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Modern Epidemics: From the Spanish Flu to COVID-19
by Salvador MacipCOVID-19 has made us all aware of the fact that we live in a world full of invisible enemies. Normally, we don’t even realize they’re there, but from time to time one of these microscopic creatures becomes powerful enough to turn everything upside down. What are these invisible enemies, and how can we prepare ourselves for the pandemics of the future? A specialist in the cellular biology of diseases, Salvador Macip explains, in a language everyone can understand, what it means to share the planet with millions of microbes – some wonderful allies, others terrible foes. He provides a concise account of epidemics that changed history, and focuses on the great modern plagues that are still causing millions of deaths every year, from influenza, TB and malaria to COVID-19. Macip also examines the methods we have used – from vaccines to improved sanitation and social distancing – to try to control these invisible enemies. This authoritative overview of modern epidemics and the pathogens that cause them will be essential reading for anyone who wants to understand our world today, a world in which some of the greatest threats to the human species come from the invisible microbes with which we share this planet.
Modern Epidemiology
by Timothy L. Lash Tyler J. VanderWeele Sebastien Haneause Kenneth RothmanNow in a fully revised Fourth Edition, Modern Epidemiology remains the gold standard text in this complex and evolving field. This edition continues to provide comprehensive coverage of the principles and methods for the design, analysis, and interpretation of epidemiologic research. Featuring a new format allowing space for margin notes, this edition • Reflects both the conceptual development of this evolving science and the increasing role that epidemiology plays in improving public health and medicine. • Features new coverage of methods such as agent-based modeling, quasi-experimental designs, mediation analysis, and causal modeling. • Updates coverage of methods such as concepts of interaction, bias analysis, and time-varying designs and analysis. • Continues to cover the full breadth of epidemiologic methods and concepts, including epidemiologic measures of occurrence and effect, study designs, validity, precision, statistical interference, field methods, surveillance, ecologic designs, and use of secondary data sources. • Includes data analysis topics such as Bayesian analysis, probabilistic bias analysis, time-to-event analysis, and an extensive overview of modern regression methods including logistic and survival regression, splines, longitudinal and cluster-correlated/hierarchical data analysis, propensity scores and other scoring methods, and marginal structural models. • Summarizes the history, specialized aspects, and future directions of topical areas, including among others social epidemiology, infectious disease epidemiology, genetic and molecular epidemiology, psychiatric epidemiology, injury and violence epidemiology, and pharmacoepidemiology.
Modern Forensic Tools and Devices: Trends in Criminal Investigation
by Deepak Rawtani Chaudhery Mustansar HussainMODERN FORENSIC TOOLS AND DEVICES The book offers a comprehensive overview of the latest technologies and techniques used in forensic investigations and highlights the potential impact of these advancements on the field. Technology has played a pivotal role in advancing forensic science over the years, particularly in modern-day criminal investigations. In recent years, significant advancements in forensic tools and devices have enabled investigators to gather and analyze evidence more efficiently than ever. Modern Forensic Tools and Devices: Trends in Criminal Investigation is a comprehensive guide to the latest technologies and techniques used in forensic science. This book covers a wide range of topics, from computer forensics and personal digital assistants to emerging analytical techniques for forensic samples. A section of the book provides detailed explanations of each technology and its applications in forensic investigations, along with case studies and real-life examples to illustrate their effectiveness. One critical aspect of this book is its focus on emerging trends in forensic science. The book covers new technologies such as cloud and social media forensics, vehicle forensics, facial recognition and reconstruction, automated fingerprint identification systems, and sensor-based devices for trace evidence, to name a few. Its thoroughly detailed chapters expound upon spectroscopic analytical techniques in forensic science, DNA sequencing, rapid DNA tests, bio-mimetic devices for evidence detection, forensic photography, scanners, microscopes, and recent advancements in forensic tools. The book also provides insights into forensic sampling and sample preparation techniques, which are crucial for ensuring the reliability of forensic evidence. Furthermore, the book explains the importance of proper sampling and the role it plays in the accuracy of forensic analysis. Audience The book is an essential resource for forensic scientists, law enforcement officials, and anyone interested in the advancements in forensic science such as engineers, materials scientists, and device makers.
Modern German Midwifery, 1885–1960 (Studies for the Society for the Social History of Medicine #13)
by Lynne FallwellBetween the late 18th and the early 20th century, the industrialized world experienced a transition in birth practices. While in many countries this led to a separation of midwifery from modern medicine, in Germany new standards of health care were embraced. Fallwell’s study explores this transition and sets it in its wider historical context.
Modern Hip Preservation: New Insights In Pathophysiology And Surgical Treatment
by Reinhold GanzThis book comprehensively discusses both the history and the current concepts of modern hip preservation surgery. Offering an overview of the game-changing studies on the hip and pelvis vascular anatomy it thoroughly describes the evolution of a new and comprehensive pathophysiology of the hip joint degeneration. Moreover, in the first part, particular emphasis is devoted to the history and current knowledge of femoroacetabular impingement and hip dysplasia.The second part examines the main surgical procedures that have evolved and matured since the 1980s, culminating in a new class of open surgical approaches, such as hip surgical dislocation, periacetabular osteotomies, proximal femoral osteotomies and corrections, and widening the door for hip-arthroscopy. Based on over 40 years of practical and pioneering experience by the editor and 15 years of collaboration with the GICCA Study Group, this book offers a valuable resource to residents, researchers and practicing orthopedic surgeon wishing to gain insights into hip preservation surgery.
Modern Hip Resurfacing
by Derek J. McminnHip replacement surgery is a radical and traumatic procedure that has enormous disadvantages to the patient in terms of postoperative mobility and morbidity. Hip resurfacing is a more conservative approach resulting in less of the patient's hip and femur being lost, which has great advantages to a younger patient group. The author of Hip Resurfacing is the world's leading authority on this surgery, making this the definitive resource in hip resurfacing
Modern Hospice Design: The Architecture of Palliative and Social Care
by Ken WorpoleThe new edition of this acclaimed book comprehensively updates its timely advocacy of the need for good quality palliative care, today more necessary than ever. Rooted in the social history of the care of the elderly and terminally ill, Modern Hospice Design: The Architecture of Palliative and Social Care takes cognisance of the new conditions of social care in the 21st century, principally in the UK, Europe and North America. It does so with regard to the development of new building types, but also in response to new philosophies of palliative care and the status of the elderly and the dying. Benefitting from a clearer methodological approach and conceptual framework, the expanded book allows a broad section of readers to navigate the text more easily. At its core is a public discussion of a philosophy of design for providing care for the elderly and the vulnerable, taking the importance of architectural aesthetics, the use of quality materials, the porousness of design to the wider world, and the integration of indoor and outdoor spaces as part of the overall care environment. In doing so it advocates care settings that, in the words of Maggie Jencks whose life and ideas inspired the Maggie’s Centres, ‘rise to the occasion’. Including new chapters and new in-depth case studies, complete will full colour illustrations, this book is for architects and interior designers and their students, healthcare professionals, social care providers, estate and facility managers, hospital administrators and Healthcare Trust Boards.
The Modern Hospital: Patients Centered, Disease Based, Research Oriented, Technology Driven
by Rifat LatifiThe rapidly growing developments in medicine and science in the last few decades has evoked a greater need for modern institutions, with modern medicine, advanced technologies, and cutting edge research. Today, the modern hospital is a highly competitive, multibillion dollar industry that plays a large role in our healthcare systems. Far different from older institutions, modern hospitals juggle the dynamics of running a business that proves financially fruitful and sustainable, with maintaining and staying ahead of medical developments and offering the best possible patient care. This comprehensive book explores all aspects of the inner workings of a modern hospital, from research and technology driven treatment and patient centered care, to the organizational, functional, architectural, and ergonomic aspects of the business. The text is organized into three parts. The first part covers a number of important aspects of the modern hospital including hospital transformation over the centuries, the new medical world order, overall concept, academic mission and economics of new healthcare. Additionally, experts in the field address issues such as modern design functionally and creating an environment that is ergonomically friendly, technologically advanced, and easy to navigate for both worker and patient. Other topics covered include, the role of genomics and nano-technologies, controversies that come with introducing new technologies, the world-wide pharmaceutical industry, electronic medical health records, informatics, and quality of patient care. Part II addresses nine specific elements of modernization of the hospital that deal with high acuity, life and death situations, and complex medical and surgical diseases. These chapters cover the organization of new emergency departments, trauma room, hybrid operating rooms, intensive care units, radiology, pharmaceutical and nutritional support, and most essential, patient and public relation services. These nine elements reflect the most important and most visible indicators of modernization and transformation of the hospital. Part III examines and highlights the team approach as a crucial component of the transformation, as well as specific perspectives on the modern hospital from nurses, physicians, surgeons and administrators. Finally, a chapter dedicated to patient perspective is also presented. The Modern Hospital provides an all-inclusive review of the hospital industry. It will serve as a valuable resource for administrators, clinicians, surgeons, nurses, and researchers. All chapters will be written by practicing experts in their fields and include the most up-to-date scientific and clinical information.
Modern HPLC for Practicing Scientists
by Michael W. DongHigh-Performance Liquid Chromatography (HPLC) is the most widely used analytical technique for organic compounds and biomolecules. This book is both concise in its treatment of HPLC and broad in its scope, providing the essence of HPLC fundamentals, applications, and developments, as well as providing a modern operating guide for the practicing scientist. The book includes a comprehensive overview of the principles and practices of HPLC in diverse industries; describes basic fundamentals and terminologies for the novice; and introduces more advanced concepts, best practices, and modern trends for the more experienced practitioner. While systematic and broad in scope, the book has a definite focus on reversed-phase HPLC with an emphasis on pharmaceutical applications.
Modern Immunohistochemistry
by Peiguo Chu Lawrence WeissDiagnostic pathology is an inherently flawed science due to the many possible interpretations of various tissues. However, the application of immunohistochemical stains as a diagnostic tool has been widely used since the 1990s as an extremely effective ancillary technique that removes much subjectivity from the practice. In fact, immunohistochemistry has supplanted simple morphologic evaluation as the definitive diagnostic method for a wide array of tumor types. This book offers a new and modern atlas-based resource for this science. Every anatomic region is covered in detail, and major diseases contain side-by-side examples of other ancillary staining techniques for comparison. The text is geared toward both the resident and practitioner of anatomic pathology and is supplemented with histograms, algorithms, and guides to the application and interpretation of uncommon antigens and immunostains. Not only is the book illustrated with more than 600 high-quality photomicrographs, but a companion CD-ROM of all images in downloadable format is included.
Modern Industrial Microbiology and Biotechnology
by Nduka Okafor Benedict C. OkekeThe field of industrial microbiology involves a thorough knowledge of the microbial physiology behind the processes in the large-scale, profit-oriented production of microbe-related goods which are the subject of the field. In recent times a paradigm shift has occurred, and a molecular understanding of the various processes by which plants, animals and microorganisms are manipulated is now central to industrial microbiology. Thus the various applications of industrial microbiology are covered broadly, with emphasis on the physiological and genomic principles behind these applications. Relevance of the new elements such as bioinformatics, genomics, proteomics, site-directed mutation and metabolic engineering, which have necessitated the paradigm shift in industrial microbiology are discussed.
Modern Infectious Disease Epidemiology
by Johan GieseckeHighly practical yet authoritative, the new edition of Modern Infectious Disease Epidemiology has been thoroughly updated and revised in line with changing health concerns. This successful book continues to outline the tools available to the infectious disease student or clinician seeking a thorough background in the epidemiology of infectious and communicable diseases. Building on many case studies and practical scenarios included, the book then uses the tools learnt to illustrate the fundamental concepts of the study of infectious diseases, such as infection spread, surveillance and control, infectivity, incubation periods, seroepidemiology, and immunity in populations. New edition of this popular book, completely revised and updated Retains the clarity and down-to-earth approach praised in previous editions Successfully combines epidemiological theory with the principles of infectious disease treatment and control A highly experienced author brings a personal and unique approach to this important subject All students of epidemiology, infectious disease medicine and microbiology will find this text invaluable, ensuring its continued popularity.
Modern Infectious Disease Epidemiology
by Mirjam Kretzschmar Alexander Krämer Klaus KrickebergHardly a day goes by without news headlines concerning infectious disease threats. Currently the spectre of a pandemic of influenza A|H1N1 is raising its head, and heated debates are taking place about the pro's and con's of vaccinating young girls against human papilloma virus. For an evidence-based and responsible communication of infectious disease topics to avoid misunderstandings and overreaction of the public, we need solid scientific knowledge and an understanding of all aspects of infectious diseases and their control. The aim of our book is to present the reader with the general picture and the main ideas of the subject. The book introduces the reader to methodological aspects of epidemiology that are specific for infectious diseases and provides insight into the epidemiology of some classes of infectious diseases characterized by their main modes of transmission. This choice of topics bridges the gap between scientific research on the clinical, biological, mathematical, social and economic aspects of infectious diseases and their applications in public health. The book will help the reader to understand the impact of infectious diseases on modern society and the instruments that policy makers have at their disposal to deal with these challenges. It is written for students of the health sciences, both of curative medicine and public health, and for experts that are active in these and related domains, and it may be of interest for the educated layman since the technical level is kept relatively low.
Modern Issues and Methods in Biostatistics
by Mark ChangClassic biostatistics, a branch of statistical science, has as its main focus the applications of statistics in public health, the life sciences, and the pharmaceutical industry. Modern biostatistics, beyond just a simple application of statistics, is a confluence of statistics and knowledge of multiple intertwined fields. The application demands, the advancements in computer technology, and the rapid growth of life science data (e.g., genomics data) have promoted the formation of modern biostatistics. There are at least three characteristics of modern biostatistics: (1) in-depth engagement in the application fields that require penetration of knowledge across several fields, (2) high-level complexity of data because they are longitudinal, incomplete, or latent because they are heterogeneous due to a mixture of data or experiment types, because of high-dimensionality, which may make meaningful reduction impossible, or because of extremely small or large size; and (3) dynamics, the speed of development in methodology and analyses, has to match the fast growth of data with a constantly changing face. This book is written for researchers, biostatisticians/statisticians, and scientists who are interested in quantitative analyses. The goal is to introduce modern methods in biostatistics and help researchers and students quickly grasp key concepts and methods. Many methods can solve the same problem and many problems can be solved by the same method, which becomes apparent when those topics are discussed in this single volume.
Modern Keratoplasty: Surgical Techniques and Indications (Essentials in Ophthalmology)
by Jorge L. Alió Jorge L. Alió del BarrioKeratoplasty techniques have evolved in the last 15 years into a variety of forms, which have diversified the previous monographic presence of the penetrating keratoplasty technique. The development of anterior lamellar graft (DALK), and posterior lamellar graft (DSAEK), makes an important change in the approach to lamellar surgery. Later on, the appearance of DMEK and superficial lamellar keratectomy broadened the spectrum. Today, intralamellar surgery has evolved with a number of techniques that involve stromal enhancement with biologically active or acellular corneal laminas from donors, customized lenticles from SMILE surgeries or customized by corneal topography, and more recently, corneal regeneration of the stroma by advanced techniques using mesenchymal stem cells.This book offers a comprehensive overview of modern keratoplasty techniques, the technology, surgical skills, and outcomes. It highlights the practical uses of keratoplasty for all cornea surgeons and anterior segment surgeons. The book is divided into sections, each covering a specific type of keratoplasty, including chapters on innovations within each surgery type. The goal of this book is to unify all recent knowledge about the different keratoplasty techniques and outcomes, creating a one-stop resource for ophthalmaolgy surgeons.Modern Keratoplasty is a must-have resource for corneal specialists and surgeons, anterior segment surgeons, refractive surgeons, cataract surgeons, residents, fellows, and corneal researchers.
Modern Magnetic Resonance: Part 1: Applications In Chemistry, Biological And Marine Sciences, Part 2: Applications In Medical And Pharmaceutical Sciences, Part 3: Applications In Materials Science And Food Science
by Graham A. WebbA comprehensive collection of the applications of Nuclear Magnetic Resonance (NMR), Magnetic Resonance Imaging (MRI) and Electron-Spin Resonance (ESR). Covers the wide ranging disciplines in which these techniques are used:* Chemistry;* Biological Sciences;* Pharmaceutical Sciences;* Medical uses;* Marine Science;* Materials Science;* Food Science. Illustrates many techniques through the applications described, e.g.:* High resolution solid and liquid state NMR;* Low resolution NMR, especially important in food science;* Solution State NMR, especially important in pharmaceutical sciences;* Magnetic Resonance Imaging, especially important for medical uses;* Electron Spin Resonance, especially important for spin-labelling in food, marine and medical studies.
Modern Management of Cancer of the Rectum
by Walter E. Longo Vikram Reddy Riccardo A. AudisioModern Management of Cancer of the Rectum is intended to provide a comprehensive overview of all aspects of rectal neoplasms. It addresses epidemiology, biology, screening and chemoprevention, the role of imaging in diagnosis, staging and prognosis, radiation therapy, medical and surgical treatment, as well as new modalities of therapy, including laparoscopy, and transanal endoscopic surgery. A greater understanding of prognostic factors, patterns of spread and natural history has occurred during the past decade; together with new diagnostic modalities this has led to significant changes in the management of patients with rectal cancer. This book will be invaluable for all those who treat rectal cancer.
Modern Management of Uterine Fibroids
by Mostafa Metwally Tin-Chiu LiUterine fibroids are very common in women of reproductive age and are mostly benign. However, they are often a cause of abnormal bleeding and, in severe cases, can cause infertility. This comprehensive guide reviews the clinical management of uterine fibroids, with a particular focus on practical surgical techniques. Engage with topics such as the anatomy of the pelvis, key theatre equipment and surgical treatments including hysteroscopic and laparoscopic techniques. Features also include debates around morcellation, and less invasive treatments such as uterine artery embolisation are also covered. An online video library of surgical procedures reinforces the practical techniques taught in the book and detailed colour images supplement the book's thorough coverage of fibroid management. This makes Modern Management of Uterine Fibroids an essential resource for practicing gynaecologists and IVF specialists, as well as students.
Modern Medicine: Biomedical Devices, Medical Gases, Radiopharmaceuticals, New Drug Discovery, Volume 2
by Pronobesh Chattopadhyay Danswrang GoyaryModern Medicine: Biomedical Devices, Medical Gases, Radiopharmaceuticals, New Drug Discovery, Volume 2 discusses the procedures of drug approval and regulatory requirements that must be met according to the United States Food and Drug Administration (FDA), the European Medical Agency (EMA), and the Central Drug Standard Control Organization (CDSCO). In the rapidly evolving landscape of modern medicine, groundbreaking innovations have emerged that are reshaping the way we approach healthcare. Modern Medicine delves into the cutting-edge realms of medical devices, medical gases, radiopharmaceuticals, and new drug discovery, offering a comprehensive exploration of these transformative fields that are revolutionizing patient care and medical practices. Discover the future of healthcare technology, and uncover the intricate world of biomedical engineering, where state-of-the-art devices seamlessly merge with the human body to monitor, diagnose, and treat ailments Dive deep into the utilization of medical gases for respiratory conditions, pain management, and even novel applications in regenerative medicine Unravel the mysteries of radiopharmaceuticals, a fusion of molecular imaging and therapy that offers unprecedented insights into the inner workings of the human body Embark on a journey through the intricate processes of drug discovery, where groundbreaking research and cutting-edge technologies are yielding therapies that were once deemed impossible Modern Medicine is a must-read for medical professionals, researchers, students, and anyone intrigued by the remarkable intersection of science, technology, and patient well-being. Join us on a journey to the forefront of medical innovation, where the unimaginable becomes reality, and the future of healthcare takes shape before our eyes. The chapter on regulatory implications for the approval process in this book will be the most useful resource for researchers and students, particularly those with backgrounds in pharma, forensic medicine, regulatory affairs, or those who aspire to succeed in drug research. Additionally, the information contained in this volume of the book could be of great interest to researchers working in the pharmaceutical and health industries.
Modern Medicine: Lay Perspectives And Experiences
by Simon J. Williams Michael CalnanDo lay people view modern medicine as a fountain of hope or a font of despair? What are their experiences of modern medical care and technology, and how do their views and experiences differ across different social groups? Combining theoretical insights with a range of qualitative and ethnographic research, this volume examines lay experiences and evaluation of medicines and drugs, chronic illness and life-saving technology, and reproductive technologies. It also considers the growing popularity of complementary therapies as a potential challenge to orthodox medicine.
Modern Menopausal Hormone Treatment: Facts and Myths About Sex Hormones
by Hilde LöfqvistThis unique book is structured to give the reader a comprehensive view to understand the decline of hormones at midlife and the risks and benefits of evidence based hormonal treatments. The difference between bio-identical and synthetic hormones is shown.With this book the author intends to restore the trust of the mostly positive effects of hormone treatment during menopause. In this book effective hormone treatments that may be carried on for years are discussed. Those hormones may even prevent age related diseases (arthralgia, osteoporosis, cardiovascular diseases) if started at the right time frame directly after menopause, known as "window of opportunity". This book fills a gap for medical health providers and can be of benefit for all women searching evidence-based information and answers on hormone menopausal changes and treatments. The book provides the reader with case histories to show how different women are at the menopausal transition, and what the doctor has to consider in the choice of investigation and treatment.
Modern Methods for Epidemiology
by Yu-Kang Tu Darren C. GreenwoodRoutine applications of advanced statistical methods on real data have become possible in the last ten years because desktop computers have become much more powerful and cheaper. However, proper understanding of the challenging statistical theory behind those methods remains essential for correct application and interpretation, and rarely seen in the medical literature. Modern Methods for Epidemiology provides a concise introduction to recent development in statistical methodologies for epidemiological and biomedical researchers. Many of these methods have become indispensible tools for researchers working in epidemiology and medicine but are rarely discussed in details by standard textbooks of biostatistics or epidemiology. Contributors of this book are experienced researchers and experts in their respective fields. This textbook provides a solid starting point for those who are new to epidemiology, and for those looking for guidance in more modern statistical approaches to observational epidemiology. Epidemiological and biomedical researchers who wish to overcome the mathematical barrier of applying those methods to their research will find this book an accessible and helpful reference for self-learning and research. This book is also a good source for teaching postgraduate students in medical statistics or epidemiology.
Modern Methods in Carbohydrate Synthesis (Frontiers In Natural Product Research Ser. #Vol. 1)
by Shaheer H. KhanModern Methods in Carbohydrate Synthesis presents in one volume a sequence of chapters leading from classical methods through to today's newest state-of -the-art technology for oligosaccharide synthesis. It places particular emphasis on the most recent breakthroughs in the field, including emerging technologies for both oligosaccharide and glycoconjugate synthesis. Chapters describing the synthesis of increasingly important glycosidic linkage analogs, as well as the oligosaccharides containing derivatives and analogs of natural sugars are included. While chemical-synthetic methods constitute the major part of the book, completing the volume is a section on the rapidly expanding and important field of enzymatic synthesis, also covering combined chemical and enzymatic synthesis.Chapters are written by leading experts in the field. Wherever possible, methods of synthesis are provided in sufficient detail to allow the reader to implement the techniques described. More than 1700 references are provided in the 21 chapters comprising the book. This volume should provide a wealth of information to a large number of synthetic organic chemists, medicinal chemists, protein chemists, biochemists, glycobiologists and cell biologists, including students in these fields.
Modern Microtia Reconstruction: Art, Science, and New Clinical Techniques
by John F. Reinisch Youssef TahiriMicrotia is a rare congenital deformity where the external ear is underdeveloped or absent. Occurring on average in one out of 12,000 children born in the world, there are very few books dedicated to ear reconstruction and microtia, specifically. Microtia reconstruction is a relatively uncommon and notoriously difficult procedure, where hearing as well as external ear deformity need to be addressed. This book is the result of 30 years dedicated to the surgical treatment of microtia: understanding in depth the pathophysiology and trying various surgical techniques to provide long lasting and pleasing aesthetic and functional results. With the limited amount of published information on microtia and ear reconstruction, Modern Microtia Reconstruction shines significant light on the new techniques and advances currently available. It presents advanced surgical techniques alongside inventive approaches that will lay the foundation on which surgeons can continue to expand their knowledge and know-how of the surgical approach of ear reconstruction. While the literature that is currently available on ear reconstruction focuses primarily on cartilage-based surgery, this book explores several other techniques detailing their advantages and disadvantages for both the surgeon and the patient discussing techniques for primary ear reconstruction, secondary ear reconstruction, reconstruction in the unsatisfied patient, as well as for post-traumatic ear reconstruction. Providing not only full-color images and illustrations but extensive video clips of each surgical technique to truly see and experience the subtleties of the surgery in a variety of patients. The primary audience is plastic surgeons, ENT surgeons, oral/maxillofacial surgeons, audiologists, physician’s assistants, and nurse practitioners with a secondary audience of course being highly knowledgeable parents of patients with microtia. With over a quarter of a century experience between the two editors, this book represents a major advance in showing a reliable approach to ear reconstruction surgery
Modern Molecular Biology:
by William B. Isaacs Srinivasan YegnasubramanianMolecular biology has rapidly advanced since the discovery of the basic flow of information in life, from DNA to RNA to proteins. While there are several important and interesting exceptions to this general flow of information, the importance of these biological macromolecules in dictating the phenotypic nature of living creatures in health and disease is paramount. In the last one and a half decades, and particularly after the completion of the Human Genome Project, there has been an explosion of technologies that allow the broad characterization of these macromolecules in physiology, and the perturbations to these macromolecules that occur in diseases such as cancer. In this volume, we will explore the modern approaches used to characterize these macromolecules in an unbiased, systematic way. Such technologies are rapidly advancing our knowledge of the coordinated and complicated changes that occur during carcinogenesis, and are providing vital information that, when correctly interpreted by biostatistical/bioinformatics analyses, can be exploited for the prevention, diagnosis, and treatment of human cancers. The purpose of this volume is to provide an overview of modern molecular biological approaches to unbiased discovery in cancer research. Advances in molecular biology allowing unbiased analysis of changes in cancer initiation and progression will be overviewed. These include the strategies employed in modern genomics, gene expression analysis, and proteomics.