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Introducing the Core: Demystifying the Body of an Athlete
by Michael J. Bradley Rob Gordon Marc J. Philippon Adam C. Zoga Alexander E. Poor Johannes B. Roedl Jim McCrossin Alex McKechnieThere is no more important area of the body for an athlete than the core, the region of our body from our chest to our knees. The core is our engine, our hub of activity. Strength there makes life easier for shoulders and knees. It produces speed and explosiveness. Endurance and grit.The core is so important. So why has it remained such a medical mystery?This book will explain that.Introducing the Core: Demystifying the Body of an Athlete traces the arc of the journey from injury to restoration of power to the return to normal life.Dr. William Meyers is the nation’s foremost authority on core health. Along with over 40 world-renowned expert contributors, Dr. Meyers explains how the core functions through stories from his work in locker rooms, the operating room, and the playing fields of elite athletes, giving readers a thorough understanding of the core’s widespread influence on athleticism and the human anatomy.The book: Dissects the events that led Dr. Meyers and his team of experts to their new appreciation of this anatomy Brings multiple world-renowned arthroscopists into the overall core picture, providing their perspectives on how the core works, with the pubic bone as “the sun” of the body’s universe Offers insight into the many causes of pelvic pain, demonstrating why the term “sports hernia,” should be banished forever Emphasizes the fact that a wide spectrum of professionals treat the core -- from traditional surgeons to alternative therapists Brings it all together and proposes a new future, and perhaps a new medical specialty, that is the core “Strength, power, and endurance all flow from the core. This book, and the work Bill Meyers has done in the field, will bring good core health to the forefront and help everyone—elite athletes and others.”—Michael William Krzyzewski“Even in baseball, injury patterns in the shoulder and elbow are related to core imbalance. This book has been needed for a long time… Bill has helped the idea of core strength become more popular, and this book could be what is needed to get it more attention.”—James Rheuben Andrews, MD“To understand the core, you must put on new eyes.” —Marshawn Lynch
Introducing the Social Sciences for Midwifery Practice: Birthing in a Contemporary Society
by Ian Peate Patricia LindsayIntroducing the Social Sciences for Midwifery Practice makes clear the links between social, anthropological and psychological concepts, midwifery practice and women’s experience of birth. Demonstrating how empathising with women and understanding the context in which they live can affect childbirth outcomes and experiences, this evidence-based text emphasises the importance of compassionate and humane care in midwifery practice. Exploring midwifery as an art, as well as a science, the authors collected here make the case for midwives as professionals working ‘with women’ rather than as birth technicians, taking a purely competency-based approach to practice. The book incorporates a range of pedagogical features to enhance student learning, including overall chapter aims and learning outcomes, ‘recommendations for practice’, ‘learning triggers’ to encourage the reader to delve deeper and reflect on practice, ‘application to practice’ case studies which ensure that the theory is related to contemporary practice, and a glossary of terms. The chapters cover perspectives on birth from sociology; psychology; anthropology; law; social policy and politics. Other chapters address important issues such as disability, politics and sexuality. Outlining relevant theory from the social sciences and clearly applying it to practice, this text is an essential read for all student midwives, registered midwives and doulas. ?
Introductie in de gezondheidszorg
by M. van der Burgt E. van Mechelen-Gevers M. te Lintel HekkertIntroductie in de gezondheidszorgIntroductie in de gezondheidszorg biedt een helder overzicht over de organisatie en het functioneren van de gezondheidszorg in Nederland. In deze herziene druk wordt het zorgstelsel helder uitgelegd. De contouren van de meest recente veranderingen worden geschetst, zoals de invoering van de Wet langdurige zorg als opvolger van de AWBZ en de decentralisatie van de Jeugdzorg en Participatiewet. In de loop van de komende jaren zal blijken hoe deze wetten zullen uitpakken.Ketenzorg, vraagsturing en marktwerking in de zorg komen aan bod. Daarnaast worden verzekerde zorg, bekostiging, dbc’s en kostenbeheersing besproken. Ook wordt verhelderd in welke opzichten de zorgmarkt afwijkt van de ‘gewone’ markt. Daarmee worden in begrijpelijke taal vragen beantwoord, zoals: Wat maakt het uit of zorg via de Zorgverzekeringswet, de Wet langdurige zorg of Wet maatschappelijke opvang is geregeld? En: Waarom zit preventie niet in de basiszorg?Kortom, een boek dat het ingewikkelde veld van de gezondheidszorg voor studenten en beginnende professionals inzichtelijk maakt.Op de bijbehorende website staan toetsvragen en links naar sites en documenten.Door de overzichtelijke tabellen, figuren en trefwoordenlijst is Introductie in de gezondheidszorg onmisbaar als basisboek voor studenten in het hoger beroepsonderwijs die in de gezondheidszorg gaan werken. Daarnaast is het een praktische en toegankelijke introductie voor iedere geïnteresseerde en een handig naslagwerk voor mensen die al in de gezondheidszorg werkzaam zijn.Marieke van der Burgt is arts en voorlichtingsdeskundige in de gezondheidszorg en docent aan het Rijn IJssel in Arnhem. Els van Mechelen-Gevers is werkzaam als publicist op het gebied van gezondheidszorg en patiëntenvoorlichting.Marieke van der Burgt en Els van Mechelen-Gevers zijn auteur van onder andere ‘Preventie en gezondheidsbevordering door paramedici’ en ‘Patiëntenvoorlichting door verpleegkundigen. Stappen naar zelfmanagement’.Martin te Lintel Hekkert is verpleegkundige, verplegingswetenschapper en docent verpleegkunde aan de Christelijke Hogeschool te Ede. Hij is onder meer auteur van de ‘Richtlijn zelfmanagement van patiënten met COPD in de huisartspraktijk’.
Introduction in Synthetic Biology: About Modeling, Computation, And Circuit Design (Learning Materials in Biosciences)
by Mario Andrea MarchisioThe textbook is based on the lectures of the course “Synthetic Biology” for Master’s students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT.
Introduction to Addictive Behaviors (4th Edition)
by Dennis L. Thombs Cynthia J. OsbornThis widely adopted text introduces students and practitioners to major contemporary models of addiction. Assuming no prior knowledge in the field, the book shows how theory and research can offer a roadmap for effective intervention. It presents multiple perspectives on the causes and mechanisms of substance use problems, reviews their strengths and limitations, and examines their implications for helping people change their behavior. Evidence-based treatment and prevention strategies are described.Pedagogical Features Include:*Accessible style and clear organization.*Concise end-of-chapter summaries.*Review questions in every chapter.New to This Edition*The latest research on prevention and treatment, including current data and revised discussions of genetic influences, family treatment models, and many other topics.*Updated for DSM-5.*Chapter on behavioral addictions.*Chapter on promoting motivation and autonomy.*Chapter on evidence-based practice.
Introduction to Addictive Behaviors, Fifth Edition
by Dennis L. Thombs Cynthia J. OsbornNow revised and updated, this widely used text comprehensively reviews theories of addiction to give students and professionals a multidisciplinary foundation for clinical practice. It explores the causes and mechanisms of substance and behavioral addictions, as well as implications for helping people recover. Providing a science-based perspective, the text emphasizes the importance of using treatment and prevention strategies that are grounded in evidence. Thoroughly updated chapters address disease models; public health approaches; understanding and treating comorbidity; psychoanalytic, behavioral, cognitive, and family systems models; sociocultural approaches; behavioral addiction; and motivational models. Student-friendly features include end-of-chapter summaries and review questions. New to This Edition *Updated throughout with current research and clinical advances. *Discussions of cutting-edge topics: genetics of addiction, addiction stigma, and the opioid epidemic. *New and revised clinical vignettes and review questions.
Introduction to Advanced Nursing Practice
by Madrean SchoberPrepared under the auspices of the International Council of Nurses (ICN), this first volume provides a comprehensive overview of the rapidly emerging field of advanced nursing practice. It addresses central issues in the role and practice development that are fundamental to defining and differentiating the nature of this field. Topics include defining the role, role characteristics, scope of practice, education, regulation and research. Obstacles to and facilitators of that role are addressed and include ethical questions arising in the context of practice development. With an international focus, this volume examines international developments in the field, as reflected in country-specific case studies and examples. It offers a valuable resource for advanced practice nurses, educators and administrators at healthcare institutions.
Introduction to Advanced Nursing Practice: An International Focus (Advanced Practice in Nursing)
by Madrean SchoberPrepared under the auspices of the International Council of Nurses (ICN), this first volume provides a comprehensive overview of the rapidly emerging field of advanced nursing practice. It addresses central issues in the role and practice development that are fundamental to defining and differentiating the nature of this field. Topics include defining the role, role characteristics, scope of practice, education, regulation and research. Obstacles to and facilitators of that role are addressed and include ethical questions arising in the context of practice development. With an international focus, this volume examines international developments in the field, as reflected in country-specific case studies and examples. It offers a valuable resource for advanced practice nurses, educators and administrators at healthcare institutions.
Introduction to Alternative and Complementary Therapies
by Terry S Trepper Anne Strozier Joyce E Carpenter Lorna L HeckerDiscover creative new ways to facilitate the therapeutic process Therapeutic modalities that psychotherapists usually rely on--such as psychodynamic, humanistic, systems, cognitive, narrative, analytic and solution focused--are all verbal interventions. Introduction to Complementary and Alternative Therapies presents a comprehensive overview of complementary and alternative therapeutic interventions that go beyond the standard verbal approaches. The therapies presented in this book--including mindfulness and meditation, spirituality, poetry therapy, art therapy, psychodrama, dance/movement therapy, music therapy, animal-assisted therapy, and touch therapy--provide the reader with creative non-traditional modalities that are effective in conjunction with traditional treatment, or as substitutes. They may enrich talk-therapy, especially when therapists and/or clients get "stuck," or they may provide healing on their own. Introduction to Complementary and Alternative Therapies explains the basics about how these nontraditional therapies work and provides vivid examples for utilizing them in treatment. Each chapter is written by an expert in the field of expertise, and includes a description of the approach, research evidence about its effectiveness, guidelines on how to use the therapy in practice, and case examples. This excellent volume also provides practitioners with a wide range of resources, including Web sites, information on state and national organizations, accrediting board info, and more. Topics in Introduction to Complementary and Alternative Therapies include: the mind-body relationship ways to integrate spirituality in counseling the healing components of poetry research studies on art therapy different techniques available in Psychodrama using body movement as a means of expressing conflicts and desires how music therapy promotes positive changes in the client the healing aspects of animals and much more! Introduction to Complementary and Alternative Therapies is a horizon-expanding guide for therapists, social workers, psychologists, counselors, physicians, educators, and students.
Introduction to Anatomy and Physiology for Healthcare Students
by David SturgeonThis book provides a highly accessible introduction to anatomy and physiology. Written for students studying the subject for the first time, it covers the human body from the atomic and cellular levels through to all the major systems and includes chapters on blood, immunity and homeostasis. Logically presented, the chapters build on each other and are designed to develop the reader’s knowledge and understanding of the human body. By the end of each chapter, the reader will understand and be able to explain how the structures and systems described are organised and contribute to the maintenance of health. Describing how illness and disease undermine the body’s ability to maintain homeostasis, this text helps readers to predict and account for the consequences when this occurs. Complete with self-test questions, full colour illustrations and a comprehensive glossary, this book is an essential read for all nursing and healthcare students in both further and higher education.
Introduction to Animal and Veterinary Anatomy and Physiology
by Victoria Aspinall BVSc, MRCVS Melanie Cappello BSc (Hons) ZooloA sound knowledge of anatomy and physiology is an essential basis for the effective clinical treatment of companion animals and farm animals alike. The fourth edition of this bestselling book continues to provide a comprehensive description of the anatomy and physiology of dogs and cats. The book builds on these foundations with detailed descriptions of exotic small species including birds, and domestic farm animals, including cows, sheep and pigs, as well as the horse. The text: Contains detailed descriptions of the systematic anatomy and physiology of a wide range of animal species. Covers clinical conditions and disease examples related to the individual body systems. Includes applied anatomy tips that relate theory to clinical practice. Is written by expert authors with a wealth of veterinary, animal science and teaching experience. Includes more clinical application examples and question and answer tests to reinforce student learning. Has been updated with more information for animal science students. This text provides an essential basis for all those embarking upon a veterinary, animal science or animal management career.
Introduction to Animal Behavior and Veterinary Behavioral Medicine
by Meghan E. HerronIntroduction to Animal Behavior and Veterinary Behavioral Medicine Understand and apply key concepts of animal behavior in veterinary practice Animal behavior is a critical aspect of veterinary medicine, often underappreciated despite its pervasiveness throughout the field. Understanding animal behavior can facilitate communication with patients, refine diagnoses and indications of ill health, and aid in processes of learning and socialization. Introduction to Animal Behavior and Veterinary Behavioral Medicine offers a comprehensive overview of the key concepts underlying the behavior of multiple animal species before demonstrating how to apply these concepts clinically. The result is an indispensable resource for veterinary students and practitioners who want to deepen their understanding of patient needs. Introduction to Animal Behavior and Veterinary Behavioral Medicine readers will also find: Comprehensive coverage of companion animal behavior and additional coverage of livestock and wild animal behavior Detailed discussion of topics including social development, animal learning, and applied behavior analysis In depth review of diagnosis and treatment strategies for common behavior disorders in companion animals, extending to various additional species Companion website with videos, handouts for downloading, and links to pertinent scientific articles and informative websites Introduction to Animal Behavior and Veterinary Behavioral Medicine is ideal preparation for veterinary medical students as part of “day one readiness” in their professional careers, as well as veterinary practitioners looking for a solid foundation in animal behavior and the treatment of key issues.
Introduction to Antibody Engineering (Learning Materials in Biosciences)
by Florian Rüker Gordana Wozniak-KnoppThis highly readable textbook serves as a concise and engaging primer to the emerging field of antibody engineering and its various applications. It introduces readers to the basic science and molecular structure of antibodies, and explores how to characterize and engineer them. Readers will find an overview of the latest methods in antibody identification, improvement and biochemical engineering. Furthermore, alternative antibody formats and bispecific antibodies are discussed.The book’s content is based on lectures for the specializations “Protein Engineering” and “Medical Biotechnology” within the Master’s curriculum in “Biotechnology.” The lectures have been held at the University of Natural Resources and Life Sciences, Vienna, in cooperation with the Medical University of Vienna, since 2012 and are continuously adapted to reflect the latest developments in the field. The book addresses Master- and PhD students in biotechnology, molecular biology and immunology, and all those who are interested in antibody engineering.
Introduction to Artificial Intelligence (Imaging Informatics for Healthcare Professionals)
by Michail E. Klontzas Salvatore Claudio Fanni Emanuele NeriThis book aims to provide physicians and scientists with the basics of Artificial Intelligence (AI) with a special focus on medical imaging. The contents of the book provide an introduction to the main topics of artificial intelligence currently applied on medical image analysis. The book starts with a chapter explaining the basic terms used in artificial intelligence for novice readers and embarks on a series of chapters each one of which provides the basics on one AI-related topic. The second chapter presents the programming languages and available automated tools that enable the development of AI applications for medical imaging. The third chapter endeavours to analyse the main traditional machine learning techniques, explaining algorithms such as random forests, support vector machines as well as basic neural networks. The applications of those machines on the analysis of radiomics data is expanded in the fourth chapter to allow the understanding of algorithms used to build classifiers for the diagnosis of disease processes with the use of radiomics. Chapter five provides the basics of natural language processing which has revolutionized the analysis of complex radiological reports and chapter six affords a succinct introduction to convolutional neural networks which have revolutionized medical image analysis enabling automated image-based diagnosis, image enhancement (e.g. denoising), protocolling etc. The penultimate chapter provides an introduction to data preprocessing for use in the aforementioned artificial intelligence applications. The book concludes with a chapter demonstrating AI-based tools already in radiological practice while providing an insight about the foreseeable future. It will be a valuable resource for radiologists, computer scientists and postgraduate students working on medical image analysis.
Introduction to Audiology (10th edition)
by Frederick N. Martin John Greer ClarkThe ninth edition of Martin's (U. of Texas at Austin) and Clark's (U. of Cincinnati) textbook features updated material throughout the text, including more detailed discussions of recent objective measures; new material on licensing/certification, outcome measures, and evidence-based practice; a revised discussion of the rapidly evolving measures of auditory evoked potentials; and separate discussions of pediatric and adult hearing aid selection/verification and hearing loss management.
Introduction to Audiology 12th Edition
by Frederick N. Martin John Greer ClarkThis comprehensive, well-organized introduction to hearing and balance disorders gives students a number of vital tools to help them better understand, retain, and analyze the material. Introduction to Audiology, 12/e by Martin and Clark continues to update the material to keep content current with recent research, while retaining and improving a user-friendly approach to the topics and an abundance of how-to information which shows the rewarding, fascinating aspects of a career in audiology.
Introduction to Aural Rehabilitation (Second Edition)
by Raymond H. HullNow in its second edition, Introduction to Aural Rehabilitation continues to provide all the elements necessary for a comprehensive, practice-oriented course in the habilitation/rehabilitation of children, adults, and the elderly with impaired hearing. This user-friendly text focuses on the most important clinical and practical aspects of providing services to the hearing impaired, while avoiding the technical detail of theoretical texts. . This second edition offers more in-depth information on cochlear implantation-including surgical procedures as well as the benefits for children and adults-and is approached from an amplification standpoint across several chapters by new contributing authors. . New and expanded information for Introduction to Aural Rehabilitation, Second Edition, includes the following topics: Speech development for children with impaired hearing; Listening and language development for children with impaired hearing; Hearing aids and non-hearing aid assistive listening devices; Hearing aids for children with impaired hearing; Educational management of children with impaired hearing; Non-hearing assistive listening devices for adults; Physiology and psycho-social impact of hearing loss in older adulthood; Rehabilitation procedures for adults with impaired hearing; and Expanded appendixes on communication scales and questionnaires
Introduction to Basics of Pharmacology and Toxicology: Volume 2 : Essentials of Systemic Pharmacology : From Principles to Practice
by Abialbon Paul Nishanthi Anandabaskar Jayanthi Mathaiyan Gerard Marshall RajThis book explains the pharmacological relationships between the various systems in the human body. It offers a comprehensive overview of the pharmacology concerning the autonomic, central, and peripheral nervous systems. Presenting up-to-date information on chemical mediators and their significance, it highlights the therapeutic aspects of several diseases affecting the cardiovascular, renal, respiratory, gastrointestinal, endocrinal, and hematopoietic systems. The book also includes drug therapy for microbial and neoplastic diseases. It also comprises sections on immunopharmacology, dermatological, and ocular pharmacology providing valuable insights into these emerging and recent topics. Covering the diverse groups of drugs acting on different systems, the book reviews their actions, clinical uses, adverse effects, interactions, and subcellular mechanisms of action. It is divided into 11 parts, subdivided into several chapters that evaluate the basic pharmacological principles that govern the different types of body systems. This book is intended for academicians, researchers, and clinicians in industry and academic institutions in pharmaceutical, pharmacological sciences, pharmacy, medical sciences, physiology, neurosciences, biochemistry, molecular biology and other allied health sciences.
Introduction to Basics of Pharmacology and Toxicology: Volume 3 : Experimental Pharmacology : Research Methodology and Biostatistics
by Gerard Marshall Raj Mageshwaran Lakshmanan Deepak Gopal ShewadeThis volume is designed to impart the fundamental concepts in experimental pharmacology, research methodology and biostatistics. Through this book, the readers will learn about different methods involved in drug discovery, experimental animals and their care, equipments and the various bioassays used in experimental pharmacology. This book contains special sections on various drug screening methods involved in the evaluation of different body systems. Certain sections provide the healthcare professionals with the knowledge necessary to interpret clinical research articles, design clinical studies, and learn essential concepts in biostatistics in an expedient and concise manner. Basic principles and applications of simple analytical methods employed in drug analysis are well written under one section. It focuses on the basic and advanced laboratory techniques and also on computer simulated data, written extensively under the Biostatistics section. The methods used for drug analysis have been described in adequate detail with cross-references for further studies and comprehension. Overall, the book is designed systematically with four broad sections with extensive subdivisions for easy tracking, interpretation, and understanding.
Introduction to Basics of Pharmacology and Toxicology: Volume 1: General and Molecular Pharmacology: Principles of Drug Action
by Gerard Marshall Raj Ramasamy RaveendranThis book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases.Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.
Introduction to Bayesian Methods in Ecology and Natural Resources
by William E. Strawderman Edwin J. Green Andrew O. FinleyThis book presents modern Bayesian analysis in a format that is accessible to researchers in the fields of ecology, wildlife biology, and natural resource management. Bayesian analysis has undergone a remarkable transformation since the early 1990s. Widespread adoption of Markov chain Monte Carlo techniques has made the Bayesian paradigm the viable alternative to classical statistical procedures for scientific inference. The Bayesian approach has a number of desirable qualities, three chief ones being: i) the mathematical procedure is always the same, allowing the analyst to concentrate on the scientific aspects of the problem; ii) historical information is readily used, when appropriate; and iii) hierarchical models are readily accommodated.This monograph contains numerous worked examples and the requisite computer programs. The latter are easily modified to meet new situations. A primer on probability distributions is also included because these form the basis of Bayesian inference.Researchers and graduate students in Ecology and Natural Resource Management will find this book a valuable reference.
Introduction to Bayesian Statistics
by William M. BolstadThe use of Bayesian methods in applied statistical analysis has become increasingly popular, yet most introductory statistics texts continue to only present the subject using frequentist methods. Introduction to Bayesian Statistics, Second Edition focuses on Bayesian methods that can be used for inference, and it also addresses how these methods compare favorably with frequentist alternatives. Teaching statistics from the Bayesian perspective allows for direct probability statements about parameters, and this approach is now more relevant than ever due to computer programs that allow practitioners to work on problems that contain many parameters.This book uniquely covers the topics typically found in an introductory statistics book--but from a Bayesian perspective--giving readers an advantage as they enter fields where statistics is used. This Second Edition provides:Extended coverage of Poisson and Gamma distributionsTwo new chapters on Bayesian inference for Poisson observations and Bayesian inference for the standard deviation for normal observationsA twenty-five percent increase in exercises with selected answers at the end of the bookA calculus refresher appendix and a summary on the use of statistical tablesNew computer exercises that use R functions and Minitab® macros for Bayesian analysis and Monte Carlo simulationsIntroduction to Bayesian Statistics, Second Edition is an invaluable textbook for advanced undergraduate and graduate-level statistics courses as well as a practical reference for statisticians who require a working knowledge of Bayesian statistics.
Introduction to Biliary Atresia
by Masaki NioThis book offers a comprehensive overview of the latest standard medical procedures and surgical techniques for biliary atresia (BA), as well as the perioperative care, long-term follow-up and transitions. Experts on pediatrics in such fields as hepatology, surgery, pathology, and liver transplantation present their research findings and analyses of this rare and intractable disease of unknown etiology. In Japan, shared experience and sound understanding based on conferences and guidelines have led to standardization of management and clinical care and, as a result, better outcomes. Providing insights into improving surgical outcomes, and including special chapters focusing on social support systems for patients and families as well as recent advances in early diagnosis, this book a valuable resource for medical professionals around the globe who are involved in treating biliary atresia. It is especially useful for pediatric hepatologists, pediatric surgeons and transplant surgeons.
An Introduction to Bioanalysis of Biopharmaceuticals (AAPS Advances in the Pharmaceutical Sciences Series #57)
by Seema KumarThe book provides a comprehensive review of the fundamental and practical aspects of bioanalytical support and the integral role it plays in the development of safe and efficacious biopharmaceutical drugs with speed and cost-effectiveness. The book focuses on a broad range of conventional and emerging biopharmaceutical modalities including monoclonal antibody-based therapeutics, gene therapy, cell therapy, peptides and oligonucleotides. The book starts with an introductory overview of bioanalysis showcasing the integral role it plays in understanding the drug disposition (pharmacokinetics/pharmacodynamics and immunogenicity) and the progression of bioanalytical strategy as the drug progresses through discovery and development stages of the program, taking into consideration the continually evolving regulatory landscape. The book further diversifies into individual biopharmaceutical modalities - monoclonal antibodies, antibody-drug conjugates, bispecifics, Fc-fusion proteins, gene therapies, cell therapies, peptides and oligonucleotides. The individual chapters focus on modality-specific bioanalytical assay strategies, critical reagents, assay formats, analytical platforms, associated bioanalytical challenges and mitigation strategies, industry best practices, and the latest understanding of regulatory guidance as applicable to the fast-growing biopharmaceutical landscape.
Introduction to Bioinformatics and Clinical Scientific Computing
by Paul S. GanneyThis textbook provides an introduction to computer science theory, informatics best practice, and the standards and legislation that apply to computing in a healthcare environment. It delivers an accessible discussion of databases (construction, interrogation and maintenance); networking (design and low-level application); programming (best practice rather than the specifics of any one language – design, maintenance, safety). It can be used to accompany the NHS Modernising Scientific Careers syllabus. It is also targeted towards those creating software rather than those using it, particularly computer scientists working in healthcare, specifically those in or close to the Physical Sciences, including radiotherapy, nuclear medicine, and equipment management and those working with genomics and health informatics.