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Mergers and Acquisitions: The Pharmaceutical and Biotechnology Industries (Routledge Studies in International Business and the World Economy)
by Mark Thomas Janna L. RoseCovid-19 has brought so much uncertainty, but one certainty is that the vaccine race will generate winners and losers in the pharmaceutical and biotechnology industries. This will have a major impact on merger and acquisition activity. While the plethora of merger and acquisition deals are abundantly reported by the news media, there is a clear lack of in-depth analysis on the multiple rationales and various challenges in the life sciences industry. By offering contributions from a variety of experts in the biotechnology and pharmaceutical industries, as well as experts on mergers and acquisitions, this edited collection will draw upon the knowledge of a variety of different actors within the fields of pharma and biotech. This book offers a timely exploration of the complexities of mergers and acquisitions in the pharmaceutical and biotechnology industries while seeking to bridge the gap between theory and practice. It presents a critical analysis of the rationale for acquisitions and studies the challenges of ensuring a successful deal. In the light of the Covid-19 pandemic, it will also explore the impact this may have on the industry, which may further stimulate merger and acquisition activity. It will be of interest to researchers, academics, policymakers, and students in the fields of strategy, management, governance, and the biotechnology and pharmaceutical industries.
Meridians: Maps of the Soul
by Mike MandlMeridians are the bridge between the psyche and soma, the system that allows our life force to flow through our body. Each of the twelve main meridians stand for a fundamental life principle and by examining them, we can begin a journey towards better health- as well as freedom and contentment.In this inspirational, easy-to-read deep dive, Mike Mandl uses his own wit and humour to explore the life principles of the meridians and offers a toolbox for self-diagnostic purposes, demonstrating how to strengthen these principles, correct imbalances, and keep in harmony with yourself through daily observation and maintenance.Translating the principles of Traditional Chinese Medicine into an engaging, accessible resource for practitioners and novices alike, this is the perfect first step in harnessing the meridians for your own self-actualisation.
Meridians: Maps of the Soul
by Mike MandlAn accessible explanation of the essence of TCM and Meridians.Meridians are the bridge between the psyche and soma, the system that allows our life force to flow through our body. Each of the twelve main meridians stand for a fundamental life principle and by examining them, we can begin a journey towards better health- as well as freedom and contentment.In this inspirational, easy-to-read deep dive, Mike Mandl uses his own wit and humour to explore the life principles of the meridians and offers a toolbox for self-diagnostic purposes, demonstrating how to strengthen these principles, correct imbalances, and keep in harmony with yourself through daily observation and maintenance.Translating the principles of Traditional Chinese Medicine into an engaging, accessible resource for practitioners and novices alike, this is the perfect first step in harnessing the meridians for your own self-actualisation.(P)2023 Hodder & Stoughton Limited
Meridians and Acupoints
by Bing Zhu Hongcai WangAn in-depth understanding of the meridians and acupoints lies at the heart of effective practice in traditional Chinese medicine. This book outlines everything that practitioners and students need to know. The book explains how meridians relate to the major organs, where they are located in the body, and how they are linked to the healthy flow of Qi and blood. A large section of the book is devoted to descriptions of specific acupoints - their names, how to locate them, an introduction to the symptoms they can be used to treat, and how. Also included is a thorough introduction to the basics of acupuncture practice, including how to prepare a patient prior to treatment, how to insert and manipulate acupuncture needles, how and when to use moxibustion and cupping techniques, and what to do if treatment goes wrong. This useful and authoritative textbook, compiled by the China Beijing International Acupuncture Training Centre (CBIATC), under the editorial direction of leading Chinese clinicians Zhu Bing and Wang Hongcai, is essential reading for students of traditional Chinese medicine, and an excellent reference for acupuncture practitioners at all levels.
Merkel Cell Carcinoma
by Murad Alam Siegrid S. Yu Jeremy S. BordeauxMerkel Cell Carcinoma is one of the first comprehensive, single-source clinical texts on the subject. Although not as common as melanoma, Merkel cell carcinoma is not rare - and it is both more deadly than melanoma and increasing at an epidemic rate. The book is clinical in focus and emphasizes treatment of this poorly understood cancer. Contributing authors include dermatologists, surgical oncologists, radiation oncologists, and medical oncologists from the US and around the world. Features: · Comprehensive single-source clinical reference · Treatment focus · Written for practitioners, with emphasis on clinical relevance and quick retrieval of information · Contributing authors represent all disciplines involved in treatment of Merkel cell carcinoma: dermatology, surgical oncology, radiation oncology, and medical oncology · International in perspective, with contributors from US and abroad · Members of active Merkel Cell Carcinoma Multicenter Interest Group have authored some of the chapters
Merritt’s Neurology
by Elan D Louis Stephan A MayerFor more than 60 years, Merritt’s Neurology has remained a trusted landmark text in clinical neurology, providing unparalleled guidance on neurologic protocols, treatment guidelines, clinical pathways, therapeutic recommendations, and imaging. The fourteenth edition reflects the state of today’s practice, with fully updated content and timely new sections and chapters. With this edition, Dr. James Noble joins Drs. Elan Louis and Stephan A. Mayer as co-editor, all of whom trained at Columbia University where Dr. H. Houston Merritt wrote the initial editions of this book. Lauded for its comprehensive coverage, colorful and dynamic visual style, readability, and ease of use, this up-to-date reference is ideal for neurologists, primary care physicians, and residents alike.
MERS Coronavirus: Methods and Protocols (Methods in Molecular Biology #2099)
by Rahul VijayThis volume provides various techniques and methodologies currently used in the study of MERS-CoV. Chapters are divided into four parts detailing evolution and entry of MERS-coronavirus, genetic alteration and structural determination of MERS-coronavirus proteins, quantitation of virus and anti-viral factors, and mouse models for MERS -coronavirus. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, MERS Coronavirus: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Mesenchymal Stem Cell in Veterinary Sciences
by Mudasir Bashir Gugjoo Amar PalThis book focuses on mesenchymal stem cells (MSCs) of animal origin, including their isolation, characterization, and clinical applications. After briefly discussing the historical development of the field of stem cell research, it describes the basic properties and nature of stem cells particularly in relation to MSCs. In turn, it reviews materials and methods used to isolate MSCs from various sources, culture expansion, characterization and long-term storage. It also explores the therapeutic efficacy, immunomodulation and anti-inflammatory, and differentiation properties of MSCs. Importantly, the book discusses the applications of genetic engineering to enhance the efficacy and potential of MSCs in regenerative medicine. The book largely addresses the potential applications of mesenchymal stem cells in therapies for important species of domesticated animals including sheep, goats, cattle, buffalo, cats, dogs and horses. Finally, the book presents an abridgement of challenges and future prospects of stem cell research and application in medicine, in general and veterinary sciences, in particular.
Mesenchymal Stem Cells
by Massimiliano GnecchiThis volume aims to outline the current status of the Mesenchymal Stem Cells(MSC) field in regenerative medicine and to propose clear and reproducible protocols to better define the identity, function and use of these cells that are today, more than ever, "under the spotlight". Mesenchymal Stem Cells: Methods and Protocols, Second Edition is organized into four sections. The first guides the reader through a series of state-of-the-art reviews summarizing the use of MSC for the treatment of various diseases. The other three sections are a collection of methodological chapters covering several aspects: isolation and characterization of MSC; expansion of MSC for clinical use; production and characterization of the MSC secretome. Written in the highly successful Methods in Molecular Biology series format, the method chapters include introductions to their respective topics, complete lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting which will help the researcher to avoid known pitfalls. Authoritative and cutting-edge, Mesenchymal Stem Cells: Methods and Protocols, Second Edition, aims to ensure successful results in the further study of this vital field.
Mesenchymal Stem Cells
by Darwin J. Prockop Bruce A. Bunnell Donald G. PhinneyFor over forty years, mesenchymal stem cells (MSCs) have been scrutinized and studied, garnering much attention due to their broad therapeutic efficacy. In this essential book, leaders in the field were assembled to contribute detailed methodologies for the isolation and characterization of human and rodent MSCs. Cutting edge and easy to use, this book is the perfect resource for scientists attempting to pursue this important and ever-developing field of research.
Mesenchymal Stem Cells and Immunomodulation
by Charles J. Malemud Eben AlsbergThis essential volume explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response. It also further defines the methodologies required to develop research on MSCs in vitro into established preclinical animal models including those which are proven replicas of autoimmunity and pre-term labor, to name but two. Mesenchymal Stem Cells and Immunomodulation, part of Springer's Stem Cell Biology and Regenerative Medicine, is an invaluable resource for researchers and clinicians working with stem cells, autoimmune disease, oncology, and reproductive medicine.
Mesenchymal Stem Cells - Basics and Clinical Application I
by Cornelia Kasper Massimo Dominici Roland Jacobs Ralf Hass Birgit WeyandProspective Isolation and Characterization of Human Bone Marrow-Derived MSCs, by A. Harichandan, K. Sivasubramaniyan, H.-J. Bühring Urine as a Source of Stem Cells, by Christina Benda, Ting Zhou, Xianming Wang, Weihua Tian, Johannes Grillari, Hung-Fat Tse, Regina Grillari-Voglauer, Duanqing Pei, Miguel A. Esteban Expansion of Mesenchymal Stem/Stromal Cells under Xenogenic-Free Culture Conditions, by Sven Kinzebach, Karen Bieback Adipose-Derived Mesenchymal Stem Cells: Biology and Potential Applications, by Danielle Minteer, Kacey G Marra, J Peter Rubin Potential for Osteogenic and Chondrogenic Differentiation of MSC, by Antonina Lavrentieva, Tim Hatlapatka, Anne Neumann, Birgit Weyand, Cornelia Kasper Potential for Neural Differentiation of Mesenchymal Stem Cells, by Letizia Ferroni, Chiara Gardin, Ilaria Tocco, Roberta Epis, Alessandro Casadei, Vincenzo Vindigni, Giuseppe Mucci, Barbara Zavan Migratory Properties of Mesenchymal Stem Cells, by Thomas Dittmar, Frank Entschladen Dissecting Paracrine Effectors for Mesenchymal Stem Cells, by Stefania Bruno, Federica Collino, Ciro Tetta, Giovanni Camussi Proteomics Approaches in the Identification of Molecular Signatures of Mesenchymal Stem Cells, by Yin Xiao, Jiezhong Chen Does the Adult Stroma Contain Stem Cells?, by Richard Schäfer
Mesenchymal Tumors of the Breast and Their Mimics: A Diagnostic Approach
by J. Jordi Rowe Erinn Downs-KellyThis book utilizes a uniform approach to provide a framework for the diagnosis of mesenchymal tumors of the breast while highlighting their mimics. Emphasis is placed on a practical approach to the morphologic interpretation and useful ancillary tests while exploring the differential diagnoses in depth. Given the overall low incidence of mesenchymal lesions of the breast along with their mimics, surgical pathologists are not consistently exposed to these spindle cell lesions. Compounding this problem is the broad differential that these lesions engender, with entities ranging from reactive/reparative lesions to poorly differentiated spindle cell malignancies. Furthering the challenge, the diagnoses may be complicated by fixation issues, sampling method, small sample size, lack of clinical history and prior treatment effects. The goal of this book is to introduce readers to the spectrum of these lesions while providing a systematic approach that helps establish accurate diagnoses that in turn drive appropriate clinical follow up and treatment. Chapters cover the spectrum of benign and malignant mesenchymal tumors and their mimics that are found in the breast in an easy to read format with richly detailed images to aid in diagnoses. The text also discusses practical components to aid in establishing and evaluating the differential diagnosis. Given how morphologically and clinically diverse these lesions are, Mesenchymal Tumors of the Breast and Their Mimics provides a construct for integrating the varied components that go into establishing a diagnosis for this challenging aspect of breast pathology.
The Mesenteric Organ in Health and Disease
by Eli D. Ehrenpreis John C. Alverdy Steven D. WexnerRecent discoveries and clarifications of known information about the mesentery have now established that these complex structures function together as an individual organ within the human body. As such, conditions that affect the mesentery can now be grouped within a single area of study and clinical practice. The various aspects of mesenteric diseases have not been brought together in a single source and this book aims to bring them together for the first time. It will cover general areas such as anatomy, histology and physiology of the mesentery. A description of diagnostic procedures used to evaluate patients with mesenteric disorders will follow. A practical survey with detailed descriptions of medical, surgical, and neoplastic disorders of the mesentery is also be included. This book is intended to be a guide for clinical practitioners including gastroenterologists, general surgeons, colorectal surgeons, primary care physicians, nurse practitioners and physician assistants who manage patients with mesenteric disorders.
Mesenteric Principles of Gastrointestinal Surgery: Basic and Applied Science
by John Calvin Coffey Rishabh Sehgal Dara WalshMesenteric-based gastrointestinal and colorectal surgery has been practiced internationally for over a century. However, it is not yet universally adopted, and considerable variations exist. Such variations are explained by the historical disparity that has persisted between anatomic and surgical approaches to the intestinal mesentery. While mesenteric-based surgery is far from new, it is remarkable that its anatomic basis has only recently been formally described. This means that key mesenteric principles of intestinal and colorectal surgery can now be taught, conducted and developed, in an entirely standardised manner. This book is composed of two parts. In this new book surgical anatomy, activities and operations are carefully defined, and beautifully illustrated, to enable all surgeons to conduct mesenteric-based intestinal and colorectal surgery, appropriately and with confidence.
Mesenteric Vascular Disease
by Gustavo S. OderichThis book represents the first comprehensive textbook devoted to the standard of care, current guidelines and innovations in the field of mesenteric vascular disease. The book reviews imaging modalities, diagnostic work up, physiologic tests, traditional open surgical techniques and novel endovascular approaches. Technical aspects of both open surgical and endovascular techniques are provided by experts in the field, with illustrations and photographs of key steps for each type of procedure. Results of epidemiologic studies and national databases are summarized, as well as large institutional experiences. An evidence-based approach is used for recommendations regarding best therapies. Diagnostic approaches including imaging and novel physiologic tests, including gastric tonometry and oxygen light spectroscopy are covered. Mesenteric Vascular Disease: Current Therapy will serve as a very useful resource for clinicians, surgeons, interventionalists, gastroenterologists and researchers dealing with and interested in mesenteric vascular diseases.
The Mesentery and Inflammation (Progress in Inflammation Research #90)
by J. Calvin CoffeyThe volume summarizes the most recent advances in our understanding of the mesentery and explains the how these are important in inflammation. It comprises a series of state of the art chapters by leading authorities in each area. It explains how recent advances in our understanding of the mesenteric organ, have advanced the diagnosis and treatment abdominal and systemic conditions including cancer, inflammatory bowel disease and endocrine conditions such as diabetes, and circulatory disorders such as atherosclerosis.
Meshless Methods in Biomechanics
by Jorge BelinhaThis book presents the complete formulation of a new advanced discretization meshless technique: the Natural Neighbour Radial Point Interpolation Method (NNRPIM). In addition, two of the most popular meshless methods, the EFGM and the RPIM, are fully presented. Being a truly meshless method, the major advantages of the NNRPIM over the FEM and other meshless methods, are the remeshing flexibility and the higher accuracy of the obtained variable field. Using the natural neighbour concept, the NNRPIM permits to determine organically the influence-domain, resembling the cellulae natural behaviour. This innovation permits the analysis of convex boundaries and extremely irregular meshes, which is an advantage in the biomechanical analysis, with no extra computational effort associated. This volume shows how to extend the NNRPIM to the bone tissue remodelling analysis, expecting to contribute with new numerical tools and strategies in order to permit a more efficient numerical biomechanical analysis.
Mesmerized
by Alissa WalserMozart's Vienna. A crucible for scientific experimentation and courtly intrigue, as Europe's finest minds vie for imperial favour. In a colourful, chaotic private hospital that echoes with the shrieks of hysterical patients, Franz Anton Mesmer is developing a series of controversial cure-alls for body and mind. When he is asked to help restore the sight of a blind musical prodigy favoured by the Empress herself, he senses that fame, and even immortality, is within his grasp. Mesmer knows that he will have to gain her trust if he is to open her eyes. But at what cost to her fragile talent? And will their intimacy result in scandal?
Mesmerized
by Alissa WalserMozart's Vienna. A crucible for scientific experimentation and courtly intrigue, as Europe's finest minds vie for imperial favour. In a colourful, chaotic private hospital that echoes with the shrieks of hysterical patients, Franz Anton Mesmer is developing a series of controversial cure-alls for body and mind. When he is asked to help restore the sight of a blind musical prodigy favoured by the Empress herself, he senses that fame, and even immortality, is within his grasp. Mesmer knows that he will have to gain her trust if he is to open her eyes. But at what cost to her fragile talent? And will their intimacy result in scandal?
Mesoamerican Healers
by Brad R. Huber Alan R. SandstromHealing practices in Mesoamerica span a wide range, from traditional folk medicine with roots reaching back into the prehispanic era to westernized biomedicine. These sometimes cooperating, sometimes competing practices have attracted attention from researchers and the public alike, as interest in alternative medicine and holistic healing continues to grow.<P><P>Responding to this interest, the essays in this book offer a comprehensive, state-of-the-art survey of Mesoamerican healers and medical practices in Mexico and Guatemala. The first two essays describe the work of prehispanic and colonial healers and show how their roles changed over time. The remaining essays look at contemporary healers, including bonesetters, curers, midwives, nurses, physicians, social workers, and spiritualists. Using a variety of theoretical approaches, the authors examine such topics as the intersection of gender and curing, the recruitment of healers and their training, healers' compensation and workload, types of illnesses treated and recommended treatments, conceptual models used in diagnosis and treatment, and the relationships among healers and between indigenous healers and medical and political authorities.
Mesothelioma
by Bruce W.S. Robinson A. Philippe ChahinianMesothelioma used to be a rare disease, but because of the widespread use of asbestos it has now been described as an epidemic around the world. The disease has proven exceptionally resistant to common forms of treatment (chemotherapy, radiotherapy and surgery). Mesothelioma has a very aggressive natural history with a median survival of around 9 m
Mesothelioma: From Research to Clinical Practice
by Giovanni Luca Ceresoli Emilio Bombardieri Maurizio D’IncalciThis book offers an updated review of malignant mesothelioma, including the latest advances in our understanding of its genetic control and molecular biology, as well as pre-clinical and clinical research. It also presents state-of-the-art diagnostic approaches and therapeutic options, and an open discussion on the future prospects for patient management. Malignant mesothelioma is an enormous global health problem related to asbestos exposure. Despite the best efforts of scientists and oncologists, the prognosis for those affected remains poor. Due to anatomical characteristics and non-specific symptoms, the diagnosis of mesothelioma at an early stage is often difficult, while surgery and radiotherapy are only of limited use, even if some multimodality approaches seem promising. In turn, medical treatments are sometimes successful in tumor control, but have little impact on overall survival. However, advances in our understanding of the disease’s biology, together with the availability of new drugs and combinations, make mesothelioma an essential and highly topical field for pre-clinical and clinical studies. This book is subdivided into four parts: epidemiology and preclinical data, diagnosis, therapy, and extrathoracic mesothelioma. It highlights the progress made in a variety of areas – e.g. in vitro and in vivo experimental models, genetics, environment, biomarkers, targeting agents, immunotherapy, metabolic imaging and ongoing clinical trials – and describes the standard clinical management of mesothelioma patients, including those with extra-thoracic localizations. Given its scope, the book offers an invaluable tool for researchers, oncologists and clinicians alike.
Mesotheliomas of Animals: A Comprehensive, Tabular Compendium of the World's Literature
by Edward B. IlgrenMesotheliomas of Animals is the first book to provide a comprehensive compilation of the diverse and often disparate literature regarding animal mesotheliomas. The compendium presents evidence to support the existence of "background" and "threshold," both of which are concepts central to the controversy surrounding nonasbestos-related mesotheliomas. Examples of "background" tumors (those which are nonasbestos-related) are described in detail, and indications of "threshold" for the induction of mesotheliomas following exposure to asbestiform and nonasbestiform agents are evident from the "positive dose-response" studies that are discussed. This compendium also allows for easy comparison of tumor yields elicited in "inoculation" studies performed with the same fiber types at similar doses. These comparisons often demonstrate markedly different tumor yields and highlight the limitations of injection techniques for fiber safety assessment. Mesotheliomas of Animals will be an essential reference for industrial hygienists, environmental lawyers, cancer researchers, and pulmonary scientists. It will be particularly useful to anyone involved with the design of fiber safety tests or with developing experimental models and protocols to assess the manner in which mesotheliomagenesis occurs.
Message in a Bottle: The Making of Fetal Alcohol Syndrome
by Janet GoldenA generation has passed since a physician first noticed that women who drank heavily while pregnant gave birth to underweight infants with disturbing tell-tale characteristics. Women whose own mothers enjoyed martinis while pregnant now lost sleep over a bowl of rum raisin ice cream. In Message in a Bottle, Janet Golden charts the course of Fetal Alcohol Syndrome (FAS) through the courts, media, medical establishment, and public imagination. Long considered harmless during pregnancy (doctors even administered it intravenously during labor), alcohol, when consumed by pregnant women, increasingly appeared to be a potent teratogen and a pressing public health concern. Some clinicians recommended that women simply moderate alcohol consumption; others, however, claimed that there was no demonstrably safe level for a developing fetus, and called for complete abstinence. Even as the diagnosis gained acceptance and labels appeared on alcoholic beverages warning pregnant women of the danger, FAS began to be de-medicalized in some settings. More and more, FAS emerged in court cases as a viable defense for people charged with serious, even capital, crimes and their claims were rejected. Golden argues that the reaction to FAS was shaped by the struggle over women's relatively new abortion rights and the escalating media frenzy over "crack" babies. It was increasingly used as evidence of the moral decay found within marginalized communities--from inner-city neighborhoods to Indian reservations. With each reframing, FAS became a currency traded by politicians and political commentators, lawyers, public health professionals, and advocates for underrepresented minorities, each pursuing separate aims.