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Melatonin: Methods and Protocols (Methods in Molecular Biology #2550)
by Ralf Jockers Erika CeconThis volume covers the latest techniques that study the synthesis of melatonin, its receptor function, and its effects at the cellular and systemic level. The chapters are organized into three parts. Part One describes methods for the detection of melatonin and its biological derivatives in various biological samples, the manipulation of melatonin synthesis by the pineal gland in animals, and the principal source of melatonin in mammals. Part Two explores methods to measure the biological effects and consequences of melatonin binding to high-affinity G protein-coupled receptors. Part Three describes methods to measure the physiological effects that are regulated by melatonin in animals, particularly in rodent models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Melatonin: Methods and Protocols is a valuable resource for any researcher interested in investigating melatonin, from its production to its mechanisms of action and systemic effects.
Melatonin and Melatonergic Drugs in Clinical Practice
by V. Srinivasan Amnon Brzezinski Sukru Oter Samuel D. ShillcuttThe book aims to cover basic physiologic functions of melatonin, and its therapeutic applications in humans for a variety of clinically relevant disorders. This book contains chapters on the recent aspects of melatonin physiology, its receptors and their role in mitochondrial function, its immunomodulatory role and importance in seasonal dependent diseases, role in human reproduction, role in sleep, circadian rhythm and sleep disorders, role in neurologic disorders such as Parkinson's disease, Alzheimer's disease. Additionally, melatonin's therapeutic use in neurobehavioral disorders in children, migraine and tension headache is also covered in this book. Melatonin's antioxidant role in Duchenne's muscular dystrophy and in glaucoma have also been discussed in short chapters. Two major melatonin agonists, ramelteon and agomelatine are discussed extensively on their current clinical application and ongoing research. Two chapters on agomelatonin and its role in mood disorders, particularly depressive disorders, are an important feature of this book. The chapters are written by experts from the global academia recognized for their original research and published work in the field of melatonin science.
Melatonin, Neuroprotective Agents and Antidepressant Therapy
by Francisco López-Muñoz Venkataramanujam Srinivasan Domenico De Berardis Cecilio Álamo Takahiro A. KatoThis work is a guidebook for clinicians who are involved in treating depressive patients and also serves the research scientists who are working on the psychopharmacological mechanisms of antidepressant actions and psychopathological mechanisms underlying mood disorders. Mood disorders such as major depressive disorder (MDD), bipolar disorder (BPD) and seasonal affective disorder (SAD) are the most disabling disorders that are among the most expensive of all medical illnesses. The pathophysiology of mood disorders is very complex and involves many mechanisms like circadian rhythm disruption, sleep abnormalities, melatonin rhythm abnormalities and alterations in melatonin receptor mechanisms, abnormalities in monoaminergic neurotransmitter mechanisms, glutamatergic release mechanisms, hippocampal neurogenesis, and abnormal immune and cytokine release mechanisms. Many antidepressants that are in clinical use today including the recently introduced novel agents like agomelatine or other antidepressants cause clinical remission by resynchronizing disrupted circadian rhythms and melatonin receptor functions, enhancing monoaminergic neurotransmission, promoting hippocampal neurogenesis, and regulating immune mechanisms. This book explains various etiological factors that are involved in the pathogenesis of mood disorders and the mechanisms of therapeutic actions of antidepressants including the recently introduced agomelatine and other antidepressants that exhibit rapid onset of action with greater efficacy and fewer side effects. .
Melioidosis and Glanders: Global Status 2010 edition
by Gideon Informatics Dr Stephen BergerMelioidosis and Glanders: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into six subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status of the disease4. Potential use in Bioterrorism 5. Status of the disease in a specific country 6. References Melioidosis and Glanders: Global Status includes separate sections on Glanders, and Melioidosis.
Melt Extrusion
by Michael A. Repka Nigel Langley James DinunzioThis volume provides readers with the basic principles and fundamentals of extrusion technology and a detailed description of the practical applications of a variety of extrusion processes, including various pharma grade extruders. In addition, the downstream production of films, pellets and tablets, for example, for oral and other delivery routes, are presented and discussed utilizing melt extrusion. This book is the first of its kind that discusses extensively the well-developed science of extrusion technology as applied to pharmaceutical drug product development and manufacturing. By covering a wide range of relevant topics, the text brings together all technical information necessary to develop and market pharmaceutical dosage forms that meet current quality and regulatory requirements. As extrusion technology continues to be refined further, usage of extruder systems and the array of applications will continue to expand, but the core technologies will remain the same.
The MELT Method: A Breakthrough Self-Treatment System to Eliminate Chronic Pain, Erase the Signs of Aging, and Feel Fantastic in Just 10 Minutes a Day!
by Sue HitzmannIn The MELT Method, therapist Sue Hitzmann offers a breakthrough self-treatment system to combat chronic pain and erase the effects of aging and active living—in as little as ten minutes a day.With a focus on the body's connective tissues and the role they play in pain, stress, weight gain, and overall health, Hitzmann's life-changing program features techniques that can be done in your own home.A nationally known manual therapist and educator, Hitzmann helps her clients find relief from pain and suffering by taking advantage of the body's natural restorative properties. The MELT Method shows you how to eliminate pain, no matter what the cause, and embrace a happier, healthier lifestyle.
MELT Performance: A Step by-Step Program to Accelerate Your Fitness Goals, Improve Balance and Control, and Prevent Chronic Pain and Injuries for Life
by Sue HitzmannThis long-awaited follow-up to the New York Times bestselling The MELT Method introduces a unique, scientific-based proactive training program for improving overall balance, performance, and control while preventing pain and injury.Are you an athlete facing constant injuries that hold you back from achieving peak performance? Are you someone who wants to stay fit, but are dealing with aches and pains that make it more difficult to work out? Do you want to exercise or train without being sidelined by stress fractures, strained ligaments, and painful joints? If you answered yes to any of these questions, you need MELT Performance.The conditioning you do to stay in shape and perfect and improve performance—running on a treadmill, doing squats or bicep curls, practicing our backhand, even doing downward dog—requires repetitive movements. Yet 80% of orthopedic injuries are the result of repetitive motion, not trauma or accidents. In MELT Performance, nationally recognized educator, manual therapist, and exercise physiologist Sue Hitzmann introduces a revolutionary program centered on neurological joint stability or Neurostrength, that will revolutionize your health and performance.The foundation of MELT Performance is stability. To stay injury free, our joints must stable before we do repetitive motions. Acquiring stability allows the body to respond to the demands of motion. It’s the way we were designed to function—and allows us to move more efficiently, improve coordination, and save our joints. Knowing how to check in, restore, and reintegrate joint stability before it’s compromised gives an unparalleled advantage to anyone who trains hard to perform at their best. Hitzmann’s techniques are proven to work—they’re already used by world renowned professional athletes and fitness enthusiasts. If you’re ready to improve your performance and prevent injury, MELT Performance is essential no matter what sport or activity you pursue.MELT Performance includes black-and-white instructional images throughout.
Melting the Surgeon's Heart
by Becky WicksCan the new search and rescue paramedic break through the brooding surgeon&’s icy barriers? Escape on an Icelandic adventure with Becky Wicks&’s latest Harlequin Medical Romance to find out! CAN SHE THAW HIS FROZEN HEART? Haunted by his father&’s infamous financial crimes, renal surgeon Gunnar Johansson has sworn off marriage and children. He won&’t subject anyone else to an entire country&’s scorn! Isolating himself, he volunteers for Reykjavik&’s search and rescue. But new paramedic Mahlia is a temptation he never saw coming! Soon her warmth and courage when battling Iceland&’s harshest elements—and her own painful past—threaten to melt his icy resolve…From Harlequin Medical: Life and love in the world of modern medicine.
Melting the Trauma Doc's Heart: From Heartache To Forever (yoxburgh Park Hospital) / Melting The Trauma Doc's Heart (Harlequin Lp Medical Ser.)
by Alison RobertsHe ran away from his past…Is she a reason to stop running?Trauma doctor Zac Cameron escaped the horrors of the battlefield and settled in a small community hospital. He’s just about coping until an unexpected visitor—renowned surgeon Dr. Olivia Donaldson—whirls into town. She might be his boss’s estranged daughter, but their chemistry’s instant—and irresistible! Yet Zac’s emotions are completely off-limits, unless Olivia’s the one who can thaw his frozen heart…?“I read this in one sitting. This was such a heart-felt story. I loved the characters.The author really did a fantastic job…. I highly recommend this story to anyone. It was a real treat to read.”— Goodreads on Pregnant with Her Best Friend’s Baby“This had a little bit of everything, dipping its toes into fairytale waters and bringing a Cinderella-like feel…. And Alison Roberts balances everything pretty-much perfectly bringing an uplifting romance between two endearing characters which simply leaves your heart sighing happily.”—Goodreads on Their Newborn Baby Gift
Membrane Abnormalities In Hypertension (Routledge Revivals #1)
by Chiu-Yin KwanFirst Published in 1989, this two-volume set offers a full insight into membrane abnormalities during a state of hypertension. Carefully compiled and filled with diagrams, references and information this set is recommended for students of medicine and other professionals in their respective fields.
Membrane Fusion
by Jan WilschutThis balanced volume provides a broad and coherent overview of recent progress in membrane fusion research—highlighting an interdisciplinary treatment of the subject from the fields of biophysics, biochemistry, cell biology, virology, and biotechnology—in a single volume., Featuring easy-access sections on the general properties of membranes and applications of membrane fusion techniques, this valuable sourcebook outlines membrane structure, lipid polymorphism, and intermembrane forces ... covers membrane fusion in model systems ... presents the fusogenic properties of enveloped viruses ... discusses the fusion and flow of intracellular membranes and cell-cell fusion occurring during fertilization and myogenesis ... offers applications of membrane fusion techniques in cell-biological research and biotechnology ... and more. Supplying a comprehensive view of this exciting topic, Membrane Fusion is a working resource for molecular, cell, and membrane biologists; biophysicists; biochemists; virologists; biotechnologists; microbiologists; immunologists; physiologists; and graduate and medical school students in biophysics, biochemistry, physiology, virology, cell biology, and biotechnology.
Membrane Potential Imaging in the Nervous System
by Dejan Zecevic Marco CanepariThe book is structured in five sections, each containing several chapters written by experts and major contributors to particular topics. The volume starts with a historical perspective and fundamental principles of membrane potential imaging and continues to cover the measurement of membrane potential signals from dendrites and axons of individual neurons, measurements of the activity of many neurons with single cell resolution, monitoring of population signals from the nervous system, and concludes with the overview of new approaches to voltage-imaging. The book is targeted at all scientists interested in this mature but also rapidly expanding imaging approach.
Membrane Proteins in Aqueous Solutions: From Detergents to Amphipols (Biological and Medical Physics, Biomedical Engineering)
by Jean-Luc PopotThis book is the first to be entirely devoted to the challenging art of handling membrane proteins out of their natural environment, a key process in biological and pharmaceutical research, but one plagued with difficulties and pitfalls. Written by one of the foremost experts in the field, Membrane Proteins in Aqueous Solutions is accessible to any member of a membrane biology laboratory. After presenting the structure, functions, dynamics, synthesis, natural environment and lipid interactions of membrane proteins, the author discusses the principles of extracting them with detergents, the mechanisms of detergent-induced destabilization, countermeasures, and recent progress in developing detergents with weaker denaturing properties. Non-conventional alternatives to detergents, including bicelles, nanodiscs, amphipathic peptides, fluorinated surfactants and amphipols, are described, and their relative advantages and drawbacks are compared. The synthesis and solution properties of the various types of amphipols are presented, as well as the formation and properties of membrane protein/amphipol complexes and the transfer of amphipol-trapped proteins to detergents, nanodiscs, lipidic mesophases, or living cells. The final chapters of the book deal with applications: membrane protein in vitro folding and cell-free expression, solution studies, NMR, crystallography, electron microscopy, mass spectrometry, amphipol-mediated immobilization of membrane proteins, and biomedical applications. Important features of the book include introductory sections describing foundations as well as the state-of-the-art for each of the biophysical techniques discussed, and topical tables which organize a widely dispersed literature. Boxes and annexes throughout the book explain technical aspects, and twelve detailed experimental protocols, ranging from in vitro folding of membrane proteins to single-particle electron cryomicroscopy, have been contributed by and commented on by experienced users. Membrane Proteins in Aqueous Solutions offers a concise, accessible introduction to membrane protein biochemistry and biophysics, as well as comprehensive coverage of the properties and uses of conventional and non-conventional surfactants. It will be useful both in basic and applied research laboratories and as a teaching aid for students, instructors, researchers, and professionals within the field.
Membrane Receptors, Channels and Transporters in Pulmonary Circulation
by Jason X. Yuan Jeremy P. WardMembrane Receptors, Channels and Transporters in Pulmonary Circulation is a proceeding of the 2008 Grover Conference (Lost Valley Ranch and Conference Center, Sedalia, Colorado; September 3-7, 2008), which provided a forum for experts in the fields of those receptors, channels and transporters that have been identified as playing key roles in the physiology and pathophysiology of the pulmonary circulation. The book rigorously addresses: i) recent advances in our knowledge of receptors, channels and transporters and their role in regulation of pulmonary vascular function; ii) how modulation of expression and function of receptors, channels and transporters and their interrelationships contribute to the pathogenesis of pulmonary vascular disease; and iii) the therapeutic opportunities that may be revealed by enhancing our understanding of this area. The overall goal was to explore the mechanisms by which specific receptors, channels and transporters contribute to pulmonary vascular function in both health and disease, and how this knowledge may lead to novel interventions in lung dysplasia, pulmonary edema, lung injury, and pulmonary and systemic hypertension to reduce and prevent death from lung disease. Membrane Receptors, Channels and Transporters in Pulmonary Circulation is divided into six parts. Part 1 (Ion Channels in the Pulmonary Vasculature: Basics and New Findings) is designated for basic knowledge and recent findings in the research field of ion channels in pulmonary circulation. There are five chapters in Part I discussing the function, expression, distribution and regulation of various ion channels present in pulmonary vascular smooth muscle cells and how these channels are integrated to regulate intracellular Ca2+ and cell functions. Part II (TRP Channels in the Pulmonary Vasculature: Basics and New Findings) is composed of five chapters that are exclusively designed to discuss the role of a recently identified family of cation channels, transient receptor potential (TRP) channels, in the regulation of pulmonary vascular tone and arterial structure. Part III (Pathogenic Role of Ion Channels in Pulmonary Vascular Disease) includes four chapters that discuss how abnormal function and expression of various ion channels contribute to changes in cell functions and the development of pulmonary hypertension. Part IV (Receptors and Signaling Cascades in Pulmonary Arterial Hypertension) consists of five chapters devoted to the role of bone morphogenetic protein receptors, Notch receptors, serotonin receptors, Rho kinase and vascular endothelial growth factor receptors in the development of pulmonary arterial hypertension. Part V (Receptors and Transporters: Role in Cell Function and Hypoxic Pulmonary Vasoconstriction) includes four chapters designed to illustrate the potential mechanisms involved in oxygen sensing and hypoxia-induced pulmonary vasoconstriction and hypertension. Part VI (Targeting Ion Channels and Membrane Receptors in Developing Novel Therapeutic Approaches for Pulmonary Vascular Disease) consists five chapters which discuss the translational research involving on membrane receptors, channels and transporters, including their potential as novel drug targets. We hope that Membrane Receptors, Channels and Transporters in Pulmonary Circulation will allow readers to foster new concepts and new collaborations and cooperations among investigators so as to further understand the role of receptors, channels and transporters in lung pathophysiology. The ultimate goal is to identify new mechanisms of disease, as well as new therapeutic targets for pulmonary vascular diseases. An additional outcome should be enhanced understanding of the role of these entities in systemic vascular pathophysiology, since the conference will include researchers and clinicians with interests in both pulmonary and systemic circulations.
Membrane Structure in Disease and Drug Therapy
by Svante CornellThis study asserts that cellular and intracellular membranes are active in every aspect of the body's physiology and pathophysiology. It compares secondary through to quaternary structures and protien sequences and guages their influence on health, disease and drug therapy. The book highlights the importance of correlations, homologies and categori
Membrane Transporters in Drug Discovery and Development
by Qing YanStudies of membrane transporters have had a great impact on our understanding of human diseases and the design of effective drugs. In Membrane Transporters in Drug Discovery and Development: Methods and Protocols, expert researchers provide practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development. Chapters include new and useful fields and methodologies, including pharmacogenomics, nutrigenomics, systems biology, bioinformatics, nuclear magnetic resonance (NMR), imaging, and quantitative real-time-PCR. Transporter studies in drug discovery and development for various diseases are discussed, including neuropsychiatric disorders, cardiovascular diseases, ophthalmic diseases, cancer, and diabetes. Composed in the highly successful Methods in Molecular BiologyTM series format, each chapter contains a brief introduction, step-by-step methods, a list of necessary materials, and a Notes section which shares tips on troubleshooting and avoiding known pitfalls. Wide-ranging and current, Membrane Transporters in Drug Discovery and Development: Methods and Protocols delivers a collection of practical protocols that can be used immediately in the lab, along with critical surveys of key topics by leading researchers in the field.
Membranverfahren bei künstlichen Organen: Transportmodelle zur Auslegung extrakorporaler Verfahren (essentials)
by Manfred RaffKünstliche Organe sind Membranmodule, welche in einem extrakorporalen Kreislauf Blutinhaltsstoffe austauschen bzw. entfernen. Dabei kommen die klassischen Prinzipien der Crossflow- und der Gegenstromverfahren zur Anwendung. Manfred Raff zeigt, wie für die Auslegung derartiger Membranverfahren aus Modellen am differentiellen Membranelement funktionale Zusammenhänge von Zielgrößen und geometrischen, stofflichen und Betriebsparametern für das gesamte Modul abgeleitet werden. Die Ergebnisgleichungen können auch für technische Anwendungen eingesetzt werden. Der Autor:Manfred Raff hat sich in seinem Berufsleben mit dem wissenschaftlichen Schwerpunkt Membrantechnologie beschäftigt. Er war zunächst in der Industrie in der Forschung, Entwicklung und Produktion von Membranen und Modulen tätig. Später hat er als Hochschullehrer an der Hochschule Furtwangen Verfahrenstechnik gelehrt und Membranthemen, wie Messung der Porengrößenverteilung in Membranen, Untersuchung des Stofftransports in der künstlichen Leber, Simulation des Stofftransports bei der Highflux-Dialyse, erforscht. Nach der Pensionierung arbeitet er weiterhin als Lehrbeauftragter an der HFU, Campus Schwenningen.
Memmler's The Human Body in Health and Disease (11th Edition)
by Jason James Taylor Barbara Janson CohenThis widely read classic is an excellent primer on normal and abnormal anatomy, physiology and pathophysiology, basic microbiology, chemistry, and the human disease process. With a new design and a robust new multimedia electronic ancillary package, this Eleventh Edition will be even more engaging and understandable for students with diverse learning styles. This edition's new artwork includes real dissection photographs from Rohen's Color Atlas of Anatomy, Sixth Edition. New Disease in Context case scenarios integrated throughout each chapter show how content is applied to real-life situations. Icons direct students to relevant electronic materials.
Memmler's The Human Body in Health and Disease (12th Edition)
by Barbara Janson Cohen Jason James Taylor Kerry L. HullMemmler's The Human Body in Health and Disease is a textbook for introductory-level health professions and nursing students who need a basic understanding of anatomy and physiology, the interrelationships between structure and function, and the effects of disease on body systems.
Memmler's The Human Body In Health And Disease, Enhanced Edition With Navigate 2 Premier Access
by Kerry L. Hull Barbara Jansen CohenMemmler's The Human Body in Health and Disease, Fourteenth Edition is a textbook for introductory-level allied health and nursing students who need a basic understanding of anatomy and physiology, the interrelationships between structure and function, and the effects of disease on body systems. The features and content specifically meet the needs of those who may be starting their health career preparation with little or no science background. The Fourteenth Edition has been revised and updated where needed to improve organization of the material and to reflect current scientific thought.
Memoirs of Childhood and Youth
by Albert SchweitzerAutobiographical reflections on a boyhood that led to an astonishing intellectual career.
Memoirs Of A Woman Doctor
by Catherine Cobham Nawal El Saadawi<P>Rebelling against the constraints of family and society, a young Egyptian woman decides to study medicine, becoming the only woman in a class of men. Her encounters with the other students- as well as the male and female corpses in the autopsy room- intensify her dissatisfaction with and search for identity. She realizes men are not gods as her mother had taught her, that science cannot explain everything, and that she cannot be satisfied by living a life purely of the mind. <P>After a brief and unhappy marriage, she throws herself into her work, becoming a successful physician, but at the same time, she becomes aware of injustice and hypocrisy in society. Fulfillment and love come to her at last in a wholly unexpected way.
Memories After Abortion
by Vivian Wahlberg Beverley HancockThis book contains a foreword by Ann Thompson, Professor of Midwifery, University of Manchester. This illuminating book describes young people's thoughts and feelings before and after an abortion, and includes their experiences in the long term. It increases understanding and stimulates discussion of abortion issues without bias, and incorporates political, religious, social, physical and mental considerations in its wide-ranging approach. The personal narratives from both women and men make the issues particularly powerful. "Memories After Abortion" offers thought provoking ideas for all health and social care professionals involved in pregnancy issues. Undergraduate and postgraduate health and social care students, counsellors, therapists, teachers and youth/religious leaders will also find it invaluable. 'Consideration of abortion causes a lot of distress, anxiety and debate within society. This book should be read by women and men so that they can debate and understand each others' views and experiences in their relationships. It should also be read by nurses, midwives, doctors, health-service administrators and those providing social care.' - Ann M Thomson, in the Foreword.
Memorizing Medicine: Second Edition
by Paul Bentley Ben LovellThis book takes a unique approach to 'learning medicine' in a manner that places primary emphasis on recall. Drawing upon well-established psychological principles, it uses a broad range of strategies to maximize the ability of the reader to recollect large swathes of information at a later date. The result is an original and refreshing book in which no two pages are quite alike, and where facts are presented in a hierarchical fashion so that essential features of each condition or symptom can be grasped immediately, while finer points are given in more detailed reading.