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Marginal Space Learning for Medical Image Analysis
by Yefeng Zheng Dorin ComaniciuAutomatic detection and segmentation of anatomical structures in medical images are prerequisites to subsequent image measurements and disease quantification, and therefore have multiple clinical applications. This book presents an efficient object detection and segmentation framework, called Marginal Space Learning, which runs at a sub-second speed on a current desktop computer, faster than the state-of-the-art. Trained with a sufficient number of data sets, Marginal Space Learning is also robust under imaging artifacts, noise and anatomical variations. The book showcases 35 clinical applications of Marginal Space Learning and its extensions to detecting and segmenting various anatomical structures, such as the heart, liver, lymph nodes and prostate in major medical imaging modalities (CT, MRI, X-Ray and Ultrasound), demonstrating its efficiency and robustness.
Marie Equi: Radical Politics and Outlaw Passions
by Michael HelquistMarie Equi explores the fiercely independent life of an extraordinary woman. Born of Italian-Irish parents in 1872, Marie Equi endured childhood labor in a gritty Massachusetts textile mill before fleeing to an Oregon homestead with her first longtime woman companion, who described her as impulsive, earnest, and kind-hearted. These traits, along with courage, stubborn resolve, and a passion for justice, propelled Equi through an unparalleled life journey. Equi self-studied her way into a San Francisco medical school and then obtained her license in Portland to become one of the first practicing woman physicians in the Pacific Northwest. From Pendleton, Portland, Seattle and beyond to Boston and San Francisco, she leveraged her professional status to fight for woman suffrage, labor rights, and reproductive freedom. She mounted soapboxes, fought with police, and spent a night in jail with birth control advocate Margaret Sanger. Equi marched so often with unemployed men that the media referred to them as her army. She battled for economic justice at every turn and protested the U. S. entry into World War I, leading to a conviction for sedition and a three-year sentence in San Quentin. Breaking boundaries in all facets of life, she became the first well-known lesbian in Oregon, and her same-sex affairs figured prominently in two U. S. Supreme Court cases. Marie Equi is a finely written, rigorously researched account of a woman of consequence, who one fellow-activist considered "the most interesting woman that ever lived in this state, certainly the most fascinating, colorful, and flamboyant. " This much anticipated biography will engage anyone interested in Pacific Northwest history, women's studies, the history of lesbian and gay rights, and the personal demands of political activism. It is the inspiring story of a singular woman who was not afraid to take risks, who refused to compromise her principles in the face of enormous opposition and adversity, and who paid a steep personal price for living by her convictions.
Marijuana: A Short History
by John HudakFrom Reefer Madness to legal purchase at the corner store.With long-time legal and social barriers to marijuana falling across much of the United States, the time has come for an accessible and informative look at attitudes toward the dried byproduct of Cannabis sativa. Marijuana: A Short History profiles the politics and policies concerning the five-leaf plant in the United States and around the world.Millions of Americans have used marijuana at some point in their lives, yet it remains a substance shrouded by myth, misinformation, and mystery. This book offers an up-to-date, cutting-edge look at how a plant with a tumultuous history has emerged from the shadows of counterculture and illegality. Today, marijuana has become a remarkable social, economic, and even political force, with a surprising range of advocates and opponents. Public policy toward marijuana, especially in the United States, is changing rapidly. Marijuana: A Short History provides a brief yet compelling narrative that discusses the social and cultural history of marijuana but also tells us how a once-vilified plant has been transformed into a serious, even mainstream, public policy issue. Focusing on politics, the media, government, and education, the book describes why public policy has changed, and what that change might mean for marijuana's future place in society.
Marijuana and Cannabinoid Research
by Emmanuel S. OnaiviA cutting-edge collection of readily reproducible in vitro and in vivo methods to elucidate the mechanisms associated with cannabinoid function in health and disease. The techniques can be used in studies across the board from genes to behavior. The molecular neurobiological methods are invaluable in analyzing the structure, the polymorphisms, and the molecular expression of the cannabinoid receptors (CBrs), as well as their association with polysubstance abuse. There are also methods for localizing cannabinoid receptors in different systems, visualizing cannabinoid effects using brain slice imaging and elctrophysiological approaches, and designing and synthesizing cannabinoids and endocannabinoids. The protocols follow the successful Methods in Molecular MedicineTM series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls.
Marijuana and Madness
by David J. Castle Deepak Cyril D’Souza Murray, Sir Robin M.An updated third edition of this award-winning book provides a comprehensive overview of the complex associations between cannabis and mental illness. Organised into easy to navigate sections, the book has been fully revised to feature eight entirely new chapters covering important novel aspects. Marijuana and Madness incorporates new research findings on the potential use of cannabinoids, and synthetic cannabinoids, in an array of mental illnesses, balanced against the potential adverse effects. The associations between cannabis and psychosis, developing putative models of 'cannabis induced' psychosis and pathways to schizophrenia are all covered. The book importantly discusses the impact of exposure to cannabis at various stages of neurodevelopment (in utero, in childhood, and during adolescence) and it thoroughly reviews the treatments for cannabis dependence and health policy implications of the availability of increasingly high potency cannabis. This book will quickly become an essential resource for all members of the mental health team.
Marijuana and Medicine: Assessing the Science Base
by Institute of MedicineThe medical use of marijuana is surrounded by a cloud of social, political, and religious controversy, which obscures the facts that should be considered in the debate.This book summarizes what we know about marijuana from evidence-based medicine--the harm it may do and the relief it may bring to patients. The book helps the reader understand not only what science has to say about medical marijuana but also the logic behind the scientific conclusions.Marijuana and Medicine addresses the science base and the therapeutic effects of marijuana use for medical conditions such as glaucoma and multiple sclerosis. It covers marijuana's mechanism of action, acute and chronic effects on health and behavior, potential adverse effects, efficacy of different delivery systems, analysis of the data about marijuana as a gateway drug, and the prospects for developing cannabinoid drugs. The book evaluates how well marijuana meets accepted standards for medicine and considers the conclusions of other blue-ribbon panels.Full of useful facts, this volume will be important to anyone interested in informed debate about the medical use of marijuana: advocates and opponents as well as policymakers, regulators, and health care providers.
Marijuana as Medicine? The Science Beyond the Controversy
by Alison MackSome people suffer from chronic, debilitating disorders for which no conventional treatment brings relief. Can marijuana ease their symptoms? Would it be breaking the law to turn to marijuana as a medication? There are few sources of objective, scientifically sound advice for people in this situation. Most books about marijuana and medicine attempt to promote the views of advocates or opponents. To fill the gap between these extremes, authors Alison Mack and Janet Joy have extracted critical findings from a recent Institute of Medicine study on this important issue, interpreting them for a general audience. Marijuana As Medicine? provides patients--as well as the people who care for them--with a foundation for making decisions about their own health care. This empowering volume examines several key points, including: Whether marijuana can relieve a variety of symptoms, including pain, muscle spasticity, nausea, and appetite loss. The dangers of smoking marijuana, as well as the effects of its active chemical components on the immune system and on psychological health. The potential use of marijuana-based medications on symptoms of AIDS, cancer, multiple sclerosis, and several other specific disorders, in comparison with existing treatments. Marijuana As Medicine? introduces readers to the active compounds in marijuana. These include the principal ingredient in Marinol, a legal medication. The authors also discuss the prospects for developing other drugs derived from marijuana's active ingredients. In addition to providing an up-to-date review of the science behind the medical marijuana debate, Mack and Joy also answer common questions about the legal status of marijuana, explaining the conflict between state and federal law regarding its medical use. Intended primarily as an aid to patients and caregivers, this book objectively presents critical information so that it can be used to make responsible health care decisions. Marijuana As Medicine? will also be a valuable resource for policymakers, health care providers, patient counselors, medical faculty and students--in short, anyone who wants to learn more about this important issue.
Marijuana/Cannabinoids: Neurophysiology and Neurobiology (Routledge Revivals)
by Laura Murphy Andrzej BartkeFirst Published in 1992, Marijuana/Cannabinoids: Neurophysiology and Neurobiology is the first book to specifically address the effects of marijuana and cannabinoids on the physiology and behavior of the brain. The book discusses the dramatic effects of marijuana use on brain chemistry, pharmacology, and behavior. It also examines the isolation of natural cannabinoids and the synthesis of new cannabinoid-like compounds that have been important in research leading to the discovery and function of the cannabinoid receptor in the brain. Up-to-date research findings and in-depth reviews on marijuana and cannabinoids in the brain and their potential therapeutic value make Marijuana/Cannabinoids: Neurophysiology and Neurobiology essential for students, practitioners, and researchers involved in researching drugs of abuse.
Marijuana Is Safer
by Steve Fox Paul Armentano Mason TvertNationally recognized marijuana-policy experts Steve Fox, Paul Armentano, and Mason Tvert compare and contrast the relative harms and legal status of the two most popular recreational substances in the world--marijuana and alcohol. Through an objective examination of the two drugs and the laws and social practices that steer people toward alcohol, the authors pose a simple yet rarely considered question: Why do we punish adults who make the rational, safer choice to use marijuana instead of alcohol?Marijuana Is Saferreaches for a broad audience. For those unfamiliar with marijuana, it provides an introduction to the cannabis plant and its effects on the user, and debunks some of the government's most frequently cited marijuana myths. For current and aspiring advocates of marijuana-law reform, as well as anyone else who is interested in what is becoming a major political battle, the authors spell out why the message that marijuana is safer than alcohol must be a prominent part of the public debate over legalization. Most importantly, for the millions of Americans who want to advance the cause of marijuana-policy reform--or simply want to defend their own personal, safer choice--this book provides the talking points and detailed information needed to make persuasive arguments to friends, family, coworkers, and elected officials.
Marijuana Medical Handbook
by Dale Gieringer Ed Rosenthal Gregory T. CarterAn estimated 40 million Americans have medical symptoms that marijuana can relieve. Marijuana Medical Handbook is a one-stop resource that gives candid, objective advice on using marijuana for healing, understanding its effects on the body, safe administration, targeting illnesses, side effects, and the various delivery methods from edibles and tinctures to smokeless vaporizer pipes. The book also details supply issues, cultivation solutions (in a chapter by renowned expert Ed Rosenthal), and legal consequences. This thoroughly revised edition incorporates the most up-to-date information on the ever-changing politics of marijuana, the plant's usage, and medical research on it.
Marijuana Medical Handbook: Practical Guide to Therapeutic Uses of Marijuana
by Ed Rosenthal Dale Gieringer Gregory T. CarterAn estimated 40 million Americans have medical symptoms that marijuana can relieve. Marijuana Medical Handbook is a one-stop resource that gives candid, objective advice on using marijuana for healing, understanding its effects on the body, safe administration, targeting illnesses, side effects, and the various delivery methods from edibles and tinctures to smokeless vaporizer pipes. The book also details supply issues, cultivation solutions (in a chapter by renowned expert Ed Rosenthal), and legal consequences. This thoroughly revised edition incorporates the most up-to-date information on the ever-changing politics of marijuana, the plant's usage, and medical research on it.
Marijuana on My Mind: The Science and Mystique of Cannabis
by Timmen CermakMarijuana is on everyone's mind. Why do so many people enjoy it? What is it doing in our brains? Is it safe for everyone to use? What should we be telling our children? What are the benefits of medical marijuana? How does CBD live up to its hype? Does marijuana have spiritual power? And with so much conflicting information out there, how do we begin to make up our own minds about cannabis? Marijuana on My Mind is for anyone who has ever experienced the mystique of cannabis or wondered exactly how cannabis works. With over 40 years of clinical experience, Dr Timmen Cermak uses science to make sense of the endless debate between advocates and opponents of cannabis and provides answers to some of the greatest mysteries surrounding marijuana.
Marine Algal Bloom: Characteristics, Causes and Climate Change Impacts
by Santosh Kumar SarkarIn the marine environment, single-celled, microscopic, plant-like organisms naturally occur in the well-lit surface layer of any body of water. These organisms, referred to as phytoplankton or microalgae, form the base of the food web upon which nearly all other marine organisms depend. Algal bloom is a rapid increase in or accumulation of the population of about 300 species of algae due to excess nutrients (eutrophication), and is of major global interest as it causes reduction in species diversity, abrupt changes in water quality, and discoloration of the water (green, yellow, brown or red) depending on the species of algae and the type of pigments they contain. Dying blooms can also be an environmental concern as when the cells sink and decay, bacteria break down the organic material, which in turn strips oxygen from the water. This microbial oxygen demand at times leads to very low oxygen levels in the bottom waters, harming aquatic life. Documentation of this sporadic high abundance of algae, together with the significant species richness of the diatoms, requires comprehensive studies in the Sundarban coastal environment, which is facing severe degradation due to natural & anthropogenic stressors. In addition, a better understanding of the effects of algal blooms on seafood quality, the complex biological, chemical and physical interactions and subsequent effects on trophodynamics is needed to develop strategies for effective coastal zone management. The book discusses the occurrence of harmful algal blooms (HABs) caused by the dinoflagellates of the genus Alexandrium and Karenia, or diatoms of the genus Pseudo-nitzschia, which have large and varied impacts on marine ecosystems (such as large-scale marine mortality events that have been associated with various types of shellfish poisonings) depending on the species involved, the environment where they are found, and the mechanism by which they exert negative effects. HABs represent a major environmental problem in all regions of the U.S., and their occurrence is on the rise due to increased nutrient pollution. HABs have severe impacts on human health, aquatic ecosystems, and the economy. Such blooms, known colloquially as red tides due to their red or brown hues, are increasing in frequency and magnitude worldwide as a result of changes in oceanic climate, increased coastal eutrophication and enhanced long-distance dispersal in ballast water. As such, the book offers an in-depth account of the complex biological, chemical and physical interactions of the algal blooms (both innocuous and harmful ones). It also discusses the highly topical issue of the impact of global climate change on the frequency and severity of HABs in the context of alterations in temperature, stratification, light and ocean acidification.Focusing on both basic and applied limnology, this book is a reliable and up-to-date reference resource for students, teachers and researchers engaged in the field of coastal research/management at regional and global scales.
Marine Bioactive Compounds
by Maria HayesThe aim and scope of this book is to highlight the sources, isolation, characterization and applications of bioactive compounds from the marine environment and to discuss how marine bioactive compounds represent a major market application in food and other industries. It discusses sustainable marine resources of macroalgal origin and gives examples of bioactive compounds isolated from these and other resources, including marine by-product and fisheries waste streams. In addition, it looks at the importance of correct taxonomic characterization.
Marine Bioactive Molecules for Biomedical and Pharmacotherapeutic Applications
by Pallaval Veera Bramhachari Chanda Vikrant BerdeThis book explores cutting-edge research on the discovery and application of marine bioactive molecules for biomedical and pharmacotherapeutic purposes. The book begins by delving into the bioprospection of marine sponge microbiomes for bioactive metabolites using advanced metagenomics tools. It then explores metagenome mining approaches for the discovery of marine microbial natural products. The use of marine-derived fungi as a source of anticancer secondary metabolites is also discussed. The book then turns to the biomedical applications of marine-derived biomaterials, including marine biopolymers in tissue engineering and regenerative medicine. Marine-derived pharmaceuticals and polymeric nanostructures for cancer treatment are also examined. Next, the book looks at the use of marine microbial sources for the synthesis of metallic nanomaterials, prospects, current development, and challenges in nanomedicine. The book continues by exploring the treasure trove of natural polymers for tissue engineering in the marine environment. It also discusses the immunomodulatory and therapeutic potential of marine-derived astaxanthin, current developments, and prospects. Finally, the book concludes by exploring the recent progress in marine-derived nutraceuticals and marine phytoplankton bioactive compounds and their applications in medicine.
Marine Biochemistry: Isolations and Techniques
by Se-Kwon KimThis book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances. There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones produced in the endocrine system to regulate the respective metabolisms, thereby providing a safe and healthy life to humans. The overall presentation and clear demarcation of the contents by worldwide contributions is a novel entry point into the market of medicinal foods from the sea. The exploration of marine habitats for novel materials are discussed throughout the book. The exploration and exploitation of the biochemistry of sea flora and fauna are limited, and this book extends the research possibilities into numerous marine habitats. Various approaches for extracting and applying the flora and fauna are discussed. This book will be of value to researchers, marine biotechnologists, and medical practitioners, due to the vast information, as well as industrial and medical applications of marine substances all in one place.
Marine Biochemistry: Applications
by Se-Kwon KimThis book provides the latest comprehensive methods for isolation and other novel techniques for marine product development. Furthermore, this book offers knowledge on the biological, medical, and industrial applications of marine-derived medicinal food substances. There has been a tremendous increase in the products derived from marine organisms for commercial application in industries every year. Functional foods of medicinal value are particularly in demand as new technology allows the stabilization of natural ingredients and their availability in pure forms to solve various human diseases. Marine flora and fauna have essential elements and trace minerals that nurture various hormones produced in the endocrine system to regulate the respective metabolisms, thereby providing a safe and healthy life to humans. The overall presentation and clear demarcation of the contents by worldwide contributions is a novel entry point into the market of medicinal foods from the sea. The exploration of marine habitats for novel materials are discussed throughout the book. The exploration and exploitation of the biochemistry of sea flora and fauna are limited, and this book extends the research possibilities into numerous marine habitats. Various approaches for extracting and applying the flora and fauna are discussed. This book will be of value to researchers, marine biotechnologists, and medical practitioners, due to the vast information, as well as industrial and medical applications of marine substances all in one place.
Marine Biomaterials: Drug Delivery and Therapeutic Applications
by Sougata Jana Subrata JanaThis book is focused on marine based biomedical carriers for delivery of therapeutics. Marine biomaterials and bio-based carriers show wide applications in pharmaceutical as well as biomedical fields for delivery of small and large molecules. Biomaterial-based composites, scaffolds or matrix systems are promising systems for controlled and prolonged release of drug in target site and control the premature release of drugs or bioactive compounds. This book discusses the targeted delivery of drugs and therapeutic applications. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. The marine biomaterial-based systems are widely used for tissue engineering, and biomedical imaging. This book is meant for industry experts, students and researchers in the area of pharmaceutical sciences, biomedical engineering and material science and pharmacology.
Marine Biomaterials: Therapeutic Potential
by Sougata Jana Subrata JanaThis book provides updated information on marine-based biomedical carriers and their therapeutic potential. Marine biomaterials and bio-based carriers show wide application in pharmaceutical and biomedical fields to deliver small and large molecules. Biomaterial-based composites, scaffolds, or matrix systems are sound systems for controlled and prolonged drug release in target sites and control the premature release of drugs or bioactive compounds. This book discusses essential topics such as the therapeutic potential of marine collagen, management of bone disorders, gene delivery, natural marine compounds in immunomodulation, theranostic applications, tissue engineering, and regeneration. It also describes the use of marine biopolymers in cancer therapy. Different chapters describe the tissue engineering techniques to develop these carriers. Marine biomaterial-based systems are popular for tissue engineering and biomedical imaging.This book is ideal for industry experts, students, and researchers in pharmaceutical sciences and pharmacology.
Marine Climate of Russian Coastal Territories: Public Health Aspects of Biological Adaption
by Andrei Vyacheslavovich Tarasov Rofail Salykhovich RakhmanovThe monograph was written based on the material of the post-doctoral thesis prepared under the supervision of Prof. Dr. Rakhmanov and it has been translated from its original version in Russian. It presents a comprehensive analysis of the process of biological adaptation and adaptation capacity of the population to the marine climate of Russia’s North, the Black and Caspian Sea regions and the Baltic Sea coast. The authors explore different biological reactions to adaptation and offer their classification depending on the type of climate. Special attention is given to the prevention of prenosological conditions and diseases typical of coastal areas. Evidence suggests that the human body has a remarkable capacity to adapt to a range of climatic and weather conditions through a variety of targeted adaptation measures.
Marine-Derived Biomaterials for Tissue Engineering Applications (Springer Series in Biomaterials Science and Engineering #14)
by Andy H. Choi Besim Ben-NissanThis book presents the latest advances in marine structures and related biomaterials for applications in both soft- and hard-tissue engineering, as well as controlled drug delivery. It explores marine structures consisting of materials with a wide variety of characteristics that warrant their use as biomaterials. It also underlines the importance of exploiting natural marine resources for the sustainable development of novel biomaterials and discusses the resulting environmental and economic benefits. The book is divided into three major sections: the first covers the clinical application of marine biomaterials for drug delivery in tissue engineering, while the other two examine the clinical significance of marine structures in soft- and hard-tissue engineering, respectively. Focusing on clinically oriented applications, it is a valuable resource for dentists, oral and maxillofacial surgeons, orthopedic surgeons, and students and researchers in the field of tissue engineering.
Marine Glycobiology: Principles and Applications
by Se-Kwon KimMarine glycobiology is an emerging and exciting area in the field of science and medicine. Glycobiology, the study of the structure and function of carbohydrates and carbohydrate-containing molecules, is fundamental to all biological systems and represents a developing field of science that has made huge advances in the last half-century. This book revolutionizes the concept of marine glycobiology, focusing on the latest principles and applications of marine glycobiology and their relationships.
Marine Mammal Welfare
by Andy ButterworthMarine mammals attract human interest – sometimes this interest is benign or positive – whale watching, conservation programmes for whales, seals, otters, and efforts to clear beaches of marine debris are seen as proactive steps to support these animals. However, there are many forces operating to affect adversely the lives of whales, seals, manatees, otters and polar bears – and this book explores how the welfare of marine mammals has been affected and how they have adapted, moved, responded and sometimes suffered as a result of the changing marine and human world around them. Marine mammal welfare addresses the welfare effects of marine debris, of human traffic in the oceans, of noise, of hunting, of whale watching and tourism, and of some of the less obvious impacts on marine mammals – on their social structures, on their behaviours and migration, and also of the effects on captivity for animals kept in zoos and aquaria. There is much to think and talk about – how marine mammals respond in a world dramatically influenced by man, how are their social structures affected and how is their welfare impacted?
Marine Mammals: A Deep Dive into the World of Science
by Dennis Brennecke Katrin Knickmeier Iwona Pawliczka Ursula Siebert Magnus WahlbergThis highly-readable Open Access textbook provides basic background information about marine mammals and anthropogenic impacts on them. The book includes inspiring exercises for education school programs in natural sciences. The book also provides advice on career paths using case studies of marine scientists and veterinarians describing their journeys from student to profession. By sharing real-life career paths, readers find answers to questions such as “What needs to be considered when choosing a career in science?” and “What kind of tasks do scientists undertake on a daily basis?” Marine mammals are amongst some of the most celebrated creatures on Earth, with their high intelligence, social and communicating skills, and capacity for deep diving. Alongside general information about marine mammals, the book aims at generating awareness of the impact of litter and noise pollution on the marine environment using marine mammals as an example. Huge numbers of marine animals, including marine mammals, die every year from entanglement in fishing gear, by ingestion of litter or because of chemical pollution. In the last decade many technological and scientific tools have been developed to aid research, for instance miniaturised sound recorders which can be attached to cetaceans and seals and record noise levels around them, their vocal production as well as their diving behaviour. This Open Access textbook can be used by undergraduate students interested in the fundamentals of marine mammal biology and medicine, and in pursuing the profession of a marine scientist.
Marine Metagenomics: Technological Aspects and Applications
by Takashi Gojobori Tokio Wada Takanori Kobayashi Katsuhiko MinetaThis book presents the state-of-art marine metagenome research and explains the method of marine metagenomic analysis in an easy-to-understand manner.Changes in the marine environment due to global warming and pollution have become a major global problem. Maintaining a healthy marine ecosystem requires advanced environmental monitoring and assessment systems. As such, the book presents a novel metagenomic monitoring method, which has been developed for comprehensive analyses of the DNA of microorganisms living in seawater to further our understanding of the dynamics of the marine environment. The book can be used as a primer for new researchers and as a manual on experimental methods.