- Table View
- List View
Locking Plates in Veterinary Orthopedics (AVS Advances in Veterinary Surgery)
by Matthew D. Barnhart Karl C. MaritatoLocking Plates in Veterinary Orthopedics is a comprehensive and state-of-the-art guide to all aspects of using locking plates to treat orthopedic conditions in dogs, cats, and large animals. • Offers a proven approach to using locking plates in veterinary practice • Highlights practical clinical applications with illustrative clinical cases • Includes information on the history, principles, and materials as well as specific techniques • Presents data on both traumatic and non-traumatic applications • Provides instructive color photographs to demonstrate the procedures
Lockout-Tagout: Verriegelung Von Stellgliedern Zur Umfassenden Wartungssicherung Von Maschinen (essentials)
by Lars Schnieder Tim-Colin UhdeDas Inverkehrbringen und der Betrieb von Maschinen erfordern, das Einhalten von (Sicherheits-)Anforderungen zu dokumentieren, in Gefährdungsbeurteilungen das Risiko zu ermitteln, Schutzmaßnahmen abzuleiten und umzusetzen. Trotz des einheitlichen Rechtsrahmens kommt es gerade bei Instandhaltungsarbeiten weiterhin zu schweren Arbeitsunfällen, z.B. durch unkontrolliert austretende Energien wegen deaktivierter Schutzmechanismen. Die Autoren führen in den Rechtsrahmen der Maschinen- und Betriebssicherheit ein und leiten daraus die wichtige Absicherung unkontrollierter Energiequellen während der Instandhaltung ab. Mit Lockout-Tagout stellen sie ein anerkanntes Verfahren zur Verbesserung der Betriebssicherheit vor. Hierzu kombinieren die Autoren Verfahrensanweisungen, technische Maßnahmen und Schulungen mit einer kontinuierlichen Überwachung der Wirksamkeit der Maßnahmen.Die AutorenDr.-Ing. Lars Schnieder verantwortet in einer Software-Entwicklungsfirma das Geschäftsfeld Sicherheitsbegutachtung. Er ist international als Sachverständiger für die Maschinen- und Betriebssicherheit tätig.Tim-Colin Uhde ist in dieser Firma als Sachverständiger für die Maschinen- und Betriebssicherheit tätig.
Lockout-Tagout: Verriegelung von Stellgliedern zur umfassenden Wartungssicherung von Maschinen (essentials)
by Lars Schnieder Tim-Colin UhdeDas Inverkehrbringen und der Betrieb von Maschinen erfordern, das Einhalten von (Sicherheits-)Anforderungen zu dokumentieren, in Gefährdungsbeurteilungen das Risiko zu ermitteln, Schutzmaßnahmen abzuleiten und umzusetzen. Trotz des einheitlichen Rechtsrahmens kommt es gerade bei Instandhaltungsarbeiten weiterhin zu schweren Arbeitsunfällen, z.B. durch unkontrolliert austretende Energien wegen deaktivierter Schutzmechanismen. Die Autoren führen in den Rechtsrahmen der Maschinen- und Betriebssicherheit ein und leiten daraus die wichtige Absicherung unkontrollierter Energiequellen während der Instandhaltung ab. Mit Lockout-Tagout stellen sie ein anerkanntes Verfahren zur Verbesserung der Betriebssicherheit vor. In der 2. Auflage dieses Buches wurde die systematische Vorgehensweise zur Umsetzung eines Programms zur Gefährdungsbeherrschung von Betreibern von Maschinen grundlegend erweitert und ergänzt. Hierzu kombinieren die Autoren Verfahrensanweisungen, technische Maßnahmen und Schulungen mit einer kontinuierlichen Überwachung der Wirksamkeit der Maßnahmen.
Locomotion and Posture in Older Adults
by Fabio Augusto Barbieri Rodrigo VitórioThis book is an attempt to advance the discussion and improve our understanding about the effects of aging and movement disorders on motor control during walking and postural tasks. Despite these activities are performed daily, there is a high requirement of motor and neural systems in order to perform both tasks efficiently. Both walking and posture require a complex interaction of musculoskeletal and neural systems. However, the mechanisms used to control these tasks, as well as how they are planned and coordinated, are still a question of discussion among health professionals and researchers. In addition, this discussion is more interesting when the effects of aging are included in the context of locomotion and the postural control. The number of older individuals is 841 million in 2015, which is four times higher than the 202 million that lived in 1950. Aging causes many motor, sensorial and neural deficits, which impair locomotion and postural control in the elderly. The severity of this framework is worsened when the aging goes along with a movement disorder, such as Parkinson disease, Chorea, Dystonia, Huntington disease, etc. Therefore, the aim of this book is to highlight the influence of different aspects on planning, controlling and performing locomotion and posture tasks. In attempting to improve current knowledge in this field, invited authors present and discuss how environmental, sensorial, motor, cognitive and individual aspects influence the planning and performance of locomotor and postural activities. The major thrust of the book is to address the mechanisms involved in controlling and planning motor action in neurological healthy individuals, as well as in those who suffer from movement disorders or face the effects of aging, indicating the aspects that impair locomotion and postural control. In addition, new technologies, tools and interventions designed to manage the effects of aging and movement disorders are presented in the book.
Locomotion and Posture in Older Adults: The Role of Aging and Movement Disorders
by Fabio Augusto Barbieri Rodrigo Vitório Paulo Cezar Rocha dos SantosThis book sheds new light on the effects of aging and movement disorders on movement control during walking and postural tasks. Understanding these dynamics is more important than ever as we face a future where the number of older adults is projected to double by 2050. The severity of this framework is exacerbated when aging is accompanied by movement disorders such as Parkinson's disease, Chorea, Multiple Sclerosis, Dystonia, and Huntington's disease. The book explores how complex interactions between musculoskeletal and neural systems are required for efficient execution of daily activities like walking and maintaining posture. The chapters in this comprehensive volume address the multifaceted challenges posed by aging and movement disorders in gait and postural control, including innovative rehabilitation strategies and the role of artificial intelligence. Expert contributors examine how environmental, sensorial, motor, cognitive, and individual factors influence locomotor and postural activities. Readers will discover cutting-edge research findings that address critical questions about planning, performance, and impairment in these essential functions. This book is a must-read for anyone seeking to understand and reduce the effects of aging and movement disorders on gait and posture. This book is an invaluable resource for clinicians, physical therapists, occupational therapists, psychologists, biologists, researchers, health professionals, as well as those involved in physical education and sports medicine. It highlights the mechanisms involved in controlling and planning postural and gait tasks in both neurologically healthy older individuals and those who suffer from movement disorders, offering new perspectives on interventions and technologies designed to improve understanding or delay impairments due to aging or movement disorders on gait and posture. Whether you're a practitioner or researcher in related fields, this book equips you with the essential knowledge to enhance the quality of life for older adults facing these challenges.
Locoregional Radionuclide Cancer Therapy: Clinical and Scientific Aspects
by Franklin C. L. WongThis book reviews locoregional radionuclide cancer therapies (LRCT). Proving an increasingly viable alternative to radiotherapy, radionuclide therapy includes a diversity of choices of well characterized biochemical and physiologic target molecules. The delivery and retention of radionuclides may be monitored by advanced imaging for exact tissue localization and for real-time dosimetry to enable personalized precision medicine. Radiopharmaceuticals in human cancer therapies are typically delivered in systemic routes but can also be designed for locoregional routes to harness pharmacokinetic advantages of higher payload and lower systemic toxicities. This book explores the latest advancements and clinical considerations of the locoregional approach.Throughout the chapters, the clinical and scientific bases of cancer treatment and the locoregional use of radionculides are explored. Mathematical models of radiation dosimetry of locoregional radionculdies on tissues are studied using common models for multiple commercially available radionuclides. Rodent and canine tumor models of LRCT are compared for selected radionuclides and radiopharmaceuticals. The practical aspects of radiopharmaceuticals production, marketing, transport, as well as radiation protection are reviewed. Finally, the combination of LRCT with immunotherapy and other cancer therapies and prospective future use of LRCT are discussed.This is a guide for practicing nuclear physicians, interventional radiologists, radiation oncologists, radiation scientists, veterinarians and oncologists to expand their knowledge base and to prepare for designing locoregional radionuclide cancer therapies in animals and in humans.
Locoregional Tumor Therapy
by Eric Van Cutsem Thomas J. Vogl Franco Orsi Alberto SobreroRecent years have witnessed a renaissance in the use of locoregional tumor therapy as part of a multimodal therapeutic approach to a variety of solid tumors, and attempts are underway to define its value in the overall therapeutic strategy for individual tumor entities. This flourishing of interest in locoregional tumor therapy derives from a series of important new developments concerning methodology, drug treatments, and instrumentation. The resulting approaches include not only optimized locoregional chemotherapy and chemoembolization for hepatocellular carcinoma and other tumors, but also other "targeted" therapies such as stereotactic radiosurgery, radiofrequency ablation, intra-arterial administration of radiopharmaceuticals, and complex new methods of chemoembolization of liver metastases involving the use of multiagent chemotherapy in combination with targeted drugs, drug-eluting beads/microspheres, or nanoparticles. In addition, intraperitoneal and intrapleural therapies, e. g. , cytoreduction plus hyperthermic intraperitoneal chemotherapy, are now a standard element of the strategy for a range of tumors. It is vital that practitioners have the necessary expertise in the use of these locoregional treatment methods and understand how to combine them optimally with modern systemic therapies. With that goal in mind, this book presents, in condensed form, the clinical results achieved using various locoregional tumor therapies. In so doing, it will allow the reader to rapidly retrieve the information on indications and effectiveness that is required for optimal integration of these highly effective therapies into modern, yet more complex treatment strategies.
Locoregional Tumor Therapy
by Eric Van Cutsem Thomas J. Vogl Franco Orsi Alberto SobreroThis book presents, in condensed form, the clinical results achieved by means of various locoregional tumor therapies employed for different indications. In so doing, it will allow the reader to rapidly retrieve the information on indications and effectiveness that is required for optimal integration of these highly effective therapies into modern, complex treatment strategies. The renaissance in locoregional tumor therapies is an ongoing process. New chemotherapeutic schedules, especially for liver and lung tumors, have been developed during the past few years. Other targeted therapies, such as radioembolization, microwave ablation, and HIFU techniques, and new pharmaceuticals for intra-arterial therapy have been developed and implemented in clinical practice. Furthermore, the advantages of unlimited combination of starch microspheres with various antitumor agents, supported by effective ischemia, have been increasingly exploited. The second edition of this book reflects these advances and includes entirely new chapters on the role of intraperitoneal perfusion in treating peritoneal carcinomatosis and the use of limb perfusion. Locoregional Tumor Therapy will be invaluable for all practitioners who work with cancer patients.
Log-Linear Models and Logistic Regression (Springer Texts in Statistics)
by Ronald ChristensenThis book examines statistical models for frequency data. The primary focus is on log-linear models for contingency tables but also includes extensive discussion of logistic regression. Topics such as logistic discrimination, generalized linear models, and correspondence analysis are also explored. The treatment is designed for readers with prior knowledge of analysis of variance and regression. It builds upon the relationships between these basic models for continuous data and the analogous log-linear and logistic regression models for discrete data. While emphasizing similarities between methods for discrete and continuous data, this book also carefully examines the differences in model interpretations and evaluation that occur due to the discrete nature of the data. Numerous data sets from fields as diverse as engineering, education, sociology, and medicine are used to illustrate procedures and provide exercises. A major addition to the third edition is the availability of a companion online manual providing R code for the procedures illustrated in the book. The book begins with an extensive discussion of odds and odds ratios as well as concrete illustrations of basic independence models for contingency tables. After developing a sound applied and theoretical basis for frequency models analogous to ANOVA and regression, the book presents, for contingency tables, detailed discussions of the use of graphical models, of model selection procedures, and of models with quantitative factors. It then explores generalized linear models, after which all the fundamental results are reexamined using powerful matrix methods. The book then gives an extensive treatment of Bayesian procedures for analyzing logistic regression and other regression models for binomial data. Bayesian methods are conceptually simple and unlike traditional methods allow accurate conclusions to be drawn without requiring large sample sizes. The book concludes with two new chapters: one on exact conditional tests for small sample sizes and another on the graphical procedure known as correspondence analysis.
Logan Turner's Diseases of the Nose, Throat and Ear: Head and Neck Surgery, 12th Edition
by S. Musheer Hussain Quentin GardinerThis classic ENT textbook has been updated and expanded to reflect the increasing sophistication of diagnostic and management skills. All sub-specialities are covered, with the content grouped into five major sections: Rhinology, Head and Neck, Otology, Paediatric Otorhinolaryngology, Imaging.New material includes:- A new chapter on middle ear devices- Information on recent technical advances, including implant devices, immunotherapy and monoclonal antibodies- Updated coverage of imaging and diagnostic techniquesEach chapter includes key learning points, up-to-date references and suggestions for further reading. Many chapters benefit from updated figures which provide clarity and enhance the effectiveness of the text. ENT trainees and other practitioners with an interest in otorhinolaryngology will find this all-purpose textbook ideal for a thorough understanding of the specialty.From the Foreword by the President of the Royal College of Surgeons of England‘This iconic ENT textbook has guided generations of aspiring ENT surgeons around the world, as well as practitioners from other disciplines seeking a general grounding in the specialty.’‘By bringing together recognised experts in their fields, the editors have ensured that this Twelfth Edition of Logan Turner’s Diseases of the Nose, Throat and Ear will remain a definitive text for those working in the UK and also in those many countries around the world in which previous editions of the book have gained popularity.’- Mr Tim MitchellReviews of the Eleventh Edition‘It is a modern, well-illustrated textbook with plenty of illustrations and figures, and the text is clear, well written and broken up into easy-to-read sections. It is also a suitable textbook both for primary and secondary care doctors and has a good depth of coverage. If you want to learn more about ENT and want an established, yet up-to-date book which is not expensive then look no further. It is an excellent general all-purpose ENT textbook which will satisfy a wide audience.’ - Dr Harry Brown
Logan's Illustrated Human Anatomy
by Bari M. LoganThis concise illustrated volume presents a pictorial guide to human anatomy through the meticulous dissections of Bari Logan, assembled during his long career as a distinguished prosector, and representing an unrivalled collection of superb photographic images. Illustrations are fully labelled, and accompanied by brief clinical notes to provide additional guidance for the student. Material covering anatomical preparation and cadaver preservation, orientation and planes of section, the bones, muscles and cranial nerves and an extensive glossary provides supplemental detail. The book will be a convenient photographic companion to all core textbooks of anatomy and ideal during exam preparation.
Logic Synthesis for Genetic Diseases
by Pey-Chang Kent Lin Sunil P. KhatriThis book brings to bear a body of logic synthesis techniques, in order to contribute to the analysis and control of Boolean Networks (BN) for modeling genetic diseases such as cancer. The authors provide several VLSI logic techniques to model the genetic disease behavior as a BN, with powerful implicit enumeration techniques. Coverage also includes techniques from VLSI testing to control a faulty BN, transforming its behavior to a healthy BN, potentially aiding in efforts to find the best candidates for treatment of genetic diseases.
Logic of Discovery and Diagnosis in Medicine (Pittsburgh Series in Philosophy and History of Science)
by Kenneth F. SchaffnerThis title is part of UC Press's Voices Revived program, which commemorates University of California Press’s mission to seek out and cultivate the brightest minds and give them voice, reach, and impact. Drawing on a backlist dating to 1893, Voices Revived makes high-quality, peer-reviewed scholarship accessible once again using print-on-demand technology. This title was originally published in 1985.
Logos Run (Runner #2)
by William C. DietzAfter interstellar courier Jak Rebo agrees to deliver a powerful artificial intelligence named Logos to a distant planet, he quickly comes to realize that it's no ordinary assignment. Logos has the power to not only reactivate the ancient stargates, but to restore interstellar travel, and bring the far flung remnants of humanity back together again.Some, like the members of the ruthless Techno Society, want to harness Logos and control it. Others, including those who fear technology, seek to destroy it.Together with Lonni Norr, the beautiful clairvoyant who can channel spirits from the afterlife, and the bodyguard Hoggles, Rebo will have to outrun his many enemies, and prevent Logos from falling into the wrong hands if he is to prevent humanity from falling into oblivion.With electrifying action, unstoppable heroes and gripping adventure, Logos Run is the thrilling conclusion to Runner by acclaimed military science fiction author William C. Dietz.
London and its Asylums, 1888-1914: Politics and Madness (Mental Health in Historical Perspective)
by Robert EllisThis book explores the impact that politics had on the management of mental health care at the turn of the nineteenth and twentieth centuries. 1888 and the introduction of the Local Government Act marked a turning point in which democratically elected bodies became responsible for the management of madness for the first time. With its focus on London in the period leading up to the First World War, it offers a new way to look at institutions and to consider their connections to wider issues that were facing the capital and the nation. The chapters that follow place London at the heart of international networks and debates relating to finance, welfare, architecture, scientific and medical initiatives, and the developing responses to immigrant populations. Overall, it shines a light on the relationships between mental health policies and other ideological priorities.
London's Most Eligible Doctor
by Annie O'NeilThe talk of the town... When a devastating dancing injury forces prima ballerina Lina Keminsky to walk away from her dreams, she takes a receptionist job to make ends meet. But working for London's most sought after doc, Cole Manning, isn't what she expects... While Cole might not bear physical scars, he's become a pro at hiding wounds that run deep. But working alongside the feisty Lina, Cole sees his guard slowly but surely beginning to crumble. Together, can they mend each other's hearts?
Lone Wolf: the unputdownable story of one family’s impossible decision by the number one bestselling author of A Spark of Light
by Jodi PicoultTHE SUNDAY TIMES BESTSELLER'A gripping human story' Mail on SundayFollowing a terrible accident, Luke Warren lies comatose in a hospital bed. His family have been told he might never wake up. After seven years of estrangement, Edward has come to face his father for what he believes to be one final time before he discontinues his life support. To Edward, this is a painful but necessary decision which his father would have approved of.However, this one decision throws the Warren family into bitter conflict and soon, long-held secrets will be forced into the light.'Picoult's pitch and pace are masterly' Financial TimesTHE BOOK OF TWO WAYS, Jodi's stunning new novel about life, death and missed opportunities is available to pre-order now.
Loneliness in Europe: Determinants, Risks and Interventions (Population Economics)
by Sylke V. Schnepf Béatrice D’Hombres Caterina MauriThis open-access volume accompanies the microdata release of the EU Loneliness Survey. Loneliness, often referred to as the ‘epidemic of the 21st century’, has emerged as a grave public health concern. For years, a lack of comprehensive European cross-national data hindered a thorough examination of this issue. In 2022, the European Commission's Joint Research Centre conducted the inaugural EU Loneliness Survey, covering around 30,000 individuals in 27 European nations. The book sheds light on who is most affected by loneliness, identifies contributing experiences and behaviours, addresses the stigmatisation of loneliness and discusses its societal impact. Furthermore, it emphasises the importance of interventions to combat loneliness. Finally, the book discusses the challenges of survey design and offers valuable insights for the monitoring of loneliness in Europe in the future. This makes the book a must-read for scholars and academics interested in population economics, public health and social well-being.
Lonely Children and Adolescents
by Malka MargalitFrom texting and social networking sites to after-school activities, young people have many opportunities to interact with one another, and yet loneliness and isolation trouble today's youth in increasing numbers. Many children and teens report feeling lonely even in the midst of family and friends, and childhood loneliness is a prime risk factor for adult alienation. Lonely Children and Adolescents: Self-Perceptions, Social Exclusion, and Hope illuminates seldom-explored experiences of social isolation among young people as well as the frustrations of the parents and teachers who wish to help. This groundbreaking book conceptualizes loneliness not simply as the absence of social connections, but as a continuum of developmental experience, often growing out of the conflict between opposite needs: to be like one's peers yet be one's unique self. The author draws clear distinctions between loneliness and solitude and identifies genetic and environmental characteristics (i.e., social, psychological, familial, and educational) that can be reinforced to help children become more resilient and less isolated. In addition, therapeutic approaches are described that challenge loneliness by encouraging empowerment, resilience, and hope, from proven strategies to promising tech-based interventions. Highlights include: * Developmental perspectives on loneliness. * Schools and the role of teachers, from preschool to high school. * Peer relations (e.g., cliques, bullies, exclusion, and popularity). * Lonely children, lonely parents: models of coping. * Loneliness in the virtual world. * Prevention and intervention strategies at home, at school, in therapy. Asking its readers to rethink many of their assumptions about social competence and isolation, this volume is essential reading for researchers and professionals in clinical child, school, developmental, and educational psychology; allied education disciplines; social work; and social and personality psychology.
Long Acting Animal Health Drug Products: Fundamentals and Applications (Advances in Delivery Science and Technology)
by Michael J. Rathbone Arlene McdowellLong acting veterinary formulations play a significant role in animal health, production and reproduction within the animal health industry. Such technologies offer beneficial advantages to the veterinarian, farmer and pet owner. These advantages have resulted in them growing in popularity in recent years. The pharmaceutical scientist is faced with many challenges when innovating new products in this demanding field of controlled release. This book provides the reader with a comprehensive guide on the theories, applications, and challenges associated with the design and development of long acting veterinary formulations. The authoritative chapters of the book are written by some of the leading experts in the field. The book covers a wide scope of areas including the market influences, preformulation, biopharmaceutics, in vitro drug release testing and specification setting to name but a few. It also provides a detailed overview of the major technological advances made in this area. As a result this book covers everything a formulation scientist in industry or academia, or a student needs to know about this unique drug delivery field to advance health, production and reproduction treatment options and benefits for animals worldwide.
Long Acting Injections and Implants
by Jeremy C. Wright Diane J. BurgessLong acting injections and implants improve therapy, enhance patient compliance, improve dosing convenience, and are the most appropriate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability. An intriguing variety of technologies have been developed to provide long acting injections and implants. Many considerations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient. This book surveys and summarizes the field. Topics covered in Long Acting Injections and Implants include the historical development of the field, drugs, diseases and clinical applications for long acting injections and implants, anatomy and physiology for these systems, specific injectable technologies (including lipophilic solutions, aqueous suspensions, microspheres, liposomes, in situ forming depots and self-assembling lipid formulations), specific implantable technologies (including osmotic implants, drug eluting stents and microfabricated systems), peptide, protein and vaccine delivery, sterilization, drug release testing and regulatory aspects of long acting injections and implants. This volume provides essential information for experienced development professionals but was also written to be useful for scientists just beginning work in the field and for others who need an understanding of long acting injections and implants. This book will also be ideal as a graduate textbook.
Long COVID Fatigue: Clinical Sciences, Artificial Intelligence and the Future of Brain Health
by Thorsten RudroffThis book offers the first comprehensive analysis of long COVID fatigue using advanced neuroimaging and artificial intelligence (AI). It bridges the gap between basic science and patient care in post-viral syndromes. The volume guides readers from fundamental concepts to future innovations, making complex neurobiological mechanisms accessible to researchers and clinicians. Each chapter builds on the previous, connecting molecular mechanisms to clinical manifestations. The integration of AI in diagnosis and treatment is a pioneering approach in long COVID literature. The book provides detailed analysis of brain metabolic patterns in long COVID fatigue, insights into protective mechanisms like metabolic heterogeneity in the basal ganglia, practical guidelines for AI-enhanced diagnostic and treatment approaches, and pathways for translating research into clinical practice. It combines rigorous scientific analysis with practical applications, serving as both a reference and a roadmap for future developments in long COVID research and treatment. The main objectives are to provide a comprehensive understanding of long COVID fatigue mechanisms, present evidence-based approaches for diagnosis and treatment, showcase innovative AI applications in medical imaging, establish a framework for future research, and offer practical clinical management guidelines. This book is tailored for neurologists, neuroscientists, COVID-19 specialists, radiologists, healthcare providers, AI researchers, and graduate students in related fields.
Long Lever Techniques: An Illustrated Guide for Practitioners to Treat Neuro-Musculoskeletal Pain
by Bobby Nourani Richard HuffA full-color introductory guide to a revolutionary new osteopathic treatment: a direct manual medicine approach for reestablishing cranial rhythmic impulse, improving primary respiration mechanism, and restoring potency at the site of dysfunction.In the first book to discuss the long lever technique, Bobby Nourani, DO, introduces a manual medicine treatment for treating somatic dysfunction, reducing pain, and manipulating the body for effective and efficient healing. Written for professionals--osteopaths, physicians, bodyworkers, physical therapists, occupational therapists, craniosacral therapists, and other practitioners who want to integrate osteopathic techniques into an existing practice--Long Lever Techniques focuses on how we can mobilize interconnected structures to positively restore the body to better health and function. The long lever approach--using the arm or leg as lever and fulcrum to mobilize an area of somatic dysfunction--is a manual application of corrective force that can be applied once or multiple times. It has wide-ranging applications, from pain reduction to autonomic rebalancing to improved respiration rate, and is presented with full-color photos and illustrations so that medical professionals can put it into practice quickly. Readers will learn about: • The history and development of long lever techniques • Its clinical applications to cervical, thoracic, rib, lumbar, sacral, and pelvic dysfunction • Coccyx and craniococcygeal anatomy, evaluation, indications, and informed consent and documentation • How to integrate long lever techniques in practice
Long Life Strategy: A Guide for Living a Longer, Healthier, and More Fulfilling life
by Ronald M. CaplanThe second edition of Long Life Strategy builds upon the practical tips and knowledge in the first edition by providing readers with an outline to living a longer, healthier, more enjoyable life and late life. The book elaborates on three major areas, which include what you can do to live a long life, what your doctor should be doing to help you achieve this goal, and what society, of which we are all part, should be doing to better accommodate a growing number of older people in the coming decades. Dr. Caplan begins by introducing what it means to live a longer life and explaining the current research on delaying, preventing, and reversing aging in our cells. The next chapters detail how to prevent diseases and conditions commonly associated with aging, including diabetes, cancer, osteoporosis, mental health decline, sexual dysfunction, and heart disease. The author provides instruction for good diet and exercise choices. The concluding chapters provide useful advice for managing a fixed income, becoming a grandparent, dealing with the sickness and loss of a life partner, and how to maintain social relationships into late life. No matter where you are on life’s journey, Long Life Strategy can provide a roadmap to living a longer, healthier, and more fulfilling life.
Long Non-Coding RNAs
by Durdica UgarkovicLong non-coding RNAs (lncRNAs), tentatively defined as ncRNAs of more than two hundred nucleotides in length, are characterized by the complexity and diversity of their sequences and mechanisms of action. Based on genome-wide studies, more than 3,300 of them exist, but to date only the limited number of functional lncRNAs have been identified and characterized. Nonetheless, lncRNAs have emerged as key molecules involved in the control of transcriptional and posttranscriptional gene regulatory pathways. They take part in the recruitment of chromatin modifying complexes and regulate splicing, localization, stability and translation of the target mRNAs. This book provides an overview of the rapidly advancing field of long ncRNAs, describing the epigenetic and non-epigenetic mechanisms by which they regulate various biological functions in model systems, from yeast to mammals. The role of ncRNAs in sex chromosome dosage compensation in flies and mammals is described, as well as their role in centromere and telomere biology. Long non-coding RNAs involved in environmental stress response and development are presented and their mechanisms of action discussed.