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Non-Sighted and Sighted Adults' Volumetric Perceptions of Functional Objects
by T. M. Nelson C. J. Ladan J. EppsA report on the study of the manner in which sighted, sighted-but-blindfolded, late-blind (subsequent to 7 years of age), and congenitally blind (blind since birth) persons employ physical parameters in determining weight and volume of functional objects.
Non-Steroidal Anti-Inflammatory Drugs in Water: Emerging Contaminants and Ecological Impact (The Handbook of Environmental Chemistry #96)
by Leobardo Manuel Gómez-OlivánThis book gathers the main international research findings on non-steroidal anti-inflammatory drugs (NSAIDs) as emerging contaminants in water. It focuses on the major routes of exposure, and the destinations and life cycles of NSAIDs in water, as well as the manifestations of toxicity in different organisms. It also reviews the methods used in the detection, analysis and quantification of NSAIDs in water as well as the biological and chemical methods of removing them. Lastly, the book offers an overview of the legal frameworks in place and provides conclusions and recommendations for the future. Given its scope, the book is an indispensable resource for scientists in academia and industry, as well as for decision-makers involved in contamination assessment and environmental analysis and NGOs interested in the problem of water contamination by NSAIDs.
Non-Suicidal Self-Injury in Eating Disorders
by Laurence Claes Jennifer J. MuehlenkampNon-suicidal self-injury and eating disorders represent significant problems among today's youth and pose unique challenges for clinicians, particularly when they co-occur. This book is a rare resource in that it provides cutting-edge information on the interactions between self-injury and disordered eating, empirically informed treatments for the co-occurrence of these behaviors, and specific topics relevant to understanding nuances in the risk factors, treatment, and prevention of both self-injury and eating disorders. Practitioners, graduate students, and researchers working within this specialized area will find this text to be instrumental in advancing their knowledge and improving the treatment of self-injury in those with eating disorders.
Non-surgical Ablation Therapy for Early-stage Breast Cancer
by Takayuki KinoshitaCovering the history of breast cancer, theory of radiofrequency ablation (RFA), resection of carcinoma, imaging before and after non-surgical ablation therapy and quality of life, this book focuses on extensive breast-conserving treatment for the preservation of a cosmetically acceptable breast. It investigates the feasibility of percutaneous, minimally invasive techniques to ablate breast tumors and several modalities such as cryosurgery, laser ablation, thermoablation and high-intensity focused ultrasound. Non-surgical Ablation Therapy for Early-stage Breast Cancer centers on RFA and provides insights into cryoablation and focused ultrasound surgery. RFA has been shown to be effective for treating tumors in many types of tissue, including liver, bone, brain, kidney, pancreas and prostate. As such this book is a valuable resource for breast and general surgeons, radiation oncologists and medical oncologists in all areas. The extensive discussions enable scholars to gain radiological expertise and a basic understanding of molecular biology, leading to better surgery without scalpels.
Non-Surgical Control of Periodontal Diseases
by Paul A. Levi Y. Natalie Jeong Robert J. Rudy Daniel K. ColemanThis handbook has been designed for practicing dental clinicians and students, which includes dental hygienists, general dentists, periodontists, and students of dental hygiene and dentistry who are responsible for treating patients with a broad spectrum of periodontal diseases. The book will enable practicing clinicians and students to successfully meet the challenge of excellent patient care, by providing , in a concise and simplified format, both classic and contemporary practical measures that address all aspects of non-surgical periodontal disease management. Readers are carefully guided through an extensive body of accumulated knowledge in eight broad chapters which includes: the patient's involvement in disease control and prevention, the clinician's instrumentation for the diagnosis and basic treatment of gingivitis/periodontitis along with pharmacotherapeutics and supportive maintenance therapy to ensure long-term success. Numerous illustrations help to bring the presented ideas and suggestions to life and the succinct nature of the text will allow readers to transfer useful information quickly to their own clinical settings.
Non-Surgical Rejuvenation of Asian Faces
by Souphiyeh SamizadehThis book provides a practically applicable guide to facial aesthetics, non-surgical treatment and enhancement in patients of Asian descent. The available evidence base for the use of a range of available techniques when treating an Asian patient is presented and relevant aspects of facial analysis, treatment planning and provision are covered. Detailed instruction is given on how to use cutting edge techniques enabling the reader to develop a thorough understanding of how to proficiently perform these approaches in their clinical practice. Non-Surgical Rejuvenation of Asian Faces systematically reviews the evidence base for and details how to use the latest available non-surgical techniques for facial rejuvenation in this group of patients. It is a valuable resource for aesthetic medicine professionals and trainees alike seeking a reference on the topic.
Non-Surgical Rhinoplasty (The PRIME Series)
by Dario Bertossi Riccardo Nocini Ali Pirayesh*Brings together all a surgeon needs to know for safe and effective non-invasive rhinoplasty *Offers a one-stop resource for surgeons wishing to add injection techniques to their practice *Presents a master-class from world experts
Non-Surgical Thread Procedures: The Future of Aesthetic Medicine
by Nancy M. KimThis book provides knowledge and instruction about thread procedures that are the current state of the art in the United States. The book offers a comprehensive overview of the threads available and in favor of use in the US. The chemical and biological activity of the threads also will be explained. Chapters will discuss research that support the theory and clinical efficacy of the threads, thus laying the foundation for understanding the purpose of the threads. Chapters discuss the different types, sizes and styles of threads in current use. The various areas and procedures that are possible with the threads will be described in detail to allow practitioners a greater comfort level when learning these procedures. The book will also include tips to help practitioners succeed with these procedures as it is generally not as straight forward as some other aesthetic procedures. In addition, the book compares and contrasts thread procedures with other current modalities. This will delineate the advantages of threads over other treatments for aesthetic treatment including surgery. The book also contains multiple videos that show the use of threads in various procedures.Non-Surgical Thread Procedures is a must-have resource for clinicians and physicians that practice minimally invasive aesthetic procedures as well as those interested in thread procedures.
Non-Surgical Treatment of Keratinocyte Skin Cancer
by Gregor Jemec Lajos Kemeny Donald MiechWith more and more patients suffering from field cancerisation, an alternative for repeated surgery for the diagnosis and treatment of non-melanoma skin cancer is becoming necessary. Although surgery remains the gold standard for treatment of non-melanoma or keratinocyte skin cancer, it also has its downside. Surgery leaves scars and nowadays the cosmetic outcome of therapy is becoming increasingly important. Since many cases can effectively be managed without surgery, the possibilities of non-surgical therapy are gaining popularity, particularly in low malignancy tumours. This reader-friendly clinical guide offers treatment options for the growing group of these patients. It describes the current state-of-the art for non-surgical treatment of this type of skin cancer, and gives factual knowledge to beginners and new inspirations to experts.
Non-traditional Approaches to Combat Antimicrobial Drug Resistance
by Mohmmad Younus Wani Aijaz AhmadThis book provides a detailed overview of the progress and challenges of non-traditional approaches for tackling antimicrobial resistance. The first chapter covers the factors that make microbes more likely to develop multidrug resistance. The book goes on to discuss the antimicrobial properties of propolis, essential oils and other microbial constituents that are used or under investigation to treat multidrug-resistant infections. Additionally, it covers alternative compounds that work as antimicrobial agents, their mechanisms of action, and how they might be utilized in conjunction with conventional drugs to circumvent drug resistance. The book explores the application of phage therapy and recent advancements in phage-based infection control with an emphasis on multidrug-resistant infections and discusses drug repurposing as a strategy to develop new antimicrobial agents efficiently and expeditiously. Additionally, it discusses the uses of nanoparticles in the treatment of infections brought on by multidrug-resistant pathogens and examines the use of different nanotechnology-based approaches to fudge microbial resistance mechanisms. It concludes by reviewing recent studies on microbial quorum-sensing systems and focuses on the significance of quorum-sensing systems in controlling microbial resistance mechanisms and at the same time highlights the importance and role of antimicrobial stewardship program to fight microbial infections. The book is an invaluable source of knowledge and information for academics, basic and clinical researchers, clinicians, and paramedic staff involved in one way or the other in the development and use of antimicrobial agents and strategies to combat multidrug resistance.
Non-Traditional Feeds for Use in Swine Production (CRC Press Revivals)
by Phillip A Thacker Roy N KirkwoodFeed represents the single greatest expense associated with bringing pigs to market weight. Therefore, if you can reduce the cost of feeding without detriment to pig performance, the economics of swine production will improve. The ingredient list for swine rations has become fairly limited, and the majority of diets fed to pigs consist of a few staples, such as corn, wheat, barley, and soybean meal. Non-Traditional Feeds for Use in Swine Production explores over fifty non-traditional feedstuffs in terms of their nutritional content and their viability as alternative, cost effective food sources
The Non-training Route to the Specialist Register in Psychiatry: How to Make a Successful Application for a CESR and Beyond
by Nandini ChakrabortySubstantive consultants in the UK need to be on the GMC specialist register. Non-consultant psychiatrists might work towards the GMC specialist register in psychiatry through various routes, of which CESR is one. This book, written by experts with first-hand experience, provides guidance to doctors planning to use this route. Specialist registration is the acknowledgement of a doctor's expertise in their field and the achievement of competences as outlined in specialist curricula. This book provides a succinct overview of what to expect from the process of applying for CESR, with practical advice on how to submit a successful application. It will appeal primarily to Speciality and Associate Specialist (SAS) Doctors with extensive experience in psychiatry, psychiatrists who have completed their training overseas and wish to practice in the UK, as well as medical managers and educators supporting their workforce towards consultant grade.
Non-Vascular Interventional Radiology of the Abdomen
by Ronald S. ArellanoThis book is designed to provide a foundation for physicians-in-training and a quick guide to further enhance the skills set of practicing interventionalists. It is a concise reference manual covering the major aspects of clinical scenarios, procedures, and techniques. Non-Vascular Interventional Radiology of the Abdomen expertly addresses the planning and execution of commonly encountered procedures, including organ specific biopsies, abscess drainage, urinary interventions, gastrostomy, gastrojejunostomy, and biliary interventions.
Non-Venereal Treponematoses: Global Status 2010 edition
by Dr Stephen Berger Gideon InformaticsNon-Venereal Treponematoses: Global Status is one in a series of GIDEON ebooks which summarize the status of individual infectious diseases, in every country of the world. Data are based on the GIDEON database (www.gideononline.com) which relies on standard text books, peer-review journals, Health Ministry reports and ProMED, supplemented by an ongoing search of the medical literature. Chapters are arranged alphabetically, by country name. Each section is divided into five subsections. 1. Descriptive epidemiology 2. Summary of clinical features 3. Global status of the disease 4. Status of the disease in a specific country 5. References Non-Venereal Treponematoses: Global Status includes separate sections on Endemic syphilis (bejel), Pinta, and Yaws.
Non-violent Communication and Narrative Medicine for Promoting Sustainable Health (New Paradigms in Healthcare)
by Maria Giulia MariniThe Covid-19 pandemic and current international circumstances have left many individuals feeling vulnerable, both economically and psychologically. At the same time, pressure is put on healthcare systems, particularly in Europe, resulting in doctor shortages, heavy workloads, and low salaries for healthcare workers. Patients are experiencing longer waiting lists, shorter visiting times, and emergency rooms that underestimate patients' clinical problems. As a result, episodes of self-violence and violence resulting from different causes are happening more frequently, also in hospitals. However, there is hope, and it starts with sharing our needs, thoughts, and feelings. This is where narrative medicine comes into play, as it helps bring stories to light, listen, ask open questions, analyze the spoken words, metaphors, and timing of communication, and promote a non-violent narrative. The key is to transition from violent to non-violent narratives and the consideration of relationship as a fundamental part of the therapeutic process, deserving an in-depth educational program. This is even more true if one considers that the ecosystem of health, together with the inclusion of diversity and the promotion of peace, is one of the main pillars of the UN Sustainable Development Goals.This book aims to inspire care for one another through the narratives of people with disabilities, patients, nurses, doctors, students, carers, and individuals who meet otherness and resolve conflicts.
Non-Viral Gene Delivery Vectors
by Gabriele CandianiThis volume provides readers with a wide collection of the latest and readily reproducible technical protocols available in the field of non-viral gene delivery vectors. The chapters in this book are organized into three major parts: Part I is a section on conventional bolus gene delivery vectors that introduces typical transfection approaches relying on the addition of transfectants to the cell culture medium where the cells are grown in; Part II covers stimuli-responsive bolus transfectants and topics on gene delivery complexes made of smart polymers or stimuli-responsive polymers that change according to the environment they are in and delivered by dripping into cells; Part III discusses examples of substrate-mediated gene delivery also termed reverse transfection and the immobilization of a gene delivery vector onto a surface as opposed to more typical bolus delivery from the medium. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, "Non-Viral Gene Delivery Vectors: Methods and Protocols "is written for experimentalists, and is an essential part of many laboratory bookshelves. This book will help novice and professionals alike succeed in their research in this field. "
Nonadrenergic Innervation of Blood Vessels: Putative Neurotransmitters (Routledge Revivals #1)
by Geoffrey Burnstock Susan G. GriffithFirst Published in 1988, this book offers a full, comprehensive guide into the functions and treatment of the Blood Vessels. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.
Nonadrenergic Innervation of Blood Vessels: Regional Innervation (Routledge Revivals #2)
by Geoffrey Burnstock Susan G. GriffithFirst Published in 1988, this book offers a full, comprehensive guide into the workings and treatment of the Blood Vessels. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.
Nonclinical Drug Administration: Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems
by Shayne C. Gad Charles B. SpainhourIf we will ever achieve Paul Ehrlich’s "magic bullet," that is, a molecule which goes with high selectivity to the therapeutic target site, does what it needs to do, and is subsequently cleared from the body, the practice of safety assessment will have to change. Nonclinical Drug Administration: Formulations, Routes and Regimens for Solving Drug Delivery Problems in Animal Model Systems seeks to address a trio of objectives that, though separate, are linked and central to biomedical science and, ultimately, medicine. Rather seeing these as separate "silos," those working in nonclinical safety assessment will have to view these three in an integrated manner and to regularly and thoughtfully incorporate new information and technology. The trio of objectives this book explores are: first, to present how to deliver more of a drug product systemically to facilitate the regulatory need for evaluating safety and efficacy in animal species (at elevated exposure levels) prior to advancing the drug to human testing; second is to achieve better tolerance to therapeutics administration in test animals and humans which achieves objectives 1 and 3; and third, to explore ways to improve on therapeutic target receptor delivery performance, therefore improving both clinical pharmacodynamics bioavailability and specificity. The book’s ten chapters assemble the basic concepts, principles and hypotheses involved in quantitative receptor and chronological organism interaction dynamics central to the successful development of new therapeutics which depend on systemic administration to achieve desired therapeutic goals and in so doing avoid outcomes which limit, marginalize, or preclude the therapeutic use of so many molecules.
Nonclinical Safety Assessment
by Kathy M. Mcgown William J. Brock Kenneth L. HastingsBringing a new drug to market is a costly time-consuming process. Increased regional and international regulation over the last twenty years, while necessary, has only served to amplify these costs. In response to this escalation, developmental strategies have shifted towards a more global approach. In order to create the most cost-effective and safe processes, it is critical for those bringing drugs to market to understand both the globally accepted regulations and the local variations. Nonclinical Safety Assessment: A Guide to International Pharmaceutical Regulations provides a practical description of nonclinical drug development regulations and requirements in the major market regions.It includes:ICH - the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human UseNational regulations, including US FDA, Canada, Mercosur and Brazil, South Africa, China, Japan, India and AustraliaRepeated dose toxicity studiesCarcinogenicity; Genotoxicity; Developmental and reproductive toxicology; ImmunotoxicologyBiotechnology-derived pharmaceuticalsVaccine developmentPhototoxicity and photocarcinogenicityDegradants, impurities, excipients and metabolitesPrimarily intended for those professionals actively involved in the nonclinical and clinical development of a pharmaceutical product, including toxicologists, pharmacologists, clinicians and project managers, this book provides a roadmap for successful new drug approval and marketing.
Nonclinical Statistics for Pharmaceutical and Biotechnology Industries
by Lanju ZhangThis book serves as a reference text for regulatory, industry and academic statisticians and also a handy manual for entry level Statisticians. Additionally it aims to stimulate academic interest in the field of Nonclinical Statistics and promote this as an important discipline in its own right. This text brings together for the first time in a single volume a comprehensive survey of methods important to the nonclinical science areas within the pharmaceutical and biotechnology industries. Specifically the Discovery and Translational sciences, the Safety/Toxiology sciences, and the Chemistry, Manufacturing and Controls sciences. Drug discovery and development is a long and costly process. Most decisions in the drug development process are made with incomplete information. The data is rife with uncertainties and hence risky by nature. This is therefore the purview of Statistics. As such, this book aims to introduce readers to important statistical thinking and its application in these nonclinical areas. The chapters provide as appropriate, a scientific background to the topic, relevant regulatory guidance, current statistical practice, and further research directions.
Noncoding RNAs and Bone
by Airong Qian Ye TianThe book provides an in-depth and comprehensive overview of the essential role of non-coding RNAs (ncRNAs) in bone formation. In combination with researches from multiple scholars in this field, the book reviews the mechanisms of ncRNA-related bone diseases, as well as the potential applications of RNA synthesis technology in bone disorder treatments. This volume covers the following topics: 1) basic introduction of non-coding RNA and bone development, how 2) microRNAs and 3) long noncoding RNAs (LncRNAs) regulate bone formation, 4) how ncRNAs and the corresponding pathways participate in bone metabolism diseases, 5) RNA synthesis technology and the possible RNA therapies in bone disease. Researchers and students in the fields of human genetics, human physiology, developmental biology and biomedical engineering, as well as professionals and scientists in Orthopedics, will particularly find this book helpful.
Noncolorectal, Nonneuroendocrine Liver Metastases
by Isidoro Di CarloThis book offers a complete overview on non colorectal non neuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history and diagnosis. NCRNNE liver metastases are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.
Noncommunicable Diseases: A Compendium
by Nick Banatvala and Pascal BovetNoncommunicable Diseases: A Compendium introduces readers to noncommunicable diseases (NCDs) – what they are, their burden, their determinants and how they can be prevented and controlled. Focusing on cardiovascular disease, diabetes, cancer and chronic respiratory disease and their five shared main risk factors (tobacco use, harmful use of alcohol, unhealthy diet, physical inactivity and air pollution) as defined by the United Nations, this book provides a synopsis of one of the world’s biggest challenges of the 21st century. NCDs prematurely claim the lives of millions of people across the world every year, with untold suffering to hundreds of millions more, trapping many people in poverty and curtailing economic growth and sustainable development. While resources between and within countries largely differ, the key principles of surveillance, prevention and management apply to all countries, as does the need to focus resources on the most cost-effective and affordable interventions and the need for strong political will, sufficient resources, and sustained and broad partnerships. This compendium consists of 59 short and accessible chapters in six sections: (i) describing and measuring the burden and impact of NCDs; (ii) the burden, epidemiology and priority interventions for individual NCDs; (iii) social determinants and risk factors for NCDs and priority interventions; (iv) global policy; (v) cross-cutting issues; and (vi) stakeholder action. Drawing on the expertise of a large and diverse team of internationally renowned policy and academic experts, the book describes the key epidemiologic features of NCDs and evidence-based interventions in a concise manner that will be useful for policymakers across all parts of society, as well as for public health and clinical practitioners.
Noncommunicable Diseases
by Mieczyslaw PokorskiDiseases of the respiratory system often cause multisystem dysfunction and morbidity. Respiratory diseases not transmissible by a direct contact are rarer than those of inflammatory or infectious background. Such noncommunicable diseases, often entailing genetic and immune aspects, are areas of limited understanding; sarcoidosis being a case in point. This book tackles the issues relevant to such diseases. The research on novel cytokine markers, which may help in the diagnosis and management of sarcoidosis, is described. Modern approaches to the management of pneumothorax, a frequent accompaniment of lung diseases or chest wall trauma are dealt with as well. There are also chapters that underscore the immuno-inflammatory mechanisms of disorders seemingly unrelated to respiration, such as obesity or aplastic anemia, which may appreciably affect the control of the respiratory system and thus its vulnerability to diseases. The book will be of interest to clinicians and medical researchers.