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The Systemic Effects of Advanced Cancer: A Textbook on Cancer-Associated Cachexia
by Swarnali AcharyyaThis textbook discusses the systemic consequences of cancer, covering a range of topics from tumor-promoting systemic effects to the development of cachexia, as summarized in the introductory chapter 1. Part I of this textbook focuses on tumor-promoting systemic effects and begins with a chapter on how tumor-derived extracellular vesicles and particles lay the foundation for future metastases (Chapter 2). Chapter 3 discusses how metastatic cells that have colonized the bone impact the local bone microenvironment, neighboring muscles, and host physiology. Chapter 4 summarizes the available strategies for targeting metastatic cancer and emphasizes the need to incorporate a systemic view of the disease. Following this overview of the systemic effects of cancer progression, Part II of the textbook discusses cancer-induced cachexia, a debilitating systemic effect of advanced cancer. Chapters 5-7 examine the key signaling pathways (interleukin-6/GP130, NF-kB, and muscle proteolysis) that drive the development of cancer cachexia. Chapters 8 and 9 in Part III of this textbook explore how toxicities from anti-cancer therapy are associated with the onset of cachexia in cancer patients, and provide insight into potential approaches to simultaneously target both cancer and cachexia. Chapters 10 and 11 (Part IV) conclude this textbook by outlining promising approaches for the diagnosis and treatment of cachexia as well as strategies to prevent the development of cachexia through exercise. An understanding of the systemic effects of cancer is essential for the design of effective anti-cancer and anti-cachexia treatment strategies. As such, this textbook provides key information for both students and scientists engaged in cancer research and oncology.
Systemic Fibroinflammatory Disorders
by Augusto VaglioThis book provides detailed information on the nosology, pathology, pathogenesis, clinical presentation, diagnosis and treatment of fibro-inflammatory disorders, rare diseases that often display systemic organ involvement. Among the conditions considered are IgG4-related disease, sclerosing cholangitis, Hashimoto's and Riedel's thyroiditis, retroperitoneal fibrosis/chronic periaortitis, mediastinal fibrosis, Erdheim-Chester disease, gadolinium-induced fibrosis, and sclerosing mesenteritis. This group of entities is still poorly defined and is characterized by the common denominator of chronic inflammatory infiltrate admixed with abundant fibrosis. IgG4-related disease is the prototypical example. Systemic Fibroinflammatory Disorders is the first book to draw together information on these conditions. As these diseases often require an interdisciplinary approach, the book is addressed to specialists of different disciplines, especially internists, rheumatologists, nephrologists, clinical immunologists, and hematologists.
Systemic Lupus Erythematosus
by Paul Eggleton Frank J. Ward"Systemic Lupus Erythematosus: Methods and Protocols" describe a number of genetic, biochemical and immunological techniques. These techniques provide an advancing understanding of the pathology, breakdown of the immune system and therapeutic challenges of SLE in both humans and animal models. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, "Systemic Lupus Erythematosus: Methods and Protocols" appeal to biomedical and clinical scientists in a number of pathology disciplines at the doctoral and post-doctoral level.
Systemic Sclerosis: An Illustrated Guide to Manifestation and Management in Asian Skin
by Aparna Palit and Arun C. InamadarThis book presents a wide variety of cutaneous features of systemic sclerosis under one cover as cutaneous manifestations are often the first to appear and help in diagnosing this condition early. It has a multidisciplinary approach as systemic sclerosis is a multi-system disorder which comes under the purview of various medical specialties like dermatology, rheumatology and nephrology. Numerous cutaneous features are illustrated with explanatory notes. This book would help the students, teachers and professionals in identification, followed by subsequent treatment and management at an early stage. Key Features Focuses exclusively on systemic sclerosis Includes diagnostic tips Explores systemic sclerosis in dark skinned people Consists of key points at the end of each chapter Discusses diagnostic algorithms and flow charts
Systemic Sclerosis
by Kazuhiko Takehara Manabu Fujimoto Masataka KuwanaThis book provides a comprehensive review of the recent advances in the research of systemic sclerosis (scleroderma). Systemic sclerosis is a complex autoimmune disease characterized by vasculopathy, fibrosis, and immune activation. This disease is also associated with certain susceptibility genes and is affected by epigenetic regulation. Recent studies have revealed a variety of new evidence suggestive of the pathogenesis of the disease. These include endothelial progenitor cells, cytokines and growth factors, and B cells. Studies using animal models have also provided novel insight into the pathomechanisms. In addition to these topics, the book covers clinical research regarding biomarkers and autoantibodies. This volume will benefit all rheumatologists and dermatologists as well as basic scientists, especially immunologists, molecular biologists, and biochemists.
Systemic Vasculitides: Current Status and Perspectives
by Franco Dammacco Domenico Ribatti Angelo VaccaIn spite of their relatively low prevalence, systemic vasculitides have been the object of intensive basic and clinical investigations over the last few years. As a consequence, important advancements have been achieved: from updated diagnostic and classification criteria and a more rational nomenclature to the recognition of an expanding spectrum of clinical manifestations and potentially devastating complications; from the recognition of the viral etiology of conditions such as HCV-related cryoglobulinemic vasculitis and HBV-associated polyarteritis nodosa to newly named variable vessel vasculitis exemplified by Beh#65533;et's disease; from single-organ vasculitis such as central nervous system vasculitis to the more recently emerging features of the IgG4-related, immune-mediated diseases that are showing remarkable clinical heterogeneity. In addition, intriguing pathogenetic hypotheses are being reported for certain chronic, relapsing vasculitides that are improving our understanding of their biology and basic pathophysiology. New avenues are being explored that will hopefully allow a deeper comprehension of the relationships between certain virus-driven vasculitides and lymphoproliferation, and possibly lead to the identification of novel biomarkers that may be used to single out patients at an increased risk of relapse. This explosion of knowledge is obviously resulting in state-of-the-art, personalized treatments of systemic vasculitides. This book is a collection of reviews on the major vasculitides, written by scientists and clinicians with a multi-year experience in this field. We hope it will provide the reader with a stimulating container of new advances in scientific knowledge and more rational therapeutic approaches to this fascinating chapter of pathology.
Systemic Vasculitis
by M. Habib Bouhaouala Anthony W. Stanson Lotfi Hendaoui Francis JoffreThe prompt diagnosis of systemic vasculitis is essential as a missed diagnosis can be disastrous. Imaging is of vital importance in achieving a correct diagnosis and in some cases also plays a role in endovascular treatment. In this book, the imaging features of the many different types of vasculitis are clearly demonstrated by means of numerous high-quality illustrations. All relevant imaging modalities are considered, and key distinctive characteristics are highlighted. In addition, each chapter discusses the etiology, epidemiology, pathogenesis, clinical presentation, biology, and treatment of the vasculitis in question. This book is the result of cooperation between expert teams from a range of countries. The wealth of illustrations and informative clinical case studies will prove invaluable for all who may be confronted with these problematic disorders.
Systemisch-konstruktivistisches Clinical Reasoning: Im Präsenz- und Telesetting für Mediziner und Therapeuten (essentials)
by Andreas WolfsSystemisch-konstruktivistisch ausgedeutetes Clinical Reasoning bringt einen Mehrwert für die patientenorientierte Gestaltung von medizinischen, pflegerischen und therapeutischen Interventionen. Es bietet teilhabeorientierte Blickwinkel bei der Analyse von Interventionen als Störungen für die Patient*innen, Beziehungen und Interaktionen der Beteiligten von Behandlungssystemen sowie der Gestaltungen von Lehr- / Lernsituationen. Dabei kann es sowohl im Präsenz- als auch im Telesetting erfolgsversprechend als Grundlage der eigenen Reflexion eingesetzt werden.
Systemisch-konstruktivistisches Didaktisches Reasoning: Lernen im Behandlungsprozess mit Beispielen aus der Sprachtherapie (essentials)
by Andreas WolfsLernen ist ein zentraler Aspekt von Behandlungen in der Medizin, Pflege und Therapie. Der systemisch-konstruktivistische Blick auf die Gestaltung von Lehr-/Lernsituationen im Rahmen des didaktischen Reasonings ermöglicht relevante Erkenntnisse für die patienten- und teilhabeorientierte Gestaltung. Dieses essential stellt die Unterschiedlichkeit der Lehr-/Lernaktivitäten in sechs Handlungsebenen von drei Behandlungsphasen dar. Dabei bietet es eine Differenzierung zwischen bewusstem und unbewusstem didaktischen Reasoning sowie zwischen Tele- und Präsenzsetting. Zwei sprachtherapeutische Beispiele unterstützen den Übertrag in den eigenen beruflichen Alltag.
Systemisch-konstruktivistisches Interaktives Reasoning: Kommunikation und Beratung im Behandlungsprozess an Beispielen der Logopädie (essentials)
by Andreas WolfsIndividuelle und personenzentrierte Kommunikation ist essentieller Bestandteil jeder Behandlung in Medizin, Pflege und Therapie. In diesem essential werden die Aspekte des interaktiven Reasonings systemisch-konstruktivistisch ausgedeutet und im Kontext von sechs Handlungsebenen in drei Behandlungsphasen betrachtet. Begriffe wie Kontingenz, Anschlussfähigkeit und Perturbationstoleranz bieten dabei Möglichkeiten, eine teilhabeorientierte Kommunikation zu differenzieren. Zur Veranschaulichung der einzelnen Betrachtungsebenen unterstützen zwei sprachtherapeutische Beispiele und Ausführungen zum bewussten interaktiven Reasoning als Grundlage der Reflexion. Besonderes Augenmerk wird auf die behandlungsinduzierte Beratung als spezielle und relevante Form der Kommunikation gelegt.
Systemized Prevention of Oral Disease: Theory and Practice (Routledge Revivals)
by Lars Granath William D. McHughFirst published in 1986: This book presents a new approach to oral diseases. Recent decades have seen the proliferation of methods to prevent these diseases and enormous growth in the underlying scientific knowledge and mechanisms of prevention.
Systems Analysis of Chromatin-Related Protein Complexes in Cancer
by Andrew Emili Shoshana Wodak Jack GreenblattEpigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned "on" or "off" and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.
Systems Analysis of Human Multigene Disorders
by Natalia Maltsev Andrey Rzhetsky T. Conrad GilliamUnderstanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance.
A Systems Analysis of Medicine: Healing Medicine (Studies in Medical Philosophy #6)
by Ken A. BrysonThis book is a must read for anyone interested in transforming the impersonal character of the medical experience into a personalized, relational, spiritual, and holistic dialogue about human health. It promotes a holistic vision of the doctor-patient relationship, a medicine that ought to be based on the totality of the human experience rather than on the reductive view of the patient as a person with a certain disease. Ken A. Bryson describes the character of medicine as the gateway to holistic healing and argues that we need to secure the ethical foundation of universal medicine as not relative to a cultural setting, thus establishing the Oath of Hippocrates as the universal gateway to human dignity. This view emboldens us to raise medicine from the level of an impersonal technological encounter with disease to its rightful place as a sacred activity that includes all the levels of the human experience. The book offers practical suggestions on how to accomplish that objective.
Systems Analysis Tools for Better Health Care Delivery
by Britta Neugaard Petraq Papajorgji Panos M. Pardalos Pando G. GeorgievThis book presents some recent systems engineering and mathematical tools for health care along with their real-world applications by health care practitioners and engineers. Advanced approaches, tools, and algorithms used in operating room scheduling and patient flow are covered. State-of-the-art results from applications of data mining, business process modeling, and simulation in healthcare, together with optimization methods, form the core of the volume. Systems Analysis Tools for Better Health Care Delivery illustrates the increased need of partnership between engineers and health care professionals. This book will benefit researchers and practitioners in health care delivery institutions, staff members and professionals of specialized hospital units, and lecturers and graduate students in engineering, applied mathematics, business administration and health care.
Systems and Synthetic Biotechnology for Production of Nutraceuticals
by Long Liu Jian ChenThis book discusses systems and synthetic biotechnologies for the production of nutraceuticals, and summarizes recent advances in nutraceutical research in terms of the physiological effects on health, potential applications, drawbacks of traditional production processes, characteristics of production strains, and advances in microbial production based on systems and synthetic biotechnology. It also examines future directions in the microbial production of nutraceuticals using systems and synthetic biology. The book is intended for researchers and graduate students in the field of molecular biology and industrial biotechnology as well as staff working in the nutraceutical industry.
Systems and Synthetic Immunology
by Shailza SinghSystems and Synthetic Immunology focuses on the similarities between biology and engineering at the systems level, which are important for applying engineering theories to biology problems. With the advent of new genomic techniques, there are numerous systematic investigations underway in the scientific world. This volume highlights techniques that can be used to effectively combine two of the most essential biological fields - Systems Biology and Synthetic Immunology.The respective chapters discuss the role of synthetic immunology in biotechnology, production of biomaterials, and their use in vaccine delivery. Further topics include the importance of cytokines; the use of genomic engineering tools in immunotherapy; immunosensors; nanotherapeutics; and bioinformatics tools in biomedical applications. Given its scope, the book offers readers an up-to-date and comprehensive review of this unique and dynamic field of research.
Systems Biology (Rna Technologies Ser.)
by Jan Barciszewski Stefan Jurga Nikolaus RajewskyMany breakthroughs in experimental devices, advanced software, as well as analytical methods for systems biology development have helped shape the way we study DNA, RNA and proteins, on the genomic, transcriptional, translational and posttranslational level. This book highlights the comprehensive topics that encompass systems biology with enormous progress in the development of genome sequencing, proteomic and metabolomic methods in designing and understanding biological systems.Topics covered in this book include fundamentals of modelling networks, circuits and pathways, spatial and multi cellular systems, image-driven systems biology, evolution, noise and decision-making in single cells, systems biology of disease and immunology, and personalized medicine. Special attention is paid to epigenomics, in particular environmental conditions that impact genetic background. The breadth of exciting new data towards discovering fundamental principles and direct application of epigenetics in agriculture is also described.The chapter “Deciphering the Universe of RNA Structures and Trans RNA-RNA Interactions of Transcriptomes in vivo - from Experimental Protocols to Computational Analyses” is available open access under a CC BY 4.0 license via link.springer.com.
Systems Biology
by Stefan Hohmann Sang Yup Lee Jens Nielsen J. Nielsen Gregory StephanopoulosComprehensive coverage of the many different aspects of systems biology, resulting in an excellent overview of the experimental and computational approaches currently in use to study biological systems. Each chapter represents a valuable introduction to one specific branch of systems biology, while also including the current state of the art and pointers to future directions. Following different methods for the integrative analysis of omics data, the book goes on to describe techniques that allow for the direct quantification of carbon fluxes in large metabolic networks, including the use of 13C labelled substrates and genome-scale metabolic models. The latter is explained on the basis of the model organism Escherichia coli as well as the human metabolism. Subsequently, the authors deal with the application of such techniques to human health and cell factory engineering, with a focus on recent progress in building genome-scale models and regulatory networks. They highlight the importance of such information for specific biological processes, including the ageing of cells, the immune system and organogenesis. The book concludes with a summary of recent advances in genome editing, which have allowed for precise genetic modifications, even with the dynamic control of gene expression. This is part of the Advances Biotechnology series, covering all pertinent aspects of the field with each volume prepared by eminent scientists who are experts on the topic in question.
Systems Biology
by Michael G. KatzeFirst, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies--oligonucleotide microarrays, mass spectrometry, and next-generation sequencing--and the analysis of this data through sophisticated mathematical algorithms. It is perhaps the use of mathematics, to integrate abundant and diverse types of data and to generate models of interconnected molecular networks, that best characterizes systems biology.
Systems Biology: Functional Strategies of Living Organisms
by Leszek Konieczny Irena Roterman-Konieczna Paweł SpólnikThis open-access textbook is an excellent introduction to systems biology, which has developed rapidly in recent years. It discusses the processes in living organisms in an integrated way, enabling the reader to understand the fundamental principles and cause-effect relationships in biology and biochemistry. The authors have chosen an original but at the same time clear way of presenting the topics, repeatedly drawing comparisons and models from the macroscopic world and making the reader aware of the unity of the laws of physics, chemistry and biology. The fully updated 2nd edition also contains information that has only become available as a result of the increase in knowledge in recent years. This includes information on tumorigenesis, where significant progress has been made due to the explosive development of genetic knowledge as well as bioengineering with a highly effective technique adopted from the solutions of the bacterial world, such as CRISPR/CAS. This richly illustrated book is essential for postgraduate students and scientists of the following disciplines: biology, biotechnology, medicine, bioinformatics, robotics and automation, biocybernetics, and biomedical engineering. It is also an exciting read for anyone interested in biology.
Systems Biology: A Textbook
by Christoph Wierling Hans Lehrach Axel Kowald Edda Klipp Wolfram Liebermeister Ralf HerwigThis advanced textbook is tailored to the needs of introductory course in Systems Biology. It has a compagnion website (WWW.WILEY-VCH.DE/HOME/SYSTEMSBIOLOGY) with solutions to questions in the book and several additional extensive working models. The book is related to the very successful previous title 'Systems Biology in Practice' and has incorporated the feedback and suggestions from many lecturers worldwide. The book addresses biologists as well as engineers and computer scientists. The interdisciplinary team of acclaimed authors worked closely together to ensure a comprehensive coverage with no overlaps in a homogenous and compelling style.
Systems Biology and Bioinformatics: A Computational Approach
by null Kayvan Najarian null Siamak Najarian null Shahriar Gharibzadeh null Christopher N. EichelbergerThe availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods
Systems Biology and Machine Learning Methods in Reproductive Health (Chapman & Hall/CRC Computational Biology Series)
by Abhishek Sengupta Priyanka Narad Dinesh Gupta Deepak ModiSystems Biology and Machine Learning Methods in Reproductive Health is an innovative and wide-ranging book that discovers the synergetic combination of disciplines: systems biology and machine learning, with an application in the field of reproductive health. This book assembles the expertise of leading scientists and clinicians to present a compilation of cutting-edge techniques and case studies utilizing computational methods to elucidate intricate biological systems, elucidate reproductive pathways, and address critical issues in the fields of fertility, pregnancy, and reproductive disorders. Bringing science and data science together, this groundbreaking book provides scientists, clinicians, and students with a step-by-step guide to uncovering the complexities of reproductive health through cutting-edge computational tools.
A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment
by Natàlia Garcia-Reyero Cheryl A. MurphySocial pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.