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Ion and Molecule Transport in Lysosomes (Methods in Signal Transduction Series)
by Bruno Gasnier Michael X. ZhuLysosomes are key subcellular organelles that regulate the cell function. Many of the essential activities of the cell are dependent on lysosomes. Dysfunction is linked to multiple diseases - storage disorders, neurodegeneration, immunological diseases and cancer. This book discusses concepts and methods used to study lysosome ion and small molecule transport. The contents will not only attract accomplished investigators in need of a broad review and synthesis of this important subject but will also appeal to young investigators and trainees needing to acquire comprehensive knowledge and technical skills working with lysosomal ion channels and small molecule transporters. Key selling features: Summarizes the endocellular role that lysosomes play with respect to cellular waste disposal Reviews essential cellular functions of lysosomes Explores how lysosome dysfunction is the cause of many metabolic disorders Examines how lysomes are involved in storage diseases Describes various technologies and methods used in lysosome research
Ion-Pair Chromatography and Related Techniques (Analytical Chemistry)
by Teresa CecchiIon-Pair Chromatography (IPC) is a rapidly evolving method for difficult analyses of organic and inorganic ions and ionogenic, neutral, and zwitterionic compounds. The possibilities for this technology continue to grow as novel ion-pair reagents and strategies are introduced at an accelerated level. Compensating for a dearth in the literature, Ion-
Ion-Radical Organic Chemistry: Principles and Applications, Second Edition
by Zory Vlad TodresConsolidating knowledge from a number of disciplines, Ion-Radical Organic Chemistry: Principles and Applications, Second Edition presents the recent changes that have occurred in the field since the publication of the first edition in 2003. This volume examines the formation, transformation, and application of ion-radicals in typical conditions of
Ion-Selective Electrodes
by Konstantin N. MikhelsonIon-selective electrodes (ISEs) have a wide range of applications in clinical, environmental, food and pharmaceutical analysis as well as further uses in chemistry and life sciences. Based on his profound experience as a researcher in ISEs and a course instructor, the author summarizes current knowledge for advanced teaching and training purposes with a particular focus on ionophore-based ISEs. Coverage includes the basics of measuring with ISEs, essential membrane potential theory and a comprehensive overview of the various classes of ion-selective electrodes. The principles of constructing ISEs are outlined, and the transfer of methods into routine analysis is considered. Advanced students, researchers, and practitioners will benefit from this expedient introduction.
Ion-Selective Electrodes for Biological Systems
by Christopher Fry Stephen Langley E. N. Stephen LangleyIon -Selective Electrodes for Biological Systems provides a user-friendly and practical guide to the manufacture and use of ion-selective electrodes for a wide variety of experimental systems used in biology. The book is aimed at researchers with little practical experience in the field and will direct them through the steps involved in making elec
Ionic Equilibria in Analytical Chemistry
by Jean-Louis BurgotThis book of general analytical chemistry - as opposed to instrumental analysis or separation methods - in aqueous solutions is focuses on fundamentals, which is an area too often overlooked in the literature. Explanations abound of the chemical and physical principles of different operations of chemical analysis in aqueous solutions. Once these principle are firmly established, numerous examples of applications are also given.
Ionic Transport in Hypertension: New Perspectives (Routledge Revivals)
by Antonio Coca Ricardo GarayFirst Published in 1994: Ionic Transport in Hypertension is devoted to examining the hypothesis that essential hypertension is a heterogeneous disease in its pathophysiological mechanisms as well as in its clinical and therapeutic considerations.
Ionically Gelled Biopolysaccharide Based Systems in Drug Delivery (Gels Horizons: From Science to Smart Materials)
by Amit Kumar Nayak Md Saquib Hasnain Dilipkumar PalThis volume provides a thorough insight into the chemistry and mechanism of ionic gelations of various ionic biopolysaccharides, like alginate, gellan gum, pectin, chitosan, carboxymethyl cellulose, etc., and the applications of various ionically gelled biopolysaccharides in drug delivery fields, with chapters emphasizing the recent advances in the field by the experts. This book will be of interest to graduate students and academic and industry researchers from pharmacy, biotechnology, bioengineering, biomedical and material sciences fields.
Ionizing Radiation Effects in Electronics: From Memories to Imagers (Devices, Circuits, and Systems)
by Marta Bagatin Simone GerardinIonizing Radiation Effects in Electronics: From Memories to Imagers delivers comprehensive coverage of the effects of ionizing radiation on state-of-the-art semiconductor devices. The book also offers valuable insight into modern radiation-hardening techniques.The text begins by providing important background information on radiation effects, their underlying mechanisms, and the use of Monte Carlo techniques to simulate radiation transport and the effects of radiation on electronics. The book then: Explains the effects of radiation on digital commercial devices, including microprocessors and volatile and nonvolatile memories—static random-access memories (SRAMs), dynamic random-access memories (DRAMs), and Flash memories Examines issues like soft errors, total dose, and displacement damage, together with hardening-by-design solutions for digital circuits, field-programmable gate arrays (FPGAs), and mixed-analog circuits Explores the effects of radiation on fiber optics and imager devices such as complementary metal-oxide-semiconductor (CMOS) sensors and charge-coupled devices (CCDs) Featuring real-world examples, case studies, extensive references, and contributions from leading experts in industry and academia, Ionizing Radiation Effects in Electronics: From Memories to Imagers is suitable both for newcomers who want to become familiar with radiation effects and for radiation experts who are looking for more advanced material or to make effective use of beam time.
Ionotropic Glutamate Receptor Technologies
by Gabriela K. PopescuThis detailed volume explores key technologies that are used currently to investigate iGluR structure, function and physiology. Chapters in this book cover methods to help illuminate the assembly, trafficking, molecular composition and subcellular location of iGluRs; approaches used to understand the atomic organization of iGluRs; and techniques to monitor receptor activity in real time. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory. Concise and easy-to-use, Ionotropic Glutamate Receptor Technologies aims to facilitate the implementation of specific methods to iGluR investigations.
Iris Grace: How Thula the Cat Saved a Little Girl and Her Family
by Arabella Carter-JohnsonIris Grace is a beautiful little girl who, from a very young age, barely communicated, avoided social interaction with other people, and rarely smiled. From both before her diagnosis of autism and after, she seemed trapped in her own world, unable to connect with those around her. One day, her mother brought home a Maine Coon kitten for Iris, even though cats aren’t typically thought of as therapy pets. Thula, named after one of Iris’s favorite African lullabies and meaning ?peace” in Zulu, immediately bonded with Iris. Thula knew right away how to assuage Iris when she became overstimulated; when to intervene when Iris became overwhelmed; and how to provide distraction when Iris started heading toward a meltdown. Whether exploring, playing, sleeping, or taking a bath with Iris or accompanying the family on a bike ride, Thula became so much more than a therapy cat. With Thula’s safe companionship, Iris began to talk and interact with her family. This heartwarming story is illustrated with sixty of Iris’s gorgeous impressionistic paintings, works of art that have allowed her to express herself since the age of three. A gifted artist, Iris sees the natural world in a profoundly vivid and visceral way. With Thula by her side, she’ll sit and paint for hours, and the results are stunning. Inspiring and touching, Iris Grace follows the struggles and triumphs of a family?and a miracle cat?as they learn to connect with an amazing child.
Irish Insanity: 1800–2000 (Routledge Advances in Sociology)
by Damien BrennanThe national public asylum system in Ireland was established during the early nineteenth century and continued to operate up to the close of the twentieth century. These asylums / mental hospitals were a significant physical and social feature of Irish communities. They were used intensively and provided a convenient form of institutional intervention to manage a host of social problems. Irish Insanity identifies the long-term trends in institutional residency through the development of a detailed empirical data set, based on an analysis of original copies of the reports of Inspector of Asylums/Mental Hospitals in Ireland. Damien Brennan explores core social and historical features linked to this data including: the political context governance and social policy the relationship between church and state changing economic structures and social deprivation professionalization legislation and systems of admission and discharge categorisation and diagnostic criteria international developments family dynamics This book demonstrates that the actual rate of asylum utilisation in Ireland was the highest by international standards, but challenges the idea that an "epidemic of Irish insanity" actually existed. Offering a historical and sociological insight into an institutional legacy that is unusual within the international context, this book will be of particular relevance and interest to scholars within the fields of sociology, criminology, law, history, Irish studies, social policy, anthropology, nursing and medicine.
Iron Acquisition by the Genus Mycobacterium
by B. Rowe ByersIron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
Iron Deficiency and Overload
by David I. Mostofsky Shlomo YehudaIron deficiency is ever-present among all populations throughout the world irrespective of race, culture, or ethnic background. Even with the latest advances in medicine, improved nutrition, and the ready availability of cheap oral iron, there is still no satisfactory explanation for the widespread occurrence of iron deficiency or for the absence of an effective treatment. Iron Deficiency and Overload: From Biology to Clinical Medicine is an important new text that provides a timely review of the latest science concerning iron metabolism as well as practical, data-driven options to manage at-risk populations with the best accepted therapeutic nutritional interventions. Chapter topics reflect the excitement in current theoretical development and laboratory activity in this area. The distinguished authors address their presentations to professionals and graduate students who need to be better informed about the concepts, methodologies, and current status of the field. Iron Deficiency and Overload: From Biology to Clinical Medicine is an essential text that presents a sampling of the major issues in iron research, from the most basic research level to human applications.
Iron Metabolism in Infants
by Bo LonnerdalThere is a critical need for iron intake during the first period of life. The growing infant requires iron to synthesize hemoglobin and to supply expanding tissues with iron-containing enzymes. A lack of iron will eventually lead to iron deficiency anemia, one of the most common single nutrient deficiencies in the world. Today, detailed information has increased our understanding of iron bioavailability from different dietary sources, uptake mechanisms of iron into the small intestinal mucosa for transport to hepatocytes and erythropoietic cells and subsequent receptor mediated cellular acquisition. Metabolic effects of iron deficiency have also been investigated in several tissues. This comprehensive text integrates recent information and address it from a nutritional perspective. It takes this focus because of the increased knowledge on the interrelationship between iron and other essential nutrients. Specific problems of iron nutriture and oxidant stress in prematurely born infants are also addressed in this informative new text
Iron Physiology and Pathophysiology in Humans
by Gordon D. Mclaren Gregory J. AndersonIron Physiology and Pathophysiology in Humans provides health professionals in many areas of research and practice with the most up-to-date and well-referenced volume on the importance of iron as a nutrient and its role in health and disease. This important new volume is the benchmark in the complex area of interrelationships between the essentiality of iron, its functions throughout the body, including its critical role in erythropoiesis, the biochemistry and clinical relevance of iron-containing enzymes and other molecules involved in iron absorption, transport and metabolism, he importance of optimal iron status on immune function, and links between iron and the liver, heart, brain and other organs. Moreover, the interactions between genetic and environmental factors and the numerous co-morbidities seen with both iron deficiency and iron overload in at risk populations are clearly delineated so that students as well as practitioners can better understand the complexities of these interactions. Key features of the volume include an in-depth index and recommendations and practice guidelines are included in relevant chapters. The volume contains more than 100 detailed tables and informative figures and up-to-date references that provide the reader with excellent sources of information about the critical role of iron nutrition, optimal iron status and the adverse clinical consequences of altered iron homeostasis. Iron Physiology and Pathophysiology in Humans is an excellent new text as well as the most authoritative resource in the field.
Iron Transport and Storage
by Prem Ponka Herbert M. Schulman Robert C. Woodworth Goetz W. RichterThe objective of this book is to review and summarize recent developments in our understanding of iron transport and storage in living systems. It includes an overview of the evolutionary aspects of iron metabolism and bacterial iron transport, as well as a detailed discussion of molecules with specific roles in iron metabolism in higher organisms. It also presents relationships between intracellular iron metabolism and cell proliferation. Iron Transport and Storage addresses the comparative aspects of iron transport and storage in different tissues. This essential volume is very useful for hematologists, physical and biological chemists, cell and molecular biologists, physiologists, and clinicians with an interest in the biology and metabolism of iron.
Iron in Clinical Practice
by Sue Pavord Noemi RoyLearn the tools for addressing a widespread public health issue with this practical guide Iron deficiency and iron overload are among the most common health conditions encountered in the course of clinical practice, with the potential to produce a range of morbidities and increase overall mortality. However, these conditions are often under-recognized, resulting in unnecessary disease and loss of well-being. There is an urgent need to raise awareness among clinicians of the causes, effects and management of iron imbalance. Iron in Clinical Practice meets this need with a brisk, practical guide to recognizing and treating both iron deficiency and iron overload in clinical settings. Edited by two Oxford haematologists and leading specialists in iron management, it covers major areas of medicine and surgery impacted by these disorders. The result is an essential resource for both beginning and experienced clinicians. Iron in Clinical Practice readers will find: Introductory chapters outlining the role of iron in the body, its utilization and mechanisms of trafficking and distribution, and how these are impacted by disease.Coverage of a range of clinical settings across medicine, surgery and primary care.Illustrations, tables, and graphs throughout. Iron in Clinical Practice is ideal for all health care practitioners of any specialty.
Irrationality in Health Care: What Behavioral Economics Reveals About What We Do and Why
by Douglas E. HoughThe health care industry in the U.S. is peculiar. We spend close to 18% of our GDP on health care, yet other countries get better results—and we don't know why. To date, we still lack widely accepted answers to such simple questions as "Would requiring everyone to buy health insurance make all of us better off?" The standard tools of health economics can only take us so far. This book draws on behavioral economics as an alternative lens to provide more clarity in diagnosing the ills of health care today. A behavioral perspective makes sense of key contradictions—from the seemingly irrational choices that we sometimes make as consumers, to the incongruous behavior of providers, to the morass of the long-lived debate surrounding reform. With the new health care law in effect, it is more important than ever that consumers, the health care industry, and the policymakers who are governing change reckon with the power and sources of our behavior when it comes to health.
Irreversible Electroporation in Clinical Practice
by Martijn R. Meijerink Hester J. Scheffer Govindarajan NarayananThis book provides a comprehensive overview of the clinical use of irreversible electroporation (IRE) - better known by its commercial name, NanoKnife - which is one of the most exciting new needle-guided cancer treatments. The coverage includes the history of IRE, general technique, preclinical research, applications in clinical practice and early clinical results, and future perspectives. Contraindications, treatment planning, potential complications, follow-up imaging, and other practical aspects are fully discussed, with highlighting of useful tips and tricks. Through the delivery of short but highly intense electrical pulses, IRE results in tumor cell membrane permeabilization, causing cells to go into apoptosis. The minimally invasive nature of IRE, combined with the prospect of completely eradicating tumors while preserving delicate structures in the ablation zone, makes IRE the object of worldwide clinical research. This book will be of value for practitioners and trainees in interventional and diagnostic radiology, surgery, medical oncology, HPB and gastroenterology, urology, and radiation oncology.
Irritable Bowel Syndrome
by Anton Emmanuel Eamonn M. QuigleyThis comprehensive yet concise guide to the diagnosis and management of IBS is divided into four main parts: Overview, Diagnosis, Symptom-specific Treatment, and What's Next in IBS. Each chapter includes a summary of key points, and most chapters include cases and multiple choice questions for rapid review. Clinicians who manage patients with IBS will want to keep this dependable reference close at hand.
Irritable Bowel Syndrome
by Takeshi Kamiya Shin FukudoThis edited book brings together 5 general themes of irritable bowel syndrome (IBS), presenting the latest information on the epidemiology, pathophysiology, diagnosis, treatment and a number of current topics. IBS is a functional bowel disorder associated with chromic abdominal pain and altered bowel habits without identifiable organic etiology, however, to date there is no known, agreed-upon disease mechanism. This book offers insights into the various factors potentially contributing to the symptoms, and provides data on the various globally recognized strategies, including novel pharmacological treatment agents. It also discusses geographical differences and region-specific factors such as medical systems, life styles, dietary habits, gut microbiota, social stress, and genetics. The book promotes further exploration of the disease by offering a comprehensive bibliography for each chapter. It is a valuable and thought-provoking resource for clinicians, researchers, residents and PIs who are interested in the latest basic and clinical research on IBS.
Irritable Bowel Syndrome: pocketbook
by Roger JonesIrritable bowel syndrome has emerged from relative obscurity to become widely recognised as the cause of considerable morbidity, reduction in quality of life and costs to patients and health services. This review of the current state of knowledge of the condition will act as a ready source of reference to both generalists and specialists and will a
Irwin and Rippe's Intensive Care Medicine
by Richard S. IrwinWith a focus on evidence-based, state-of-the-art information throughout, the eighth edition of Irwin and Rippe’s Intensive Care Medicine offers authoritative guidance to the wide variety of specialty physicians and non-physicians practicing in the adult intensive care environment. This comprehensive textbook covers both the theoretical and practical aspects of the field, and has been completely updated to provide encyclopedic, interprofessional coverage to support practitioners in every area of this complex field.
Is Acupuncture Right for You? What It Is, Why It Works, and How It Can Help You
by Ruth Lever KidsonIs Acupuncture Right for You? is regarded by many practitioners as the most concise and useful book to introduce prospective patients to the principles, processes, and benefits of acupuncture.