and bizarre cases - and how he's learned to live with his mistakes when the worse happens.Compelling, enlightening and candid, if you enjoyed Unnatural Causes, Dark Side of the Mind or The Prison Doctor, you'll love IN TWO MINDS.
In Two Minds: Stories of murder, justice and recovery from a forensic psychiatrist
by Dr Sohom Das'thought provoking'Gwen AdsheadShocking, eye-opening and grimly fascinating, these are the true stories, patients and cases that have characterised a career spent treating mentally disordered offenders.As a forensic psychiatrist, it's Dr Das's job to treat and rehabilitate what the tabloids might call the 'criminally insane', many of whom assault, rob, rape, and even kill. His work takes him to high-security prisons and securely locked hospital wards across the country, as well as inside courtrooms, giving evidence as an expert witness.From the young woman who smothered her two-year-old nephew in a flash of psychosis, to the teenager who set his house on fire with his mother locked inside, Dr Das must delve into the minds of these violent offenders to elicit their symptoms of mental illness, understand their actions and prevent future atrocities.In this honest, revealing and at times humorous memoir, Dr Das shares stories from his fifteen years as a psychiatric doctor working with this dangerous clientele, detailing some of his most extreme, heart-breaking and bizarre cases - and how he's learned to live with his mistakes when the worse happens.Compelling, enlightening and candid, if you enjoyed Unnatural Causes, Dark Side of the Mind or The Prison Doctor, you'll love IN TWO MINDS.
In Two Minds: Stories of murder, justice and recovery from a forensic psychiatrist
by Dr Sohom DasShocking, eye-opening and grimly fascinating, these are the true stories, patients and cases that have characterised a career spent treating mentally disordered offenders.Listen to the end of the audiobook for an exclusive bonus chapter, written and read by the author.As a forensic psychiatrist, it's Dr Das's job to treat and rehabilitate what the tabloids might call the 'criminally insane', many of whom assault, rob, rape, and even kill. His work takes him to high-security prisons and securely locked hospital wards across the country, as well as inside courtrooms, giving evidence as an expert witness.From the young woman who smothered her two-year-old nephew in a flash of psychosis, to the teenager who set his house on fire with his mother locked inside, Dr Das must delve into the minds of these violent offenders to elicit their symptoms of mental illness, understand their actions and prevent future atrocities.In this honest, revealing and at times humorous memoir, Dr Das shares stories from his fifteen years as a psychiatric doctor working with this dangerous clientele, detailing some of his most extreme, heart-breaking and bizarre cases - and how he's learned to live with his mistakes when the worse happens.Compelling, enlightening and candid, if you enjoyed Unnatural Causes, Dark Side of the Mind or The Prison Doctor, you'll love IN TWO MINDS.
In Utero Diagnosis of Skeletal Disorders An Atlas of Prenatal Sonographic and Postnatal Radiologic Correlation
by Jacob Bar-Ziv Israel MeiznerIn Utero Diagnosis of Skeletal Disorders is a unique compendium of current information and 350 original ultrasound images covering the physiology and pathophysiology of osteogenesis. Syndromes are presented schematically and describe the mode of inheritance, definition and morphology, sonographic and radiologic manifestations, and associated malformations. The book is an excellent reference for obstetricians, sonographers, radiologists, and anyone dealing with the early detection of fetal malformations.
In Utero Pediatrics: Research & Practice
by Kun SunThis book is to provide readers with an overview of in utero Pediatrics, an interdisciplinary medicine focusing on sequential and comprehensive care for fetuses and children who have functional and/or structural disorders originated from in utero. It covers congenital disorders in cardiology, neurosurgery, urology, general surgery, endocrine genetics, and other related topics. Each chapter starts with the basic theory, illustrates clinical practices on certain congenital disorders, and summaries recent research and advances in the field. Written by experts with wealthy experiences, this case-based book will be a valuable reference for pediatricians and perinatologists, as well as those who are interested in this field.
In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development
by Dhanya Sunil Pooja R Kamath Raghu Chandrashekhar HThis comprehensive and useful handbook represents a definitive up-to-date compendium of key in vitro bioassay methods that are employed to quantify and validate the anticancer activity of a drug candidate before it makes its way in to animal or clinical trials. <P><P>In Vitro Bioassay Techniques for Anticancer Drug Discovery and Development covers the screening and evaluation of potential drug candidates in a wide category of anticancer assays demonstrating the specific ways in which various pharmaceutical bioassays interpret the activity of drug molecules. The major emphasis of the book is to present those bioassays which can be readily set up and practiced in any laboratory with limited funds, facilities or technical know-how.