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Varicella-zoster Virus: Genetics, Pathogenesis and Immunity (Current Topics in Microbiology and Immunology #438)
by Ann M. Arvin Jennifer F. Moffat Allison Abendroth Stefan L OliverThis edited volume provides insights about the molecular virology, pathoenesis of infection and host responses to varicella-zoster virus, which is a medically important human herpesvirus. The chapters not only discuss genetics and molecular evolution of the virus, but also new structure-based knowledge on the functions of viral glycoproteins. Further, the authors illustrate how mechanisms from the virus are used to take over and remodel host cells during pathogeneis. These mechanisms also enable viral modulation of host cells and evasion of the host immune response. Part of these evasion and survival strategies, is the reaction to triggered host cell responses like autophagy, the stress response, modulation of apoptosis and other cell death pathways. This hands-on knowledge is crucial for students and clinicians in Virology, Immunology, and Infectious Diseases.Chapter "Common features between stroke following varicella in children and stroke following herpes zoster in adults" is available open access under a Creative Commons Attribution 4.0 International License via Springerlink.com.
Varicella-Zoster Virus Epithelial Keratitis in Herpes Zoster Ophthalmicus: In Vivo Morphology in the Human Cornea
by Helena M. TaberyHerpes zoster ophthalmicus (HZO) is a common disease in the elderly and the immunosuppressed, with potentially devastating sequelae. Diagnosis of HZO is clinical but almost all its manifestations are non-specific. The exception is varicella-zoster virus epithelial keratitis, which is frequently the only indicator of the true nature of the disease. This book is unique in presenting high-magnification images, obtained by non-contact in vivo photomicrography, that capture the distinctive features of varicella-zoster virus epithelial keratitis in HZO. Both the morphology and the dynamics of the corneal epithelial lesions are splendidly documented, including in patients with HZO sine herpete and recurrent disease. Three rare cases of ocular surface involvement in acute HZO are included, and the final chapter carefully compares varicella-zoster virus epithelial keratitis in HZO and the lesions of herpes simplex virus.
Varicocele and Male Infertility
by Ashok Agarwal Sandro C. Esteves Alaa HamadaThis SpringerBrief analyzes varicocele from a novel approach, and provides the reader with a comprehensive view of its scientific and clinical significance. The Brief covers all the important aspects of varicocele related to infertility, from epidemiology to assisted reproduction techniques, contemplating pathophysiology, semen analysis, specialized sperm function tests, and clinical management including all available treatment options form three distinct perspectives, i. e. , current concepts, consensus and controversies. Each topic is addressed using the same template, offering the best information from all angles to readers. This SpringerBrief is aimed at both clinicians and scientists involved in the study and care of male and female fertility, and is written by a team of three internationally recognized authors with expertise in andrology and male infertility. The text is the first of its kind, and presents an invaluable tool both for the basic scientists with an interest in reproductive medicine and for clinicians working in the field of infertility.
Varicocele and Male Infertility: A Complete Guide (Springerbriefs In Reproductive Biology Ser. #0)
by Sandro C. Esteves Chak-Lam Cho Ahmad Majzoub Ashok AgarwalThis unique textbook – the first of its kind – presents a thoughtful and comprehensive discussion of the significance of varicocele and its impact on male fertility. This hot topic is covered from a multitude of angles in seven thematic sections: origin and pathophysiology, clinical evaluation, medical and surgical therapy, controversies, pro and con debates, and clinical case scenarios. The scope of varicocele includes basic and transitional research, genetics, diagnostic testing with conventional and advanced molecular biology approaches, hormonal control, interventional therapy and assisted reproductive technology (ART). Repair of varicocele, which can be carried out by various methods, not only alleviates oxidative stress‐associated infertility but also prevents and protects against the progressive character of varicocele and its consequent upregulations of systemic oxidative stress. Even with the advances in the understanding of this intriguing disease and consensus on some areas such as diagnosis and pathophysiology, substantial controversy still exists, in particular concerning the benefits of treatment and to whom treatment should be offered. Additional chapters discuss, in depth, such controversies surrounding the role of varicocele in male infertility and present clinical case scenarios dealing with management of subclinical and clinical varicocele. A series of editorial comments is provided by the editors at the end of selected chapters, containing an objective and concise summary of the information from each chapter. In addition, chapters open up with key points for quick references and conclude with multiple choice questions and answers for immediate review and retention of the rich content. Generously illustrated, Varicocele and Male Infertility: A Complete Guide represents an invaluable tool for medical students in reproductive medicine as well as researchers and clinicians working in the field of infertility (e.g., urologists, gynecologists, reproductive endocrinologists, and embryologists) and is comprised of chapters written by leading and internationally recognized clinicians and scientists with expertise in varicocele, skillfully edited by leaders in the field.
The Varieties of Psychedelic Experience: The Classic Guide to the Effects of LSD on the Human Psyche
by Jean Houston Robert MastersOne of the most important books written on the effects of LSD on the human psyche. • Its authoritative research has great relevance to the current debate on drug legalization. • Prolific authors Robert Masters and Jean Houston are pioneer figures in the field of transpersonal psychology and founders of the Human Potentials Movement. The Varieties of Psychedelic Experience was published in 1966, just as the first legal restrictions on the use of psychedelic substances were being enacted. Unfortunately, the authors' pioneering work on the effects of LSD on the human psyche, which was viewed by its participants as possibly heralding a revolution in the study of the mind, was among the casualties of this interdiction. As a result, the promising results to which their studies attested were never fully explored. Nevertheless, their 15 years of research represents a sober and authoritative appraisal of what remains one of the most controversial developments in the study of the human psyche. Avoiding the wild excesses taken by both sides on this issue, this book is unique for the light it sheds on the possibilities and the limitations of psychedelic drugs, as well as on the techniques for working with them. With drug legalization an increasingly important issue, The Varieties of Psychedelic Experience provides a welcome and much needed contrast to the current hysteria that surrounds this topic.
The Varieties of Psychedelic Experience: The Classic Guide to the Effects of LSD on the Human Psyche
by Robert Masters Jean HoustonThe research in this book has great significance to the current debate on drug legalization and on the effects of LSD on the human psyche.
Varikose: Diagnostik - Therapie - Begutachtung
by Thomas Noppeney Helmut NüllenAllen Ärzten, die Patienten mit Varizen behandeln, gibt dieses durchgehend farbig illustrierte Buch eine präzise und systematische Gesamtdarstellung der Diagnostik und Therapie, wobei das ganze Spektrum der konservativen und operativen Verfahren berücksichtigt wird.Die zahlreichen Methoden werden von den jeweiligen Experten detailliert beschrieben; neben Durchführung und Indikationen sind auch mögliche Komplikationen und bisherige Behandlungsergebnisse berücksichtigt. Ausführlich geht das Buch auf die Klinik der einzelnen Beschwerdebilder und die spezifischen Therapieindikationen ein. Kapitel zu Ätiologie und Pathophysiologie der Varikose sowie zur Begutachtung runden die Darstellung ab. Für die 2. Auflage wurden die Kapitel aktualisiert und teilweise neu verfasst, Beiträge zu neu entwickelten Ablationsverfahren sowie zur Therapie der kutanen Varikose wurden ergänzt.
Varney's Midwifery
by Julia Phillippi Ira Kantrowitz-GordonVarney's Midwifery continues to be the gold standard for midwifery practice in an updated seventh edition. New lead editors assembled a team of expert contributors and authors to continue the legacy of Varney's Midwifery as the trusted, must-have resource for students, professional midwives, and women's health practitioners. Varney's Midwifery uses current evidence-based guidelines to address the care of women throughout the lifespan, including primary care, gynecology, maternity care in a variety of settings, and newborn care. The Seventh Edition reflects the new Core Competencies for Basic Midwifery Practice published in 2020, including care of transgender individuals and abortion-related care. It also provides updated information on chronic conditions in pregnancy including a section discussing COVID-19, new techniques for fetal screening, diagnosis across the lifespan, and updated content on health equity.
Vasculaire geneeskunde in beeld
by Jacqueline De GraafVasculaire geneeskunde in beeld bevat 41 casussen voor huisarts en specialist. Voorzien van full color beeldmateriaal. Iedere casus bevat een vraag met 4 antwoordmogelijkheden. In deel 2 worden de antwoorden uitgebreid toegelicht
Vascular Access in Neonates and Children
by Daniele G. Biasucci Nicola Massimo Disma Mauro PittirutiThis is a practical guide to pediatric vascular access. It covers how to use ultrasound appropriately, how to prevent and manage early and late complications, and how to correctly place the catheter tip using ECG or radiology. It includes all the most modern approaches and devices. In particular, the best approach for some specific populations is covered, including neonates and infants, complex patients, and children with cancer or renal failure requiring long term treatments. A guide on how to establish a vascular access team in a pediatric hospital is included, including the costs and benefits of having this hospital-based team. Vascular Access in Neonates and Children is aimed at pediatric anesthesists and surgeons, and radiologists, pediatricians and other specialities may also find it of interest.
Vascular Anatomy of the Spinal Cord
by Armin K. ThronThis book systematically describes the angioarchitecture of the spinal cord. Microradiographs of superficial and intrinsic arterial supply and venous drainage patterns provide the anatomical basis needed to understand spinal vascular disorders. These post mortem studies are supplemented by clinical spinal angiographies and case studies. Rapid advances in imaging technology have facilitated the solution of many diagnostic problems concerning diseases of the spine and spinal cord. But this is less true for vascular diseases of the spinal cord or diseases secondarily involving them. Furthermore, safely using interventional procedures or open surgery still requires a profound knowledge of the vascular anatomy involved. Accordingly, a growing demand for training in this special field has become evident over the last 25 years, making improvement of this knowledge in all Neuro-Specialities dealing with diagnostic and therapeutic problems of spinal disorders a highly desirable goal.
Vascular and Endovascular Complications: A Practical Approach
by Sachinder Singh Hans Mark F. ConradPrevention of complications in vascular and endovascular surgery is an important consideration for all practicing surgeons. The keys to achieving clinical success are based on careful selection of both patient and procedure, along with meticulous operative and endovascular techniques. Management of complications requires careful planning and urgent intervention. This concise, practical text provides the reader with A stepwise approach to diagnosis Guidance on avoiding technical pitfalls Advice on re-interventions Case examples to aid clinical practice The early diagnosis of complications, followed by prompt action and intervention, is key to improving clinical outcomes. This well-illustrated, concise, and practical book ensures that vascular and endovascular surgeons will be able to optimize clinical results and patient care.
Vascular and Endovascular Surgery at a Glance
by Morgan Mcmonagle Matthew StephensonFollowing the popular and accessible at a Glance format, Vascular and Endovascular Surgery at a Glance demystifies the important concepts of vascular disease and vascular surgery. Featuring in-depth details of common vascular topics, to rarer presentations, this is an ideal guide for those interested in a variety of subjects relating to this rapidly expanding area. This is a must-read for any specialist at all levels who has an on-going commitment to vascular disease management and medical education.Vascular and Endovascular Surgery at a Glance:* Comprehensively covers the key concepts and core practical procedures with superb illustrations* Is a brilliant companion to the emerging curriculum for specialist vascular training* Is an excellent source of information and management guidelines for interdisciplinary specialties* Includes a companion website atwww.ataglanceseries.com/vascular featuring a wide range of interactive multiple choice questionsThis title forms a succinct overview of vascular disease management, giving salient points relevant to general surgery examinations, for those requiring an in-depth yet manageable introduction to vascular diseases, and for those entering this prevalent field as a stand-alone specialty.
Vascular and Interventional Radiology: A Core Review
by Brian Strife Jeffrey ElbichDesigned specifically for the Core Exam, Vascular and Interventional Radiology : A Core Review covers all key aspects of the field, mimicking the image-rich, multiple-choice format of the actual test. Ideal for residents preparing for the Core Examination, as well as practitioners taking recertification exams, this unique review follows the structure and content of what you’ll encounter on the test, effectively preparing you for Core Exam success!
Vascular Anomalies: A Guide for the Hematologist/Oncologist
by Cameron C. Trenor Denise M. AdamsThis volume is a practical resource for the diagnosis and multi-disciplinary management of patients with vascular anomalies. Although designed by and for hematologists and oncologists, this text also assists clinicians in many specialties with appropriate nomenclature, diagnosis, and management of the heterogeneous disorders considered as vascular anomalies, including kaposiform hemangioendothelioma, capillary malformations, venous malformations, lymphatic anomalies, and arteriovenous malformation. The book features full-color clinical photographs and diagnostic imaging to enrich descriptions of these conditions and to ensure accurate diagnosis for appropriate management recommendations. Written by experts in their fields, Vascular Anomalies: A Guide for the Hematologist/Oncologist is a valuable resource for clinicians treating and researchers studying patients with vascular anomalies.
Vascular Biology Protocols
by Jun Ren Nair SreejayanOver the past decades, the pathogenesis, diagnosis, treatment and prevention of cardiovascular diseases have been benefited significantly from intensive research activities. In order to provide a comprehensive "manual" in a field that has become as broad and deep as cardiovascular medicine, this volume of "Methods in Molecular Medicine" covers a wide spectrum of in vivo and in vitro techniques encompassing biochemical, pharmacological and molecular biology disciplines which are currently used to assess vascular disease progression. Each chapter included in this volume focuses on a specific vascular biology technique and describes various applications as well as caveats of these techniques. The protocols included here are described in detail, allowing beginners with little experience in the field of vascular biology to embark on new research projects.
Vascular Biomechanics: Concepts, Models, and Applications
by T. Christian GasserThis textbook serves as a modern introduction to vascular biomechanics and provides the comprehensive overview of the entire vascular system that is needed to run successful vascular biomechanics simulations. It aims to provide the reader with a holistic analysis of the vascular system towards its biomechanical description and includes numerous fully through-calculated examples. Various topics covered include vascular system descriptions, vascular exchange, blood vessel mechanics, vessel tissue characterization, blood flow mechanics, and vascular tissue growth and remodeling. This textbook is ideally suited for students and researchers studying and working in classical and computational vascular biomechanics. The book could also be of interest to developers of vascular devices and experts working with the regulatory approval of biomedical simulations.Follows the principle of “learning by doing” and provides numerous fully through-calculated examples for active learning, immediate recall, and self-examination;Provides a holistic understanding of vascular functioning and the integration of information from different disciplines to enable students to use sophisticated numerical methods to simulate the response of the vascular system;Includes several case studies that integrate the presented material. Case studies address problems, such as the biomechanical rupture risk assessment of Abdominal Aortic Aneurysms, Finite Element analysis of structural and blood flow problems, the computation of wall stress and wall shear stress in the aorta.
Vascular Complications of Surgery and Intervention: A Practical Guide
by Ramyar Gilani Joseph L. MillsThe concept for this book evolved over many years of intense clinical practice during which a wide variety of vascular complications were encountered as a result of other surgical or interventional procedures. In this book, the authors describe cohesive efforts by experts in the field as they commit to advancing health care quality by all professionals. It should be noted at the outset that the book does not discuss various non-vascular or systemic complications of patients undergoing vascular interventions such as myocardial infarction, renal or respiratory failure. Instead, the content is divided into four separate sections. The material begins with an introduction to vascular anatomy and function. There follows a section addressing specific complications of the vascular system that can occur in any patient, sometimes even without intervention. The third section addresses complications specific to interventions and surgical procedures. The final section is dedicated to the delayed and long-term sequelae attributable to the most commonly encountered vascular complications.Vascular Complications of Surgery and Intervention: A Practical Guide is targeted towards dedicated health care professionals managing patients affected by inadvertent but potentially disastrous vascular complications and for those practitioners performing interventions either directly upon the vascular system or procedures that have potential for collateral impact.
Vascular Control of Hemostasis
by Victor vanHinsberghHemostasis represents a group of balanced activities that keep the blood flowing It is a complete response system which has developed to guarantee blood fluidity and to limit blood loss after wounding, and adapts after exposure to infectious micro-organisms The failure of this control system causes ischemia, severe damage to the distal tissues and, ultimately, death This book provides an up-to-date and comprehensive account of the control of hemostasis by vascular cells It is an indispensable guide for researchers in hemostasis and vascular biology, from the post-graduate level onwards It will also be of great interest to clinicians in vascular medicine and cardiology Topics covered include: hemostatic properties of the vessel wall; anticoagulant properties of the vessel wall; other aspects of coagulation; and changes in vascular hemostatic properties
Vascular CT Angiography Manual
by Robert Pelberg Wojciech MazurDespite the exponential growth in the use of peripheral CTA in the diagnosis and follow-up of vascular disease patients, practical sources from which to gain valuable expertise in this field remain scarce. There is becoming a great need for experts in the field of peripheral CTA, yet learning this imaging modality may be intimidating and time consuming. Very few if any, small, concise and portable books exist to ease training in this field and current books in this field are overwhelming, difficult to manage, text books that often combine CTA and MRI. A so called " how to manual" and reference guide to explain this technique from beginning to end, which compiles valuable, and difficult to obtain clinical pearls and descriptions of disease processes will be of tremendous value. The Peripheral CT Angiography Manual aims to make learning this intimidating technique and the diseases for which it applies simple and fun.
Vascular Damage in Neglected Tropical Diseases: A Surgical Perspective
by Valeria Silvestri Vivian Mushi Billy NgasalaIn the realm of surgical pathology, specifically within regions endemic to neglected tropical diseases (NTDs), this book serves as a comprehensive reference on nonclassical vascular risk factors from an epidemiological standpoint. It addresses the often-overlooked issue of vascular damage in patients afflicted with parasitic diseases and other NTDs. Current literature primarily consists of rare individual case reports and case series for each specific disease, making this book a valuable contribution to the field. The book describes various aspects related to vascular involvement in NTDs, including parasitological, vector borne diseases and snakebite-associated vascular lesions. Although these cases and their underlying pathophysiologic mechanisms are rarely reported and remain understudied, this book describes the various nuances of surgical vascular pathology in this setting, encouraging further research in this area. Five main topics are covered: the vascular problems in patients with 1. Schistosomiasis, 2. Amebiasis, 3. Hydatidosis, 4. Lymphatic filariasis, and 5. Snakebites. This work raises awareness of these rarely reported diseases in areas where they are more common or in countries where they are imported, among physicians directly involved in the management of these cases. It serves as a guide to treatment from presentation through the various steps of patient care. The book is a reference for all professionals concerned with morbidity associated with neglected tropical diseases, particularly vascular morbidity of surgical interest, both research and clinical, in endemic and non-endemic settings. It is a valuable resource for the continuing education of health professionals working in this field. It serves as a textbook for vascular surgery fellows interested in non-classical cardiovascular risk factors leading to surgical conditions. This specific topic related to non-communicable comorbidities in diseases of parasitological interest is useful for parasitologists and public health specialists at master level and above.
Vascular Disease
by Andrew H. BakerAndrew Baker and a noted panel of expert investigators describe today's most powerful molecular methods for investigating the pathogenesis of vascular disease. These detailed, easy-to-follow techniques range from methods that have been used successfully to identify specific mutations involved in cardiovascular disorders, to those for transferring genes associated with cardiovascular disease into various vascular cell types by in vitro and in vivo routes. There are methods to identify novel genes and generate full-length cDNAs, to study gene transcription and promoter activity easily and effectively, and to ascertain precisely gene expression levels within the individual cell types in different pathophysiological conditions. Vascular Disease: Molecular Biology and Gene Therapy Protocols offers today's vascular biologist and gene therapist an unprecedented ability to study the pathogenesis of vascular disease and readily to probe the potential for gene-based therapies.
Vascular Disease in Older Adults
by Rabih ChaerThis book presents acomprehensive and state-of the-art approach to vascular disease for the geriatricpatient, focusing on vascular pathology and interventions but also onperioperative care, anesthetic care, functional outcomes and quality of life,as well as ethical considerations that impact decision making. The bookaddresses open and endovascular interventions in different vascular beds, aswell as preoperative workup and optimization, anesthetic considerations, allaspects and expectations of the postoperative care and recovery and is the onlybook to include specialize in the intricacies of the care of the geriatricpatients, the challenging recovery and neurocognitive changes, and ethicalconsiderations for the end stage geriatric patient or in the setting ofpostoperative complications. Written by experts in the field, each section addressespatient selection, pre-operative considerations, technical conduct of the mostcommon operations with open or endovascular options, and avoidingcomplications. A brief review of the existing literature addressing theparticular topic follows in each section. Extensive illustrations, angiographicimages, and treatment algorithms, as well as a summary bullet point table ofthe key messages at the end of each chapter makes this an interactive text. With its concise yetcomprehensive summary of the field, Care of the Elderly Patient With VascularDisease is the ultimate resource for physicians of different specialties whocare for the geriatric patient with vascular disease.
Vascular Diseases for the Non-Specialist
by Tulio Pinho Navarro Alan Dardik Daniela Junqueira Ligia CisnerosThis book aims to provide non-specialist healthcare practitioners with current, focused and objective information on the most common vascular diseases encountered in daily clinical practice. In day-to-day clinical practice many healthcare practitioners do not have a working knowledge of the most common vascular diseases that frequently arise in patient care. Some of these topics include: aneurysms, peripheral arterial disease, diabetic foot, venous thromboembolism, cerebrovascular disease, aortic dissection, and acute limb ischemia. These commonly encountered vascular diseases are becoming public health issues due to their high morbidity and mortality as well as increasing healthcare costs. Since patients with vascular diseases are often referred to non-specialists, the general practitioner must know how to proper handle the most common vascular diseases encountered in daily clinical practice. For each disease the concept, epidemiology, natural history, diagnosis and treatment are described, followed by essential advice on what the non-specialist can do for the patient and when to refer the patient to a specialist.
Vascular Disorders of the Liver: VALDIG's Guide to Management and Causes
by Dominique Valla Juan Carlos Garcia-Pagan Andrea De Gottardi Pierre-Emmanuel RautouThis book provides a comprehensive account on individually rare, but collectively frequent diseases of the liver. In the first part, conditions such as hepatic vascular malformations, ischemic cholangiopathy, hepatic artery occlusion, sinusoidal conditions and Budd-Chiari syndrome are discussed among others. The second part examines the causes of vascular liver disease namely, coagulation disorders, neoplasm disorders, non-malignant blood disorders, systemic diseases and toxins, among others. The unique expertise of the authors, who are all members of the Vascular Liver Disease Disorders Group, an independent network of researchers with a common interest in Vascular Liver Diseases, are merged for an optimal pragmatic and individualized approach. This book is of interest to a broad range of experts, such as hepatologists, internists, radiologists and angiologists.