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Multiple Sclerosis: Practical Advice To Help You Manage Your Multiple Sclerosis
by Ian RobinsonMultiple Sclerosis affects hopes and expectations, restructures relationships, modifies careers and changes lives. It is a disease of variable onset, problematic diagnosis, unpredicatable prognosis and no effective treatment. Using unique autobiographical accounts of people with the disease, Ian Robinson sensitively portrays the difficulties and frustrations of the struggle to make sense of the clinical diagnosis and management of an illness which is effectively a way of life.
Multiple Sclerosis: Understanding the Cognitive Challenges
by Nicholas Larocca Rosalind KalbWritten by two clinical psychologists with contributions from two neuropsychologists -- each an MS specialist -- Multiple Sclerosis: Understanding the Cognitive Challenges answers all questions patients may have about their condition, including: A definition of cognition and discussion of the processes that underlie human thought The emotional and social impact of cognitive changes The neuropsychological evaluation of cognitive symptoms Detailed overview of treatment options Vignettes describing the real-life experiences of people with cognitive dysfunction Extensive references to the scientific literature Combining detailed, referenced advice with hands-on strategies for living, this is the only book to provide in-depth information about cognitive dysfunction. It will be an invaluable reference to patients, families, and caregivers, as well as to health professionals who care for people with MS.
Multiple System Atrophy
by Gregor K. Wenning Alessandra FanciulliThis textbook provides a comprehensive monography on multiple system atrophy (MSA), a rare and fatal neurodegenerative disorder that presents with autonomic failure and either parkinsonism (MSA-P) or cerebellar ataxia (MSA-C). The underlying neuropathology of MSA is characterized by striatonigral degeneration (SND), olivopontocerebellar atrophy (OPCA) and unique oligodendroglial cytoplasmic alpha-synuclein inclusions. MSA is therefore classified among the alpha-synucleinopathies such as Parkinson`s disease, pure autonomic failure and dementia with Lewy bodies. Over the last decade there have been important advances in early diagnosis, pathogenesis research and clinical trial activity. The monography will cover the entire spectrum ranging from molecular and genetic work to symptomatic and interventional therapies. The book is written for movement disorder clinicians and basic neuroscientists interested in degenerative movement disorders.
Multiple Testing Problems in Pharmaceutical Statistics (Chapman & Hall/CRC Biostatistics Series)
by Ajit C. Tamhane Alex Dmitrienko Frank BretzUseful Statistical Approaches for Addressing Multiplicity IssuesIncludes practical examples from recent trials Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple c
Multiple True False Questions for the Final FFICM
by Mbbs Frca Fficm Emma Bellchambers Bmedsci Bmbs Mrcp FRCA Keith Davies MA Fficm Abigail Ford Mbchb FRCA Benjamin Walton MBChB Keith Davies Ma Abigail Ford Benjamin Walton MbchbFollowing the introduction in 2013 of the FFICM exam for trainees in intensive care, this book provides candidates with practice materials for the MCQ section. Written by a team of specialists in intensive care medicine, including senior trainees who have recently passed the new exam and authors of the popular FRCAQ website, the book contains 270 multiple true-false questions that cover the breadth of the current Faculty of Intensive Care Medicine curriculum. These are presented as three 90-question practice papers, providing candidates with a faithful simulation of the style, standard and format of the questions they will encounter. With short and long explanations for each question, presented with up-to-date references for extended reading, this book is both an ideal tool for in-depth exam preparation, and an excellent resource for practising consultants in intensive care medicine. It is also suitable for candidates taking the EDIC and other intensive care exams worldwide.
Multiple-Monitored Electroconvulsive Therapy (Routledge Revivals)
by Barry M. MaletzkyFirst published in 1981: This book will explain the development and rationale for MMECT, document its safety and efficacy, and just as importantly, describe the equipment and technique in sufficient detail to allow the reader to duplicate it if he desires.
Multiplex Biomarker Techniques: Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification (Methods in Molecular Biology #2511)
by Paul C. GuestThis detailed volume explores the application of multiplex biomarker methods in the critical area of COVID-19 research through state-of-the-art technologies in the fields of genomics, proteomics, transcriptomics, metabolomics, and imaging. The book features a series of protocols from labs across the globe employing multiplex molecular approaches, which can be applied to accelerate progress in the research of SARS-CoV-2 and other infectious illnesses. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and essential, Multiplex Biomarker Techniques: Methods and Applications for COVID-19 Disease Diagnosis and Risk Stratification serves as a vital resource for researchers in the areas of virology, metabolic diseases, respiratory disorders, as well as to clinical scientists, physicians, pharmacologists, and the healthcare services.
Multipotent Stem Cells of the Hair Follicle
by Robert M HoffmanThis volume discusses methods for the study of multipotent and pluripotent stem cells of the hair follicle. The stem cells described are involved in both the growth of the hair follicle and its production of the hair shaft, as well as the growth of the hair follicle sensory nerve. "Multipotent Stem Cells of the Hair Follicle: Methods and Protocols" also explores very unexpected results such as that of the hair follicle-associated-pluripotent (HAP) stem cells, which not only have the capability for regenerating the hair follicle sensory nerve, but also can differentiate ex vivo and in vivo to multiple cell types not associated with the hair follicle these include glial cells, motor neurons, and beating cardiac muscle cells. The potential for HAP stem cells for regenerative medicine is also discussed in detail. Written in the highly successful "Methods in Molecular Biology "series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, "Multipotent Stem Cells of the Hair Follicle: Methods and Protocols "is a valuable resource for researchers interested in this field. "
Multiregional Clinical Trials for Simultaneous Global New Drug Development (Chapman & Hall/CRC Biostatistics Series)
by Joshua Chen Hui QuanIn a global clinical development strategy, multiregional clinical trials (MRCTs) are vital in the development of innovative medicines. Multiregional Clinical Trials for Simultaneous Global New Drug Development presents a comprehensive overview on the current status of conducting MRCTs in clinical development. International experts from academia, in
Multiresistente Erreger: Diagnostik - Epidemiologie - Hygiene - Antibiotika-„Stewardship"
by Rolf Mahlberg Sebastian Schulz-Stübner Markus Dettenkofer Frauke Mattner Elisabeth MeyerIn dem vorliegenden Werk beschreiben ausgewiesene Experten, welche diagnostischen und allgemeinen therapeutischen Maßnahmen bei Infektionen mit multiresistenten Erregern sinnvoll und erfolgsversprechend sind. Das Werk wendet sich an alle Ärzte in allen Einrichtungen des Gesundheitswesen, die Patienten mit Infektionen durch multiresistente Erreger betreuen. Es beschreibt darüber hinaus die Mechanismen der Resistenzentwicklung gegen Antibiotika und wie sich diese vermeiden lassen – im Krankenhaus, in der Arztpraxis und in der Veterinärmedizin. Auch auf die psychologischen Aspekte im Umgang mit Patienten, Angehörigen, medizinischem Personal und der Öffentlichkeit bei Infektionen durch MRE gehen die Autoren ein. Die 2. Auflage erscheint komplett aktualisiert mit Ausblicken auf zukünftige Entwicklungen. Aus dem InhaltGeschichtliche Entwicklung und Public Health-Aspekte von Infektionen mit multiresistenten ErregernArt der Resistenz, Diagnostik, Screening, Epidemiologie, krankenhaushygienische Maßnahmen und Therapie von multiresistenten Staphylococcus aureus (MRSA), multiresistenten gramnegativen Erregern (MRGN), Vancomycin resistenten Enterokokken (VRE) und „multidrug resistent tuberculosis“ (MDR-TB)Primärprävention der Resistenzentwicklung gegen AntibiotikaPsychologische Aspekte im Umgang mit MRE aus Sicht von Patienten, Angehörigen, des medizinischen Personals und der Öffentlichkeit
Multiresistente Erreger: Diagnostik - Epidemiologie - Therapie
by Rolf Mahlberg Sebastian Schulz-Stübner Markus Dettenkofer Frauke Mattner Alik DawsonIn diesem Buch erläutern Experten praxisnah die wichtigsten Fakten zu Diagnostik und Therapie von Infektionen mit multiresistenten Erregern wie MRSA, VRE, MRGN und MDR-TB. Sie zeigen auf, welche diagnostischen Verfahren sinnvoll sind und welche Antibiotika bei welchen Infektionen greifen. Die Autoren beschreiben, durch welche Hygienemaßnahmen und Präventionskonzepte des Antiotika-Stewardship, sich Infektionen und Resistenzen vermeiden lassen. Auch auf die psychologischen Aspekte im Umgang mit Patienten, Angehörigen, medizinischem Personal und der Öffentlichkeit bei Infektionen durch MRE gehen die Autoren ein. Das Werk wendet sich an alle Ärzte in allen Einrichtungen des Gesundheitswesens, die Patienten mit Infektionen durch multiresistente Erreger betreuen. Die 3. Auflage erscheint komplett aktualisiert und fasst nun auch die therapeutischen Aspekte in einem Werk zusammen.
Multiscale Biomechanics and Tribology of Inorganic and Organic Systems: In memory of Professor Sergey Psakhie (Springer Tracts in Mechanical Engineering)
by Valentin L. Popov Georg-Peter Ostermeyer Evgeny V. Shilko Olga S. VasiljevaThis open access book gathers authoritative contributions concerning multiscale problems in biomechanics, geomechanics, materials science and tribology. It is written in memory of Sergey Grigorievich Psakhie to feature various aspects of his multifaceted research interests, ranging from theoretical physics, computer modeling of materials and material characterization at the atomic scale, to applications in space industry, medicine and geotectonics, and including organizational, psychological and philosophical aspects of scientific research and teaching as well. This book covers new advances relating to orthopedic implants, concerning the physiological, tribological and materials aspects of their behavior; medical and geological applications of permeable fluid-saturated materials; earthquake dynamics together with aspects relating to their managed and gentle release; lubrication, wear and material transfer in natural and artificial joints; material research in manufacturing processes; hard-soft matter interaction, including adhesive and capillary effects; using nanostructures for influencing living cells and for cancer treatment; manufacturing of surfaces with desired properties; self-organization of hierarchical structures during plastic deformation and thermal treatment; mechanics of composites and coatings; and many more. Covering established knowledge as well as new models and methods, this book provides readers with a comprehensive overview of the field, yet also with extensive details on each single topic.
Multiscale Cancer Modeling (Chapman & Hall/CRC Mathematical Biology Series)
by Thomas S. Deisboeck Georgios S. StamatakosCancer is a complex disease process that spans multiple scales in space and time. Driven by cutting-edge mathematical and computational techniques, in silico biology provides powerful tools to investigate the mechanistic relationships of genes, cells, and tissues. It enables the creation of experimentally testable hypotheses, the integration of dat
Multiscale Characterization of Biological Systems
by Yang Zhang Vikas Tomar Tao Qu Devendra K. Dubey Devendra VermaThis book covers the latest research work done in the area of interface mechanics of collagen and chitin-based biomaterials along with various techniques that can be used to understand mechanics of biological systems and materials. Topics covered include Raman spectroscopy of biological systems, scale dependence of the mechanical properties and microstructure of crustaceans thin films as biomimetic materials, as well as the role of molecular-level modeling. The use of nanomechanics to investigate interface thermomechanics of collagen and chitin-based biomaterials is also covered in detail. This book also: * Details spectroscope experiments as well as nanomechanic experiments * Reviews exhaustively phenomenological models and Raman spectroscopy of biological systems * Covers the latest in multiscaling for molecular models to predict lab-scale sample properties and investigates interface thermomechanics
Multiscale Mechanobiology of Bone Remodeling and Adaptation
by Peter PivonkaThe book presents state-of-the-art developments in multiscale modeling and latest experimental data on multiscale mechanobiology of bone remodeling and adaptation including fracture healing applications. The multiscale models include musculoskeletal models describing bone-muscle interactions during daily activities such as walking or running, micromechanical models for estimation of bone mechanical properties, bone remodeling and adaptation models, cellular models describing the complex bone-cell interactions taking into account biochemical and biomechanical regulatory factors. Also subcellular processes are covered including arrangement of actin filaments due to mechanical loading and change of receptor configurations.
Multiscale Models in Mechano and Tumor Biology: Modeling, Homogenization, And Applications (Lecture Notes in Computational Science and Engineering #122)
by Alf Gerisch Raimondo Penta Jens LangThis book presents and discusses the state of the art and future perspectives in mathematical modeling and homogenization techniques with the focus on addressing key physiological issues in the context of multiphase healthy and malignant biological materials. The highly interdisciplinary content brings together contributions from scientists with complementary areas of expertise, such as pure and applied mathematicians, engineers, and biophysicists. The book also features the lecture notes from a half-day introductory course on asymptotic homogenization. These notes are suitable for undergraduate mathematics or physics students, while the other chapters are aimed at graduate students and researchers.
Multiscale Models of Brain Disorders (Springer Series in Cognitive and Neural Systems #13)
by Vassilis CutsuridisThis book focuses on our current understanding of brain dynamics in various brain disorders (e.g. epilepsy, Alzheimer’s and Parkinson’s disease) and how the multi-scale, multi-level tools of computational neuroscience can enhance this understanding. In recent years, there have been significant advances in the study of the dynamics of the disordered brain at both the microscopic and the macroscopic levels. This understanding can be furthered by the application of multi-scale computational models as integrative principles that may link single neuron dynamics and the dynamics of local and distant brain regions observed using human EEG, ERPs, MEG, LFPs and fMRI. Focusing on the computational models that are used to study movement, memory and cognitive disorders as well as epilepsy and consciousness related diseases, the book brings together physiologists and anatomists investigating cortical circuits; cognitive neuroscientists studying brain dynamics and behavior by means of EEG and functional magnetic resonance imaging (fMRI); and computational neuroscientists using neural modeling techniques to explore local and large-scale disordered brain dynamics. Covering topics that have a significant impact on the field of medicine, neuroscience and computer science, the book appeals to a diverse group of investigators.
Multisensory Imagery
by Simon Lacey Rebecca LawsonIs a pear sweeter than a peach? Which of Mona Lisa's hands is crossed over the other? What would the Moonlight Sonata sound like played by a brass band? Although these are questions that appeal to mental imagery in a variety of sensory modalities, mental imagery research has been dominated by visual imagery. With the emergence of a well-established multisensory research community, however, it is time to look at mental imagery in a wider sensory context. Part I of this book provides overviews of unisensory imagery in each sensory modality, including motor imagery, together with discussions of multisensory and cross-modal interactions, synesthesia, imagery in the blind and following brain damage, and methodological considerations. Part II reviews the application of mental imagery research in a range of settings including individual differences, skilled performance such as sports and surgical training, psychopathology and therapy, through to stroke rehabilitation. This combination of comprehensive coverage of the senses with reviews from both theoretical and applied perspectives not only complements the growing multisensory literature but also responds to recent calls for translational research in the multisensory field.
Multisensory Object Perception in the Primate Brain
by Marcus Johannes Naumer Jochen KaiserTraditionally, a large proportion of perceptual research has assumed a specialization of cortical regions for the processing of stimuli in a single sensory modality. Perception in everyday life, however, usually consists of inputs from multiple sensory channels. Recently the question of how the brain integrates multisensory information has become the focus of a growing number of neuroscientific investigations. This work has identified both multisensory integration regions and crossmodal influences in brain areas traditionally thought to be specific to one sensory modality. Furthermore, several factors have been identified that enhance integration such as spatio-temporal stimulus coincidence and semantic congruency. Multisensory Object Perception in the Primate Brain elucidates the mechanisms of multisensory integration of object-related information with a focus on the visual, auditory, and tactile sensory modalities. Evidence is presented in four sections: methodological considerations, audio-visual processing, visuo-tactile processing, and plasticity, and includes studies in both human and nonhuman primates at different levels of analysis. Studies range from intracranial electrophysiological recordings to non-invasive electro- or magnetoencephalography, functional magnetic resonance imaging, behavioral approaches, and computational modeling.
Multisensory Processes: The Auditory Perspective (Springer Handbook of Auditory Research #68)
by Arthur N. Popper Richard R. Fay Allison B. Coffin Mark T. Wallace Adrian K. LeeAuditory behavior, perception, and cognition are all shaped by information from other sensory systems. This volume examines this multi-sensory view of auditory function at levels of analysis ranging from the single neuron to neuroimaging in human clinical populations.Visual Influence on Auditory Perception Adrian K.C. Lee and Mark T. WallaceCue Combination within a Bayesian Framework David Alais and David BurrToward a Model of Auditory-Visual Speech Intelligibility Ken W. Grant and Joshua G. W. BernsteinAn Object-based Interpretation of Audiovisual Processing Adrian K.C. Lee, Ross K. Maddox, and Jennifer K. Bizley Hearing in a “Moving” Visual World: Coordinate Transformations Along the Auditory Pathway Shawn M. Willett, Jennifer M. Groh, Ross K. MaddoxMultisensory Processing in the Auditory Cortex Andrew J. King, Amy Hammond-Kenny, Fernando R. NodalAudiovisual Integration in the Primate Prefrontal Cortex Bethany Plakke and Lizabeth M. RomanskiUsing Multisensory Integration to Understand Human Auditory Cortex Michael S. BeauchampCombining Voice and Face Content in the Primate Temporal Lobe Catherine Perrodin and Christopher I. PetkovNeural Network Dynamics and Audiovisual Integration Julian Keil and Daniel SenkowskiCross-Modal Learning in the Auditory System Patrick Bruns and Brigitte RöderMultisensory Processing Differences in Individuals with Autism Spectrum Disorder Sarah H. Baum Miller, Mark T. Wallace Adrian K.C. Lee is Associate Professor in the Department of Speech & Hearing Sciences and the Institute for Learning and Brain Sciences at the University of Washington, SeattleMark T. Wallace is the Louise B McGavock Endowed Chair and Professor in the Departments of Hearing and Speech Sciences, Psychiatry, Psychology and Director of the Vanderbilt Brain Institute at Vanderbilt University, NashvilleAllison B. Coffin is Associate Professor in the Department of Integrative Physiology and Neuroscience at Washington State University, Vancouver, WAArthur N. Popper is Professor Emeritus and research professor in the Department of Biology at the University of Maryland, College ParkRichard R. Fay is Distinguished Research Professor of Psychology at Loyola University, Chicago
Multislice CT (Medical Radiology)
by Andrea Laghi Fabian Bamberg Konstantin Nikolaou Geoffrey D. RubinThe fourth edition of this well-received book offers a comprehensive update on recent developments and trends in the clinical and scientific applications of multislice computed tomography. Following an initial section on the most significant current technical aspects and issues, detailed information is provided on a comprehensive range of diagnostic applications. Imaging of the head and neck, the cardiovascular system, the abdomen, and the lungs is covered in depth, describing the application of multislice CT in a variety of tumors and other pathologies. Emerging fields such as pediatric imaging and CT-guided interventions are fully addressed, and emergency CT is also covered. Radiation exposure, dual-energy imaging, contrast enhancement, image postprocessing, CT perfusion imaging, and CT angiography all receive close attention. The new edition has been comprehensively revised and complemented by contributions from highly experienced and well-known authors who offer diverse perspectives, highlighting the possibilities offered by the most modern multidetector CT systems. This book will be particularly useful for general users of CT systems who wish to upgrade and enhance not only their machines but also their knowledge.
Multislice-CT of the Abdomen
by Richard Baron Maximilian F. Reiser Carlo Bartolozzi Christoph Johannes ZechThis book provides a lucid summary of modern multislice CT imaging of the abdomen, with a focus on the essential imaging findings. After a concise technical introduction, the most important abdominal diseases are described and illustrated with high-quality images. Sections are devoted to the liver and biliary system, the pancreas and spleen, the kidneys and urogenital system, and the bowel and peritoneal cavity. Throughout, key differential diagnostic features are highlighted. The editorial team is composed of internationally renowned radiologists from Europe and the United States, and all chapters have been written by recognized experts in the topic under consideration. Multislice CT of the Abdomen will serve as an excellent reference for radiologists participating in further professional training and will prove an ideal source of information for all who wish to deepen their personal knowledge of the subject.
Multispecies Biofilms: Technologically Advanced Methods to Study Microbial Communities (Springer Series on Biofilms #12)
by Karishma S. Kaushik Sophie E. DarchIn an age of antibiotic resistant infections, the study of biofilms is increasingly important. Microbes more than often exist in complex multi-species or polymicrobial communities, making infections difficult to detect, diagnose and treat. Given the increased focus on studying biofilms in research and laboratory settings, particularly under conditions that closely mimic the clinical state, it is important to get an overview of the recent methods, model systems and tools being developed and employed in this context.This book offers readers the opportunity to learn more about current methods being used in the investigation of multi-species biofilms, both in vivo and in vitro. For this, the book highlights new technologies built and designed for the study of multiple species within biofilm communities, including those that can be leveraged for the evaluation of antimicrobial treatment approaches. The application of these state-of-the-art techniques to further our understanding of multi-species biofilms will be discussed and the reader will learn how the clinical microenvironment and the development of biofilm communities are considered when developing such tools.With cutting-edge contributions from experts in the respective domains, this book will benefit translational and basic research scientists, as well as clinicians, and is an informative resource for educators and their students.
Multisystemic Therapy for Antisocial Behavior in Children and Adolescents
by Scott Henggeler Sonja SchoenwaldMultisystemic therapy (MST) has grown dramatically since the initial publication of this comprehensive manual. Today, over 400 MST programs operate in more than 30 states and 10 countries, supported by a strong empirical evidence base. This book explains the principles of MST and provides clear guidelines for clinical assessment and intervention with delinquent youth and their families. Practitioners are guided to implement proven strategies for engaging clients and helping them to address the root causes of antisocial behavior, improve family functioning and peer relationships, enhance school performance, and build meaningful social supports. New to This Edition Includes the latest MST data and clinical refinements. Revised to be even more user-friendly, with many new examples added. A chapter on treating youth and caregiver substance abuse. Expanded coverage of safety concerns, enhancing vocational outcomes, and MST adaptations for other clinical problems. A chapter detailing the MST system for sustaining high-quality programs.
Multisystemische Therapie bei dissozialem Verhalten von Kindern und Jugendlichen
by Scott W Henggeler Christian Bachmann Melisa D. Rowland Phillippe B. Cunningham Charles M. Borduin Sonja K. SchoenwaldDie multisystemische Therapie (MST) ist ein empirisch abgesichertes Verfahren, das als Alternative zu stationären Behandlungskonzepten auch ambulant angewendet werden kann. In über 30 Ländern wird MST inzwischen erfolgreich mit Kindern und Jugendlichen in über 400 Programmen praktiziert. In diesem Buch werden die Prinzipien der multisystemischen Therapie erläutert. Außerdem bekommen Leser klare Leitlinien an die Hand: für die Indikation und um individuelle Interventionen bei delinquenten Jugendlichen und Kindern zu planen und durchzuführen.