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Inflammatory Pathways in Diabetes
by Michael PugiaThis book discusses recent advances in new anti- and pro-inflammatory pathways in diabetic disease, and identifies new diagnostic immunological methods that offer potential companion diagnostics for diabetic diseases. New methods in proteomics, mass spectroscopy, immunological assay design, measurement of cellular signal transduction and protease inhibition are used to clarify new biochemical pathways. Biomarker validation in animal models and correlations in humans for diagnostic clinical trials shed new light on the impact of diabetic diseases. The book reviews current understanding of inflammatory pathways in the pathophysiology of insulin resistance, metabolic syndrome, nephritis and other diabetic inflammatory conditions, and is the first to describe the impact of novel adipokines, protease inhibitors and complement markers. By presenting new methodologies for biomarker discovery, it provides a valuable resource for researchers studying clinical diagnosis, drug development, bio-analytical chemistry, proteomics and biochemistry. It is also useful for those conducting clinical and biological studies for targeted drug development. The methodologies and approaches can be applied to other markers, and the information will be helpful in the preparation of research grant applications.
Inflammatory Response in Cardiovascular Surgery
by Edmo Atique Gabriel Sthefano Atique GabrielIn recent years, The impact of the inflammatory response in cardiovascular surgery has been a focus of much attention within the field of cardiac surgery. Despite that, scientific research on the topic is still lacking in the health science literature. To develop the bank of information available to all involved in the field, the Editors of this book have assembled a group of leading experts to investigate the most current and exciting topics related to inflammation and cardiovascular surgery. As such Inflammatory Response in Cardiovascular Surgery is vital reading for all involved in the management of cardiovascular surgical patients, such as cardiovascular and transplant surgeons, anesthesiologists, intensive care physicians, cardiovascular and vascular fellows, and researchers.
Inflammatory and Infectious Ocular Disorders (Retina Atlas)
by Hyeong Gon YuThis atlas covers most ocular inflammatory and infectious diseases of importance with clinical significance. It includes chapters on non-infectious diseases and chapters on infectious diseases. For each chapter, essential information regarding the clinical features, diagnosis, and management is described in the text based on the up-to-date knowledge, and more than 240 carefully selected photographs are provided. World-famous experts in this field have included as many as valuable photographs of patients as possible. New imaging tests of ultra-wide field retinal images and high-resolution optical coherence tomography are included in addition to conventional fundus photos and fluorescein angiographs. Especially, chapters on infectious diseases provide invaluable photos of rare but clinically important diseases. Designed to assist in the diagnosis and treatment of ocular inflammation and infection, this book is meant for the retina specialist, researchers of ocular inflammation, general ophthalmologist, resident and retina fellow. Inflammatory and Infectious Ocular Disorders atlas is one of the nine volumes of the series Retina Atlas. This series provides global perspective on vitreoretinal diseases, covering imaging basics, retinal vascular disease, macular disorders, ocular inflammatory and infectious disorders, retinal degeneration, surgical retina, ocular oncology, pediatric retina and trauma. This comprehensive atlas is spread over 9 volumes and about 100 chapters, covering validated and comprehensive information on retinal disorders.
Inflammatory and Neoplastic Diseases of Craniofacial Bones
by Yue HeThis book covers the full scope of fundamental oral and maxillofacial surgery, while supporting readers to focus on the essential information and disorders which are the most common, or have significant implications for modern clinical practice. It presents an overview of the most common clinical presentations, physical examination findings, diagnostic tools, complications, treatments, and discussions of differential diagnosis and related issues. Detailed illustrations including clinical photographs, radiological images and pathological slides provide a visual guide to conditions, techniques, diagnoses and key concepts. The most current clinical information also cover the minor and major complications which may occur in all facets of oral maxillofacial surgery. Readers can focus on the prompt recognition of each diagnosis, and consider differential diagnosis as well as precise management strategies in preventing complication and relapse. Case-based approach discussion can actively engage and raise the reader interest and retention of the information. Overall, the book provides a uniquely contemporary approach, reflecting the exciting developments of technique and instrumentation within this surgical field, built on technical innovation and state-of-art clinical practice. It is a readable resource, identifying commonalities and shedding light on controversies through reasoned discussion and balanced presentation of the evidence.
Influence of Microplastics on Environmental and Human Health: Key Considerations and Future Perspectives
by Yvonne LangMicroplastics have received increased attention in the research world over the last ten years. A number of significant publications by the World Health Organisation, European Union, SAPEA, and GESAMP have highlighted this growing environmental and health emergency. This book provides an accessible introduction to the microplastic problem and details its potential impact both on nature and human health. Filled with the latest developments in the field, it attempts to address the gaps in our knowledge of microplastics and will also propose additional areas of research and impact to be considered to resolve this crisis. It will be of interest to researchers and academics working in the areas of microplastic pollution, microplastic detection, and the impact of microplastics on environmental and human health. It will also be of use to undergraduate students of environmental programmes, analytical programmes, and public health programmes. Key Features: Chapters describe the impact of our reliance on plastics in certain sectors and how they relate to microplastic pollution Investigates emerging solutions to the microplastic pollution Presents a multi-disciplinary perspective, covering topics such as analytical techniques, quantitative techniques, environmental monitoring, and human health monitoring
Influence of Pregnancy Weight on Maternal and Child Health: WORKSHOP REPORT
by National Research Council Institute of Medicine of the National AcademiesThe National Academies Press (NAP)--publisher for the National Academies--publishes more than 200 books a year offering the most authoritative views, definitive information, and groundbreaking recommendations on a wide range of topics in science, engineering, and health. Our books are unique in that they are authored by the nation's leading experts in every scientific field.
Influential Leadership: Change Your Behavior, Change Your Organization, Change Health Care (ACHE Management)
by Michael FrisinaLeaders make things happen. Influential leaders go a step further by making a positive difference in organizations and in the lives of people who both serve and are served by the organization. Influential leaders perform at a higher level, are more productive, and achieve greater results than other leaders with similar circumstances and resources. Influential Leadership reveals: How good people skills—trust and accountability, not processes—can strengthen the organization’s pursuit of performance excellence How leaders and staff will change their behavior when they understand how it affects the outcome of their work, the lives of those around them, and the organization’s performance How self-aware, influential leaders are in a better position to collaborate and connect with others and to lead the organization to success “Dr. Frisina’s words get right to the heart of what sets apart truly great leaders, and are a road map for the journey.” —Lynn B. Wythe, RN, MSN, CNOR, director of nursing, Palmetto Health Baptist, Columbia, South Carolina “The author exhibits a passion for leadership excellence. . . . This book is a must for everyone entering into a leadership position, from the front-line manager to the CEO.” —Philip K. Beauchamp, LFACHE, president and CEO (ret.), Morton Plant Mease Healthcare, Inc., Clearwater, Florida “Chock full of examples and self-assessment tools. . . . The powerful takeaways from each section form an agenda for leading transformational change.” —Laura Avakian, leadership consultant, author, and past president of the American Society for Healthcare Human Resources Administration “Dr. Frisina leverages a lifetime of observations and hard-earned wisdom to give us a handful of guiding principles to make us all better leaders in our professional and personal lives.” —William R. Berry, MD, MPH, FACS, research associate, Department of Health Policy and Management, Harvard School of Public Health
Influenza Pathogenesis and Control - Volume II
by Michael B. A. Oldstone Richard W. CompansThis two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection. . Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
Influenza Vaccines for the Future
by Rino Rappuoli Giuseppe Del GiudiceThe emergence of H5N1 avian influenza in 1997 and of the influenza A H1N1 of swine origin in 2009 calls for new, rapid and sustainable solutions for both seasonal and pandemic influenza viruses. During the last ten years, science and technology have made enormous progress, and we are now able to monitor in real time the genetics of viruses while they spread globally, to make more powerful vaccines using novel adjuvants, and to generate viruses in the laboratory using reverse genetics. This volume not only provides state-of-the-art information on the biology of influenza viruses and on influenza vaccines, but is also designed to be a resource to face the present H1N1 pandemic and to plan for long-term global and sustainable solutions.
Influenza Virus
by Gabriele Neumann Yoshihiro KawaokaReports of influenza-like illnesses date back to the Middle Ages, and outbreaks of influenza likely afflicted humans long before that. Over the last half century, influenza virus research has led to the development of two classes of antivirals - ion channel and neuraminidase inhibitors. Recently, a method of the artificial generation of an influenza virus was established. This system has been instrumental in the development of novel influenza vaccines and in the understanding of viral pathogenicity and the functions of viral proteins. Influenza Virus: Methods and Protocols summarizes the current techniques that have made this progress possible, ranging from protocols for virus isolation, growth, and subtyping to procedures for the efficient generation of any influenza virus. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Influenza Virus: Methods and Protocols seeks to serve both professionals and novices with the techniques used in numerous laboratories around the world that are, thus, the building blocks that underpin almost all influenza virus research.
Influenza Virus Sialidase - A Drug Discovery Target
by Mark Von ItzsteinInfluenza continues to be an ongoing problem despite the existence of vaccines and drugs. Disease outbreaks can occur relatively quickly as witnessed with the recent emergence of the influenza virus A/H1N1 pandemic. The development of new anti-influenza drugs is thus a major challenge. This volume describes all aspects of the virus structure and function relevant to infection. The focus is on drug discovery of inhibitors to the enzyme sialidase, which plays a key role in the infectious lifecycle of the virus. Following an overview of the influenza virus, the haemagglutinin, the interactions with the cell receptors and the enzymology of virus sialidase, recent results in drug design are presented. These include a full coverage of the design, synthesis and evaluation of carbohydrate as well as non-carbohydrate influenza virus sialidase inhibitors. Further reviews of the clinical experience with influenza virus sialidase inhibitors and of the development of resistance to these inhibitor drugs complement the topic.
Influenza Virus: Methods And Protocols (Methods in Molecular Biology #1836)
by Yohei YamauchiThis book provides researchers with widely used techniques for the study of virology, focusing on molecular biology and imaging to encourage mechanistic investigation of virus-host interactions. Chapters detail a broad range of methods from diagnosis, virus propagation, proteomics, haploid screening, lentiviral screening, virus entry, single molecule RNA imaging, correlative light and electron microscopy (CLEM), EM, light-sheet microscopy, biochemistry, viral transcription, physiological infection models, animal models, in vivo imaging, antigenic evolution, immunology to mathematical modelling. Reviews cover general influenza, clinical trials, both sides of the gain-of-function debate, and computational modelling. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Influenza Virus: Methods and Protocols aims to motivate experienced researchers and newcomers in the field and improve our overall understanding of influenza.
Influenza Viruses: Disease Modeling and Laboratory Methods (Life Science Research Fundamentals)
by WileyInfluenza virus infections are a serious health problem. Each year, about 500 million people are infected by the virus, resulting in about 500,000 deaths worldwide. The occurrence of new influenza subtypes has caused severe pandemics, including the 2009 swine flu (vH1N1). In addition, highly pathogenic viruses, like subtypes H7N7 and H5N1, also called the fowl plague and bird flu, respectively, represent enormous economic threats to livestock farming. This book begins with descriptions of the molecular make-up of influenza viruses, their replication cycles and functions of viral proteins. A history of major influenza pandemics is provided as is a detailed article discussing how viral growth and decay is mathematically modeled to evaluate the biological parameters governing interaction between host and virus. Several laboratory protocols describe how influenza virus is handled and used in animal models to study host-pathogen interactions and test potential new therapies. This e-book — a curated collection from eLS, WIREs, and Current Protocols — offers a fantastic introduction to the field of influenza research for students or interdisciplinary collaborators.
Influenza and Public Health: Learning from Past Pandemics (The\earthscan Science In Society Ser.)
by Susan Craddock Jennifer Gunn Tamara Giles-VernickMajor influenza pandemics pose a constant threat. As evidenced by recent H5N1 avian flu and novel H1N1, influenza outbreaks can come in close succession, yet differ in their transmission and impact. With accelerated levels of commercial and population mobility, new forms of flu virus can also spread across the globe with unprecedented speed. Responding quickly and adequately to each outbreak becomes imperative on the part of governments and global public health organizations, but the difficulties of doing so are legion. One tool for pandemic planning is analysis of responses to past pandemics that provide insight into productive ways forward. This book investigates past influenza pandemics in light of today's, so as to afford critical insights into possible transmission patterns, experiences, mistakes, and interventions. It explores several pandemics over the past century, from the infamous 1918 Spanish Influenza, the avian flu epidemic of 2003, and the novel H1N1 pandemic of 2009, to lesser-known outbreaks such as the 1889-90 influenza pandemic and the Hong Kong Flu of 1968. Contributors to the volume examine cases from a wide range of disciplines, including history, sociology, epidemiology, virology, geography, and public health, identifying patterns that cut across pandemics in order to guide contemporary responses to infectious outbreaks.
Influenza and Respiratory Care
by Mieczyslaw PokorskiRespiratory infections constitute a major public health concern. The goal of this book is to share knowledge on the best advances in influenza and influenza-like viral infections, and new molecular-based diagnostic methods that discern the antigenic shift providing viruses the ability to constantly evolve and elude the host immune response. Co-infections, co-morbidities, persistently meager anti-flu vaccination coverage, and infection complications are dealt with. The chapters also further insight into such topics as the effect of sex hormones, and socioeconomic and anthropometric measures, on respiratory and immune functions underlying the severity of asthma and respiratory allergy. Psychological functioning in respiratory disorders, taking into account quality of life, illness acceptance, and depressive symptoms is also reviewed as it is all too often underestimated by healthcare providers. The book is intended for clinicians, researchers, students, and all other actors in health-related issues.
Influenza: Advances in Diagnosis and Management (Respiratory Disease Series: Diagnostic Tools and Disease Managements)
by Jiro FujitaThis book explores the latest research and practical data on the clinical management of influenza. Starting with the definition, epidemiology and pathogenesis, the first part reviews the basic science of the influenza virus and infection. The next three parts then discusses the diagnosis, complications and management, providing practical data and insights that are useful in day-to-day patient care. The last part focuses on the trending topics, including a new drug, oral baloxavir marboxil, which was introduced in Japan in 2018 and is the first polymerase inhibitor to be licensed for the treatment of uncomplicated influenza. In Japan, since the medical insurance system is well-established, patients receive medical examinations quickly after the onset of influenza viral infection, making it easy to implement early diagnostic tools and early treatment. Providing practical data and insights, Influenza - Advances in Diagnosis and Management is a useful resource for clinicians, residents and trainees around the globe.
Influenza: The Hundred Year Hunt to Cure the Deadliest Disease in History
by Jeremy BrownOn the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure? <P><P>While influenza is now often thought of as a common and mild disease, it still kills over 30,000 people in the US each year. Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu's deadly past to solve the mysteries that could protect us from the next outbreak. <P><P>In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come. Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. \ <P><P>Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts. <P><P>Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.
Infoglut: How Too Much Information Is Changing the Way We Think and Know
by Mark AndrejevicToday, more mediated information is available to more people than at any other time in human history. New and revitalized sense-making strategies multiply in response to the challenges of "cutting through the clutter" of competing narratives and taming the avalanche of information. Data miners, "sentiment analysts," and decision markets offer to help bodies of data "speak for themselves"—making sense of their own patterns so we don’t have to. Neuromarketers and body language experts promise to peer behind people’s words to see what their brains are really thinking and feeling. New forms of information processing promise to displace the need for expertise and even comprehension—at least for those with access to the data. Infoglut explores the connections between these wide-ranging sense-making strategies for an era of information overload and "big data," and the new forms of control they enable. Andrejevic critiques the popular embrace of deconstructive debunkery, calling into question the post-truth, post-narrative, and post-comprehension politics it underwrites, and tracing a way beyond them.
Informal Caregivers: From Hidden Heroes to Integral Part of Care
by Andreas CharalambousThis book builds on the current trends in informal caregivers’ role in the supportive care of cancer patients (as well as other diseases) across the care continuum covering topics from the healthcare professionals and the users’ perspectives. Informal caregivers are a critical resource to their care recipients and an essential component of the health care system. The book introduces a comprehensive view of the topic and acknowledges the importance and the complexity of caregiving. Here lays one of the uniqueness of this book, which highlights the areas and the ways that for example interventions in specific settings/groups of patients can actually facilitate the caregiving process. The increasing number of care-dependent people, the adoption of the principle “outpatient before inpatient”, the shift of care from inpatient to outpatient and the preference for home care (i.e. majority) are only some of the reasons that contributed to Informal caregiving becoming a central feature of the health care landscape and will become even more prominent in the decades ahead. The book draws on the experts’ high-end, current systematic research evidence and real-life examples on these topics to provide an insightful perspective on undertaking research within this context, and to demonstrate informal caregivers’ impact on patients’ outcomes. The structure of the book provides multiple perspectives to the topic and makes it appealing to a wide range of recipients including the nursing community, clinicians, social workers, researchers, policy makers, technology experts as well as postgraduate students especially to those practicing specifically in supportive care in cancer. The book fills a gap in this field of expertise not only by familiarizing the reader with a wide range of topics to be considered but it also emphasizes on what the developments in the field in the future would need to take into consideration. Finally, current and future studies can be informed from the practices of preceding studies that are incorporated in the book.
Informal Healthcare in Contemporary Russia: Sociographic Essays on the Post-Soviet Infrastructure for Alternative Healing Practices (Soviet and Post-Soviet Politics and Society #165)
by Yulia KrasheninnikovaThis volume deals with one of the most understudied aspects of everyday life in Russian society. Its main characters are the providers of goods and services to whom people turn for healthcare instead of official medical institutions. This encompasses a wide range of actors—from network marketing companies to 'folk' journals on health as well as healers, complementary medicine specialists, and religious organizations.Krasheninnikova's investigation pays particular attention to the legal, social, and economic status of informal healthcare providers. She demonstrates that these agents tend to flourish in bigger towns rather than in small settlements, where public healthcare is lacking. She also emphasizes the flexibility of boundaries between formal and informal healthcare due to the evolution of rules and regulations. The study reveals the important role of institutions that are generally not connected to alternative medicine, such as pharmacies, libraries, and church shops. This book is based on rich empirical observations and avoids both positive and critical assessment of the analyzed phenomena. The result is a vivid and thorough introduction to the world of self-medication and alternative healing in contemporary Russia.
Informal Payments and Regulations in China's Healthcare System
by Jingqing YangThis text addresses the key issue of informal payments, or 'red packets', in the Chinese Healthcare system. It considers how transactions take place at the clinical level as well as their regulation. Analysing the practice from the perspectives of institutions and power structure, it examines how institutional changes in the pre-reform and reform era have changed the power structure between medical professions, patients and the Party-state, and how these changes have given rise and perpetuate the practice. Drawing from qualitative data from interviews of medical professionals, the author recognises the medical profession as a major player in the health care system and presents their perception of the practice as the taker of 'red packets' and their interactions with the patient and the state surrounding the illegal practice in an authoritarian power structure. The books considers the institutional reasons that motivate doctors to take, patients to give, and the government to "tolerate" red packets, arguing that the bureaucratization of the medical profession, society of acquaintances and shortage of quality of medical services jointly create an institutional setting that has given rise to these informal payments. Contributing to a rounded understanding of the problems of healthcare reform in China, this book is a key read for all scholars interested in the issue of informal payments and healthcare politics in transition economies.
Informatics And Nursing: Opportunities And Challenges
by Jeanne SewellInformatics and Nursing: Opportunities and Challenges is a comprehensive informatics text focused on helping the nursing student learn the basics of informatics. The contents proceed from Unit One which covers computer basics to Unit Five which examines skills and techniques for using the end product of informatics: data. The text provides the foundational knowledge to understand technology and use informatics to discover and manipulate information and access, manage, retrieve, and present clinical data. This text was designed to capture cutting-edge advancement in nursing informatics core competencies and applications and to present the theories, tools, and skills that every nurse should know. The new edition has been updated for currency and has had chapters reorganized and consolidated to help students focus on important information.
Informatics Education in Healthcare: Lessons Learned
by Eta S. BernerWith the growth of the use of electronic medical records there has been a concomitant increase in training and education programs in informatics and health IT to prepare individuals as researchers, leaders, managers and developers of informatics tools, intervention and systems. This book will provide both theoretical and practical information for educators in a variety of these programs. We will include the "tacit knowledge" of experienced teachers, which is often not captured in traditional education textbooks. The book would be a blend of strategies, methods and suggested curriculum content. The book is designed to address issues common to all programs as well as education programs for special audiences. The chapter authors are all nationally recognized for their expertise in, and commitment to, informatics education. Although some chapters appear to be addressing specialized areas, there are general lessons to be learned even from those chapters in addition to the chapters that are specifically addressing general issues. The aims of the book are as follows: To address the lack of a broad based book in best practices for informatics education To provide a educational knowledge foundation for informatics educators at all levels To provide specific lessons learned in specialized informatics education areas.
Informatics Education in Healthcare: Lessons Learned (Health Informatics #92)
by Eta S. BernerThis heavily revised second edition defines the current state of the art for informatics education in medicine and healthcare. This field has continued to undergo considerable changes as the field of informatics continues to evolve. The book features extensively revised chapters addressing the latest developments in areas including relevant informatics concepts for those who work in health information technology and those teaching informatics courses in clinical settings, techniques for teaching informatics with limited resources, and the use of online modalities in bioinformatics research education. New topics covered include how to get appropriate accreditation for an informatics program, data science and bioinformatics education, and undergraduate health informatics education. Informatics Education in Healthcare: Lessons Learned addresses the broad range of informatics education programs and available techniques for teaching informatics. It therefore provides a valuable reference for all involved in informatics education.
Informatics In Proteomics
by Sudhir SrivastavaThe handling and analysis of data generated by proteomics investigations represent a challenge for computer scientists, biostatisticians, and biologists to develop tools for storing, retrieving, visualizing, and analyzing genomic data. Informatics in Proteomics examines the ongoing advances in the application of bioinformatics to proteomics researc