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Oncodynamics: Effects of Cancer Cells on the Body
by Gurmit SinghThis volume will introduce new terminology to the field of oncology, subdividing it into oncokinetics--the mechanics of the tumor cells as they arise and spread throughout the body--and oncodynamics--the impact of abnormal cues generated by tumors on the physiological functioning of the body. The volume will outline the importance of oncodynamics from both a cancer patient's and a caregiver's perspectives, stressing its significant impact on cancer patient functionality and the opportunity that cancer researchers will have to develop cross-disciplinary interactions and predict potential consequences of tumors and/or treatment.
Oncofertility
by Lisa Campo-Engelstein Sarah Rodriguez Laurie Zoloth Teresa K. WoodruffOncofertility has emerged as a way to address potential lost or impaired fertility in cancer patients and survivors, with active biomedical research that is developing new ways to help these individuals preserve their ability to have biological children. In order to move beyond oncofertility as a science and medical technology and begin to address the ethical, legal, and social ramifications of this emerging field, we must give voice to scholars from the humanities and social sciences to engage in a multidisciplinary discussion. This book brings together a pool of experts from a variety of fields, including communication, economics, ethics, history, law, religion, and sociology, to examine the complex issues raised by recent developments in oncofertility and to offer advice from national and international perspectives as we create new technology. Given the inherent interdisciplinary nature of oncofertility, this book is not only valuable, but also necessary to cultivate a deep understanding of new issues with the eventual aim of offering proposals for addressing them. Indeed, this book will be useful for people not only within the humanities and social sciences disciplines but also for those who are confronted with cancer and the possibility of impaired fertility and the medical practitioners within oncology and reproductive medicine who are at the front lines of this emerging field.
Oncofertility Communication
by Teresa K Woodruff Marla L Clayman Kate E WaimeyOncofertility integrates the two previously distinct fields of cancer treatment and fertility research and aims to explore and expand the reproductive future of cancer survivors. In order to achieve the goal of fertility preservation, the Oncofertility community must focus on communication and the way data is provided and received. Concomitant with the rapidly changing technology of Oncofertility, there have been radical shifts and advances in the way health educators and clinicians can produce and share information. As success rates of reproductive techniques such as egg freezing and banking continue to rise, providing increasing opportunities for young cancer patients to preserve their fertility prior to the onset of cancer treatments, communication among professionals in oncology, reproductive medicine, and psychosocial work, among others, becomes crucial, and clinical demand for Oncofertility information is expected to rise considerably. Oncofertility Communication describes and addresses the myriad channels through which the multiple audiences involved in Oncofertility can be served with appropriate and accurate information about cancer-related fertility issues. The text answers frequently asked questions and provides invaluable insights to scientific and health care professionals about communication among the diverse Oncofertility audiences. It incorporates timely discussions about traditional and emerging electronic communication tools and discusses the impact of health care policy changes on the Oncofertility field.
Oncofertility Medical Practice
by Teresa K Woodruff Clarisa GraciaOncofertility is a specialty that bridges the disciplines of reproductive endocrinology and infertility and oncology, with the goal of expanding the reproductive options of cancer patients. Given fertility risks associated with specific cancer treatments, as well as the improved long-term survival made possible by these therapies, there has been growing interest in expanding reproductive options for cancer patients. Indeed, both cancer survivors and the medical community have acknowledged the importance of patient counseling and the pursuit of fertility preservation options prior to starting cancer treatment. Oncofertility Medical Practice: Clinical Issues and Implementation is the third in a series of timely and indispensable books on fertility preservation for cancer patients--the first one focused on advances in basic science research and the second one offered ethical, legal, and social perspectives on the theme. This book elucidates the latest practices and emerging treatments in oncofertility and provides necessary information on the successes, risks, and limitations of fertility preserving technologies. Authoritative and insightful, written by an impressive multi-disciplinary cadre of specialists, this book is a valuable up-to-date resource for all those practicing in this demanding field. "This excellent text is an invaluable resource and a "must read" for clinicians and researchers interested in Oncofertility. The editors and authors need to be congratulated for their fine work." Roger A. Lobo, MD, Professor of Obstetrics and Gynecology, Columbia University and Past President of the American Society for Reproductive Medicine
Oncogene-Induced Senescence
by Mikhail A. NikiforovThis book offers in a single volume a unique collection of the state-of the-art experimental procedures utilized for the induction, detection, and modeling of this complex cellular program of oncogene-induced senescence. The book encompasses protocols for studying this multi-step program in human specimens and a variety of experimental models including cultured mammalian cells, laboratory mice, and Drosophila melanogaster, as well as offering a description of high throughput approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Oncogene-Induced Senescence: Methods and Protocols represents a valuable asset for a wide audience of medical oncologists and researchers in the fields of oncology, molecular and cellular biology, biochemistry, and animal development.
Oncogenes (Routledge Revivals)
by Enrique PimentelFirst published in 1986, this comprehensive work focuses on the "Acute and Chronic Transforming Retroviruses," "Cellular and Viral Oncogenes," "Functions of Oncogene and Protooncogene Protein Products," and "Oncogenes and Cancer." The number of oncogenes presently identified has grown to more than double of that which was discussed in the first edition of this book. It more clearly explains the relation of protooncogenes to neoplastic diseases, especially to human cancer. This updated edition is an absolute must for all physicians and biologists.
Oncogenes Meet Metabolism
by Dominik Mumberg Thomas Steger-Hartmann Björn Riefke Guido Kroemer Kirstin Petersen Kector KeunIn 1920s, Otto Warburg described the phenomenon of 'aerobic glycolysis', the ability of tumour cells to convert glucose to lactate in the presence of normal oxygen conditions. Warburg's hypothesis of an altered metabolism in cancer cells found no immediate acceptance, though it was latter confirmed for most human tumours. With the advent of molecular biology the focus in tumour research has shifted towards the search for oncogenes. However, the interest in cancer molecular profiling eventually led to a renaissance of the Warburg effect trying to combine genetic alterations with effects on metabolism with the help of modern analytic technologies to rapidly analyze broad varieties of metabolites in various tissues and bodyfluids (metabonomics).
Oncogenic Herpesviruses: Volume 2 (Routledge Revivals)
by Fred RappFirst published in 1980: This book attempts to coalesce current information regarding the oncogenic properties of those human and animal herpesviruses which has been studied in some detail.
Oncoimmunology
by Laurence Zitvogel Guido KroemerIn this book, leading experts in cancer immunotherapy join forces to provide a comprehensive guide that sets out the main principles of oncoimmunology and examines the latest advances and their implications for clinical practice, focusing in particular on drugs with FDA/EMA approvals and breakthrough status. The aim is to deliver a landmark educational tool that will serve as the definitive reference for MD and PhD students while also meeting the needs of established researchers and healthcare professionals. Immunotherapy-based approaches are now inducing long-lasting clinical responses across multiple histological types of neoplasia, in previously difficult-to-treat metastatic cancers. The future challenges for oncologists are to understand and exploit the cellular and molecular components of complex immune networks, to optimize combinatorial regimens, to avoid immune-related side effects, and to plan immunomonitoring studies for biomarker discovery. The editors hope that this book will guide future and established health professionals toward the effective application of cancer immunology and immunotherapy and contribute significantly to further progress in the field.
Oncologic Breast Surgery
by Carlo MariottiThis book presents the most recent developments in oncologic breast surgery and takes full account of diagnostic, pathologic, and radiologic inputs. It is divided into three parts, the first of which discusses the premises underlying the modern surgical approach to breast cancer. The second part is devoted to what might be termed the conservative program, i. e. , breast conservation and oncoplastic surgery, conservative mastectomy, and sentinel node biopsy and axillary dissection. The final part of the book covers different forms of surgery and other treatments in particular settings. Topics include plastic and reconstructive surgery, DCIS surgery, radio-guided surgery, adjuvant systemic therapy, intraoperative radiotherapy, and the role of surgery in locally advanced and metastatic disease. The detailed descriptions of techniques are accompanied by numerous high-quality illustrations. This book will be of value to both experienced practitioners and surgical trainees.
Oncologic Emergencies
by Ellen F. Manzullo Carmen Esther Gonzalez Carmen P. Escalante Sai-Ching J. YeungThis new resource on managing oncologic emergencies is directed at all health care professionals who care for patients with cancer or survivors. Edited and written by clinician-experts at The University of Texas MD Anderson Cancer Center, the book covers the full range of oncologic emergencies, from cardiac and neurologic to orthopedic to hematologic, and addresses important palliative care, ethical, and Emergency Department considerations. Chapters are structured with busy clinicians in emergent and urgent settings in mind, and each chapter concludes with a series of key practice points and a list of suggested readings for those who wish to delve deeper into a subject. For any clinician facing the increasing number of patients who experience an oncologic emergency, this is an up-to-date, clinically focused, and authoritative resource.
Oncologic Emergency Medicine: Principles and Practice
by Knox H. Todd Charles R. Thomas Kumar AlagappanThe expanded second edition of this key clinical reference provides the most up-to-date and comprehensive review of oncologic emergencies. It covers the diagnosis and management of the full range of emergencies caused directly by cancer and/or treatment, including chemotoxicity, radiotoxicity and post-surgical complications, as well as transplant-related issues and toxicities of novel antineoplastic agents and the new immunotherapies. The book also shows how the entire spectrum of clinical medicine is brought to bear in the care of cancer patients in the unique setting of the emergency department (ED), from health promotion and prevention, to treatment and palliative care. Recognizing the multiple, overlapping contexts in which emergency care of cancer patients occurs, the book addresses clinically crucial interdisciplinary topics such as the ethics of ED cancer care, analgesic misuse and abuse, informatics, quality improvement and more. Finally, perspectives on care system and social forces that shape ED cancer care, such as cancer care disparities and care models, frame the book as a whole. Edited and written by world-renowned experts in emergency medicine and oncology, the Second Edition of Oncologic Emergency Medicine: Principles and Practice is the definitive resource for emergency physicians, oncologists, internists, family physicians, emergency nurses, nurse practitioners, physician assistants, and policy makers as well as pre and postgraduate trainees.
Oncologic Emergency Medicine
by Knox H. Todd Charles R. Thomas Jr.This is the first comprehensive clinical reference on cancer emergencies. It is edited and written by world-renowned experts in emergency medicine and oncology and covers the diagnosis and management of the full range of emergencies caused directly by cancer or by its treatment. It shows how the entire spectrum of clinical medicine is brought to bear in the care of cancer patients in the unique setting of the emergency department (ED), from health promotion and prevention, to treatment and palliative care. Recognizing the multiple, overlapping contexts in which emergency care of cancer patients occurs, the book addresses clinically crucial interdisciplinary topics such as the ethics of ED cancer care, the interface with palliative social work, substance abuse, and more. Finally, perspective on care system and social forces that shape ED cancer care, such as cancer care disparities and care models, and on how ED cancer care is delivered outside of the United States, frame the book as a whole. Against the backdrop of rising numbers of cancer patients andsurvivors as the United States population ages and a forecast shortage ofoncologists, this book is designed to serve as the authoritative, single-source clinical reference on cancer emergencies. The intended audience includes emergency physicians, oncologists, internists, family physicians, emergency nurses, nurse practitioners, physician assistants, policy makers as well aspre- and postgraduate trainees.
Oncologic Imaging: Bone Tumors
by Heung Sik Kang Joong Mo Ahn Yusuhn KangThis book aims to provide readers with a sound understanding of the spectrum of radiologic appearances of bone tumors, which reflect histopathology, and the pattern analysis of imaging findings. The first part of the book explains basic concepts and diagnostic parameters, including demographics, lesion location, biological activity, matrix mineralization, and endosteal and periosteal reactions. In the second part, typical and atypical radiologic features of bone tumors are reviewed in detail, with emphasis on the characteristic radiographic and MR imaging findings and reference to schematic drawings and pathologic or operative images when appropriate. The third part focuses on problem solving in cases encountered in real radiology practice and identifies categorical patterns on the basis of radiographic and MR variables and lesion location. Informative cases are illustrated and compared to enhance understanding of differential diagnosis using pattern analysis. The final part of the book helps readers to consolidate what they have learned and to hone their diagnostic reasoning skills by presenting about 30 typical bone tumor cases with questions, answers, and commentary.
Oncologic Imaging: Soft Tissue Tumors
by Heung Sik Kang Sung Hwan Hong Ja-Young Choi Hye Jin YooThis book helps readers to overcome the challenges encountered during the imaging diagnosis of soft tissue tumors due to their diversity and the significant overlap in imaging features between different tumors. It does so by fostering familiarization with typical findings and clearly explaining the pattern analysis of soft tissue tumors. The book opens with an overview of diagnostic considerations and discussion of the basic concepts of diagnostic imaging studies and histopathologic examinations. Grading and staging of soft tissue sarcomasare then described. In the second part of the book, radiologic features of soft tissue tumors are reviewed in detail, based on the 2013 WHO classification system. The third part summarizes diagnostic imaging clues, including characteristic imaging findings and radiologic signs that aid in specific diagnosis and differential diagnosis. The book closes by presenting 30 typical cases of soft tissue tumors, with questions, answers, and commentary, in order to help readers to consolidate what they have learned and to hone their diagnostic reasoning skills.
Oncologic Imaging: Spine and Spinal Cord Tumors
by Heung Sik Kang Joon Woo Lee Eugene LeeThis book is a detailed guide to image interpretation in patients with spine and spinal cord tumors that will enable clinicians and residents to improve their diagnostic abilities. The book opens by introducing basic concepts in the imaging of spinal tumors, namely the compartmental approach and the histologic basis for the different imaging appearances. These concepts are explained with the aid of representative cases and schematic illustrations. The second part of the book represents a "training step" in which various spinal tumors are described in detail, focusing on the imaging findings. Representative cases are presented with radiographic, CT, and MR images; in addition, schematic illustrations and pathologic or operative images are included in selected cases. The third part is a "practice step" describing tips for correct imaging diagnosis. Individual chapters in this part focus on incidence-, age-, location-, and imaging pattern-based approaches to bone, extradural, intradural extramedullary, intramedullary, and pediatric spinal tumors. The presented cases will enhance the reader's understanding of the different tumor patterns and assist in solving diagnostic problems that may be encountered in daily practice.
Oncologic Imaging: Urology
by Seung Hyup Kim Jeong Yeon ChoThis book is designed as a reference and working guide for practitioners who deal with patients with neoplastic diseases of the urinary tract and male genitalia, including tumors of the kidney, ureter and urinary bladder, prostate, testis, adrenal gland, and retroperitoneum. Each chapter describes and illustrates key imaging findings relevant to the characterization, differential diagnosis, and staging of lesions. Pattern recognition is facilitated through the use of schematic drawings, and imaging findings on post-treatment follow-up also form an important component of the book. Brief core descriptions of related multidisciplinary fields, such as nuclear medicine, pathology, urologic surgery, and radiation oncology are included whenever relevant.
Oncologic Surgical Emergencies: A Practical Guide for the General Surgeon (Hot Topics in Acute Care Surgery and Trauma)
by Antonio Tarasconi Simona Bui Mircea Chirica Gaël Roth Jeffry NahmiasThis book will offer a practical guide for the surgical management of oncologic emergencies, that pose great challenges to both surgeons and oncologists. Combining the knowledge of experienced surgeons and oncologists, it describes the experience gained from daily life into a tertiary hospital. Every chapter will be focused on radical treatment of primary tumors, metastatic disease and palliation, and will include an “Highlight” section with 4-5 key messages at the beginning of each chapter, whereas at the end a flow-diagram will be employed to summarize the subject discussed topic. Every chapter will be written by at least two authors, including a surgeon and an oncologist, to guarantee a 360 degrees analysis of each topic. This work will benefit both surgeons and oncologists: surgeons will found in it a step to step practical tool that helps the decision making process, while oncologists will find interesting indications about how and when to involve a general surgeon into the management of an oncologic emergent condition.
Oncological PET/CT with Histological Confirmation
by Juliano Cerci Stefano Fanti Dominique DelbekeThis book reviews the important new field of PET/CT-guided biopsy, which is of potential value in optimizing the diagnostic yield of biopsies. The role of this technology is examined in a range of malignancies, including lymphoma, pancreatic, breast cancer and CNS malignancies. True positive and false positive cases are presented and discussed, and many aspects of PET and pathology are addressed. The book describes many case presentations illustrated with mostly 18F-FDG PET/CT images, but also other PET radiopharmaceuticals such as 18F-FLT. The three editors are expert nuclear medicine physicians from Europe and North and South America, and the range of experiences gained in using PET/CT across the globe is reflected in the book.
Oncological Surgical Pathology
by Annikka Weissferdt Cesar A. Moran Neda KalhorThis text provides the necessary tools and up-to-date information on the morphological approach and most current use of ancillary techniques in the diagnosis and treatment of malignant tumors. The work is divided by sub specialty areas so that the reader can easily obtain the information desired. Features of histopathological lesions are presented in each area, as well as an up-to-date use of the different immunohistochemical stains and molecular biology features, when applicable, which are commonly used to determine treatment modalities. All sub specialty sections are written by sub specialty pathologists with experience in tumor pathology and who work in a cancer center. Each chapter is richly illustrated and properly referenced. Oncological Surgical Pathology will be of use not only for pathologists (including pathology residents and fellows), but also for oncological surgeons, oncologists and interventional radiologists.
Oncologie: Handboek voor verpleegkundigen en andere hulpverleners
by B.F.H. van Walle-van de Geijn H.A.M. van Muilekom J.A. van SpilEen vooral door oncologieverpleegkundigen en medisch specialisten geschreven handboek over alle gebieden binnen de oncologie waar de verpleegkundige mee te maken kan krijgen.
Oncology
by Mark Bower Jonathan WaxmanCancer is one of the most rapidly changing areas of medicine, affecting ever-increasing numbers of people, and this new edition of Lecture Notes: Oncology brings together all the information a medical student or graduate clinician needs in one accessible volume. It covers the scientific basis and social impact of cancer, describes the origins and presentations of cancer on a regional and system basis, and discusses the fundamentals of oncology treatment and patient management. Including a new section on epigenetics, clinical vignettes, clear illustrations, tables and diagrams, as well as a self-test section of MCQs, Lecture Notes: Oncology provides core knowledge for professionals involved in cancer care.
Oncology (Mount Sinai Expert Guides)
by William K. Oh Ajai ChariThe Mount Sinai Expert Guides provide quick access to point-of-care specialist clinical information for physicians across a range of therapeutic areas. For each specialty area, the guides emphasize: • Common pitfalls in diagnosis and management • How to prevent complications • Diagnostic and treatment algorithms • Key scientific trials • Evidence-based clinical content • Major society guidelines in order to summarize the very latest in diagnosis and management of diseases and related symptoms. Edited by renowned specialists from the Icahn School of Medicine at Mount Sinai, key faculty members provide the content for all chapters. To ensure consistency within each book and the series as a whole, chapters follow a unified structure throughout. Bonus features such as online case studies with related questions for self-assessment, key patient advice, and ICD codes are provided via the series companion website. Each guide also has its own mobile app available for purchase, allowing you rapid access to the key features wherever you may be.
Oncology and COVID 19: Impact of the Pandemic on Patients and Treatments
by Luigi Cavanna Chiara Citterio Gabriella Marfe Luigi MontanoThose affected by cancer or receiving cancer treatment have often been more susceptible to infections due to coexisting chronic diseases, overall poor health status, and systemic immunosuppressive states caused by both cancer and anticancer treatments. This pioneering text is an introduction to the key topics in the relationship between infection, pollution, and cancer and is an invaluable resource for residents and junior faculty in Oncology facing the practical problems arising and for those still in training. *Looks at the lessons to be learned for future Oncology patients from a series of studies. *Presents relevant international experience from Oncology clinicians and researchers. *Brings together input from different countries, systems, and specialties.
Oncology at a Glance
by Graham G. DarkThis brand new title in the market-leading at a Glance series brings together fundamental information on cancer biology and treatment to provide a holistic understanding of oncology. It explores both relevant scientific content and key human issues, including communication and palliative care.Oncology at a Glance:* Provides an accessible overview of the scientific foundation of cancer medicine* Covers the common cancers as well as key information on presentation and approaches to investigation and management* Includes young adult oncology, the multidisciplinary team, clinical trials in oncology, approach to treatment and response assessment, management of nausea, and end-of-life care* Was developed with students for students, to ensure it contains exactly what students need to knowOncology at a Glance is an ideal guide for medical students and foundation-year doctors as well as any other healthcare professionals looking to consolidate their knowledge of oncology.