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The Mathematics and Biology of the Biodistribution of Radiopharmaceuticals - A Clinical Perspective
by William C Klingensmith IIIThis book explores the mathematics and biology of the biodistribution of radiopharmaceuticals following their introduction into the body, but does so primarily from a clinical perspective - from the point of view of image interpretation and any associated image-derived quantification. All of the equations included in the book relate directly to the biodistribution of radiopharmaceuticals and are clinically useful, either conceptually or because of their value in quantifying a biological parameter, e. g. , renal clearance. In particular, the more complex equations are not meant to be solved but instead are intended to provide a conceptual basis for the analysis of clinical images, especially those that are unusual and/or difficult to interpret. The efficacy of every diagnostic and therapeutic nuclear medicine procedure is critically dependent on the biodistribution of the radiopharmaceutical in question over time. This book will enable the reader to gain a sound understanding of the relevant mathematics and biology, and the clinical orientation ensures that it will be of value in enhancing clinical practice.
Mathematics as a Laboratory Tool: Dynamics, Delays and Noise
by John Milton Toru OhiraThe second edition of Mathematics as a Laboratory Tool reflects the growing impact that computational science is having on the career choices made by undergraduate science and engineering students. The focus is on dynamics and the effects of time delays and stochastic perturbations (“noise”) on the regulation provided by feedback control systems. The concepts are illustrated with applications to gene regulatory networks, motor control, neuroscience and population biology. The presentation in the first edition has been extended to include discussions of neuronal excitability and bursting, multistability, microchaos, Bayesian inference, second-order delay differential equations, and the semi-discretization method for the numerical integration of delay differential equations. Every effort has been made to ensure that the material is accessible to those with a background in calculus. The text provides advanced mathematical concepts such as the Laplace and Fourier integral transforms in the form of Tools. Bayesian inference is introduced using a number of detective-type scenarios including the Monty Hall problem.
Mathematics Explained for Healthcare Practitioners
by Derek Haylock Paul WarburtonIf you find mathematics a struggle, or if mathematics makes you panic - whether you′re a student preparing for a calculations test, or a qualified healthcare professional - this is the book for you. Its focus is first and foremost on helping you develop a proper and lasting understanding of mathematical concepts and processes in a healthcare context, with an emphasis on developing mental strategies to reinforce your feeling for number and numerical relationships. Clear, accessible chapters take you step-by-step through specific sets of objectives, and once you feel you have fully mastered a particular mathematical process, you′re encouraged to practise your skills through a range of practical examples. Each chapter also contains a ′Spot the Errors′ feature designed to reflect the busy, pressurised healthcare environment. Written by Derek Haylock, a best-selling mathematics educator, and Paul Warburton, co-ordinator of the Non-Medical Prescribing programme at Edge Hill University, the book is directly linked to the NMC′s competencies and will give you the confidence to perform the safe, error-free calculations required of all healthcare professionals.
Mathematics for the Life Sciences
by Erin N. Bodine Suzanne Lenhart Louis J. GrossAn accessible undergraduate textbook on the essential math concepts used in the life sciencesThe life sciences deal with a vast array of problems at different spatial, temporal, and organizational scales. The mathematics necessary to describe, model, and analyze these problems is similarly diverse, incorporating quantitative techniques that are rarely taught in standard undergraduate courses. This textbook provides an accessible introduction to these critical mathematical concepts, linking them to biological observation and theory while also presenting the computational tools needed to address problems not readily investigated using mathematics alone.Proven in the classroom and requiring only a background in high school math, Mathematics for the Life Sciences doesn't just focus on calculus as do most other textbooks on the subject. It covers deterministic methods and those that incorporate uncertainty, problems in discrete and continuous time, probability, graphing and data analysis, matrix modeling, difference equations, differential equations, and much more. The book uses MATLAB throughout, explaining how to use it, write code, and connect models to data in examples chosen from across the life sciences.Provides undergraduate life science students with a succinct overview of major mathematical concepts that are essential for modern biologyCovers all the major quantitative concepts that national reports have identified as the ideal components of an entry-level course for life science studentsProvides good background for the MCAT, which now includes data-based and statistical reasoningExplicitly links data and math modelingIncludes end-of-chapter homework problems, end-of-unit student projects, and select answers to homework problemsUses MATLAB throughout, and MATLAB m-files with an R supplement are available onlinePrepares students to read with comprehension the growing quantitative literature across the life sciencesA solutions manual for professors and an illustration package is available
Mathematics for Veterinary Medical Technicians (Third Edition)
by Edward M. Stumpf Frederick R. Fritz William W. BradfordThe text provides a one-semester course in the basics of mathematics needed for Veterinary Technicians and Assistants.
Mathematics of Epidemics on Networks
by Péter L. Simon Joel C. Miller István Z. KissThis textbook provides an exciting new addition to the area of network science featuring a stronger and more methodical link of models to their mathematical origin and explains how these relate to each other with special focus on epidemic spread on networks. The content of the book is at the interface of graph theory, stochastic processes and dynamical systems. The authors set out to make a significant contribution to closing the gap between model development and the supporting mathematics. This is done by: Summarising and presenting the state-of-the-art in modeling epidemics on networks with results and readily usable models signposted throughout the book; Presenting different mathematical approaches to formulate exact and solvable models; Identifying the concrete links between approximate models and their rigorous mathematical representation; Presenting a model hierarchy and clearly highlighting the links between model assumptions and model complexity; Providing a reference source for advanced undergraduate students, as well as doctoral students, postdoctoral researchers and academic experts who are engaged in modeling stochastic processes on networks; Providing software that can solve differential equation models or directly simulate epidemics on networks. Replete with numerous diagrams, examples, instructive exercises, and online access to simulation algorithms and readily usable code, this book will appeal to a wide spectrum of readers from different backgrounds and academic levels. Appropriate for students with or without a strong background in mathematics, this textbook can form the basis of an advanced undergraduate or graduate course in both mathematics and other departments alike.
The Mathematics of Mechanobiology: Cetraro, Italy 2018 (Lecture Notes in Mathematics #2260)
by Antonio DeSimone Benoît Perthame Alfio Quarteroni Lev TruskinovskyThis book presents the state of the art in mathematical research on modelling the mechanics of biological systems – a science at the intersection between biology, mechanics and mathematics known as mechanobiology. The book gathers comprehensive surveys of the most significant areas of mechanobiology: cell motility and locomotion by shape control (Antonio DeSimone); models of cell motion and tissue growth (Benoît Perthame); numerical simulation of cardiac electromechanics (Alfio Quarteroni); and power-stroke-driven muscle contraction (Lev Truskinovsky).Each section is self-contained in terms of the biomechanical background, and the content is accessible to all readers with a basic understanding of differential equations and numerical analysis. The book disentangles the phenomenological complexity of the biomechanical problems, while at the same time addressing the mathematical complexity with invaluable clarity. The book is intended for a wide audience, in particular graduate students and applied mathematicians interested in entering this fascinating field.
The Mathematics of Medical Imaging
by Timothy G. FeemanThe basic mathematics of computerized tomography, the CT scan, are aptly presented for an audience of undergraduates in mathematics and engineering. Assuming no prior background in advanced mathematical analysis, topics such as the Fourier transform, sampling, and discrete approximation algorithms are introduced from scratch and are developed within the context of medical imaging. A chapter on magnetic resonance imaging focuses on manipulation of the Bloch equation, the system of differential equations that is the foundation of this important technology. Extending the ideas of the acclaimed first edition, new material has been adeed to render an even more accessible textbook for course usage. This edition includes new discussions of the Radon transform, the Dirac delta function and its role in X-ray imaging, Kacmarz's method and least squares approximation, spectral filtering, and more. Copious examples and exercises, new computer-based exercises, and additional graphics have been added to further delineate concepts. The use of technology has been revamped throughout with the incorporation of the open source programming environment R to illustrate examples and composition of graphics. All R code is available as extra source material on SpringerLink. From the reviews of the first edition: "This book is valuable, for it addresses with care and rigor the relevance of a variety of mathematical topics to a real-world problem. . . . T his book is well written. It serves its purpose of focusing a variety of mathematical topics onto a real-world application that is in its essence mathematics. " -The Journal of Nuclear Medicine, Vol. 51 (12), December, 2010 "This new book by Timothy Feeman, truly intended to be a beginner's guide, makes the subject accessible to undergraduates with a working knowledge of multivariable calculus and some experience with vectors and matrix methods. . . . author handles the material with clarity and grace. . . " -The Mathematical Association of America, February, 2010
Mathematics of Public Health: Mathematical Modelling from the Next Generation (Fields Institute Communications #88)
by Jummy David Jianhong WuThis volume addresses SDG 3 from a mathematical standpoint, sharing novel perspectives of existing communicable disease modelling technologies of the next generation and disseminating new developments in modelling methodologies and simulation techniques. These methodologies are important for training and research in communicable diseases and can be applied to other threats to human health. The contributions contained in this collection/book cover a range of modelling techniques that have been and may be used to support decision-making on critical health related issues such as: Resource allocation Impact of climate change on communicable diseases Interaction of human behaviour change, and disease spread Disease outbreak trajectories projection Public health interventions evaluation Preparedness and mitigation of emerging and re-emerging infectious diseases outbreaks Development of vaccines and decisions around vaccine allocation and optimization The diseases and public health issues in this volume include, but are not limited to COVID-19, HIV, Influenza, antimicrobial resistance (AMR), the opioid epidemic, Lyme Disease, Zika, and Malaria. In addition, this volume compares compartmental models, agent-based models, machine learning and network. Readers have an opportunity to learn from the next generation perspective of evolving methodologies and algorithms in modelling infectious diseases, the mathematics behind them, the motivation for them, and some applications to supporting critical decisions on prevention and control of communicable diseases. This volume was compiled from the weekly seminar series organized by the Mathematics for Public Health (MfPH) Next Generation Network. This network brings together the next generation of modellers from across Canada and the world, developing the latest mathematical models, modeling methodologies, and analytical and simulation tools for communicable diseases of global public health concerns. The weekly seminar series provides a unique forum for this network and their invited guest speakers to share their perspectives on the status and future directions of mathematics of public health.
Mathematics of Public Health: Proceedings of the Seminar on the Mathematical Modelling of COVID-19 (Fields Institute Communications #85)
by Jianhong Wu V. Kumar MurtyCurated by the Fields Institute for Research in Mathematical Sciences from their COVID-19 Math Modelling Seminars, this first in a series of volumes on the mathematics of public health allows readers to access the dominant ideas and techniques being used in this area, while indicating problems for further research. This work brings together experts in mathematical modelling from across Canada and the world, presenting the latest modelling methods as they relate to the COVID-19 pandemic. A primary aim of this book is to make the content accessible so that researchers share the core methods that may be applied elsewhere. The mathematical theories and technologies in this book can be used to support decision makers on critical issues such as projecting outbreak trajectories, evaluating public health interventions for infection prevention and control, developing optimal strategies to return to a new normal, and designing vaccine candidates and informing mass immunization program. Topical coverage includes: basic susceptible-exposed-infectious-recovered (SEIR) modelling framework modified and applied to COVID-19 disease transmission dynamics; nearcasting and forecasting for needs of critical medical resources including personal protective equipment (PPE); predicting COVID-19 mortality; evaluating effectiveness of convalescent plasma treatment and the logistic implementation challenges; estimating impact of delays in contact tracing; quantifying heterogeneity in contact mixing and its evaluation with social distancing; modelling point of care diagnostics of COVID-19; and understanding non-reporting and underestimation. Further, readers will have the opportunity to learn about current modelling methodologies and technologies for emerging infectious disease outbreaks, pandemic mitigation rapid response, and the mathematics behind them. The volume will help the general audience and experts to better understand the important role that mathematics has been playing during this on-going crisis in supporting critical decision-making by governments and public health agencies.
Mathematik der Pandemie
by Simon Syga Dieter Wolf-Gladrow Andreas DeutschDie COVID-19-Pandemie hat weltweit dramatische Folgen. Mathematische Modelle spielen bei ihrer Bewertung eine zentrale Rolle: Sie sollen die Wirkung von Maßnahmen abschätzen, die oft mit Einschränkungen individueller Freiheiten einhergehen. Umso mehr sollte das Wissen um die Mathematik der Pandemie nicht nur Experten überlassen bleiben. Dieses Buch erläutert grundlegende Begriffe und Modelle, und klärt weitverbreitete Missverständnisse auf. Das Buch gibt insbesondere Antwort auf folgende Fragen:Was sagen Kennzahlen wie Inzidenz, Reproduktionszahl, Hospitalisierungsrate oder Impfquote über die Pandemie?Was ist der Unterschied von linearem und exponentiellem Wachstum?Was ist Herdenimmunität? Warum werden sich trotz Herdenimmunität fast alle Ungeimpften anstecken?Was ist der Effekt von Kontaktbeschränkungen und Impfung?Warum sind Vorhersagen in der Pandemie schwierig?
Maths, Physics and Clinical Measurement for Anaesthesia and Intensive Care
by Hozefa Ebrahim Ashton-Cleary DavidMaths, physics and clinical measurement hold a degree of mystery and trepidation for many working and training in anaesthesia, intensive care and theatre practice. This important new book covers these core topics in a logical and structured format, creating a more enjoyable learning experience that is accessible and easy to digest. Each chapter opens with a set of learning objectives and summary of chapter contents. Following this is a clinical scenario that relates to the themes of the chapter and a number of hypothetical questions relating to the scenario are laid-out. Clinical pearls are presented in boxes for more advanced learning opportunities. Each chapter closes with a set of MCQ or SBA self-test questions to test the readers' knowledge of the chapter. This book covers everything needed for the FFICM and FRCA exams, making it an essential text for exam candidates, tutors, and those working in theatres, anaesthesia and the ICU.
Matrices, Statistics and Big Data: Selected Contributions from IWMS 2016 (Contributions to Statistics)
by S. Ejaz Ahmed Francisco Carvalho Simo PuntanenThis volume features selected, refereed papers on various aspects of statistics, matrix theory and its applications to statistics, as well as related numerical linear algebra topics and numerical solution methods, which are relevant for problems arising in statistics and in big data. The contributions were originally presented at the 25th International Workshop on Matrices and Statistics (IWMS 2016), held in Funchal (Madeira), Portugal on June 6-9, 2016. The IWMS workshop series brings together statisticians, computer scientists, data scientists and mathematicians, helping them better understand each other’s tools, and fostering new collaborations at the interface of matrix theory and statistics.
Matrix Head and Neck Reconstruction: Scalable Reconstructive Approaches Organized by Defect Location
by Brendan C. Stack Mauricio A. Moreno Jennings R. Boyette Emre A. VuralHead and neck reconstruction can be challenging due to the anatomical complexity of the area, its impact upon function, and the common need for adjuvant treatment postoperatively in cases of malignancy. Furthermore, the results are very visible and may significantly affect the patient’s ability to reintegrate socially. This unique surgical atlas is organized as a matrix of options, from simple to complex, covering all described anatomical areas of the head and neck. The organization of defects and reconstructive options, combined with illustrations and high-resolution intraoperative photography, make this the premier reconstructive reference that will be accessible when difficult reconstructive situations arise. The matrix concept is a unique approach to organizing and presenting facial, head and neck defects. Most clinical cases present as a defect or as the potential for a defect after a resection. The matrix approach is a human cognitive approach to problem solving. This atlas allows the reader to search out their potential defects and study the possible reconstructive options available to them. This spectrum of possibilities may help the surgeon to decide whether to manage on the case on their own or refer it for more expertise. It is also a visible tool to assist surgeons in reviewing options and making decisions with patients in the informed consent process.The matrix presents defects with internal consistency throughout the text and is organized in an anatomic order. Each anatomic sub-site is further subdivided into recognized clinical sub-units, and each potential defect is then illustrated in a standardized fashion to promote clarity and uniformity for easy reference. Commonly associated defects are linked. Each specific defect is then addressed, presenting reconstructive options of increasing complexity, with photography to show a staged approach to pre-reconstruction, site preparation, flap selection, flap inset, and final results acutely post-operatively and at a delayed time point.Matrix Head and Neck Reconstruction combines and distills the work of major head and neck reconstruction and facial plastic surgery to provide a broad and deep resource that is highly pictorial and practical in providing a scalable approach to reconstruction.
Matrix Metalloproteinase Inhibitors
by Satya Prakash GuptaMatrix metalloproteinases (MMPs) are proteolytic enzymes that are involved in many physiological and pathological processes. The field of MMP research is very important due to the implications of the distinct paralogs in both human physiology and pathology. Over-activation of these enzymes results in tissue degradation, producing a wide array of disease processes such as rheumatoid arthritis, osteoarthritis, tumor growth and metastasis, multiple sclerosis, congestive heart failure, and others. Thus MMP inhibitors are candidates for therapeutic agents to combat a number of diseases. The present book discusses the design and development of different classes of inhibitors of important classes of MMPs, such as gelatinases and collagenases. The articles focus specifically on structure-activity relationships of all classes of compounds and on their modes of action and specificity of binding with the receptors based on experimental and theoretical studies. These studies constitute a valuable asset for all those involved in drug development.
Matrix Pathobiology and Angiogenesis (Biology of Extracellular Matrix #12)
by Evangelia Papadimitriou Constantinos M. MikelisIn the vasculature, the extracellular matrix (ECM) is involved in the regulation of angiogenesis, vascular mechanosensing, and blood vessel stability. This book aims to provide the reader with an overview of the various roles of the ECM during angiogenesis and covers its important role for the maintenance of vascular integrity, capillary and arterial morphogenesis, as well as lymphangiogenesis. Furthermore, aspects of regulation of endothelial cell and pericyte functions by the ECM under physiological and pathological conditions are discussed. In addition, the reader will learn more about different approaches to exploit ECM molecules for designing therapeutic approaches or as biomarkers to improve therapeutic decisions. Comprehensive and cutting-edge, Matrix Pathobiology and Angiogenesis is a valuable resource for experienced researchers and early career scientist alike, who are interested in in learning more about this exciting and developing field. The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology and the International Society for Matrix Biology.
Matron at Last
by Evelyn Prentis'When do you have a bath?' I asked Mrs Turgoose. 'I hope you're not suggesting that I don't look after meself properly,' she said crossly. 'There was a woman who used to use it, but that was because she was a bit stuck up. She soon went off the idea when it started to get cold.'After working as a nurse for thirty years, Evelyn left the hospital to become a full-time Matron at The Lodge - a home for elderly ladies of reduced circumstances. Evelyn was nothing like the matrons she had known and feared in the past. In spite of broken nights and hot dinners left to get cold, Mrs Peters with her temper and Mrs Harrison with her 24-hour piano playing, her new role offered a chance to make a difference to her ladies' lives. Even though it did mean she was on call twenty-four hours a day, this is Evelyn's funny and affectionate memoir of her years - at last! - as a Matron.
Matron in Charge
by Evelyn Prentis'She should never have kept the business going after her husband died. Running a betting shop is no job for a woman. Especially when she's got bad legs.'After a short stay at hospital herself, Evelyn Prentis wondered what was in store for her when she returned to work. From the door-slamming Miss Cromwell to Mrs Silver's shoplifting and Mrs May coming over all queer, being Matron in charge of the Lodge was rarely straightforward.So when her ladies became unusually united in their grumbling about newest resident Ivy, the woman who'd kept the betting shop on the High Street, Evelyn was ready for all hell to break loose.But instead, with openness and kindness, Ivy won people over and even started bringing them together. Suddenly, being in charge of the Lodge was no trouble at all ...
Matron Knows Best
by Joan WoodcockJoan Woodcock always dreamed of becoming a nurse. And in 1966 the dream came true. From her very first day as a naive 16 year old cadet, standing nervously outside the matron's office, this is Joan's story of an eventful career spanning over forty years in NHS nursing.Working on hospital wards, casualty units and out in the community, as well as stints in a prison and a police unit dealing with sexual assault, Joan has seen it all. In this moving memoir she gives an honest, revealing account of a challenging, unpredictable and ultimately rewarding life in nursing.From an early encounter with a horrific axe injury to the patient who swallowed their suppositories, to daily dealings with difficult patients and all kinds of bodily fluids, Joan shares memories of laughter and tragedy, and of the now defunct matron system that at one time instilled nurses with such high standards of professionalism and patient care.
Matron on Call: More true stories of a 1960s NHS nurse
by Joan WoodcockJoan Woodcock always dreamed of becoming a nurse. And in 1966 the dream came true. From her very first day as a naive sixteen-year-old cadet, standing nervously outside the matron's office, this is Joan's story of an eventful career spanning over forty years in NHS nursing. Working on hospital wards, casualty units and out in the community, as well as stints in a prison and a police unit dealing with sexual assault, Joan has seen it all. In this moving memoir she gives an honest, revealing account of a challenging, unpredictable and ultimately rewarding life in nursing. From an early encounter with a horrific axe injury, to the patient who swallowed their suppositories, to daily dealings with difficult patients and all kinds of bodily fluids, Joan shares memories of laughter and tragedy, and of the now defunct matron system that at one time instilled nurses with such high standards of professionalism and patient care.
Matron on Call: More true stories of a 1960s NHS nurse
by Joan WoodcockJoan Woodcock always dreamed of becoming a nurse. And in 1966 the dream came true. From her very first day as a naive sixteen-year-old cadet, standing nervously outside the matron's office, this is Joan's story of an eventful career spanning over forty years in NHS nursing. Working on hospital wards, casualty units and out in the community, as well as stints in a prison and a police unit dealing with sexual assault, Joan has seen it all. In this moving memoir she gives an honest, revealing account of a challenging, unpredictable and ultimately rewarding life in nursing. From an early encounter with a horrific axe injury, to the patient who swallowed their suppositories, to daily dealings with difficult patients and all kinds of bodily fluids, Joan shares memories of laughter and tragedy, and of the now defunct matron system that at one time instilled nurses with such high standards of professionalism and patient care.
A Matter of Appearance: A Memoir
by Emily WellsA dazzling memoir of chronic illness that explores the fraught intersection between pain, language, and gender, by a debut author.Emily Wells spent her childhood dancing through intense pain she assumed was normal for a ballerina pushing her body to its limits. For years, no doctor could tell Wells what was wrong with her, or they told her it was all in her head.In A Matter of Appearance, Wells traces her journey as she tries to understand and define the chronic pain she has lived with all her life. She draws on the critical works of Freud, Sontag, and others to explore the intersection between gender, pain, and language, and she traces a direct line from the &“hysteria patients&” at the Salpêtrière Hospital in nineteenth-century Paris to the contemporary New Age healers in Los Angeles, her stomping ground. At the crux of Wells&’ literary project is the dilemma of how to diagnose an experience that is both private and public, subjective and quantifiable, and how to express all this in words.&“Gorgeously written and brilliantly argued, A Matter of Appearance uses chronic illness as a lever to investigate the life of a body. It&’s complex, inconclusive, and incredibly clear-eyed. Moving fluidly between histories of psychoanalysis, desire, ambition, pathology, Wells reminds us of the liminal state we all live in between sickness and health.&”—Chris Kraus, author of Aliens & Anorexia and Summer of Hate
A Matter of Gravity
by Phyllis Aronoff Hélène Vachon Howard ScottA Matter of Gravity is a playful and touching treatment of illness and tragedy, in which an enigmatic manuscript brings together two disparate male characters. Black humor and compassion brilliantly illuminate their tragic encounter.Hélène Vachon is the author of two novels and more than twenty works of children's literature. Her books have been nominated for many prizes, including the Governor General's Literary Award and the Mr. Christie's Book Award.Howard Scott is a Montreal literary translator who specializes in the genres of fiction and nonfiction.Phyllis Aronoff is former president of the Literary Translators' Association of Canada.
The Matter of the Heart: A History of the Heart in Eleven Operations
by Thomas MorrisAn eye-opening and heroic story of pioneering heart surgeons, structured around eleven operations.For thousands of years the human heart remained the deepest of mysteries; both home to the soul and an organ too complex to touch, let alone operate on. Then, in the late nineteenth century, medics began going where no one had dared go before. The following decades saw the mysteries of the heart exposed, thanks to pioneering surgeons, brave patients and even sacrificial dogs. In eleven landmark operations, Thomas Morris tells us stories of triumph, reckless bravery, swaggering arrogance, jealousy and rivalry, and incredible ingenuity: the trail-blazing ‘blue baby’ procedure that transformed wheezing infants into pink, healthy children; the first human heart transplant, which made headline news around the globe. And yet the heart still feels sacred: just before the operation to fit one of the first artificial hearts, the patient’s wife asked the surgeon if he would still be able to love her.The Matter of the Heart gives us a view over the surgeon’s shoulder, showing us the heart’s inner workings and failings. It describes both a human story and a history of risk-taking that has ultimately saved millions of lives.
Matters of Choice: The Physician, Shaman, And Matters Of Choice (The Cole Trilogy #3)
by Noah GordonA woman physician confronts the moral issues of her time in the third novel in the New York Times–bestselling author&’s historical medical trilogy. Roberta Jeanne d&’Arc Cole is favored to be named associate chief of medicine at a Boston hospital. She is married to a surgeon. They own a trophy residence on historic Brattle Street in Cambridge and a summer house in the Berkshire Hills. Everything melts away. Her gender and her work at an abortion clinic cost her the hospital appointment. Her marriage fails. Crushed, she goes to the farmhouse in Western Massachusetts, thinking to sell it, and finds an unexpected life. How she continues to fight for every woman&’s right to choose, while acknowledging her own ticking clock and maternal yearning, makes this prize-winning third story of the Cole trilogy as relevant as tomorrow.