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Optimization of Pharmaceutical Processes (Springer Optimization and Its Applications #189)
by Panos M. Pardalos Rohit Ramachandran Antonios FytopoulosOptimization of Pharmaceutical Processes presents contributions from leading authorities in the fields of optimization and pharmaceutical manufacturing. Formulated within structured frameworks, practical examples and applications are given as guidance to apply optimization techniques to most aspects of pharmaceutical processes from design, to lab and pilot scale, and finally to manufacturing. The increasing demand for better quality, higher yield, more efficient-optimized and green pharmaceutical processes, indicates that optimal conditions for production must be applied to achieve simplicity, lower costs and superior yield. The application of such methods in the pharmaceutical industry is not trivial. Quality of the final product is of major importance to human health and the need for deep knowledge of the process parameters and the optimization of the processes are imperative. The volume, which includes new methods as well as review contributions will benefit a wide readership including engineers in pharmaceuticals, chemical, biological, to name just a few.
Optimization of Pharmaceutical R&D Programs and Portfolios
by Zoran AntonijevicVery little has been published on optimization of pharmaceutical portfolios. Moreover, most of published literature is coming from the commercial side, where probability of technical success (PoS) is treated as fixed, and not as a consequence of development strategy or design. In this book there is a strong focus on impact of study design on PoS and ultimately on the value of portfolio. Design options that are discussed in different chapters are dose-selection strategies, adaptive design and enrichment. Some development strategies that are discussed are indication sequencing, optimal number of programs and optimal decision criteria. This book includes chapters written by authors with very broad backgrounds including financial, clinical, statistical, decision sciences, commercial and regulatory. Many authors have long held executive positions and have been involved with decision making at a product or at a portfolio level. As such, it is expected that this book will attract a very broad audience, including decision makers in pharmaceutical R&D, commercial and financial departments. The intended audience also includes portfolio planners and managers, statisticians, decision scientists and clinicians. Early chapters describe approaches to portfolio optimization from big Pharma and Venture Capital standpoints. They have stronger focus on finances and processes. Later chapters present selected statistical and decision analysis methods for optimizing drug development programs and portfolios. Some methodological chapters are technical; however, with a few exceptions they require a relatively basic knowledge of statistics by a reader.
Optimizing Aesthetic Toxin Results (Series in Cosmetic and Laser Therapy)
by Yates Yen-Yu ChaoBotulinum toxin injections are the most used and best-known aesthetic treatment internationally, but there remain a number of problematic topics and suboptimal results. Here an internationally known expert and his contributors explain the scientific background and aesthetic principles that can help clinicians achieve better results in problem cases.
Optimizing Cognitive Rehabilitation
by Lyn Turkstra Mckay SohlbergRehabilitation professionals face a key challenge when working with clients with acquired cognitive impairments: how to teach new skills to individuals who have difficulty learning. Unique in its focus, this book presents evidence-based instructional methods specifically designed to help this population learn more efficiently. The expert authors show how to develop, implement, and evaluate an individualized training plan. They provide practical guidelines for teaching multistep procedures, cognitive strategies, the use of external aids, and more. User-friendly features include 17 sample worksheets and forms; blank forms can be downloaded and printed in a convenient 8 1/2" x 11" size.
Optimizing Emergency Department Throughput: Operations Management Solutions for Health Care Decision Makers
by John M. Shiver David EitelAcross the country ambulances are turned away from emergency departments (EDs) and patients are waiting hours and sometimes days to be admitted to a hospital room. Hospitals are finding it hard to get specialist physicians to come to treat emergency patients. Our EDs demand a new way of thinking. They are not at a tipping point; they are at a break
Optimizing Hospital-wide Patient Scheduling
by Daniel GartnerDiagnosis-related groups (DRGs) are used in hospitals for the reimbursement of inpatient services. The assignment of a patient to a DRG can be distinguished into billing- and operations-driven DRG classification. The topic of this monograph is operations-driven DRG classification, in which DRGs of inpatients are employed to improve contribution margin-based patient scheduling decisions. In the first part, attribute selection and classification techniques are evaluated in order to increase early DRG classification accuracy. Employing mathematical programming, the hospital-wide flow of elective patients is modelled taking into account DRGs, clinical pathways and scarce hospital resources. The results of the early DRG classification part reveal that a small set of attributes is sufficient in order to substantially improve DRG classification accuracy as compared to the current approach of many hospitals. Moreover, the results of the patient scheduling part reveal that the contribution margin can be increased as compared to current practice.
Optimizing Housing for the Elderly: Homes Not Houses
by Leon A PastalanDiscover the diverse range of housing options available to the elderly population with this excellent new book. This timely volume addresses the public policy and design and development issues that must necessarily face those concerned with housing our steadily growing elderly population. The chapters cover a broad spectrum of populations including elderly people in “aging ghettoes” in suburbia, continuing care retirement community residents, full-time recreational vehicle travelers, and the homeless elderly. The authoritative contributors go beyond descriptions of wide-ranging elderly housing options and delve into the central themes that influence them all. Optimizing Housing for the Elderly explores some common considerations such as personal security, food and medical services, independence, and social interaction, that are important determining factors when selecting a style of housing, and addresses economic questions including advice on reducing costs in popular continuing care retirement communities, currently inaccessible to lower-income elderly people. Professionals involved in any aspect of housing for the elderly will benefit from the information in this insightful book.
Optimizing IUD Delivery for Adolescents and Young Adults: Counseling, Placement, and Management
by Mandy S. Coles Aisha MaysMany individuals worldwide initiate sexual activity during their adolescent and young adult (AYA) years and are in need of safe and effective contraceptive services. Because of their safety profile, ease of use, and privacy many international professional organizations recommend that long-acting reversible contraception (LARC), including intrauterine devices (IUDs), be included in contraception discussions with AYAs. IUDs are particularly advantageous because these methods are safe and highly effective (>99% efficacy), are easier to keep confidential because they are often undetectable to others, and do not require daily adherence or frequent visits for refills. Despite significant evidence of their safety, acceptability, and effectiveness among adolescents and AYAs, IUDs remain underutilized in this population. Written by experts in the field, Optimizing IUD Delivery for Adolescents and Young Adults provides a comprehensive framework that examines the history of IUDs, counseling, initiation, placement, and follow-up techniques that are unique to AYA populations. The text closes with resource chapters, including, expert clinical pearls for AYA IUD delivery, how to access IUD training, and information on IUD billing and reimbursement. In an effort to integrate the voice of youth, clinical case examples and patient stories are utilized throughout to provide both a clinical grounding for each chapter and context within which to apply the chapter material.
Optimizing Metabolic Status for the Hospitalized Patient: The Role of Macro- and Micronutrition on Disease Management
by Michael M. Rothkopf, MD, FACP, FACN Jennifer C. JohnsonThis book is a guide for clinicians seeking to use metabolic approaches in the care of hospitalized patients. Since a nutritional component exists for practically any disease process managed, it is important to properly address the macro- and micronutrient issues that can help facilitate a favourable clinical outcome. Metabolic medicine is a newly recognized speciality that applies proven nutritional approaches to support hospitalized patients within existing standards of care. Optimizing Metabolic Status for the Hospitalized Patient: The Role of Macro- and Micronutrition on Disease Management addresses the gap of nutrition knowledge among physicians who generally care for patients without addressing the nutritional and metabolic perspective. Features: · State-of-the-art guidelines for practicing metabolic medicine in the hospital setting. · “Hands on” guide for day-to-day metabolic management of hospitalized patients. · Personal insights from one of the field’s leading practitioners, drawing upon decades of experience. · Historical reviews of key scientific developments. This book is written by Dr Michael M. Rothkopf, Clinical Professor of Medicine at Rutgers/New Jersey Medical School. Dr Rothkopf founded the Metabolic Medicine Center at Morristown Medical Center and is the current Metabolic Medicine Consultant for the Heart Transplant, Lung Transplant, Cardiac Surgery and Wound Care Programs at RWJBH/Newark Beth Israel Medical Center. This book is directed at the physician level of hospital care. It provides value to a broad range of physicians regardless of their medical specialty or subspecialty. It will also be useful for medical students and resident physicians in training as well as nurse practitioners and physician assistants working in hospital settings.
Optimizing Pharmacotherapy in Older Patients: An Interdisciplinary Approach (Practical Issues in Geriatrics)
by Antonio Cherubini Arduino A. Mangoni Denis O’Mahony Mirko PetrovicThis book summarizes the broad and rapidly evolving field of geriatric pharmacotherapy, which is becoming increasingly relevant for practicing physicians who care and prescribe medications for older patients. Around the globe, ageing populations are associated with an increased prevalence of chronic diseases. Older adults are often affected by multimorbidity, i.e., suffer from more than one chronic disease. The main consequence of multimorbidity is polypharmacy, which is commonly defined as the regular use of five or more medicines. Polypharmacy has now reached epidemic proportions in our societies, and is associated with an increased risk of drug-drug interactions, drug-disease interactions and adverse drug reactions. The management of polypharmacy in older patients with complex multimorbidity poses several challenges and needs to be based on specific knowledge and prescribing expertise.The aim of this book is to provide a comprehensive update on the field, and to share the expertise needed to optimize the management of pharmacotherapy in older patients.
Optimizing Physical Performance During Fasting and Dietary Restriction: Implications for Athletes and Sports Medicine
by Roy J. Shephard Ezdine BouhlelOptimizing Physical Performance During Fasting and Dietary Restriction examines the effects of sustained fasting and food restrictions on metabolism and physical performance in athletes. It provides broad coverage including both religious and non-religious fasting and dietary restrictions.This practical and evidence-based guide outlines recent find
Optimizing Widely Reported Hospital Quality and Safety Grades: An Ochsner Quality and Value Playbook
by Armin Schubert Sandra A. KemmerlyThis practical, engaging book provides concise, real life-tested guidance to healthcare teams concerned with widely reported and incentivized hospital quality and safety metrics, offering both a conceptual approach and specific advice and frameworks for reviewing quality and safety numerator events, from the perspective and experience of clinicians and administrators working within the Ochsner Health System.The text opens with the rationale for closely managing widely (including publicly) reported hospital patient quality and safety measures. Attention is given to the financial implications of quality performance, with respect to both penalties and payment incentives used by payer organizations. It then reviews the major public ratings and their relevant methodologies, including CMS, AHRQ and NSHN. In addition, it addresses ratings by proprietary organizations that have a large member clientele, such as Vizient, USNews, Leapfrog, Healthgrades, CareChex and others. Each metric - for example, the AHRQ Patient Safety Indicators (PSIs), and other metrics such as readmission rate, risk adjusted complications, hospital-acquired conditions and mortality - is addressed in a stand-alone chapter. For each, the importance, approach to review, opportunity for optimization, and engagement of healthcare staff are reviewed and discussed. Overall, this book forefronts the benefits of a collaborative approach within a health system. The concurrent review process, multidisciplinary collaboration among quality improvement, clinical documentation, coding and medical staff personnel are all emphasized. Also described in detail is the approach to and specific opportunities for medical staff education and engagement. Additional key topics include Engagement of the Medical Staff and House Staff (i.e., residents and other trainees), Futile Care, Surgical Quality Improvement (NSQIP), Nursing Provider Partnership, and Translation of Data Review to Successful Performance Improvement. Specialty chapters on pediatric, neurologic and transplant quality metrics are also included.
Optimizing Women's Health through Nutrition
by Lilian U. Thompson Wendy E. WardIt is no surprise that women and men experience biological and physiological differences fundamentally and throughout the lifecycle. What is surprising is that faced with such a self-evident truth, there should be so little consideration to date of how these differences affect susceptibility to disease and metabolic response to dietary treatment. U
Optimizing Your Capacity to Care: A Systems Approach to Hospital and Population Health Management
by Pierce Story, MPHMOur nation's capacity to care is becoming increasingly stressed as an aging and increasingly unhealthy population collides with a relative reduction in the numbers of clinicians and ever-tightening financial resources. If even the mildest of future-state predictions are to be believed, we need a significant restructuring of our entire healthcare system and its total Capacity to Care, such that we can simultaneously improve care capacity, cost, quality, accessibility, and resource gratification.Optimizing Your Capacity to Care: A Systems Approach to Hospital and Population Health Management provides comprehensive guidance to a new way to optimize and manage community-wide Care Capacity via a unique, holistic approach to healthcare operations. Through clear examples and actual project results, the book demonstrates the outcomes of a systems-level way of thinking about a community's Capacity to Care that incorporates and integrates the full spectrum of available clinical and communal resources into the care of patients, including hospitals, physicians, emergency departments, surgical services, local churches, civic organizations, pharmacies, and volunteers.The book details operational models for each major department of the hospital and a fully integrated communal resource pool to demonstrate how the optimization of capacity, resource utilization, cost, and clinical outcomes can be attained. And by providing healthcare leaders with a deeper understanding of key elements missing from the most common process improvement methodologies and approaches, this book offers fresh perspectives and bold alternatives for hospitals, health systems, and entire communities.
Optimizing the Management of Fertility in Women over 40
by David B. Seifer Dimitrios S. NikolaouReproductive aging is a natural and universal process. Women frequently overestimate the age at which a significant decline in fertility occurs as well as overestimate the success of assisted reproductive technologies to circumvent age-related infertility. Yet there is much that modern medicine can do to improve conception rates in women who delay childbearing and to manage subsequent pregnancies. This book offers guidance on winning strategies for maximizing the live-birth rate and limiting the risk for women trying to conceive later in life. It is intended to assist in navigating this challenging journey and lead to peace of mind that women have been seen, heard, and treated as individuals in the process. Written by leading experts addressing medical options of applying advanced reproductive technologies, psychological, nutritional, lifestyle, systematic approaches to optimizing fertility care for the most challenging demographic of women in a practical, clinically orientated, and most importantly, positive way.
Options in the Management of the Open Abdomen
by Firas G. Madbak Dale A. DanglebenThis book by Madbak and Dangleben has collated lot of information that has been presented and published in many disparate arenas into a single easy to read source. In an area where there is more experience and "favorite techniques" than true evidence based answers, they provide a wealth of information along with outstanding photographic support that makes this an excellent resource for all surgeons caring for this population. Similar to many things in life, when treating patients with the open abdomen one size or methodology does not fit all and this book will assuredly contain at least one possible answer to your patient's problem. Although the numbers of "open abdomens" are decreasing due to changes in resuscitation and transfusion practices, it still represents a complex complication that can be challenging to deal with. This ambitious textbook on the management of the open abdomen provides a practical approach for addressing this complex problem. One of the more unique aspects of this textbook is its detailed "How to" approach for the wide variety of techniques utilized in the management of the open abdomen. While there may be no consensus as to what constitutes the optimal management of the open abdomen, this book articulates a number of options and their advantages. Most importantly, it provides high quality photographs that enhance the step by step "How to" approach of the text. More recent developments including using biologic mesh, implementing complex abdominal wall reconstruction and utilizing minimally invasive endoscopic techniques are described. This book is not only appropriate for all practicing surgeons that deal with this complex issue, but is also relevant for residents and fellows who are just getting their first exposure to open abdomens.
Optische Kohärenztomographie des vorderen Augenabschnitts: Atlas
by Ludwig M. Heindl Sebastian SiebelmannErster Atlas zur Vorderabschnitts-OCT mit über 500 TeilabbildungenAls schmerzfreies bildgebendes Verfahren hat die optische Kohärenztomographie (OCT) ihren festen Platz in der Früherkennung, Diagnostik und Verlaufskontrolle von Augenerkrankungen. OCT-Befunde können mit ihren hochaufgelösten Bildern wichtige Informationen bei der Diagnose von Erkrankungen der Hornhaut, Iris, Linse und der vorderen Augenkammer geben. Der Atlas trägt als einzigartige Sammlung zur Optischen Kohärenztomographie (OCT) für den vorderen Augenabschnitt zahlreiche Abbildungen seltener und häufiger Diagnosen zusammen. Die Expertise des Autorenteams fließt in die Interpretation der zahlreichen OCT-Befunde ein und erstellt somit ein wertvolles Nachschlagewerk für jede Augenärztin und jeden Augenarzt.
Optogenetics: Light-Sensing Proteins and Their Applications in Neuroscience and Beyond (Advances in Experimental Medicine and Biology #1293)
by Ryoichiro Kageyama Hiromu Yawo Hideki Kandori Amane KoizumiThis book, now in a thoroughly revised second edition, offers a comprehensive review of the rapidly growing field of optogenetics, in which light-sensing proteins are genetically engineered into cells in order to acquire information on cellular physiology in optical form or to enable control of specific network in the brain upon activation by light. Light-sensing proteins of various living organisms are now available to be exogenously expressed in neurons and other target cells both in vivo and in vitro. Cellular functions can thus be manipulated or probed by light. The new edition documents fully the extensive progress since publication of the first edition to provide an up-to-date overview of the physical, chemical, and biological properties of light-sensing proteins and their application in biological systems, particularly in neuroscience but also in medicine and the optical sciences. Underlying principles are explained and detailed information provided on a wide range of optogenetic tools for the observation and control of cellular signaling and physiology, gene targeting technologies, and optical methods for biological applications. In presenting the current status of optogenetics and emerging directions, this milestone publication will be a “must read” for all involved in research in any way related to optogenetics.
Optogenetics: Methods and Protocols (Methods in Molecular Biology #2840)
by Armin BaumschlagerThis volume explores the latest advancements in the field of optogenetics and how it uses cellular light-sensing components and genetic engineering to control proteins and biological processes. The book chapters are organized into four parts. Part One focuses on intracellular optogenetic components for control of specific cell functions; Part Two looks at externally supplied light regulators that do not require genetic manipulation of target cells; Part Three highlights optogenetic control of organelles, and Part Four introduces technical tools required for light induction in optogenetic experiments, as well as a method for performing and analyzing optogenetic cell-cell adhesion. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Optogenetics: Methods and Protocols is a valuable resource to help researchers understand and apply the concepts of optogenetics and the underlying bioengineering principles, and establish the required technical light-illumination setups for administering light inputs and analysis of experimental outcomes.
Opvoeden met gezond verstand
by J. VerhulstHoe je je kind opvoedt en of je een positieve sfeer weet te creëren, hangt niet alleen af van wat je doet, maar vooral van hoe je denkt. In Opvoeden met gezond verstand laat de bekende psycholoog Jan Verhulst zien, hoe je met een andere manier van denken de opvoeding heel wat lichter en effectiever kan maken. Gedachten heb je niet alleen bewust, maar ook onbewust. Onderzoek je de gedachten die jouw handelen bij het opvoeden beinvloeden, dan blijkt dat deze bij veel mensen niet zo reëel zijn. Zo kun je bijvoorbeeld diep van binnen denken dat je kind altijd naar je moet luisteren, of dat jij altijd de oplossing voor problemen moet hebben, maar is dat reëel? Door je bewust te worden van de impliciete verwachtingen en gedachten die je hebt en deze te vervangen door reële gedachten en haalbare doelen, haal je veel spanning uit de opvoeding. Dit boek laat je stap voor stap zien hoe je in verschillende situaties volgens de principes van de bekende RET methode (Rationeel Emotieve Therapie) verwachtingen en gedachten positief kunt sturen. Een belangrijk hulpmiddel hierbij is de in het boek opgenomen RET-test, waarmee je kunt vaststellen waar jouw grootste valkuilen liggen. Het boek biedt voorbeelden en oplossingen voor alle leeftijden en gezinssamenstellingen. Van huilbaby tot onverschillige puber, van eetprobleem tot gameverslaving. De vele voorbeelden en praktische tips roepen herkenning op, bieden je een spiegel en helpen je de meest uiteenlopende opvoedproblemen en valkuilen het hoofd te bieden. Positief en met zelfvertrouwen!
Oraciones y Promesas
by Edward G. DobsonSPANISH EDITION: Thirty short, yet powerful morning and evening reflections offer encouragement, hope, and inspiration to people dealing with a life-threatening illness, as well as their family members and caretakers. Here are honest insights and personal stories from a pastor who continues his own journey with ALS (Lou Gehrig's disease).
Oracle API Management 12c Implementation
by Andrew Bell Luis Augusto WeirLearn how to successfully implement API management using Oracle's API Management Solution 12c About This Book * Explore the key concepts, goals, and objectives of API Management and learn how to implement it using the Oracle API Management Solution * Understand the concepts and objectives of the Application Service Governance (ASG), along with the governance framework that encompasses people, processes, and technology * Get to grips with API Management readiness assessments, gap analysis, digital reference architecture, and implementation roadmaps Who This Book Is For This book is for Enterprise Architects, Solution Architects, Technical Architects, and SOA and API consultants who want to successfully implement API Management using the Oracle API Management Solution products. What You Will Learn * Understand how to manage a set of APIs * Discover the differences and similarities between API Management and SOA Governance, and where and how these two disciplines converge into Application Services Governance (ASG) * Grasp information about ASG and how to define an ASG governance framework * Understand the challenges for organizations looking to expose APIs to the external world. Identify common scenarios and how to solve them * Define an Oracle API management deployment topology * Install and configure Oracle API Catalog (OAC), Oracle API Manager (OAPIM), and Oracle API Gateway (OAG) * Learn about API subscriptions and API community management with the OAPIM portal * Implement Oracle API Manager (OAPIM) including creation, publishing, management and deprecation of APIs In Detail Oracle SOA Governance is a comprehensive, service-orientated governance solution that is designed to make the transition to SOA easier. API management is the discipline that governs the software development lifecycle of APIs. It defines the tools and processes needed to build, publish and operate APIs including the management of the community of developers around it. This book illustrates how to successfully implement API Management in your organization. To achieve this, the importance of defining an API management strategy and implementation roadmap so that capabilities are implemented in the right order and timeframes is described. It starts by describing all of the fundamental concepts around API Management and related disciplines such as SOA Governance and DevOps in order to dispel the confusion surrounding these topics. The book then takes you on the journey of implementing API Management, using a realistic case study of an organization that needs an API Management solution. You will start by identifying the key business drivers to implement APIs and then create an API Management strategy and a roadmap to realize this strategy. You'll then go through a number of use cases, each focused on addressing specific business requirements. These will help you understand each of the Oracle API Management products, how they fit into an overall architecture, and how to implement them. The book concludes by providing some tips and guidelines around defining a deployment topology for the Oracle API Management products and the steps to install them. Style and approach This book is a comprehensive guide to successfully implementing a complete API Management solution from inception to implementation. The initial chapters introduce you to Oracle SOA Governance and API Management and from there, chapters are mainly hands-on and provide a full step-by-step walkthrough of how to implement the products of the Oracle API management solution to address realistic use cases.
Oracle Case Management Solutions
by Manas Deb Prasen Palvankar Leon Smiers Joop KosterOrganizations increasingly need to deal with unstructured processes that traditional business process management (BPM) suites are not designed to deal with. High-risk, yet high-value, loan origination or credit approvals, police investigations, and healthcare patient treatment are just a few examples of areas where a level of uncertainty makes outc
Oracle SQL Developer
by Ajith NarayananLearn Database design, development,and administration using the feature-rich SQL Developer 4.1 interface About This Book * Explore all the SQL Developer 4.1 features useful for Oracle database developers, architects, and administrators * Understand how this free tool from Oracle has evolved over the years and has become a complete tool that makes life easy for Oracle and third-party database users * The author, Ajith Narayanan, has a total of 10+ years of work experience as an Oracle [APPS] DBA Who This Book Is For This book is intended for Oracle developers who are responsible for database management. You are expected to have programming knowledge of SQL and PL/SQL, and must be familiar with basic Oracle database concepts. What You Will Learn * Install and navigate through all the advanced features of SQL Developer that were introduced in version 4.1 * Browse, create, edit, and delete (drop) database objects * Use the SQL worksheet to run SQL statements and scripts, edit and debug PL/SQL code, manipulate and export (unload) data * Carry out all DBA-related activities such as exporting/importing, tuning, and analyzing database performance issues * Quickly analyze, create, and edit the data model using data modeler * Extend the SQL developer capabilities by exploring the APEX related pages, enabling and working with RESTful services * Use the available reports and create new custom reports with custom scripts * Grasp how to connect to third-party databases and work smoothly with them In Detail At times, DBAs support 100s of databases at work. In such scenarios, using a command-line tool like putty adds to the difficulty, while SQL Developer makes the life of a developer, DBA, or DB architect easier by providing a graphical user interface equipped with features that can bolster and enhance the user experience and boost efficiency. Features such as DBA panel, Reports, Data Modeler, and Data Miner are just a few examples of its rich features, and its support for APEX, REST Services, timesten, and third-party database drivers demonstrate its extensibility. You may be a newbie to databases or a seasoned database expert, either way this book will help you understand the database structure and the different types of objects that organize enterprise data in an efficient manner. This book introduces the features of the SQL Developer 4.1 tool in an incremental fashion, starting with installing them, making the database connections, and using the different panels. By sequentially walking through the steps in each chapter, you will quickly master SQL Developer 4.1. Style and approach This book follows a step-by-step approach and is in a conversational and easy-to-follow style. Screenshots , and detailed explanations of the basic and advanced features of SQL Developer 4.1 that will make your work and life easy.
Oral Bioavailability
by Ming Hu Xiaoling LiUnderstand and assess the design, delivery, and efficacy of orally administered drugs A practical guide to understanding oral bioavailability, one of the major hurdles in drug development and delivery, Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications is designed to help chemists, biologists, life science researchers, pharmaceutical scientists, pharmacologists, clinicians, and graduate and students become familiar with the fundamentals and practices of the science of oral bioavailability. The difference in rate and extent between a drug taken orally and the actual amount of a drug reaching the circulatory system, oral bioavailability is an essential parameter for determining the efficacy and adverse effects of new and developing medications, as well as finding an optimal dosing regimen. This book provides a much-needed one-stop resource to help readers better understand and appreciate the many facets and complex problems of oral bioavailability, including the basic barriers to oral bioavailability, the methods used to determine relevant parameters, and the challenges of drug delivery. In addition, this comprehensive book discusses biological and physicochemical methods for improving bioavailability, integrates physicochemistry with physiology and molecular biology, and includes several state-of-the-art technologies and approaches-Caco-2 cell culture model, MDCK, and other related cell culture models-which are used to study the science of oral bioavailability.