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Neutrophil: Methods and Protocols (Methods in Molecular Biology #2087)
by Mark T. Quinn Frank R. DeLeoNeutrophils, the most abundant white cells in humans, serve as the primary cellular defense against infection. This volume provides a concise set of protocols for assessing basic neutrophil functions and investigating specialized areas in neutrophil biology. Each of the protocols is written by leading researchers in the field and includes hints for success, as well as guidance for troubleshooting. In the third edition of Neutrophils: Methods and Protocols, chapters retained from previous editions have been have been updated and include many new approaches. In addition, the Third Edition contains a number of new chapters that were not included in the first or second editions. Part I contains overviews of neutrophil biology, function, and disorders. Part II describes commonly used methods to isolate neutrophils from humans and other animal species. Part III details methods for investigating chemotaxis, transmigration, phagocytosis, and bactericidal activity. Part IV includes protocols that measure neutrophil apoptosis, calcium signal transduction, degranulation and detection of cytoplasmic granules, gene expression, transcription factors, and apoptosis. Part V provides multiple assays for measuring production of intracellular and/or extracellular reactive oxygen species, and a method that details use of the cell-free NADPH oxidase assay, an iconic assay for studies of the neutrophil NADPH oxidase. Part VI provides chapters that describe how to analyze formation and function of neutrophil extracellular traps. Neutrophil Methods and Protocols: Third Edition is a comprehensive source for detailed explanations and applications of the most modern methodological advances in neutrophil biology. Both basic scientists and clinicians will find a collection of this caliber to be an invaluable aid in their work with neutrophils.Features• Provides neutrophil protocols that are broadly applicable to leukocyte biology• Includes protocols for isolation of neutrophils from humans and animal species• Presents an interesting and informative overview of the field of neutrophil biology• Facilitates a better understanding of the role of neutrophils in host defenseReadershipMolecular and Cell Biologists, Immunologists, Infectious Disease Specialists, Microbiologists
Neutrophilic Dermatoses
by Daniel Wallach Marie-Dominique Vignon-Pennamen Angelo Valerio MarzanoThis book provides an in depth overview of Neutrophilic Dermatoses, a group of diseases that includes Sweet’s syndrome, pyoderma gangrenosum and subcorneal pustular dermatosis. Although there are still some gaps in the knowledge, it is now clear that their pathophysiology implies that mechanisms associated with auto-inflammation are involved, while many of these dermatoses occur in the setting of other systemic inflammatory diseases (colitis, arthritis) and of malignancies (blood malignancies, solid cancers). As such it is an important area of study within internal medicine. Neutrophilic Dermatoses represents an extensive clinical review of the group of diseases and is a critical resource for all medical professionals managing these patients, including clinicians in dermatology, gastro-enterology,, rheumatology, hematology, and internal medicine.
Never Bet Against Occam
by Lawrence B. Afrin Kendra Neilsen Myles Carol Schaengold Kristi Posival Sisters MediaNever Bet Against Occam: Mast Cell Activation Disease and the Modern Epidemics of Chronic Illness and Medical Complexity
Never Better: Two Kids, Their Dad, and His Wife's Ghost
by Gonzalo RiedelHis wife died before their second son turned one. How can he keep her memory alive when there’s so much he wants to forget?There was a time before his wife got sick when Gonzalo could think about other things. They had full lives where death didn’t factor. Where humour was more than a coping mechanism. Life wasn’t all about treatments and recovery, or the emptiness he felt when she died.They had kids together. Young kids. Less than a year after their youngest was born and suddenly he was strapping them both into their car seats to drive to their mother’s funeral.He used to think he was the glue holding the household together. It didn’t take long for him to realize how wrong he’d been. A grieving husband is in no condition to raise kids alone. There were times when he wanted to toss himself into a raging river that would suck him under and bash his skull on the rocks. That’s always an option for another day. For now, he’ll just squash those feelings and drive the kids to daycare.Does it get easier? Of course. But not right away. They say that hope only comes at the end of a long dark journey, but that isn’t entirely true because the journey never really ends. But that means there’s good news: hope is everywhere you look.
Never Enough: The Neuroscience and Experience of Addiction
by Judith GriselFrom a renowned behavioral neuroscientist and recovered drug addict, an authoritative and accessible guide to understanding drug addiction: clearly explained brain science and vivid personal stories reveal how addiction happens, show why specific drugs--from opioids to alcohol to coke and more--are so hard to kick, and illuminate the path to recovery for addicts, loved ones, caregivers, and crafters of public policy.Addiction is epidemic and catastrophic. With more than one in every five people over the age of fourteen addicted, drug abuse has been called the most formidable health problem worldwide. If we are not victims ourselves, we all know someone struggling with the merciless compulsion to alter their experience by changing how their brain functions. Drawing on years of research--as well as personal experience as a recovered addict--researcher and professor Judy Grisel has reached a fundamental conclusion: for the addict, there will never be enough drugs. The brain's capacity to learn and adapt is seemingly infinite, allowing it to counteract any regular disruption, including that caused by drugs. What begins as a normal state punctuated by periods of being high transforms over time into a state of desperate craving that is only temporarily subdued by a fix, explaining why addicts are unable to live either with or without their drug. One by one, Grisel shows how different drugs act on the brain, the kind of experiential effects they generate, and the specific reasons why each is so hard to kick. Grisel's insights lead to a better understanding of the brain's critical contributions to addictive behavior, and will help inform a more rational, coherent, and compassionate response to the epidemic in our homes and communities.
Never Home Alone: From Microbes to Millipedes, Camel Crickets, and Honeybees, the Natural History of Where We Live
by Rob DunnA natural history of the wilderness in our homes, from the microbes in our showers to the crickets in our basements <P><P>Even when the floors are sparkling clean and the house seems silent, our domestic domain is wild beyond imagination. In Never Home Alone, biologist Rob Dunn introduces us to the nearly 200,000 species living with us in our own homes, from the Egyptian meal moths in our cupboards and camel crickets in our basements to the lactobacillus lounging on our kitchen counters. You are not alone. <P><P>Yet, as we obsess over sterilizing our homes and separating our spaces from nature, we are unwittingly cultivating an entirely new playground for evolution. These changes are reshaping the organisms that live with us--prompting some to become more dangerous, while undermining those species that benefit our bodies or help us keep more threatening organisms at bay. <P><P>No one who reads this engrossing, revelatory book will look at their homes in the same way again.
Never Mind the Sprouts: Simple and Easy Food That All the Family Will Enjoy...Especially Fussy Eaters
by Alastair Williams Claire PlimmerMealtimes can often feel like a battle of wills when there are fussy eaters to cater for. This handy cookbook, packed with mouth-watering, quick and easy-to-execute, nutritious recipes is your one-stop guide to introducing new flavours to a developing palate.
Never Pay the First Bill: And Other Ways to Fight the Health Care System and Win
by Marshall AllenFrom award-winning ProPublica reporter Marshall Allen, a primer for anyone who wants to fight the predatory health care system--and win.Every year, millions of Americans are overcharged and underserved while the health care industry makes record profits. We know something is wrong, but the layers of bureaucracy designed to discourage complaints make pushing back seem impossible. At least, this is what the health care power players want you to think.Never Pay the First Bill is the guerilla guide to health care the American people and employers need. Drawing on 15 years of investigating the health care industry, reporter Marshall Allen shows how companies and individuals have managed to force medical providers to play fair, and shows how you can, too. He reveals the industry's pressure points and how companies and individuals have fought overbilling, price gouging, insurance denials, and more to get the care they deserve. Laying out a practical plan for protecting yourself against the system's predatory practices, Allen offers the inspiration you need and tried-and-true strategies such as: Analyze and contest your medical bills, so you don't pay more than you should Obtain the billing codes for a procedure in advance Write in an appropriate treatment clause before signing financial documents Get your way by suing in small claims courtFew politicians and CEOs have been willing to stand up to the medical industry. It is up to the American people to equip ourselves to fight back for the sake of our families--and everyone else.
Never Pure: Historical Studies of Science as if It Was Produced by People with Bodies, Situated in Time, Space, Culture, and Society, and Struggling for Credibility and Authority
by Steven ShapinSteven Shapin argues that science, for all its immense authority and power, is and always has been a human endeavor, subject to human capacities and limits. Put simply, science has never been pure. To be human is to err, and we understand science better when we recognize it as the laborious achievement of fallible, imperfect, and historically situated human beings.Shapin’s essays collected here include reflections on the historical relationships between science and common sense, between science and modernity, and between science and the moral order. They explore the relevance of physical and social settings in the making of scientific knowledge, the methods appropriate to understanding science historically, dietetics as a compelling site for historical inquiry, the identity of those who have made scientific knowledge, and the means by which science has acquired credibility and authority.This wide-ranging and intensely interdisciplinary collection by one of the most distinguished historians and sociologists of science represents some of the leading edges of change in the scholarly understanding of science over the past several decades.
Never Somewhere Else: Book 1 in the Sunday Times bestselling detective series (DSI William Lorimer #1)
by Alex GrayDiscover your next reading obsession with this iconic first novel in Alex Gray's bestselling Scottish detective series. Perfect for fans of Ian Rankin, Val McDermid and Ann Cleeves Don't miss the latest thrilling instalment of the Lorimer series - BEFORE THE STORM IS OUT NOW WHAT THEY'RE SAYING ABOUT THE LORIMER SERIES:'Warm-hearted, atmospheric' ANN CLEEVES'Relentless and intriguing' PETER MAY'Move over Rebus' DAILY MAIL'Exciting, pacey, authentic' ANGELA MARSONS'Superior writing' THE TIMES'Immensely exciting and atmospheric' ALEXANDER MCCALL SMITH_______________When three young women are discovered strangled and mutilated in a Glasgow park, it is up to DCI Lorimer to find their killer. Frustrated by a lack of progress in the investigation, Lorimer is forced to enlist the services of Dr Solomon Brightman, psychologist and criminal profiler. Together they form an uneasy alliance. But when a homeless man is brought in for questioning the investigation takes a bizarre turn. Soon Lorimer has to scratch the surface of the polished Glasgow art world and reveal the dark layers hidden beneath...
Never Somewhere Else: Book 1 in the Sunday Times bestselling detective series (DSI William Lorimer #1)
by Alex GrayDiscover your next reading obsession with this iconic first novel in Alex Gray's bestselling Scottish detective series. Perfect for fans of Ian Rankin, Val McDermid and Ann Cleeves Don't miss the latest thrilling instalment of the Lorimer series - BEFORE THE STORM IS OUT NOW WHAT THEY'RE SAYING ABOUT THE LORIMER SERIES:'Warm-hearted, atmospheric' ANN CLEEVES'Relentless and intriguing' PETER MAY'Move over Rebus' DAILY MAIL'Exciting, pacey, authentic' ANGELA MARSONS'Superior writing' THE TIMES'Immensely exciting and atmospheric' ALEXANDER MCCALL SMITH_______________When three young women are discovered strangled and mutilated in a Glasgow park, it is up to DCI Lorimer to find their killer. Frustrated by a lack of progress in the investigation, Lorimer is forced to enlist the services of Dr Solomon Brightman, psychologist and criminal profiler. Together they form an uneasy alliance. But when a homeless man is brought in for questioning the investigation takes a bizarre turn. Soon Lorimer has to scratch the surface of the polished Glasgow art world and reveal the dark layers hidden beneath...
Never Somewhere Else: Book 1 in the Sunday Times bestselling detective series (DSI William Lorimer #1)
by Alex GrayDiscover your next reading obsession with this iconic first novel in Alex Gray's bestselling Scottish detective series. Perfect for fans of Ian Rankin, Val McDermid and Ann Cleeves Don't miss the latest thrilling instalment of the Lorimer series - ECHO OF THE DEAD is out now WHAT THEY'RE SAYING ABOUT THE LORIMER SERIES:'Warm-hearted, atmospheric' ANN CLEEVES'Relentless and intriguing' PETER MAY'Move over Rebus' DAILY MAIL'Exciting, pacey, authentic' ANGELA MARSONS'Superior writing' THE TIMES'Immensely exciting and atmospheric' ALEXANDER MCCALL SMITH_______________When three young women are discovered strangled and mutilated in a Glasgow park, it is up to DCI Lorimer to find their killer. Frustrated by a lack of progress in the investigation, Lorimer is forced to enlist the services of Dr Solomon Brightman, psychologist and criminal profiler. Together they form an uneasy alliance. But when a homeless man is brought in for questioning the investigation takes a bizarre turn. Soon Lorimer has to scratch the surface of the polished Glasgow art world and reveal the dark layers hidden beneath...
Never Too Late: Your Guide to Safer Sex after 60 (A Johns Hopkins Press Health Book)
by Shannon DowlerThe ultimate—and fun!—guide to maintaining vibrant sexual health with aging.In Never Too Late, Shannon Dowler, MD, a family physician who is also an expert on sexually transmitted diseases (STD), provides a refreshing overview of sexual education for people over 55. With the advent of dating apps, vibrant 55+ retirement communities, and sexual enhancement drugs, adults are sexually active well into their golden years. Unfortunately, the rates of STDs are dramatically increasing in older adults. In entertaining, accessible language, Dr. Dowler presents relatable patient stories and hilarious rhymes that make for an easy and fun way to learn about safe sex. This guide covers important topics, including:• How to identify the signs and symptoms of different STDs, including newer infections• The importance of regular screening• Best sexual practices, including guidance on medications • Preventative measures, tests, and treatments• Guidance on how to broach difficult conversations with romantic partners and doctors• Details about changing sexual trends, including dating apps, swinging, and normal aging changes that may impact your sexuality• Conditions commonly confused with sexually transmitted infections, such as urinary tract infections, tick-related infections, and forms of dermatitis• Common misconceptions, myths, and assumptions • Advice on seeking medical care when uninsured or financially limitedNever Too Late will help you take charge of your sexual health and learn how to protect yourself and your current and future partners.
Nevogenesis
by Ashfaq A. MarghoobThe "Abtropfung" theory that nevi develop through the migration of nevus cells from the epidermis to the dermis prevailed for almost a century until the "Hochsteigerung" theory postulated the reverse pattern of migration. Most recently, however, new insights gained from epidemiology, cross-sectional and longitudinal studies of nevi, dermoscopy and confocal microscopy, and cellular and molecular studies have brought into question both of these theories. This book provides a comprehensive guide to current knowledge about nevogenesis by presenting these latest advances and in addition discusses issues yet to be resolved. It will assist practicing physicians in effectively managing patients with a variety of nevi and will also be of great value to researchers in the field. Importantly, since nevi are associated with an increased risk of melanoma, understanding nevogenesis may help to unravel some of the mysteries of melanomagenesis.
New Advances in Gastrointestinal Motility Research
by L. K. Cheng A. J. Pullan G. FarrugiaResearch into gastrointestinal motility has received renewed interest in part due to recent advances in the techniques for measuring the structure and function of gastrointestinal cells, tissue and organs. The integration of this wealth of data into biophysically based computation models can aid in interpretation of experimental and clinical measurements and the refinement of measurement techniques. The contents of this book span multiple scales - from cell, tissue, organ, to whole body and is divided into four broad sections covering: i) gastrointestinal cellular activity and tissue structure; (ii) techniques for measuring, analyzing and visualizing high-resolution extra-cellular recordings; (iii) methods for sensing gastroelectrical activity using non-invasive bio-electro-magnetic fields and for modulating the underlying gastric electrical activity and finally (iv) methods for assessing manometric and videographic motility patterns and the application of these data for predicting the flow and mixing behavior of luminal contents by using computational fluid dynamic techniques. This book aims to provide both an overview of historical and existing research techniques as well as to highlight future directions and challenges for the community as a whole. It will be suitable for clinicians to understand the cellular and biophysical underpinnings of gastric emptying, gastroenterologists, surgeons, bioengineers and all scientists with interests in gastrointestinal motility research.
New Advances in SHR Research - Pathophysiology & Pharmacology
by H. Saito Y. Yamori M. Minami S. H. ParvezThis book deals with pathophysiology and pharmacology of spontaneously hypertensive rats (SHR) and describes new trends in SHR research from hemodynamic characteristics to immunological views. It is devoted to the use of tissue culture studies to elaborate SHR characteristics.
New Advances in Technology for Social Work Education and Practice
by Julie Miller-CribbsGain practical knowledge of the latest technological innovations in social work! This comprehensive book examines the role of technology in four areas: information management, distance education evaluation, video- and web-based learning and training, and working with vulnerable populations. New Advances in Technology for Social Work Education and Practice discusses constructive, proven applications of technology in settings from modern universities to rural India. The empirical research and case studies presented here offer practical suggestions for implementing effective technological solutions tailored to the needs of social workers and their clients.New Advances in Technology for Social Work Education and Practice includes useful strategies for creating user-friendly systems, including: involving practitioners in systems design and evaluation dealing with political issues choosing effective instructors for distance education developing multimedia testing for supervisor training designing Web pages for users with disabilities
New Advances on Disease Biomarkers and Molecular Targets in Biomedicine
by Nikki P. Lee C. Y. Cheng John M. LukRising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand our options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. We also cover topics that are more advanced in development to emerging scientific discoveries. In particular, we have included in this monograph concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. We hope that this book can renew established concepts in the field, and at the same time lead to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.
New Age Herbals: Resource, Quality And Pharmacognosy
by Brahma Singh K. V. PeterImportance of herbs (medicinal plants) can hardly be overemphasized. They are exploited for manyfold applications, ranging from phytopharmaceuticals, to nutraceuticals, to cosmetics and many others. Keeping in view the richness of herbs and their vast potential, this book collates the most up-to-date knowledge of important herbs and herbals. The book also gives an overview of some issues causing hindrance in the promotion of herbals. This book attempts to compile the rich experience of experts working on various herbs. New age single plant species, having multiple medicinal traits worth exploiting i.e. Hippophae rhamnoides (seabuckthorn), and Morinda citrifolia (noni) also find place as full chapters in the book.
New Agents for the Treatment of Acute Lymphoblastic Leukemia
by Vaskar Saha Pamela KearnsThe majority of cancers present at a relatively advanced stage in which invasion within the primary organ is well established and metastases to lymph and distant organs are either clinically apparent or present at the microscopic level. However, it is increasingly recognized that the natural history of cancer formation is a long and complex path taking many years to develop to a clinically apparent stage in most cases. Furthermore, for most solid tumours there is a pre-invasive or intraepithelial stage of disease. This affords the opportunity for early detection and prevention of invasive disease and hence a cure. However, with this advancing knowledge comes a whole plethora of questions which will be explored in this monograph. Firstly, we need to understand the global burden of pre-invasive disease and what the public health implications might be for wide-scale screening programmes. In the western world we already have experience of screening for cervical, breast, prostate and more recently colon cancer. As well as their potential benefits these programmes have financial and psychosocial implications which need to be carefully weighed. This is especially true since many pre-invasive lesions will not progress to cancer in a individual's lifetime. In addition, there are questions concerning whether screening reduces the cancer burden or in fact distorts the survival figures through lead-time bias. Secondly, at the level of epidemiology and molecular pathogenesis there are important questions regarding the aetiology of pre-invasive lesions; an understanding of which might lead to possible chemopreventive strategies. For example, it would be helpful to know the extent to which the likelihood of developing a pre-invasive lesion is influenced by lifestyle or genetic factors and how these factors influence the risk of progression to invasive disease. At the molecular level we need to understand the pathways and molecular mechanisms, both genetic and epigenetic, by which cells achieve the capacity to invade. Thirdly, in order make clinical progress we need biomarkers to identify and risk stratify individuals with pre-invasive lesions. These biomarkers might be applied to the serum as in Prostate Specific Antigen in prostate cancer or be applied to tissue samples, such as oestrogen receptor status in breast cancer. In order to utilize biomarkers in the context of a screening programme there are issue around the invasiveness of the test as well as its positive and negative predictive value. With advances in molecular imaging there is now the exciting possibility of incorporating a molecular tag to a non-invasive imaging modality. Fourthly, in order to justify screening early detection must be coupled to a treatment strategy. If the chemopreventive agent is very well tolerated, then as well as targeting high risk groups, one might consider treatment at the population level. Aspirin is one such drug which has been extensively assessed in the context of colon cancer chemoprevention trials. Trials of aspirin chemoprevention are now being applied to other cancers such as oesophageal adenocarcinoma and since many individuals take aspirin for .chemoprevention of cardiovascular disease the cancer incidence can be ascertained in these populations. In order to understand the more general issues raised from the discussions above it is useful to consider disease specific examples. Our understanding of pre-invasive disease varies according to the organ site and there are lessons to be learned from these experiences. For example, there is now the prospect of a vaccine for cervical cancer with important questions about how this might be applied to the high incidence areas of the developing world. On the other hand, ductal carcinoma in situ is currently treated by mastectomy which is more radical than the treatment received by many women with invasive disease. Oesophageal adenocarcinoma, which is my own area of expertise is interesting because of the rapid rise in incidence in the western world and the clinically accessible pre-invas...
New Anti-cancer Drug Development and Evaluation
by Yongchang Zhang Nong YangThis book aims to help researchers to understand the current status of new drug development in China and major events experienced in the development of new drugs. It also helps clinicians and basic research scientists to grasp the types, indications, and adverse reactions of common new drugs; clarifies key events experienced during the launch of new drugs; and discusses future perspectives of clinical medicine development. This book is also beneficial to clinicians by helping them to better become physician scientists.
New Antibiotic Targets
by W. Scott ChampneyThis book examines specific techniques which can be used to explore new drug targets and the effectiveness of new antibiotics. By testing new antimicrobial agents and modified existing drugs, the most vulnerable cell processes, such as cell wall and membrane synthesis, DNA replication, RNA transcription and protein synthesis, can be better exploited. This in-depth volume, however, delves even deeper by identifying additional novel cellular targets for these new therapies. The book will provide laboratory investigators with the vital tools they need to test the antimicrobial potential of products and to curb the rise of so many infectious diseases.
New Antimicrobials: For the Present and the Future (Emerging Infectious Diseases of the 21st Century)
by I.W. FongThis is a timely and essential companion to the recently published Antimicrobial Resistance in the 21st Century, Second Edition. Antimicrobial resistance is a major threat to global population health, with government reports projecting it could result in over 10 million deaths in the next 35 years. Development of new agents to combat this threat is one of the WHO's top priorities, but in 2017, it conceded that the current drug development pipeline was insufficient to mitigate the threat. This book discusses recent progress and bolster new agent discovery and development, by providing researchers and students who will soon enter the field with a thorough guide to the advancements made in the last decade. Coverage includes new systemic antimicrobials approved since 2010, with detailed analysis of antibiotics, antivirals, antifungals, and antiparasitics, as well as agents in development for future use. Discussion of each drug will include its chemical nature, pharmacology/pharmacokinetics, antimicrobial spectrum, dosage, adverse reactions, drug interactions, microbial resistance, indications, clinical efficacy compared to older agents, and lists of similar agents with cost comparison. This volume is designed for researchers and students of infectious disease and medical microbiology, as well as clinicians in need of a comprehensive guide to newly developed agents.
New Approaches for Multidimensional Signal Processing: Proceedings of International Workshop, NAMSP 2021 (Smart Innovation, Systems and Technologies #270)
by Kazumi Nakamatsu Roumen Kountchev Rumen MironovThis book comprises a collection of papers presented at the International Workshop on New Approaches for Multidimensional Signal Processing (NAMSP 2021), held at Technical University of Sofia, Sofia, Bulgaria, during 08–10 July 2021. The book covers research papers in the field of N-dimensional multicomponent image processing, multidimensional image representation and super-resolution, 3D image processing and reconstruction, MD computer vision systems, multidimensional multimedia systems, neural networks for MD image processing, data-based MD image retrieval and knowledge data mining, watermarking, hiding and encryption of MD images, MD image processing in robot systems, tensor-based data processing, 3D and multi-view visualization, forensic analysis systems for MD images and many more.
New Approaches to Asian History: Epidemics in Modern Asia
by Robert PeckhamEpidemics have played a critical role in shaping modern Asia. Encompassing two centuries of Asian history, Robert Peckham explores the profound impact that infectious disease has had on societies across the region: from India to China and the Russian Far East. The book tracks the links between biology, history, and geopolitics, highlighting infectious disease's interdependencies with empire, modernization, revolution, nationalism, migration, and transnational patterns of trade. By examining the history of Asia through the lens of epidemics, Peckham vividly illustrates how society's material conditions are entangled with social and political processes, offering an entirely fresh perspective on Asia's transformation.