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Tertiary Lymphoid Structures: Methods and Protocols (Methods in Molecular Biology #2864)
by Marie-Caroline Dieu-NosjeanThis second edition details new and updated chapters on technologies related to tertiary lymphoid structures( TLS). Chapters guide readers through TLS in cancers, different stages of TLS development, immune function of TLS, molecular, cellular, and imaging methods, and preclinical methods to uncover the function of cells composing TLS in inflammatory situations in humans. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Tertiary Lymphoid Structures: Methods and Protocols, Second Edition aims to guide you through techniques and methods used to study the biology of TLS.
Terug naar de oorsprong
by Ilse WarnersOver mensen met dementie, hun belevingswereld die van zorgverleners, is veel te zeggen. Wat is de betekenis van dementie voor de persoon in kwestie en wat vergt dit van zorgverleners aan menselijkheid en menslievendheid? Gepleit wordt voor een herwaardering van wat vaak voor een onaf, onvoltooid, oneigenlijk of onvolwaardig leven doorgaat. Terwijl mensen met dementie doodgewone mensen zijn aan wie niets menselijks vreemd is en die signalen uitzenden waarop slechts met ontferming is te antwoorden.
Tess Gerritsen's Rizzoli & Isles 8-Book Bundle
by Tess GerritsenNew York Times bestselling author Tess Gerritsen has thrilled countless readers with her acclaimed novels of suspense featuring Boston detective Jane Rizzoli and medical examiner Maura Isles--and TNT struck ratings gold with the Rizzoli & Isles series based on Gerritsen's novels. Now here's a convenient e-book bundle of the first eight installments of this compelling series: The Surgeon, The Apprentice, The Sinner, Body Double, Vanish, The Mephisto Club, The Keepsake, and Ice Cold. Includes an exclusive script excerpt from the TNT series and a special preview of Tess Gerritsen's new Rizzoli & Isles novel, The Silent Girl, on sale July 5, 2011
Test-Driven Development with Java: Create higher-quality software by writing tests first with SOLID and hexagonal architecture
by Alan MellorDrive development with automated tests and gain the confidence you need to write high-quality softwareKey FeaturesGet up and running with common design patterns and TDD best practicesLearn to apply the rhythms of TDD – arrange, act, assert and red, green, refactorUnderstand the challenges of implementing TDD in the Java ecosystem and build a planBook DescriptionTest-driven development enables developers to craft well-designed code and prevent defects. It's a simple yet powerful tool that helps you focus on your code design, while automatically checking that your code works correctly. Mastering TDD will enable you to effectively utilize design patterns and become a proficient software architect.The book begins by explaining the basics of good code and bad code, bursting common myths, and why Test-driven development is crucial. You'll then gradually move toward building a sample application using TDD, where you'll apply the two key rhythms -- red, green, refactor and arrange, act, assert. Next, you'll learn how to bring external systems such as databases under control by using dependency inversion and test doubles. As you advance, you'll delve into advanced design techniques such as SOLID patterns, refactoring, and hexagonal architecture. You'll also balance your use of fast, repeatable unit tests against integration tests using the test pyramid as a guide. The concluding chapters will show you how to implement TDD in real-world use cases and scenarios and develop a modern REST microservice backed by a Postgres database in Java 17.By the end of this book, you'll be thinking differently about how you design code for simplicity and how correctness can be baked in as you go.What you will learnDiscover how to write effective test cases in JavaExplore how TDD can be incorporated into crafting softwareFind out how to write reusable and robust code in JavaUncover common myths about TDD and understand its effectivenessUnderstand the accurate rhythm of implementing TDDGet to grips with the process of refactoring and see how it affects the TDD processWho this book is forThis book is for expert Java developers and software architects crafting high-quality software in Java. Test-Driven Development with Java can be picked up by anyone with a strong working experience in Java who is planning to use Test-driven development for their upcoming projects.
A Test of Morals: Surgical, Ethical, and Psychosocial Considerations in Human Head Transplantation
by L. Allen FurrWhile transplanting human heads is not a new concept, the idea has largely been relegated to religious lore or as a plot device in science fiction. But now, a surgical plan to perform the complex procedure exists, and though most physicians question head transplantation’s medical veracity, bioethicists have challenged the surgery on moral grounds. A Test of Morals compiles and examines the ethical questions that dog those who advocate for conducting this most radical of medical proposals in order to determine if society should move forward and allow head transplantation to occur. Current bioethical principles stand in opposition to head transplantation, causing a conflict of values rarely seen in medicine.
Test Success: Test-taking Techniques For Beginning Nursing Students
by Patricia M. Nugent Barbara A. VitaleBuild confidence and improve test scores. Success in nursing school starts here. A complete review of core concepts 900 questions (Alternate format, too!) Test-taking hints and rationales for correct and incorrect answers A complete review of core concepts, plus 900 questions based on the latest NCLEX© test plan build confidence and improve test scores from the beginning of nursing school. Master tricky alternate-format questions, even SATA (select all that apply), and develop efficient studying skills with test-taking tips and rationales for correct and incorrect responses. Purchase this title NEW and get 150 additional questions online plus all of the questions in the book.
Test Success: Clinical Judgment And Test-taking Strategies (Davis's Q&a Success Ser.)
by Patricia M. Nugent Barbara A. VitaleStrategies for a great start. Practice questions for success. Reduce the stress and anxiety you feel before an exam with test-taking strategies that really work. Practice questions introduce you to the NCLEX®-style questions you’ll encounter throughout your nursing education while developing the critical-thinking and clinical judgment skills essential to success on the Next Gen NCLEX. A complete review of core concepts, and more than 900 questions based on the latest NCLEX test plan build confidence and improve test scores from the beginning of nursing school. Master the challenging alternate-format questions, even SATA (select-all-that-apply) and develop your studying skills with test-taking tips and rationales for correct and incorrect responses.
Test Success: Test-Taking Techniques for Beginning Nursing Students
by Patricia Nugent Barbara VitaleA complete review of core concepts, plus 900 questions based on the latest NCLEX© test plan will build confidence and improve test scores from the beginning of nursing school. Master tricky alternate-format questions, even SATA (select all that apply) and develop efficient studying skills with test-taking tips and rationales for correct and incorrect responses.
Test Success: Test-taking Techniques for Beginning Nursing Students (6th Edition)
by Barbara A. Vitale Patricia M. NugentThe road to nursing success begins here! A complete review of core concepts. More than 800 questions (Alternate format, too!) Test-taking hints and rationales for correct and incorrect answers.
Test-Tube Women: What Future for Motherhood? (Routledge Library Editions: Women in Society)
by Rita Arditti Renate Duelli Klein Shelley MindenOriginally published in 1984, when new reproductive technologies were just beginning to become part of the public discussion, this edition was published with a new preface in 1989. The Editors wanted to look carefully at how much real choice reproductive technologies offered to women. Genetic engineering, sperm banks, test tube fertilization, sex selection, surrogate mothering, experimentation in the so called ‘third world’, increased technological intervention in childbirth – were we taking pregnancy and the birth process out of the dark ages or into a terrifying ‘brave new world’?They ask who controls it? Who benefits? The technological machine grinds on, in headline-grabbing leaps or in quiet developments in research laboratories: but what are the implications for women worldwide? Still a huge industry today, this reissue can be read in its historical context.
Testicular Autoimmunity
by Masahiro ItohIt has long been suspected that testicular autoimmunity could be one of the causes of idiopathic male infertility. However, it is very difficult to estimate the incidence of testicular autoimmunity in men, as most male patients first realize they are infertile when they start trying to conceive a child, and there is a possibility that their testes may already exhibit the end stage of testicular autoimmunity, in which lymphocytic inflammation and immunoglobulin deposition in their testes subsided long ago and only the spermatogenic disorder remains. Therefore, autopsy or biopsy for testicular tissues in men before the end stage of testicular autoimmunity and investigations using testicular autoimmunity model animals are needed to determine the epidemiology of testicular autoimmunity In this book, the author discusses "the immunological fragility of testis," reviewing the autopsy data in men and presenting experimental data using murine models of autoimmune orchitis that has been induced by immunizing with viable syngeneic testicular germ cells alone. Testicular autoimmunity in animals is also discussed. In summary, the book provides useful information not only to researchers who are interested in immunologic male infertility, but to clinical professionals who treat these patients at hospitals.
Testimonies: States of Mind and States of the Body in the Early Modern Period (Archimedes #57)
by Gideon ManningThis book reconnects health and thought, as the two were treated together in the seventeenth century, and by reuniting them, it adds a significant dimension to our historical understanding. Indeed, there is hardly a single early modern figure who took a serious interest in one but not the other, with their attitudes toward body-mind interaction often revealed in acts of self-diagnosis and experimentation. The essays collected here specifically reveal the way experiment and especially self-experiment, combined with careful attention to the states of mind which accompany states of body, provide a new means of assessing attitudes to body-mind interactions just as they show the abiding interest and relevance of source material typically ignored by historians of science and historians of philosophy. In the surviving records of such experimenting on one’s own body, we can observe leading figures like Francis Bacon, Robert Boyle and Robert Hooke, deliberately setting out to repeat pleasurable, or intellectually productive moods and states of mind, by applying the same medicine on successive occasions. In this way we can witness theories of the working of the human mind being developed by key members of an urban culture (London; interregnum Oxford) who based those theories in part on their own regular, long-term use of self-administered, mind-altering substances. It is hardly an overstatement to claim that there was a significant drug culture in the early modern period linked to self-experimentation, new medicines, and the new science. This is one of the many things this volume has to teach us.
Testimony of Two Men: A Novel (Rediscovered Classics Ser.)
by Taylor CaldwellA small-town doctor acquitted of murdering his pregnant wife faces new charges in this New York Times bestseller set in the early days of modern medicine. Hambledon, Pennsylvania, is still reeling from the sensational murder trial that shattered the peace of the bucolic hamlet less than a year ago. Dr. Jonathan Ferrier was accused of killing his beautiful young wife after she died following a botched abortion. The scion of a powerful old eastern family, Jonathan hired the best attorneys money could buy. When he was acquitted, many believed he had bought his freedom. Now, he has returned home to sell his practice and move on. But haunted by his wife&’s death, Jonathan still strives to heal the judgmental people of his divided town. Robert Morgan, a young, idealistic doctor, is determined to make up his own mind about the accused&’s innocence or guilt. Of one thing he is certain: Jonathan is a good doctor, perhaps even a great one. He is also a man who feels abandoned by God, his church, his family, and his friends. As Jonathan continues to be pilloried by the town, a new series of accusations are leveled at him. Is he a cold-blooded killer who murdered his wife and their unborn child? Or a man unjustly accused and wrongly maligned? Testimony of Two Men explores the evolution of modern medicine and the tireless physicians who are its unsung heroes. Author Taylor Caldwell&’s bestselling novel touches on faith, religion, and the then-new field of mental health as it tells a mesmerizing tale of desire, betrayal, and love that can destroy or redeem.
Testing Computers Systems for FDA/MHRA Compliance
by David StokesThere is no substitute for extensive testing when it comes to IT systems. Recognition that problems are easier and cheaper to fix before the system is in use (rather than after), has turned testing into a cost-effective tool. However, when developing computer systems for pharmaceuticals manufacturing, testing to meet regulatory requirements adds an
Testing Fate: Tay-Sachs Disease and the Right to Be Responsible
by Shelley Z. ReuterIn today&’s world, responsible biocitizenship has become a new way of belonging in society. Individuals are expected to make &“responsible&” medical choices, including the decision to be screened for genetic disease. Paradoxically, we have even come to see ourselves as having the right to be responsible vis-à-vis the proactive mitigation of genetic risk. At the same time, the concept of genetic disease has become a new and powerful way of defining the boundaries between human groups. Tay-Sachs, an autosomal recessive disorder, is a case in point—with origins in the period of Eastern European Jewish immigration to the United States and United Kingdom that spanned the late nineteenth and early twentieth centuries, it has a long and fraught history as a marker of Jewish racial difference. In Testing Fate, Shelley Z. Reuter asks: Can the biocitizen, especially one historically defined as a racialized and pathologized Other, be said to be exercising authentic, free choice in deciding whether to undertake genetic screening? Drawing on a range of historical and contemporary examples—doctors&’ medical reports of Tay-Sachs since the first case was documented in 1881, the medical field&’s construction of Tay-Sachs as a disease of Jewish immigrants, YouTube videos of children with Tay-Sachs that frame the disease as tragic disability avoidable through a simple genetic test, and medical malpractice suits since the test for the disease became available—Reuter shows that true agency in genetic decision-making can be exercised only from a place of cultural inclusion. Choice in this context is in fact a kind of unfreedom—a moral duty to act that is not really agency at all.
Testing Statistical Hypotheses of Equivalence and Noninferiority
by Stefan WellekWhile continuing to focus on methods of testing for two-sided equivalence, Testing Statistical Hypotheses of Equivalence and Noninferiority, Second Edition gives much more attention to noninferiority testing. It covers a spectrum of equivalence testing problems of both types, ranging from a one-sample problem with normally distributed observations
Testosteron: Von den Grundlagen zu klinischen Aspekten
by Alexandre HohlDie Forschung zu Testosteron und seine Anwendung in der Klinik sind trotz Fortschritten umstritten. Dieses Buch liefert einen umfassenden Überblick über Testosteron, von grundlegenden Merkmalen bis zu neuesten klinischen Erkenntnissen. Es werden spezifische Zustände, in denen Testosteron eine zentrale Rolle spielt, ausführlich besprochen. Dazu zählen zum Beispiel Hypogonadismus, Missbrauch, Pubertät, kardiovaskuläre Effekte und Testosterontherapie. Die Hoden, essenziell für die menschliche Reproduktion und Hauptproduzenten von Testosteron bei Männern, symbolisieren männliche biologische Funktionen. Niedrige Serumtestosteronspiegel korrelieren mit verschiedenen Gesundheitsproblemen. Serumtestosteron gilt zunehmend als wichtiger Biomarker für Männergesundheit. Hypogonadismus, charakterisiert durch verminderte Spermien- oder Testosteronproduktion, kann durch Erkrankungen der Hoden (primär) oder Störungen der Hypophyse/Hypothalamus (sekundär) verursacht werden. Die Diagnose stützt sich auf genaue Tests der hypothalamisch-hypophysär-gonadalen Achse. Das Buch beleuchtet den Einsatz von Testosteron in unterschiedlichen Formen und Applikationswegen, erörtert spezifische Eigenschaften und unterstützt bei der Auswahl geeigneter Behandlungen. Es behandelt auch Risiken des Missbrauchs und bietet Alternativen zur Unterstützung Betroffener.
Testosterone: From Basic to Clinical Aspects
by Alexandre HohlEven though research on testosterone is increasing, there is still much controversy regarding its physiology and clinical use. This book provides a broad overview on testosterone, from its basic features to the most recent evidence of clinical applicability. In addition, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. The testes are vital organs for reproduction of the human species, besides being the main source of testosterone production in men. Although not essential for survival, these singular structures represent the essence of male biological function. Testosterone is the most important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Also, there is increasing evidence that serum testosterone is a major biomarker status of men's health in general. Hypogonadism in a male refers to a decrease in one or both of the two major functions of the testes: sperm production or testosterone production. These abnormalities can result from disease of the testes (primary hypogonadism) or disease of the pituitary or hypothalamus (secondary hypogonadism). Currently, the clinical features of male hypogonadism are sufficiently well-recognized, the causes are well-known, and the tests of the hypothalamic-pituitary-testicular axis are accurate enough for the diagnosis in most patients. Testosterone, the focus hormone of this book, is used in different forms and routes of administration. Several authors unravel its peculiarities and assist in choosing the most suitable form in each case, as well as the possible risks of its misuse or even abuse in men and women, seeking alternatives to help patients in this situation.
Testosterone: From Basic to Clinical Aspects
by Alexandre HohlResearch on testosterone is increasing in many senses; however there is still much controversy regarding its physiology and clinical use. This book addresses these topics, providing a broad overview about testosterone, from its basic features to the most recent evidence of clinical applicability. Also, specific conditions in which testosterone play a pivotal role are discussed in detail, such as hypogonadism, misuse and abuse, puberty, cardiovascular effects and testosterone therapy. Although not essential for survival, testosterone represents the essence of male biological function, being the important testicular androgen in men. Low serum testosterone levels are associated with cardiovascular morbidity, metabolic syndrome, type 2 diabetes mellitus, atherosclerosis, osteoporosis, sarcopenia, and mortality. Conversely, increased serum levels of testosterone may lead to deleterious events. In general, there is increasing evidence that serum testosterone is a major biomarker status of men’s health in general. Testosterone: From Basic to Clinical Aspects is an indispensable reference for all those who seek state-of-the-art knowledge regarding this hormone, from basic issues (including pharmacology and physiology) through clinical aspects (related diseases and supplementation therapy).
Testosterone
by Eberhard Nieschlag Hermann M. Behre Susan NieschlagNow in its fourth edition Testosterone: Action, Deficiency, Substitution provides the most up-to-date and comprehensive source of information on testosterone and its role in human physiology and pathology. It covers biosynthesis and mechanisms of action and reviews their effects on brain and behavior, spermatogenesis, hair growth, bones, muscles, erythropoiesis, the cardiovascular system and the prostate. The therapeutic uses of testosterone preparations are carefully evaluated as well as its abuse and detection in competitive sport. This new edition also devotes sections to exploring the effects of testosterone on female physiology and sexual function, and the experimental use of testosterone in male hormonal contraception. Testosterone: Action, Deficiency, Substitution has been written and edited by world experts in the fields of clinical andrology and endocrinology and provides a unique and invaluable guide for andrologists, endocrinologists, urologists, internists and those working in reproductive medicine.
Testosterone: From Basic Research to Clinical Applications
by Lee B. Smith Rod T. Mitchell Iain J. McewanThis volume provides a brief résumé of the history of testosterone research, from the early pioneers through to the most recent advances in the field. We discover how steroid hormones were first identified and how testosterone was shown to be essential for male development. Moving forward we explore how and where testosterone is produced, and how the body controls testosterone production. We then investigate the impact testosterone has on different body systems both during their development and function, and how perturbation of testosterone action is associated with disease. We complete our story with an exploration of the emerging roles of testosterone in clinical therapy, and the future potential for manipulation of the testosterone signaling system for human health benefit.
TESTOSTERONE AND AGING: Clinical Research Directions
by Institute of Medicine of the National AcademiesPopular culture often equates testosterone with virility, strength, and the macho male physique. Viewed by some as an “antiaging tonic,” testosterone’s reputation and increased use by men of all ages in the United States have outpaced the scientific evidence about its potential benefits and risks. In particular there has been growing concern about an increase in the number of middle-aged and older men using testosterone and the lack of scientific data on the effect it may have on aging males. Studies of testosterone replacement therapy in older men have generally been of short duration, involving small numbers of participants and often lacking adequate controls. Testosterone and Aging weighs the options of future research directions, examines the risks and benefits of testosterone replacement therapy, assesses the potential public health impact of such therapy in the United States, and considers ethical issues related to the conduct of clinical trials. Testosterone therapy remains an attractive option to many men even as speculation abounds regarding its potential.
The Testosterone Files: My Hormonal and Social Transformation from Female to Male
by Max Wolf ValerioYoung Anita Valerio, radical lesbian feminist, poet and performance artist realizes she is transsexual and begins testosterone hormone treatment as the first stage of transitioning to the male gender and renaming herself Max Wolf Valerio. This autobiography follows Valerio from childhood into his mid 30's. He analyzes the differences between the genders that the roles of estrogen and testosterone play. As he transitions, he muses and compares various issues, such as authority, emotional intensity, territoriality, violence, social constructs, and intensity of sexual behaviors. This book is quite compelling both for the personal process and Valerio's ability to question normative male behaviors as he finds himself responding to both the testosterone and the male culture.
Tests to Evaluate Public Health Disease Reporting Systems in Local Public Health Agencies
by Roger C. Molander Nicole Lurie Alexis Diamond Barbara Meade David J. DauseyThis operations manual provides public health agencies with a set of standardized proficiency tests to aid in the development of regular and consistent strategies for testing the ability of public health disease reporting systems to receive and respond to case reports 24 hours a day, seven days a week.
TET Proteins and DNA Demethylation: Methods and Protocols (Methods in Molecular Biology #2272)
by Ozren Bogdanovic Michiel VermeulenThis volume explores the latest methods used to study various aspects of TET proteins and their biology. Chapters in this book are divided into five parts. Part One describes technologies aimed at detecting and quantifying DNA methylation turnover using massively parallel sequencing, ELISA, and mass spectrometry approaches. Part Two looks at data analyses protocols for distinguishing acting versus passive DNA demethylation and estimation of 5mC and 5hmC levels. Part Three deals with a new topic that takes advantage of modified CRISPR/Cas9 genome editing systems to target DNA demethylation activity to genomic loci of interest. Part Four discusses protocols that detail how to purify TET proteins and unravel their protein interactions, and Part Five looks at the assessment of TET protein function and activity in vivo and in vitro. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, TET Proteins and DNA Demethylation: Methods and Protocols is a valuable resource that aims to help research scientists at all levels working in the fields of DNA demethylation dynamics.Chapters 3, 7 and 17 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.