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Labster Virtual Lab Experiments: Basic Genetics
by Sarah Stauffer Aaron Gardner Wilko Duprez Dewi Ayu Ungu Philip WismerThis textbook helps you to prepare for both your next exams and practical courses by combining theory with virtual lab simulations. With the “Labster Virtual Lab Experiments” book series you have the unique opportunity to apply your newly acquired knowledge in an interactive learning game that simulates common laboratory experiments. Try out different techniques and work with machines that you otherwise wouldn’t have access to.In this volume on “Basic Genetics” you will learn how to work in a laboratory with genetic background and the fundamental theoretical concepts of the following topics:Mendelian InheritancePolymerase Chain ReactionAnimal GeneticsGene ExpressionGene RegulationIn each chapter, you will be introduced to the basic knowledge as well as one virtual lab simulation with a true-to-life challenge. Following a theory section, you will be able to play the corresponding simulation. Each simulation includes quiz questions to reinforce your understanding of the covered topics. 3D animations will show you molecular processes not otherwise visible to the human eye. If you have purchased a printed copy of this book, you get free access to five simulations for the duration of six months. If you’re using the e-book version, you can sign up and buy access to the simulations at www.labster.com/springer.If you like this book, try out other topics in this series, including “Basic Biology”, “Basic Biochemistry”, and “Genetics of Human Diseases”.
Labster Virtual Lab Experiments: Basic Biology
by Sarah Stauffer Aaron Gardner Dewi Ayu Ungu Ainara López-Córdoba Matthias HeimThis textbook helps you to prepare for both your next exams and practical courses by combining theory with virtual lab simulations. With the “Labster Virtual Lab Experiments” book series you have the unique opportunity to apply your newly acquired knowledge in an interactive learning game that simulates common laboratory experiments. Try out different techniques and work with machines that you otherwise wouldn’t have access to.In this volume on “Basic Biology” you will learn how to work in a biological laboratory and the fundamental theoretical concepts of the following topics: Lab SafetyMitosisMeiosisCellular RespirationProtein SynthesisIn each chapter, you will be introduced to the basic knowledge as well as one virtual lab simulation with a true-to-life challenge. Following a theory section, you will be able to play the corresponding simulation. Each simulation includes quiz questions to reinforce your understanding of the covered topics. 3D animations will show you molecular processes not otherwise visible to the human eye.If you have purchased a printed copy of this book, you get free access to five simulations for the duration of six months. If you’re using the e-book version, you can sign up and buy access to the simulations at www.labster.com/springer.If you like this book, try out other topics in this series, including “Basic Genetcis”, “Basic Biochemistry”, and “Genetics of Human Diseases”.
Labster Virtual Lab Experiments: Basic Biochemistry
by Sarah Stauffer Aaron Gardner Wilko Duprez Dewi Ayu Kencana Ungu Frederik Clauson-KaasThis textbook helps you to prepare for your next exams and practical courses by combining theory with virtual lab simulations. The “Labster Virtual Lab Experiments” series gives you a unique opportunity to apply your newly acquired knowledge in a learning game that simulates exciting laboratory experiments. Try out different techniques and work with machines that you otherwise wouldn’t have access to.In this book, you’ll learn the fundamental concepts of basic biochemistry focusing on:Ionic and Covalent BondsIntroduction to Biological MacromoleculesCarbohydratesEnzyme KineticsIn each chapter, you’ll be introduced to one virtual lab simulation and a true-to-life challenge. Following a theory section, you’ll be able to play the relevant simulation that includes quiz questions to reinforce your understanding of the covered topics. 3D animations will show you molecular processes not otherwise visible to the human eye.If you have purchased a printed copy of this book, you get free access to five simulations for the duration of six months. If you’re using the e-book version, you can sign up and buy access to the simulations at www.labster.com/springer.If you like this book, try out other topics in this series, including “Basic Biology”, “Basic Genetics”, and “Genetics of Human Diseases”.
Lacan with the Philosophers
by Ruth RonenClosely examining Jacques Lacan's unique mode of engagement with philosophy, Lacan with the Philosophers sheds new light on the interdisciplinary relations between philosophy and psychoanalysis. While highlighting the philosophies fundamental to the study of Lacan’s psychanalysis, Ruth Ronen reveals how Lacan resisted the straightforward use of these works. Lacan’s use of philosophy actually has a startling effect in not only providing exceptional entries into the philosophical texts (of Aristotle, Descartes, Kant and Hegel), but also in exposing the affinity between philosophy and psychoanalysis around shared concepts (including truth, the unconscious, and desire), and at the same time affirming the irreducible difference between the analyst and the philosopher. Inspired by Lacan’s resistance to philosophy, Ruth Ronen addresses Lacan’s use of philosophy to create a fertile moment of exchange. Straddling the fields of philosophy and psychoanalysis with equal emphasis, Lacan with the Philosophers develops a unique interdisciplinary analysis and offers a new perspective on the body of Lacan’s writings.
The Lacrimal System
by Adam J. Cohen Michael Mercandetti Brian BrazzoWhile there are books that review lacrimal surgery as a portion of oculoplastic practice, The Lacrimal System: Diagnosis, Management & Surgery, Second Edition, addresses the range of lacrimal disorders in one concise, practical volume. Building off of the success of the first edition, this text includes significantly updated information, as well as new chapters that are complete with high quality color images and illustrations. Lacrimal surgeries are among the most commonly performed ones in oculopastic surgery. The procedures range from unblocking tear ducts in small children with congenital dysmorphology, to correcting dry eye through surgery. As with many of these procedures, the disorders sound minor but the patients' lives are seriously affected. By broadening the scope of the subject, the editors of The Lacrimal System, Second Edition meet the needs of oculoplastic surgeons, ophthalmologists, residents and fellows who are learning these special procedures.
Lactic Acid Bacteria: A Functional Approach
by Alejandra de Moreno de LeBlancLactic acid bacteria (LAB) are a diverse group of bacteria that comprise low GC content Gram-positive cocci or rods that produces lactic acid as the major end product of the fermentation process. Bifidobacterium genera may also be considered as a part of the LAB group for possessing some similar phenotypical characteristics despite the higher GC content. The key feature of LAB metabolism is efficient carbohydrate fermentation. This contributes to the production of several microbial metabolites that result in the improvement of flavor and texture of fermented foods, in addition to its positive impact on the human health when LAB is administered as a probiotic. The book deals with advances made in the functionalities of LAB, such as their effect on vitamin D receptor expression, impact on neurodegenerative pathologies, production of B-vitamins for food bio-enrichment, production of bacteriocins to improve gut microbiota dysbiosis, production of metabolites from polyphenols and their effects on human health, effect on reducing the immunoreaction of food allergens, as biological system using time-temperature to improve food safety, and the use of probiotics in animal feed. The book also reviews the use of LAB and probiotic technologies to develop new functional foods and functional pharmaceuticals.
Lactoferrin and its Role in Wound Healing
by Yoshiharu TakayamaLactoferrin is an iron-binding glycoprotein belonging to the transferrin family. It acts as a defense in host animals against microbes and viruses, since it has a broad spectrum of antimicrobial and antiviral activities. Lactoferrin has been shown to regulate the growth and differentiation of many types of cells. The results of recent studies indicate that lactoferrin is a potent regulator of dermal fibroblasts, and promotes cutaneous wound healing. The collagen gel contraction, a model of wound contraction during wound healing process, and migration of human fibroblasts were enhanced by lactoferrin. LRP-1 (LDL Receptor related Protein-1) acts as a signaling receptor for lactoferrin that mediate fibroblast response to lactoferrin by activating ERK/MAPK signaling pathway. In addition, lactoferrin promotes biosynthesis of extracellular matrix (ECM) component such as type-I collagen and hyaluronan. Hyaluronan is a major component of ECM in connective tissue and promotes wound healing. The promoting effect of lactoferrin on hyaluronan production was accompanied by promotion of HAS2 (hyaluronan synthase 2) expression. These observations suggest that lactoferrin promotes the wound healing by providing an ECM that promotes fibroblast migration. Lactoferrin is also known for its anti-inflammatory and immune modulating properties. According to recent in vivo study, lactoferrin promotes wound repair by promoting the early inflammatory phase of wound healing. Based on this, recombinant human lactoferrin was subsequently tested clinically in a Phase II trial in patients with diabetic ulcers and was found to be effective. Lactoferrin should be further evaluated in patients with diabetic and other types of ulcers.
The Lactoperoxidase System: Chemistry and Biological Significance
by Kenneth PruittThis book reviews the major biochemical and biological properties of the lactoperoxidase system including both the bovine milk and human salivary enzymes. It focuses on the basic chemistry of peroxidase-catalyzed reactions and clinical applications of peroxide system antimicrobial effects.
The Lady and Her Monsters: A Tale of Dissections, Real-Life Dr. Frankensteins, and the Creation of Mary Shelley's Masterpiece
by Roseanne MontilloThe Lady and Her Monsters by Roseanne Motillo brings to life the fascinating times, startling science, and real-life horrors behind Mary Shelley’s gothic masterpiece, Frankenstein.Montillo recounts how—at the intersection of the Romantic Age and the Industrial Revolution—Shelley’s Victor Frankenstein was inspired by actual scientists of the period: curious and daring iconoclasts who were obsessed with the inner workings of the human body and how it might be reanimated after death.With true-life tales of grave robbers, ghoulish experiments, and the ultimate in macabre research—human reanimation—The Lady and Her Monsters is a brilliant exploration of the creation of Frankenstein, Mary Shelley’s horror classic.
Lady Lushes: Gender, Alcoholism, and Medicine in Modern America
by Michelle L. McClellanAccording to the popular press in the mid twentieth century, American women, in a misguided attempt to act like men in work and leisure, were drinking more. “Lady Lushes” were becoming a widespread social phenomenon. From the glamorous hard-drinking flapper of the 1920s to the disgraced and alcoholic wife and mother played by Lee Remick in the 1962 film “Days of Wine and Roses,” alcohol consumption by American women has been seen as both a prerogative and as a threat to health, happiness, and the social order. In Lady Lushes, medical historian Michelle L. McClellan traces the story of the female alcoholic from the late-nineteenth through the twentieth century. She draws on a range of sources to demonstrate the persistence of the belief that alcohol use is antithetical to an idealized feminine role, particularly one that glorifies motherhood. Lady Lushes offers a fresh perspective on the importance of gender role ideology in the formation of medical knowledge and authority.
Lady of the Keep
by Sharon SchulzeHER BODY WAS GREAT WITH CHILD But her guilt was far greater. For though Lady Moira Fitzgerald had sacrificed herself to keep her people safe, she knew no man would have her now. Certainly not one as noble as Sir Connor FitzClifford! And yet her heart flared with passion whenever he drew near… Sworn to protect Gerald's keep and all within, Connor FitzClifford hadn't realized such a vow would reweave the tapestry of his life. For his promise had bound him not only to the besieged fortress, but also to its mistress, the enigmatic Lady Moira, a woman whose very soul mirrored his own!
The Lady's Handbook For Her Mysterious Illness: A Memoir
by Sarah Ramey'A visceral, scathing, erudite read that digs deep into how modern medicine continues to fail women and what can be done about it' Booklist The darkly funny memoir of Sarah Ramey's years-long battle with a mysterious illness that doctors thought was all in her head - but wasn't. A revelation and an inspiration for millions of women whose legitimate health complaints are ignored. In her harrowing, defiant and unforgettable memoir, Sarah Ramey recounts the decade-long saga of how a seemingly minor illness in her senior year of college turned into a prolonged and elusive condition that destroyed her health but that doctors couldn't diagnose or treat. Worse, as they failed to cure her, they hinted that her devastating symptoms were psychological.The Lady's Handbook for Her Mysterious Illness is a memoir with a mission: to help the millions of (mostly) women who suffer from unnamed or misunderstood conditions--autoimmune illnesses, fibromyalgia and chronic fatigue syndrome, chronic Lyme disease, chronic pain and many more. Ramey's pursuit of a diagnosis and cure for her own mysterious illness becomes a page-turning medical mystery that reveals a new understanding of today's chronic illnesses as ecological in nature, driven by modern changes to the basic foundations of health, from the quality of our sleep, diet and social connections to the state of our microbiomes. Her book will open eyes, change lives and, ultimately, change medicine.'Ramey's uncanny grit and fortitude will deeply inspire the multitudes facing similar issues' Publishers Weekly'This is a book for anyone who has ever asked a question that didn't have an immediate or easy answer, anyone who has worried about themselves or a loved one who isn't getting better - despite following all the experts' advice - and anyone interested in their own health, public health or medicine; in other words, it's a book with something resonant and useful for all of us' Chelsea Clinton
Lafleur Brooks' Health Unit Coordinating (Seven Edition)
by Elaine A. Gillingham Monica Wadsworth SeibelGet the most comprehensive, in-depth coverage on health unit coordinating from the industry's most popular text! <P><P>Expert authors Elaine Gillingham and Monica Wadsworth Seibel offer in-depth discussion of key theories and concepts surrounding the profession and guide you through the common responsibilities of a health unit coordinator in both traditional and electronic medical record environments. <P><P>From greeting new patients and dealing with visitors to transcribing physicians' orders, maintaining statistical reports, and preparing patient charts, this text will prepare you for success across all areas of health unit coordination.
The Lakeland Doctor's Decision: A Captivating Medical Romance
by Gill SandersonAnother heartwarming medical romance from best-selling author Gill Sanderson! Perfect for fans of Mia Faye, Laura Scott, Helen Scott Taylor, Grey's Anatomy and ER.Readers LOVE Gill's gripping medical romances! 'Remarkable writer!!' 5* author review 'A truly wonderful writer' 5* author review 'I find all of Gill Sanderson's books very readable and enjoy the escapism they give me' 5* author review 'A truly gifted writer with an enormous amount of talent and sensitivity' 5* author review Faith has thrown herself into her work as a doctor after the death of her fiancee. Chris is trying to provide a new start and a stable home for his small daughter, Molly, after his separation from his wife. When Molly hides in Faith's shed, she brings these two damaged adults together. But neither wants a new relationship. Or so they think...Don't miss Gill Sanderson's enthralling medical romances, including the A Lakeland Practice and the Good, Bad and Ugly series.
The Lakeland Doctor's Decision: A Captivating Medical Romance
by Gill SandersonAnother heartwarming medical romance from best-selling author Gill Sanderson! Perfect for fans of Mia Faye, Laura Scott, Helen Scott Taylor, Grey's Anatomy and ER.Readers LOVE Gill's gripping medical romances! 'Remarkable writer!!' 5* author review 'A truly wonderful writer' 5* author review 'I find all of Gill Sanderson's books very readable and enjoy the escapism they give me' 5* author review 'A truly gifted writer with an enormous amount of talent and sensitivity' 5* author review Faith has thrown herself into her work as a doctor after the death of her fiancee. Chris is trying to provide a new start and a stable home for his small daughter, Molly, after his separation from his wife. When Molly hides in Faith's shed, she brings these two damaged adults together. But neither wants a new relationship. Or so they think...Don't miss Gill Sanderson's enthralling medical romances, including the A Lakeland Practice and the Good, Bad and Ugly series.
Lakeland Nurse: A Sweet Medical Romance (Medical Romances #10)
by Gill Sanderson<p>She had dreams...and he had secrets...<p> <p>Nurse Zanne Ripley was devastated to discover that her application to go to medical school had been unsuccessful- and all because of Dr Neil Calder. He'd taken an instant dislike to her at her interview, and now she had to work side by side with him at the Mountain Activities centre in the Lake District!<p> <p>But his charm soon broke down Zanne's defences, and she knew she was falling in love. But Neil had a secret and devastating plan which could all but destroy Zanne...<p>
Lakewood: A Novel
by Megan GiddingsA startling debut about class and race, Lakewood evokes a terrifying world of medical experimentation—part The Handmaid’s Tale, part The Immortal Life of Henrietta Lacks. Electric Literature: One of 55 Books by Women and Nonbinary Writers of Color to Read in 2020 | Lit Hub & The Millions: Most Anticipated Books of 2020 | Ms. Magazine: Anticipated 2020 Feminist Books | Refinery29: Books by Black Women We are Looking Forward To Reading | One of The Millions’ Most Anticipated Reads of 2020 | Amazon Book of the Month Pick | Audible Editor’s Pick | Essence’s Pick| Glamour’s Must Read | Ms. Magazine’s Anticipated Read of 2020 When Lena Johnson’s beloved grandmother dies, and the full extent of the family debt is revealed, the black millennial drops out of college to support her family and takes a job in the mysterious and remote town of Lakewood, Michigan. On paper, her new job is too good to be true. High paying. No out of pocket medical expenses. A free place to live. All Lena has to do is participate in a secret program—and lie to her friends and family about the research being done in Lakewood. An eye drop that makes brown eyes blue, a medication that could be a cure for dementia, golden pills promised to make all bad thoughts go away.The discoveries made in Lakewood, Lena is told, will change the world—but the consequences for the subjects involved could be devastating. As the truths of the program reveal themselves, Lena learns how much she’s willing to sacrifice for the sake of her family. Provocative and thrilling, Lakewood is a breathtaking novel that takes an unflinching look at the moral dilemmas many working-class families face, and the horror that has been forced on black bodies in the name of science.
Laktat: Stoffwechselgrundlagen, Leistungsdiagnostik, Trainingssteuerung
by Hermann Heck Ulrich Bartmus Volker GrabowLaktat im Energiestoffwechsel und seine Nutzung in Leistungsdiagnostik und TrainingssteuerungDieses Buch widmet sich dem Thema Laktat in seinen verschiedensten Facetten. Es beschreibt neben einem historischen Abriss den Energiestoffwechsel des Muskels sowie ein Energiestoffwechselmodell, mit dem die meisten laktatbezogenen Phänomene erklärt werden können. Gängige Laktatanalysemethoden und Laktatschwellenkonzepte werden ebenso vorgestellt und kritisch diskutiert wie die zahlreichen Einflussfaktoren auf die Laktatleistungskurve (z. B. Testprotokoll, Vorbelastungen, Umgebungsbedingungen). Darüber hinaus wird der Einsatz von Laktat in der Leistungsdiagnostik und Trainingssteuerung – mit einem speziellen Fokus auf die Sportart Rudern – ausführlich thematisiert.Das Buch richtet sich an Sportmediziner und andere Ärzte, die leistungsdiagnostische Untersuchungen durchführen, sowie an Sportwissenschaftler, Trainer und an dem Thema interessierte Leistungs- und Breitensportler.
L’Alzheimer: une maladie redoutable I
by Juan Moises de la Serna Bakrim NouryIssu d’une trilogie amplement consacrée à la maladie Alzheimer, ce livre a été conçu à la base de questionnements utiles. D’emblée un mot sur ses mérites pédagogiques : le livre adopte une démarche rationnelle simplifiée qui permet à tous les lecteurs concernés de comprendre le phénomène qui les accable, partant ontologiquement de la définition très fine en passant par la causalité pour enfin aboutir aux conséquences variées. En outre, son intelligence se traduit par une articulation des questionnements ‘’populaires’’ aux grands questionnements de la recherche contemporaine sur l’Alzheimer. Pour l’avoir lu et traduit, je peux affirmer que cet équilibre est réussi. Le livre est aussi utile et fiable quand il s’agit de diversifier les références aux solutions thérapeutiques ou celles concernant les résultats de l’état de l’art actuel en matière d’Alzheimer : dans ce sens bien précis, les données sont exposées avec un sens aigu de la critique qui permet non seulement de comprendre ‘’ce qui se fait’’ aux quatre coins du monde mais aussi de pouvoir adopter une vision claire sur ‘’ce qui peut être concrètement fait’’ afin de retarder voire même de guérir la dégénérescence des fonctions cognitives de la mémoire. D’autres apports seront certainement un atout pour les lecteurs concernés ou curieux: la distinction d’Alzheimer des autres démences, où il propose même une forme de diagnostic enrichi, une nouvelle méthode de prévention/d’anticipation publique et familiale très utile pour les proches par exemple. L’accent mis sur l’inefficacité pharmacologique est une autre voie de vulgarisation où les lecteurs sauront comment se situer face aux traitements médicamenteux actuellement disponibles. Enfin, trois pistes sont suggérées où l’argumentation du livre culmine avec des propositions claires : la piste génétique, la piste biologique et la piste psycholo
Lampedusa: Gateway to Europe
by Dr Pietro Bartolo Lidia Tilotta"Bartolo tells us about rescuing everyone he can, burying those he cannot, and saving their stories as if they were his own. This is a personal, urgent and universal book" GLORIA STEINEM"An urgent, wrenching dispatch from the frontline of the defining crisis of our times . . . Bartolo is at once the saviour and the coroner to boatload after boatload of migrants who risk everything to cross the deadly seas. It is also a damning indictment of the broader, collective indifference of humankind to both the drowned and the saved" PHILIP GOUREVITCH"Dr Pietro Bartolo has seen more suffering and death in his career than any one man should have to witness" Amnesty International"Through Bartolo we understand that it is impossible to do nothing in the face of such great human need" Vanity FairIt is common to think of the refugee crisis as a recent phenomenon, but Dr Pietro Bartolo, who runs the clinic on the Italian island of Lampedusa, has been caring for its victims - both the living and the dead - for a quarter of a century.Situated some 200 km off Italy's Southern coast, Lampedusa has hit the world headlines in recent years as the first port of call for hundreds of thousands of African and Middle Eastern migrants hoping to make a new life in Europe.The shipwrecks began in 1992. Before the Arab Spring, they came from Africa, but now they come from across the Arab world as well. And the death toll is staggering. On Christmas Eve, 1996, 286 bodies were recovered; on the night of October 3, 2003, 366 out of 500 migrants died after a shipwreck nearby.For the past twenty-five years, Doctor Bartolo has been rescuing, welcoming, helping, and providing medical assistance to those who survived. But, above all, he has been listening to them. Tales of pain and hope, stories of those who didn't make it, who died at sea, their bodies washed up on shore; stories of those who lost their loved ones, of babies that never had a chance to be born.SHORTLISTED FOR THE ITALIAN PROSE TRANSLATION AWARD (IPTA)Translated from the Italian by Chenxin Jiang
The Land of Last Chances: A Novel
by Joan CohenJeanne Bridgeton, an unmarried executive in her late forties, discovers life doesn’t begin and end on a spreadsheet when her expected menopause instead becomes an unexpected pregnancy. Though accomplished at managing risk professionally, Jeanne realizes her skills don’t extend to her personal life, where she has allowed the professional and the personal to become intertwined. She’s not even sure which of two men in her life is the father. Worse yet, a previously undisclosed family secret reveals that she may carry a rare hereditary gene for early-onset Alzheimer’s—and it’s too late to get genetic tests. This leaves Jeanne to cope with her intense fear of risk without the aid of the mountain of data she’s accustomed to relying upon. Wrestling with the question of whether her own needs, or those of her child, should prevail takes Jeanne on an intensely emotional journey—one that ultimately leads to growth and enlightenment.
Landau-Kleffner Syndrome and Central Auditory Disorders in Children (Modern Otology and Neurotology)
by Makiko Kaga Kimitaka KagaThis book addresses current topics concerning Landau-Kleffner Syndrome (LKS) and related central auditory disorders from the perspectives of epidemiology, diagnosis, genetics and clinical treatment. LKS is a rare childhood neurological disorder and manifests auditory agnosia as the central auditory verbal dysfunction. In many cases, LKS patients also suffer from epileptic seizures. The book is divided into two parts, the first of which outlines LKS from its historical background to clinical treatment. In turn, the second part examines current topics involving related central auditory disorders, for purposes of comparing them with LKS. The book offers a valuable resource for many specialists, such as pediatric neurologists, neuropsychologists, audiologists and epileptologists, with an interest in this field.
Landmark Experiments in Protein Science
by Pascal LeclairProteins are the workhorses of cells, performing most of the important functions which allow cells to use nutrients and grow, communicate among each other, and importantly, die if aberrant behavior is detected. How were proteins discovered? What is their role in cells? How do dysfunctional proteins give rise to cancers? Landmark Experiments in Protein Science explores the manner in which the inner workings of cells were elucidated, with a special emphasis on the role of proteins. Experiments are discussed in a manner as to understand what questions were being asked that prompted the experiments and what technical challenges were faced in the process; and results are presented and discussed using primary data and graphs. Key Features Describes landmark experiments in cell biology and biochemistry. Discusses the "How" and "Why" of historically important experiments. Includes primary, original data and graphs. Emphasizes biological techniques, that help understand how many of the experiments performed were possible. Documents, chronologically, how each result fed into the next experiments.
Landmark Papers in Plastic Surgery: Commented Guide by Authors and Experts
by Joon Pio Hong Ankur Khajuria Peter NeliganThere has been an exponential growth in the number of research papers published in recent decades in the field of Plastic & Reconstructive Surgery, making it difficult to identify the key papers that have truly changed practice in plastic surgery. This book provides readers with a concise reference source for the key papers that underpin contemporary surgical practice and covers all aspects of the specialty, with the content being helpful for both trainees and specialists to understand the scientific developments and pioneering surgeries that allow expert surgeons to practice as they currently do. By exploring the ground-breaking papers in Plastic Surgery, readers can gain insights into the evolution of the field and learn valuable lessons on how to innovate. For trainees preparing for board or exit exams, such as the FRCS (Plast), this book serves as an invaluable reference source and revision guide, providing access to key landmark studies. It presents over 50 key research studieson plastic surgery along with full analysis and additional commentaries from experts and world-renowned authority figures in Plastic Surgery. It provides a valuable perspective on why the study is important, constituting essential reading for busy professionals as well as trainees, residents and fellows, and surgeons studying for professional examinations while distilling all the literature into a compact guide on the must-know scientific articles.
Landmark Trials in Oncology
by Santosh YajnikThis book describes the evolution of treatment in oncology through the lens of approximately 250 landmark clinical trials. The well-designed clinical trial is essential to the practice of medicine. There is no field that has embraced or been transformed more by the clinical trial than oncology. Each primary cancer site has a remarkable story that can be told through clinical trials. For example, patients who presented decades ago with soft tissue sarcoma of the extremities would invariably undergo limb amputation. The landmark National Cancer Institute study by Rosenberg et al. randomized patients to limb sparing surgery followed by adjuvant radiation therapy compared with limb amputation. This study helped change the standard of care by allowing most patients to retain their functioning limbs with an improvement in quality of life and no compromise in overall survival. Such major clinical trials for common malignancies including breast, prostate, lung, gastrointestinal, genitourinary, and gynecologic cancers are discussed. Because oncology is multidisciplinary, this book should be of interest for radiation oncologists, surgeons, medical oncologists, and other physicians interested in learning more about the landmark trials that have shaped oncology.