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Mama Might Be Better Off Dead: The Failure of Health Care in Urban America
by Laurie Kaye Abraham“A provocative examination of our health care delivery for the poor. . . . Such an honest and candid account is essential.” —Alex Kotlowitz, national bestselling author of There Are No Children HereMama Might Be Better Off Dead immerses readers in the lives of four generations of a poor, African-American family from North Lawndale, Chicago, who are beset with the devastating illnesses that are all too common in America’s inner-cities. Headed by Jackie Banes, who oversees the care of a diabetic grandmother, a husband on kidney dialysis, an ailing father, and three children, the Banes family contends with countless medical crises. From visits to emergency rooms and dialysis units, to trials with home care, to struggles for Medicaid eligibility, Laurie Kaye Abraham chronicles their access—or lack thereof—to medical care. Their story reveals an inadequate health care system that is further undermined by the effects of poverty.Mama Might Be Better Off Dead is an unsettling, profound look at the human face of health care in America. This new edition includes an incisive foreword by David Ansell, a physician who worked at Mt. Sinai Hospital, where much of the Banes family’s narrative unfolds.“Goes to the heart of today’s problem. Powerful . . . deeply searching.” —Washington Post“A powerful indictment of the big business of medicine.” —Los Angeles Times“Abraham . . . illuminates the problems with passion and skill.” —Kirkus Reviews“This personally observed, lucid chronicle and call for reform of our ailing health system covers all levels of responsibility in the medical establishment.” —Publishers Weekly“Clearly identifies in human and policy terms how [healthcare] programs have failed a population desperately in need of help.” —Library Journal
Mammalian Artificial Chromosomes
by Vittorio Sgaramella Sandro EridaniLeading scientists in cell biology, genetics, cell culturing, and gene transfer present their most productive methods for the preparation, characterization, and use of artificial chromosomes. The authors cover all relevant areas of artificial chromosome research-from basic genetics to daring attempts at building new gene therapy tools-and describe possible applications in genetic manipulation requiring large portions of the genome. Each fully tested protocol is described in step-by-step detail and includes a background introduction outlining the principle behind the technique, reagent and equipment lists, and tips on troubleshooting and how to avoid pitfalls.
Mammalian Brain Development
by Damir JanigroThis book fills a gap in developmental books dealing with the normal prenatal mammalian brain. Most books that approach this topic work with non-human, non-vertebrate models. Mammalian Brain Development focuses on both the pre-natal and the peri-natal events that lead to brain damage as seen in the prospective of medical and research professionals, as well as examining the traditional "nature versus nurture" argument in the spectrum of brain development. The major topics addressed, in detail, in the book are sexual dimorphism, epigenetic action of gonadal hormones, environmental "programming" effects, autism, developmental learning disorders, seizures, and the etiopathogenesis of epileptic syndromes in young humans. The book also covers the general aspects of postnatal and pediatric neurological disorders in a unique and novel way by offering definitions of heredity, inheritance, genetic-epigenetic, genomic, molecular, developmental, and innate aspects of the mammalian brain in regards to its development.
Mammalian Cell Cultures for Biologics Manufacturing
by Weichang Zhou Anne KantardjieffVolumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.
Mammalian Cell Engineering: Methods and Protocols (Methods in Molecular Biology #2312)
by Ryosuke KojimaThis volume explores the latest engineering methods of mammalian cells that are useful for controlling the performance of engineered mammalian cells for future cell-based therapeutics and for better understanding of complex biological systems. The chapters in this book are organized into five parts. Part One described methods to engineer mammalian cells to sense biologically relevant inputs, such as cell contacts and soluble proteins. Part Two looks at techniques to engineer mammalian cells to sense artificial inputs, such as light and ultrasound. Part Three provides cutting-edge CRISPR-Cas-based methods to carry out highly multiplexed genome editing and spatiotemporally controlled genome editing. Part Four discusses ways to control and engineer biological events in mammalian cells in combination with chemical compounds and systems. Part Five explores techniques to engineer specific mammalian cells in targeted manners. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and authoritative, Mammalian Cell Engineering: Methods and Protocols is a valuable resource that allows scientists to successfully carry out their research, thus ultimately contributing to the future advancement of this field.
Mammalian Chromosome Engineering
by Gyula HadlaczkyThe rapid progression of genetics and molecular biology has turned chromosomal engineering from science fiction to reality, with the successful production of transgenic animals with engineered chromosomes and chromosomes developed for pharmaceutical protein production which are now ready for the medical industry. Mammalian Chromosome Engineering: Methods and Protocols provides the reader with up-to date information on this rapidly evolving field and strives to take the reader into the exciting realm of chromosomal engineering from the basic principles to the practical applications of these new technologies. The five overview and ten protocol chapters cover the engineering of chromosomes with extrachromosomal vectors and transposon systems, the manipulation of naturally occurred minichromosomes, the generation and engineering of synthetic artificial chromosomes, and the induced de novo platform artificial chromosome system. Written in the highly successful Methods in Molecular BiologyTM series format, protocols chapters contain brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammalian Chromosome Engineering: Methods and Protocols serves as a bench-side resource for current protocols and aims to help scientists to explore the many prospects for future research and vital applications.
Mammalian Egg Transfer
by Lewis AdamsEgg transfer was first performed in 1890, but for half a century it received scant attention. However, since 1950 the technique has become increasingly widely used - in the laboratory for fundamental studies and more recently in practice, both veterinary and medical, to boost reproductive potential of genetically superior cattle and to overcome sterility due to impaired rubal function in women. As a result, a considerable body of literature has accumulated, totaling well in excess of a thousand references. But till now there has not been a single comprehensive text devoted solely to this subject. The present work was designed to meet that need at a time when the field is fast expanding with new techniques and approaches constantly being evolved. One need only cite the tremendous rate of progress in human egg transfer in the last three years. The work embraces laboratory and farm animals and primates, including man, altogether representing a total of 16 species.
Mammalian Endocrinology and Male Reproductive Biology
by Shio Kumar SinghMammalian Endocrinology and Male Reproductive Biology provides comprehensive and current coverage of the area of endocrinology and male reproductive biology, covering not just humans, but mammals in general. Written by international experts in their respective fields, this multi-author book also covers the latest developments in genomics of androge
Mammalian Heme Peroxidases: Diverse Roles in Health and Disease (Oxidative Stress and Disease #47)
by Clare L. HawkinsMammalian heme peroxidase enzymes play a critical role in innate immune responses and disease prevention. The formation of potent chemical oxidants is essential to this protective physiologic activity in immunity. Although highly beneficial in the context of immune defense, it is now well established that peroxidases and their overproduction of oxidants contribute to the initiation and persistence of many chronic inflammatory conditions in the cardiovascular, neurologic, respiratory, renal, and gastrointestinal systems. Peroxidasins, a protein family related to heme peroxidases, play a novel role in tissue biogenesis and matrix assembly, which are also attracting attention in different pathological contexts. Given the diverse roles of mammalian heme peroxidases and the breadth and incidence of pathologies associated with these enzymes, there has been significant interest in modulating peroxidase activity as a therapeutic strategy. This book highlights recent developments in our understanding of the chemistry, biochemistry and biological roles of mammalian peroxidases and their associated oxidants, their involvement in both innate immunity and chronic inflammatory disease in a variety of end organs, and potential therapeutic approaches to modulate and prevent damaging reactions. Key Features Structure and biosynthesis of mammalian peroxidases Reactivity of hypohalous acids with biological substrates Peroxidases in innate immunity Peroxidases in human pathology Modulation of peroxidase-induced biological damage
Mammalian Neuroendocrinology
by Paul V. MalvenMammalian Neuroendocrinology presents a concise examination of how the nervous and endocrine systems interact to regulate physiological processes. Selected experimental results are presented to illustrate the current understanding of neuroendocrine processes. Neural influences and endocrine feedback mechanisms related to the secretion of adenohypophysial hormones are summarized for each hormone. The book's concise nature and readable style are highly suited for use as a graduate textbook.There are also chapters devoted to each of the following topics: neurohypophysis, pineal gland, adrenal medulla, hormones and behavior, and neuroendocrine immunology. Comparisons are made among species of mammals, including laboratory rodents, domesticated ungulates, and primates. Agricultural and/or clinical aspects relevant to these topics are covered when appropriate. Mammalian Neuroendocrinology is excellent for students and professionals in neuroendocrinology, neuroscience, endocrinology, reproduction studies, and animal sciences.
Mammalian Sexuality: The Act of Mating and the Evolution of Reproduction
by Alan F. DixsonThere are more than 6000 species belonging to twenty-seven orders in the Class Mammalia. Comparative studies of this diverse and magnificent array of extant species provide valuable opportunities to formulate and test hypotheses concerning the evolution of reproduction. This is the first book to explore, in depth and breadth, the complex interrelationships that exist between patterns of mating behaviour and the evolution of mammalian reproductive anatomy and physiology. It focuses upon the role that copulatory and post-copulatory sexual selection have played during the evolution of the monotremes, marsupials and placental mammals, and examines the effects of sperm competition and cryptic female choice upon coevolution of the genitalia in the two sexes. In addition, due weight is also given to discussions of the modes of life of mammals, and to the roles played by natural selection and phylogeny in determining their reproductive traits.
Mammalian Sterols: Novel Biological Roles of Cholesterol Synthesis Intermediates, Oxysterols and Bile Acids
by Damjana Rozman Rolf GebhardtThis book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology.
Mammary Gland Development
by Finian Martin Torsten Stein Jillian HowlinThis volume provides key molecular biological protocols and experimental strategies currently employed to study the various stages of mammary gland development. Chapters are divided into four parts covering genetically modified mouse models that exhibit prenatal and pubertal mammary gland phenotypes, 2D and 3D-model culture systems, methodologies for mammary stem cell isolation, and translational applications that provide a bridge between experimental studies of mammary gland development and the study of human breast cancer. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammary Gland Development: Methods and Protocols will be useful for researchers whose primary interest is in mammary gland development; developmental biologists, epithelial cell biologists, and those with an interest in molecular mechanisms underlying breast cancer.
Mammary Stem Cells
by Maria del Mar VivancoThe identification of normal and breast cancer stem cells has offered a new vision of this heterogeneous disease and new hopes for its prognosis and treatment. This volume provides an overview of recent developments in mammary stem cell research and discusses the many varieties of approaches used by researchers to investigate the properties and functions of mammary stem cells. The beginning chapters provide readers with an introduction to mammary stem cells, and the processes used to characterize stem cells and isolate them via fluorescent activated cell sorting. The next few chapters discuss DNA and mRNA sequencing, proteomic techniques to help profile cells, lentiviral cell transduction for gene expression, and in vivo lineage tracing. The final few chapters are dedicated to following stem cells from their initial niche to the new microenvironment at their metastasis site, and to studying these cells using physical and mathematical approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols aims to help members of the scientific community explore the behavior of stem cells and how to work with them in order to guide the design of new and complimentary strategies to be applied in the clinic with the ultimate end goal of fighting breast cancer.
Mammary Stem Cells: Methods and Protocols (Methods in Molecular Biology #2471)
by Maria Dm. VivancoThis second edition provides an overview of recent developments and approaches used by researchers to investigate the properties and functions of mammary epithelial and stem cells, which will contribute to understand the heterogeneity of the mammary gland and of breast cancer. Chapters detail processes used to characterize stem cells, single cell RNA sequencing, computational methods, sophisticated imaging techniques, and a variety of model systems, among others. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols, Second Edition aims to make available protocols used to navigate the intricate behavior of mammary stem cells and to gain further knowledge to take us closer to the design of innovative strategies to prevent and treat breast cancer.
Mammographic Imaging: A Practical Guide
by Shelly Lille Wendy MarshallPublisher's Note: Products purchased from 3rd Party sellers are not guaranteed by the Publisher for quality, authenticity, or access to any online entitlements included with the product. The 4th Edition of Mammographic Imaging: A Practical Guide remains the most up-to-date and comprehensive book in the field. A perfect all-in-one solution for coursework, board prep, and clinical practice, this bestseller reflects the latest ARRT educational and certification exam requirements, as well as the ASRT recommended curriculum. Technologists seeking to stay current in the profession and students preparing to enter the field will appreciate the 227 new photos, the wide range of case studies, and the interactive online exam simulator with ARRT registry-style questions.
Mammography Screening: Truth, Lies and Controversy
by Peter Gotzsche'This book gives plenty of examples of ad hominem attacks, intimidation, slander, threats of litigation, deception, dishonesty, lies and other violations of good scientific practice. For some years I kept a folder labeled Dishonesty in breast cancer screening on top of my filing cabinet, storing articles and letters to the editor that contained statements I knew were dishonest. Eventually I gave up on the idea of writing a paper about this collection, as the number of examples quickly exceeded what could be contained in a single article.' From the Introduction The most effective way to decrease women's risk of becoming a breast cancer patient is to avoid attending screening. Mammography screening is one of the greatest controversies in healthcare, and the extent to which some scientists have sacrificed sound scientific principles in order to arrive at politically acceptable results in their research is extraordinary. In contrast, neutral observers increasingly find that the benefit has been much oversold and that the harms are much greater than previously believed. This groundbreaking book takes an evidence-based, critical look at the scientific disputes and the information provided to women by governments and cancer charities. It also explains why mammography screening is unlikely to be effective today. All health professionals and members of the public will find these revelations disturbingly illuminating. It will radically transform the way healthcare policy makers view mammography screening in the future. 'If Peter Gotzsche did not exist, there would be a need to invent him ...It may still take time for the limitations and harms of screening to be properly acknowledged and for women to be enabled to make adequately informed decisions. When this happens, it will be almost entirely due to the intellectual rigour and determination of Peter Gotzsche.' From the Foreword by Iona Heath, President, RCGP 'If you care about breast cancer, and we all should, you must read this book. Breast cancer is complex and we cannot afford to rely on the popular media, or on information from marketing campaigns from those who are invested in screening. We need to question and to understand. The story that Peter tells matters very much.' From the Foreword by Fran Visco, President, National Breast Cancer Coalition
Mammography Wars: Analyzing Attention in Cultural and Medical Disputes (Critical Issues in Health and Medicine)
by Asia FriedmanMammography is a routine health screening performed forty million times each year in the United States, yet it remains one of the most deeply contested topics in medicine, with national health care organizations supporting conflicting guidelines. In Mammography Wars, sociologist Asia Friedman examines cultural and medical disagreements over mammography. At issue is whether to screen women under age fifty, which is rooted in deeper questions about early detection and the assumed linear and progressive development of breast cancer. Based on interviews with doctors and scientists, interviews with women ages 40 to 50, and newspaper coverage of mammography, Friedman uses the sociology of attention to map the cognitive structure of the “mammography wars,” offering insights into the entrenched nature of debates over mammography that often get missed when applying a medical lens. Friedman’s analysis also suggests the sociology of attention’s unique potential for analyzing cultural conflicts beyond mammography, and even beyond medicine.
Mammography and Beyond: Developing Technologies for the Early Detection of Breast Cancer
by Institute of MedicineEach year more than 180,000 new cases of breast cancer are diagnosed in women in the U.S. If cancer is detected when small and local, treatment options are less dangerous, intrusive, and costly-and more likely to lead to a cure.Yet those simple facts belie the complexity of developing and disseminating acceptable techniques for breast cancer diagnosis. Even the most exciting new technologies remain clouded with uncertainty. Mammography and Beyond provides a comprehensive and up-to-date perspective on the state of breast cancer screening and diagnosis and recommends steps for developing the most reliable breast cancer detection methods possible.This book reviews the dramatic expansion of breast cancer awareness and screening, examining the capabilities and limitations of current and emerging technologies for breast cancer detection and their effectiveness at actually reducing deaths. The committee discusses issues including national policy toward breast cancer detection, roles of public and private agencies, problems in determining the success of a technique, availability of detection methods to specific populations of women, women's experience during the detection process, cost-benefit analyses, and more.Examining current practices and specifying research and other needs, Mammography and Beyond will be an indispensable resource to policy makers, public health officials, medical practitioners, researchers, women's health advocates, and concerned women and their families.
Mamá come sano: Alimentación saludable en el embarazo y la lactancia
by Julio BasultoEl embarazo y la lactancia son etapas maravillosas, pero repletas de dudas acerca de la dieta. ¿Influye la alimentación en mi fertilidad o en la de mi pareja? ¿Conviene recurrir a vitaminas, minerales, plantas medicinales, complementos alimenticios o fármacos? ¿Cuántas calorías debo tomar? ¿Cuánta agua tengo que beber? ¿Son un síntoma de peligro las náuseas u otras molestias típicas del embarazo? ¿Qué es ganar mucho (o poco) peso en el embarazo? ¿Cómo recupero la figura tras el parto? ¿Puedo ser vegetariana? ¿Es acaso una cuestión inextricable la alimentación en la lactancia? ¿Qué es (de verdad) una dieta sana?Julio Basulto aborda estas y muchas otras inquietudes, para ayudar al lector a formarse un criterio para elegir y decidir. Este libro no propone una dieta prodigiosa gracias a la cual tendremos un bebé extraordinario, recuperaremos el tipo rápidamente tras un parto fácil e indoloro, y produciremos abundante y nutritiva leche materna. Por el contrario, nos hará cuestionar muchos de nuestros hábitos alimenticios, algo absolutamente necesario no solo para la salud maternoinfantil, sino también para la de toda la familia.
Man & His Fellowmen: Modern Chapters on Social Psychology
by Lowy, SamuelFirst published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.
Man And Nature In The Renaissance (Cambridge Studies In The History Of Science Series)
by George Basalla Allen George Debus Owen HannawayMan and Nature in the Renaissance offers an introduction to science and medicine during the earlier phases of the scientific revolution, from the mid-fifteenth century to the mid-seventeenth century. Renaissance science has frequently been approached in terms of the progress of the exact sciences of mathematics and astronomy, to the neglect of the broader intellectual context of the period. Conversely, those authors who have emphasized the latter frequently play down the importance of the technical scientific developments. In this book, Professor Debus amalgamates these approaches: The exact sciences of the period are discussed in detail, but reference is constantly made to religious and philosophical concepts that play little part in the science of our own time. Thus, the renewed interest in mystical texts and the subsequent impact of alchemy, astrology, and natural magic on the development of modern science and medicine are central to the account. Major themes that are followed throughout the book include the effects of humanism, the search for a new method of science, and the dialogue between proponents of the mystical-occult world view and the mathematical-observational approach to nature.
Man In His Relationships
by Westmann, HFirst Published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.
Man In The Picture: The Family Hunt For An Unkown Man
by Magdel RoetsAn elderly woman dies with the picture of a man in her hand. No one knows who the man is and the hunt for the truth begins.
Man for Himself: An Inquiry into the Psychology of Ethics (Routledge Classics Ser.)
by Fromm, ErichFirst published in 1999. Routledge is an imprint of Taylor & Francis, an informa company.