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Liquid Biopsies: Methods and Protocols (Methods in Molecular Biology #2695)

This book analyzes liquid biopsy applications in cancer and other diseases. Chapters guide readers through the latest technologies and analysis methods for liquid biopsy,liquid biopsy in cancer, role of liquid biopsies in rheumatoid arthriti, cell-free circulating DNA profiling in patients with skin diseases, circulating non-coding RNAs, and exomes. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and cutting-edge, Liquid Biopsies: Methods and Protocols aims to attract more researchers and clinicians to study the diagnosis, immunotherapy, and prognosis of cancer and other diseases with liquid biopsy analysis.

Liquid Biopsy in Cancer Patients

This text is designed to provide readers with a useful and comprehensive resource and state-of-the-art overview about the new, growing and fast-expanding field of "liquid biopsy" for the management of cancer patients. The liquid biopsy represents an important turning point in oncology since it provides a tool for a serial monitoring of disease. Liquid biopsy is our "hand lens" to follow molecular changes that characterize tumor development and progression. The book provide a unique and valuable resource on the clinical relevance of liquid biopsy as well as on the technical aspects of liquid biopsy analysis. All invited authors are recognized experts in their field. Liquid Biopsy in Cancer Patients: The Hand Lens for Tumor Evolution is targeted to resident and fellows physicians, medical oncologists, molecular biologists and biotechnologists.

Liquid Chromatography-Mass Spectrometry (Chromatographic Science Series)

A constructive evaluation of the most significant developments in liquid chromatography-mass spectrometry (LC-MS) and its uses for quantitative bioanalysis and characterization for a diverse range of disciplines, Liquid Chromatography-Mass Spectrometry, Third Edition offers a well-rounded coverage of the latest technological developments and

Liquid Crystals in Biotribology

This book summarizes the theoretical and experimental studies confirming the concept of the liquid-crystalline nature of boundary lubrication in synovial joints. It is shown that cholesteric liquid crystals in the synovial liquid play a significant role in the mechanism of intra-articular friction reduction. The results of structural, rheological and tribological research of the creation of artificial synovial liquids containing cholesteric liquid crystals in natural synovial liquids are described. These liquid crystals reproduce the lubrication properties of natural synovia and provide a high chondroprotective efficiency. They were tested in osteoarthritis models and in clinical practice.

Liquid Membranes: Chemical Applications

This interesting work extensively describes newer applications of liquid membrane systems which contain molecular and/or ion recognizing carrier compounds and the related characteristic membrane materials. This volume focuses on the current knowledge about chemistry, biology and related technology of liquid membranes. It reviews the most recent advances in design and characteristics of synthetic liquid membrane transport. Additionally, this fascinating reference discusses up-to-date topics in the analytical and separation science, plus biomimetic membrane technology. Because this book is presented in a compact, understandable format, readers can start from biological cell membranes, then net aspects of host-guest chemistry for effective recognition of ions and molecules, followed by its application for artificial sensors-such as neuro-systems, functionalized new detergents, mechanochemical systems, and separation chemistry. This publication is ideal for graduate-level students and will stimulate university and industry researchers.

Liquid-Liquid InterfacesTheory and Methods

Update your knowledge of the chemical, biological, and physical properties of liquid-liquid interfaces with Liquid-Liquid Interfaces: Theory and Methods. This valuable reference presents a broadly based account of current research in liquid-liquid interfaces and is ideal for researchers, teachers, and students. Internationally recognized investigators of electrochemical, biological, and photochemical effects in interfacial phenomena share their own research results and extensively review the results of others working in their area. Because of its unusually wide breadth, this book has something for everyone interested in liquid-liquid interfaces. Topics include interfacial and phase transfer catalysis, electrochemistry and colloidal chemistry, ion and electron transport processes, molecular dynamics, electroanalysis, liquid membranes, emulsions, pharmacology, and artificial photosynthesis. Enlightening discussions explore biotechnological applications, such as drug delivery, separation and purification of nuclear waste, catalysis, mineral extraction processes, and the manufacturing of biosensors and ion-selective electrodes.Liquid-Liquid Interfaces: Theory and Methods is a well-written, informative, one-stop resource that will save you time and energy in your search for the latest information on liquid-liquid interfaces.

Liquordiagnostik in der Neurologie: Paradigmenwechsel bei Hirn-Schranken, Immunsystem und chronischen Krankheiten (essentials)

Dieses essential erklärt die naturwissenschaftlichen Grundlagen für die wissensbasierte Interpretation medizinischer Labordaten. Selbstorganisation biologischer Struktur, nichtlineare Dynamik komplexer Systeme und immunologische Netzwerktheorien erlauben es, Pathomechanismen und Diagnostik, vor allem chronischer Krankheiten, als Ausdruck einer phänotypischen Biologie zu beschreiben und Konzepte für kausale Therapien zu entwickeln.Das Buch zeigt, wie in der Liquordiagnostik mit einem alle Labordaten integrierenden Befundbericht krankheitstypische Muster zur Differentialdiagnose von bakteriellen, viralen, Parasiten-bedingten, onkologischen, chronisch entzündlichen, autoimmunologischen und psychiatrischen Krankheiten erkennbar werden. Als Tutorial steht eine App zur Verfügung.

Liquorpheresis: Cerebrospinal Fluid Filtration to Treat CNS Conditions

This book provides an overview of emerging CSF management systems that filter or clear cerebrospinal fluid (CSF) as a therapeutic approach for several CNS conditions. While the term "liquorpheresis" most accurately refers to extracorporeal procedures that filter CSF (similar to plasmapheresis), this book covers any method based on devices that -either alone or in combination with drugs- can clear CSF or enhance its turnover, which in turn dilutes toxins.The book begins with an overview of CSF anatomy and physiology, followed by a discussion of the role of CSF clearance and flow dysfunction in various CNS conditions. The next section describes the different CSF management systems and procedures that are currently available or under development. The book then reviews the potential applications of these systems for treating subarachnoid hemorrhage, CNS infections, meningeal carcinomatosis, autoimmune encephalitis, polyradiculomyelitis, and neurodegenerative diseases. Finally, a chapter discusses future advances in liquorpheresis systems and applications. This book is intended for clinicians, neuro-researchers, academics, and students who are interested in the development and application of CSF management systems. It is also relevant to the medical device industry, particularly those that develop apheresis and CSF management devices, and the drug-delivery industry.

Lisa Riley's Honesty Diet: Change your life in just 8 days

Start your weight-loss journey with Lisa Riley's simple, honest and fuss-free diet plan that will help you cultivate the right mindset for a truly rewarding wellness journey'Officially the cheapest way to lose weight' PRIMA________You can feel and look great the simple way with Lisa Riley as she lets us in on the secrets behind her incredible 12-stone weight loss.After years of wearing size-30 clothes and convincing herself she was 'fat but happy', Lisa Riley finally took control of her body and shed a remarkable 12 stone.Healthier, infinitely happier and proud of her slim new figure, Lisa now reveals how she lost all that weight and - more importantly - kept it off. Lisa knows that if she can do it, anyone can.The very first thing she had to tackle was her thinking, and in this book you'll discover the strategies that helped her get honest with herself and stay on track. Inside Lisa shares:· A simple 8-day eating plan to kick things off· Fast, easy, delicious low-carb recipes· An 'honesty diary' section for keeping track of progress and motivating yourself· Tips for staying healthy when on-the-go and eating out· Everyday fitness ideas that anyone can doWith Lisa's help, you can put the fibs and excuses behind you, kick those bad habits and achieve the body and health you've always dreamed of.________What readers say about Lisa Riley's Honesty Diet . . .'I loved the food, the simplicity of the meals and the plan . . . It has changed my outlook on eating and losing weight, my portion size and my body size' Vivien'I have a dress which I last wore 3 years ago . . . today I tried the same outfit and whizzed the zip up and down. It was comfortable and a little loose! I'm with Lisa every step of my journey' Elaine'I learnt that I am a lot stronger and more determined than I thought I was and I DO have the willpower! I LOVE IT!' Louise

Lishman's Organic Psychiatry

"For three decades psychiatrists have turned to Lishman's Organic Psychiatry as the standard neuropsychiatry reference. It stood as the last great single author reference text in medicine, a combination of meticulous, exhaustive research conveyed in a beautifully clear style. Now the mantle has been passed to a group of five distinguished authors and it is to their considerable credit that the attributes which made Organic Psychiatry such a distinctive voice remain. The fourth Edition of Lishman's Organic Psychiatry is a rich blend of detailed clinical inquiry and up to date neuroscience. It should be on every psychiatrist;s book shelf."--Anthony Feinstein, MPhil, PhD., FRCP, Professor, Department of Psychiatry, University of Toronto, CanadaOver the past 30 years, thousands of physicians have depended on Lishman's Organic Psychiatry. Its authoritative and reliable clinical guidance was - and still is - beyond compare.The new edition of this classic textbook has now been extensively revised by a team of five authors, yet it follows the tradition of the original single-authored book. It continues to provide a comprehensive review of the cognitive, emotional and behavioural consequences of cerebral disorders and their manifestations in clinical practice. Enabling clinicians to formulate incisive diagnoses and appropriate treatment strategies, Lishman's Organic Psychiatry is an invaluable source of information for practising psychiatrists, neurologists and trainees.This new edition:covers recent theoretical and clinical developments, with expanded sections on neuropsychology and neuroimagingincludes a new chapter on sleep disorders whilst the chapters on Alzheimer's disease and related dementias, Epilepsy, Movement disorders and Traumatic brain injury have been extensively revised reflecting the greatly improved understanding of their underlying pathophysiologiesshowcases the huge advances in brain imaging and important discoveries in the fields of molecular biology and molecular geneticshas been enhanced with the inclusion of more tables and illustrations to aid clinical assessmentincorporates important diagnostic tools such as magnetic resonance brain images.

Listening Closely: A Journey to Bilateral Hearing

Imagine what it would be like not to hear a sound--no music, no friendly voices, no children's laughter. Arlene Romoff doesn't have to imagine how it would feel: she lived it. Although she was born with normal hearing, in her late teens it began to slip away, as if someone were lowering the volume of the world around her. Over the next twenty-five years, Arlene began a long, slow descent into deafness so profound that no hearing aid or assistive device could help. The experience was devastating.But then Arlene opted for what she considers a miracle: She got a cochlear implant. Using electrodes threaded into the cochlea, an internal computer chip, and an external computer processor, cochlear implants bypass the damaged portion of the cochlea and stimulate the auditory nerve directly, allowing sound to reach the brain. Amazingly, she could hear again.Arlene's journey, however, isn't just about the magic of technology. What she endured reveals as much about the strength of the human spirit, about the wonders of chance and fate, and about making the most of what life dishes out. For Arlene, events seemed to unfold almost as if they were a part of some elaborate plan: just when she went deaf, her insurance company began paying for the implants. And ten years later, when her old cochlear implant finally failed she received new state-of-the-art technology and underwent yet another metamorphosis--one that helped her continue to counsel others in a similar situation.LISTENING CLOSELY will give you a chance to walk in Arlene Romoff's shoes, to understand the pain of her loss and the joy of once again being able to hear the music of the world. Those suffering from hearing loss--or who have loved one who is--will find Arlene's very special journey both inspirational and informative.

Listening Skills for Effective Policing

Developing and honing effective listening skills for trainee, new and existing police officers at all levels.Learning how to be an effective listener is one of the most vital communication skills for successful policing. Drawing on the author’s vast experience as a specialist frontline police officer, this book is informal and easy-to-understand, with a sprinkle of humour, making it highly readable and accessible. It introduces an effective, tried and tested model to guide difficult conversations and covers a range of key topics of relevance to operational policing, including issues connected with diversity and with suicide. Supported by academic research, including counselling theory, it provides real-life examples to demonstrate how the tools work in practice, and questions and exercises to encourage personal reflection.

Listening Visits in Perinatal Mental Health: A Guide for Health Professionals and Support Workers

Listening Visits in Perinatal Mental Health focuses on how women and families suffering from perinatal mental illness can be supported by a wide range of practitioners. Based on the skills of attentive listening, it is designed for use by health professionals and support workers concerned with maternal mental health and the mental health of the family. This accessible guide: Covers the process and progression of perinatal mental health Discusses the types of anxiety and depression which may occur during the perinatal period Examines the impact of maternal mental illness of the infant, father and family Explores the available assessment tools, such as the EPDS Presents the theories behind the efficacy of listening and counselling skills, as well as the evidence which recommends this type of therapy Gives suggestions of alternative therapeutic approaches and further resources to explore around perinatal mental health Emphasises the importance of looking after yourself and making use of supervision and peer support. With chapters focused on listening to mothers, fathers and infants and paying attention to cultural diversity, Listening Visits in Perinatal Mental Health builds on the knowledge that many professionals working with new mothers already have about perinatal mental health. It focuses on developing the skills needed to put this knowledge into practice and includes case examples and follow-up activities throughout.

Listening as Work in Primary Care

This book encourages health professionals in primary care to reflect on listening in their work with patients — the choices they make, the relationships which emerge and the limits that they put in place. It is useful for trainee doctors and to established general practitioners.

Listening to Battered Women: A Survivor-Centered Approach to Advocacy, Mental Health, and Justice

Listening to Battered Women: A Survivor-Centered Approach to Advocacy, Mental Health, and Justice presents an in-depth, multidisciplinary look at society's responses to domestic violence. Though substantial reforms have been made in the services available to battered women since the 1970s, the book shows how the public and private systems available to victims of domestic violence are still failing to meet the needs of the women who seek help. Using a feminist perspective, authors Lisa Goodman and Deborah Epstein explore and critique the current available services in three different arenas: the domestic violence advocacy community, the mental health profession, and the justice system. In recent years, the options available to battered women have expanded dramatically. However, these reforms have been made at the expense of the contextualized, women-centered focus that was once at the heart of the anti-domestic violence movement. The authors argue that a renewed focus on the principles of the early feminist movement - for example, listening to individual women's voices, promoting supportive communities, and facilitating economic empowerment, could result in substantial progress in efforts to protect and counsel battered women. A series of concrete recommendations for improvements in the advocacy, mental health, and justice systems are also discussed. Researchers interested in the field of violence, gender studies, psychology of women, mental health trauma, or family law, as well as practitioners working with the victims of intimate partner violence, will find this book to be a valuable resource in their efforts.

Listening to Children and Young People in Healthcare Consultations

The involvement of children and young people in consultations about aspects of their health or illness is often limited, with their role in diagnosis and decision-making on treatment options secondary to that of parents or carers. However, research shows that most children and young people want greater involvement, that this can both improve their understanding of their illness and positively influence healthcare outcomes. Policy recommendations increasingly require health professionals to involve children and young people in healthcare, but there is little available guidance on building the knowledge and skills needed to do so effectively. This book meets that need, including an overview of the particular issues involved and providing structured guidance for different types of consultations, including children with learning difficulties, disabled children and children as carers. Edited by eminent researchers, and with highly experienced contributors, this book is an invaluable resource for GPs and GP registrars, paediatric and emergency consultants and specialist registrars, nurses, paramedics, healthcare educators and trainees, and all those who work with children and young people in health-related contexts.

Listening to Music in Psychotherapy (Radcliffe Ser.)

Evidence-based change is central to many recent developments in the NHS. This book brings together practical and personal experiences from a wide range of externally evaluated healthcare projects. It demonstrates how to facilitate and promote evidence-based change by drawing on realistic advice on what is, and is not, effective. It enables readers to benefit from lessons learned and provides a comprehensive insight into implementing changes based on research evidence, across broad range of settings in the NHS. 'An important book. It has many exciting insights, enjoy it.' Jenny Simpson in the Foreword 'A unique collection. There are some brave admissions and this is probably the best attempt yet to capture the nitty-gritty of the evidence-into-practice agenda in UK healthcare. I hope you find it a gripping read'. Trisha Greenhalgh in the Foreword

Listening to Prozac: The Landmark Book About Antidepressants and the Remaking of the Self

The New York Times bestselling examination of the revolutionary antidepressant, with a new introduction and afterword reflecting on Prozac&’s legacy and the latest medical research &“Peter Kramer is an analyst of exceptional sensitivity and insight. To read his prose on virtually any subject is to be provoked, enthralled, illuminated.&” —Joyce Carol Oates When antidepressants like Prozac first became available, Peter D. Kramer prescribed them, only to hear patients say that on medication, they felt different—less ill at ease, more like the person they had always imagined themselves to be. Referencing disciplines from cellular biology to animal ethology, Dr. Kramer worked to explain these reports. The result was Listening to Prozac, a revolutionary book that offered new perspectives on antidepressants, mood disorders, and our understanding of the self—and that became an instant national and international bestseller. In this thirtieth anniversary edition, Dr. Kramer looks back at the influence of his groundbreaking book, traces progress in the relevant sciences, follows trends in the use and public understanding of antidepressants, and assesses potential breakthroughs in the treatment of depression. The new introduction and afterword reinforce and reinvigorate a book that the New York Times called &“originally insightful&” and &“intelligent and informative,&” a window on a medicine that is &“telling us new things about the chemistry of human character.&”

Listening to Scent: An Olfactory Journey with Aromatic Plants and Their Extracts

The olfactory journey described in this book introduces readers to the pleasures and benefits of educating and training the 'nose', our olfactory palate. Jennifer Peace Rhind explores the process of cultivating our sense of smell and demonstrates how the process itself can be therapeutic and enjoyable, as well as informative. She highlights the different skills involved, from olfactory vocabulary, awareness, and memory, through to discrimination and fragrance creation, and the activities that can help to acquire them, emphasizing the value of experiential learning. She describes the Japanese art of koh-do or the 'way of incense' and suggests ways of creating group events inspired by this. Based on her twenty five years' experience working with essential oils and aromatic plant extracts, she also leads the reader through a variety of scent families, with information on the botanical source, odour profiles, olfactory notes, and suggestions for comparison with other scents. This method of educating and training the 'nose' is fascinating, challenging and life-enhancing and will be of interest to anyone eager to develop their sense of smell, and of incalculable use to aromatherapy students and practitioners who must acquire these skills for their career.

Listening to Women After Childbirth

It is vital that healthcare practitioners understand the psychological impact of childbirth when caring for women. This accessible guide is designed to improve the care that women receive and, as a result, public health outcomes related to maternal and infant wellbeing. This book outlines how clinicians can offer practical support to women after birth. It: discusses what we know about how women adapt to motherhood and develop a post-childbirth identity; outlines some of the causes and manifestations of post-traumatic stress following childbirth; provides practical guidance for setting up postnatal pathways for women traumatised by birth and how to communicate effectively; equips practitioners with the knowledge and skills to support pregnant women with a fear of birth; incorporates narratives from women to demonstrate how their births and related events were perceived and processed, before discussing how women’s views can be used to inform future practice; highlights the importance of restorative supervision for healthcare professionals working in this area to promote staff resilience and sustainability. Drawing together theoretical knowledge, evidence, practical skills and women’s narratives to help clinicians understand the psychology of childbirth and support women, it is of significant value to all healthcare practitioners engaged in maternity services.

Listening to the Animals: Becoming The Supervet

THE NO.1 SUNDAY TIMES BESTSELLER. A powerful, heart-warming and inspiring memoir from the UK's most famous and beloved vet, Professor Noel Fitzpatrick - star of the Channel 4 series The Supervet.Growing up on the family farm in Ballyfin, Ireland, Noel's childhood was spent tending to the cattle and sheep, the hay and silage, the tractors and land, his beloved sheepdog Pirate providing solace from the bullies that plagued him at school. It was this bond with Pirate, and a fateful night spent desperately trying to save a newborn lamb, that inspired Noel to enter the world of veterinary science - and set him on the path to becoming The Supervet.Now, in this long-awaited memoir, Noel recounts this often-surprising journey that sees him leaving behind a farm animal practice in rural Ireland to set up Fitzpatrick Referrals in Surrey, one of the most advanced small animal specialist centres in the world. We meet the animals that paved the way, from calving cows and corralling bullocks to talkative parrots and bionic cats and dogs. Noel has listened to the many lessons that the animals in his care have taught him, and especially the times he has shared with his beloved Keira, the scruffy Border Terrier who has been by Noel's side as he's dealt with the unbelievable highs and crushing lows of his extraordinary career. As heart-warming and life-affirming as the TV show with which he made his name, Listening to the Animals is a story of love, hope and compassion, and about rejoicing in the bond between humans and animals that makes us the very best we can be.

Listening to the Animals: Becoming The Supervet

THE MASSIVE NO.1 SUNDAY TIMES BESTSELLERIn this inspiring, uplifting and heart-warming memoir, world-renowned veterinary surgeon Professor Noel Fitzpatrick explores his journey to becoming The Supervet. Growing up on the family farm in Ballyfin, Ireland, Noel's childhood was spent tending to the cattle and sheep, the hay and silage, the tractors and land, his beloved sheepdog Pirate providing solace from the bullies that plagued him at school. It was this bond with Pirate, and a fateful night spent desperately trying to save a newborn lamb, that inspired Noel to enter the world of veterinary science - and set him on the path to becoming The Supervet.Now, in this long-awaited memoir, Noel recounts this often-surprising journey that sees him leaving behind a farm animal practice in rural Ireland to set up Fitzpatrick Referrals in Surrey, one of the most advanced small animal specialist centres in the world. We meet the animals that paved the way, from calving cows and corralling bullocks to talkative parrots and bionic cats and dogs. Noel has listened to the many lessons that the animals in his care have taught him, and especially the times he has shared with his beloved Keira, the scruffy Border Terrier who has been by Noel's side as he's dealt with the unbelievable highs and crushing lows of his extraordinary career. As heart-warming and life-affirming as the TV show with which he made his name, Listening to the Animals is a story of love, hope and compassion, and about rejoicing in the bond between humans and animals that makes us the very best we can be.Written and read by Noel Fitzpatrick(p) Orion Publishing Group 2018

Literacy and Deafness The Development of Reading, Writing, and Literate Thought

Literature and Meat Since 1900 (Palgrave Studies in Animals and Literature)

This collection of essays centers on literary representations of meat-eating, bringing aesthetic questions into dialogue with more established research on the ethics and politics of meat. From the decline of traditional animal husbandry to the emergence of intensive agriculture and the biotechnological innovation of in vitro meat, the last hundred years have seen dramatic changes in meat production. Meat consumption has risen substantially, inciting the emergence of new forms of political subjectivity, such as the radical rejection of meat production in veganism. Featuring essays on both canonical and lesser-known authors, Literature and Meat Since 1900 illustrates the ways in which our meat regime is shaped, reproduced and challenged as much by cultural and imaginative factors as by political contestation and moral reasoning.

Literature and Medicine: A Practical and Pedagogical Guide

Literature and Medicine: A Practical and Pedagogical Guide is designed to introduce narrative medicine in medical humanities courses aimed at pre-medicine undergraduates and medical and healthcare students. With excerpts from short stories, novels, memoirs, and poems, the book guides students on the basic methods and concepts of the study of narrative. The book helps healthcare professionals to build a set of skills and knowledge central to the practice of medicine including an understanding of professionalism, building the patient-physician relationship, ethics of medical practice, the logic of diagnosis, recognizing mistakes in medical practice, and diversity of experience. In addition to analyzing and considering the literary texts, each chapter includes a vignette taken from clinical situations to help define and illustrate the chapter’s theme. Literature and Medicine illustrates the ways that engagement with the humanities in general, and literature in particular, can create better and more fulfilled physicians and caretakers.