- Table View
- List View
The Virtuous Physician
by James A. MarcumAlthough modern medicine enjoys unprecedented success in providing excellent technical care, many patients are dissatisfied with the poor quality of care or the unprofessional manner in which physicians sometimes deliver it. Recently, this patient dissatisfaction has led to quality-of-care and professionalism crises in medicine. In this book, the author proposes a notion of virtuous physician to address these crises. He discusses the nature of the two crises and efforts by the medical profession to resolve them and then he briefly introduces the notion of virtuous physician and outlines its basic features. Further, virtue theory is discussed, along with virtue ethics and virtue epistemology, and specific virtues, especially as they relate to medicine. The author also explores the ontological priority of caring as the metaphysical virtue for grounding the notion of virtuous physician, and two essential ontic virtues--care and competence. In addition to this, he examines the transformation of competence into prudent wisdom and care into personal radical love to forge the compound virtue of prudent love, which is sufficient for defining the virtuous physician. Lastly, two clinical case stories are reconstructed which illustrate the various virtues associated with medical practice, and it is discussed how the notion of virtuous physician addresses the quality-of-care and professionalism crises.
Virulence Mechanisms of Bacterial Pathogens (ASM Books)
by Indira T. Kudva Nancy A. Cornick Paul J. Plummer Qijing Zhang Tracy L. Nicholson John P. Bannantine Bryan H. BellaireGround-breaking overview of an enduring topic Despite the use of antibiotics, bacterial diseases continue to be a critical issue in public health, and bacterial pathogenesis remains a tantalizing problem for research microbiologists. This new edition of Virulence Mechanisms of Bacterial Pathogens broadly covers the knowledge base surrounding this topic and presents recently unraveled bacterial virulence strategies and cutting-edge therapies. A team of editors, led by USDA scientist Indira Kudva, compiled perspectives from experts to explain the wide variety of mechanisms through which bacterial pathogens cause disease: the host interface, host cell enslavement, and bacterial communication, secretion, defenses, and persistence. A collection of reviews on targeted therapies rounds out the seven sections of this unique book. The new edition provides insights into some of the most recent advances in the area of bacterial pathogenesis, including how metabolism shapes the host-pathogen interface interactions across species and genera mechanisms of the secretion systems evasion, survival, and persistence mechanisms new therapies targeting various adaptive and virulence mechanisms of bacterial pathogens Written to promote discussion, extrapolation, exploration, and multidimensional thinking, Virulence Mechanisms of Bacterial Pathogens serves as a textbook for graduate courses on bacterial pathogenesis and a resource for specialists in bacterial pathogenicity, such as molecular biologists, physician scientists, infectious disease clinicians, dental scientists, veterinarians, molecular biologists, industry researchers, and technicians.
Virulent Zones: Animal Disease and Global Health at China's Pandemic Epicenter (Experimental Futures)
by Lyle FearnleyScientists have identified southern China as a likely epicenter for viral pandemics, a place where new viruses emerge out of intensively farmed landscapes and human--animal interactions. In Virulent Zones, Lyle Fearnley documents the global plans to stop the next influenza pandemic at its source, accompanying virologists and veterinarians as they track lethal viruses to China's largest freshwater lake, Poyang Lake. Revealing how scientific research and expert agency operate outside the laboratory, he shows that the search for origins is less a linear process of discovery than a constant displacement toward new questions about cause and context. As scientists strive to understand the environments from which the influenza virus emerges, the unexpected scale of duck farming systems and unusual practices such as breeding wild geese unsettle research objects, push scientific inquiry in new directions, and throw expert authority into question. Drawing on fieldwork with global health scientists, state-employed veterinarians, and poultry farmers in Beijing and at Poyang Lake, Fearnley situates the production of ecological facts about disease emergence inside the shifting cultural landscapes of agrarian change and the geopolitics of global health.
Virus: Vaccinations, the CDC, and the Hijacking of America's Response to the Pandemic
by Nina BurleighNew York Times bestselling author Nina Burleigh weaves together the key narrative strands to create an uncompromising and highly informed expose about our shared global pandemic experience and what it means for our future Virus: Vaccinations, the CDC, and the Hijacking of America&’s Response to the Pandemic takes readers on an extraordinary journey from the medical science of viruses and vaccines, to conspiracy theories, through the history of knowledge, to the precipice—where we are now—of uncertainty about the future. This is not a book for those who think they already know how the story ends, but one that asks the tough questions in terse, hard-hitting paragraphs and chapters. Virus walks a tightrope wire, in the same way that nearly all Americans are already doing, and does not presume our lives will be saved by any one approach or answer, or that any side has ownership of the truth, but puts us on a path towards a better understanding of what just happened to us and where we&’re likely to be headed when, not if, the next virus appears. Here is: • The true story behind the triumph of science in an era of unprecedented science denialism; • The other true story of government malfeasance that brought the U.S. to its knees and saw more Americans die from the pandemic than in any other nation; • An eye-opening series of interviews with researchers and creators of the mRNA vaccine, its test subjects, and other key figures; • The history behind one of the great medical milestones: the astonishingly fast development and clinical deployment of the first mRNA vaccine, and how it will change the way medicine is practiced in the future; • The alternate reality of bizarre conspiracy theories that undergird pandemic denialism and vaccine hesitancy; • The return of eugenics and how shock doctrine capitalism, crony corruption and extreme free ideology killed people of color, the poor, and the frail; • An assessment of the lessons learned and opportunities lost and what this will mean for the future of our democracy and our people. Virus includes original research and interviews with many key figures and experts including MIT engineer (&“The Edison of Medicine&”) and Moderna founder Robert Langer, Stanford microbiologist David Relman, first mRNA clinical trial (Seattle) participant Missy Pena, medical anthropologist Martha Louise Lincoln, among many others, and a deep reading of publicly available documents and reporting.
The Virus
by Stanley JohnsonFrom renowned British politician Stanley Johnson, an exciting, intelligent thriller about the rise of a mysterious virus and one man's fight to stop a deadly pandemic, perfect for fans of Michael Crichton and Dan Brown.How do you stop an invisible killer?When a young woman in New York City dies mysteriously after a trip to Europe, top epidemiologist Lowell Kaplan identifies the cause of death as the Marburg Virus—a fatal strain that has surfaced only once before in history.Determined to trace the source of the disease, Kaplan follows a trail of intrigue from the labs of Germany to the jungles of Central Africa. But powerful forces are conspiring against him, determined to keep the secrets of the virus's origin deliberately under wraps. And with a global pandemic on the rise, Kaplan must go to unimaginable lengths to stop a deadly scheme and save mankind.
The Virus and the Host: Protect Yourself from Infectious Disease by Reducing Toxicity, Improving Immunity, and Minimizing Chronic Illness
by Doctor Chris ChlebowskiLearn how to take control of your health—and decrease susceptibility to infectious viral disease before it strikes. There will almost certainly be more pandemics in our future. Yet, during the coronavirus crisis, not a single major public health official took the simple step of telling Americans what we all need to hear: Robust good health—healthy immunity, low inflammation, low toxic burden, and freedom from stealth infection and chronic disease—is our best defense against infectious viral disease. Of course, it’s not that simple. The way our bodies interact with infectious disease is complicated—both a function of the “germ” and the “terrain”—the virus and the host. In The Virus and the Host, Dr. Chlebowski succinctly describes emerging science on the virome and how toxic exposure, chronic inflammation, infections, and chronic diseases interact and predispose us to poor outcomes from acute viral infection. He then clearly outlines the tools needed for better health, including: How to eat like your life depends on it The best nutrients to supercharge your immunity How to harness the power of botanical medicine How to detoxify simply and safely at home Valuable information on simple treatment and recommended diagnostic tests for given conditions As we move forward from the tragedy of COVID-19, it is essential that we come together to learn from our mistakes, and work hard—and work together—to prevent a similar crisis in the future. When the next pandemic hits, we need to be better prepared. Now is the time to do something, and it is the best investment we can make so that when—not if—the next “big one” hits we can keep our loved ones and ourselves safe and healthy. "A gem of a book at a timely moment in history."—Stephanie Seneff, author of Toxic Legacy "This book left me feeling optimistic and empowered, and gave me greater knowledge about the history of viruses, as well as their future.”—Erin Elizabeth, author; public speaker; founder, Health Nut News
The Virus and the Vaccine: The True Story of a Cancer-Causing Monkey Virus, Contaminated Polio Vaccine, and the Millions of Americans Exposed
by Debbie Bookchin Jim SchumacherA comprehensive story of the problems and concerns associated with the polio vaccine
The Virus and the Vaccine: Contaminated Vaccine, Deadly Cancers, and Government Neglect
by Debbie Bookchin Jim SchumacherJonas Salk's polio vaccine has taken on an almost legendary quality as a medical miracle, for it largely eradicated one of the most feared diseases of the 20th century. But the story of the vaccine has a dark side, one that has never been fully told before...Between 1954 and 1963, close to 98 million Americans received polio vaccinations contaminated with a carcinogenic monkey virus, now known as SV40. A concerted government effort downplayed the incident, and it was generally accepted that although oncogenic to laboratory animals, SV40 was harmless to humans.But now SV40 in showing up in human cancers, and prominent researchers are demanding a serious public health response to this forgotten polio vaccine contaminant. A gripping medical detective story, The Virus and the Vaccine raises major questions about vaccine policy.
Virus Bioinformatics (Chapman & Hall/CRC Computational Biology Series)
by Dmitrij Frishman Manja MarzViruses are the most numerous and deadliest biological entities on the planet, infecting all types of living organisms—from bacteria to human beings. The constantly expanding repertoire of experimental approaches available to study viruses includes both low-throughput techniques, such as imaging and 3D structure determination, and modern OMICS technologies, such as genome sequencing, ribosomal profiling, and RNA structure probing. Bioinformatics of viruses faces significant challenges due to their seemingly unlimited diversity, unusual lifestyle, great variety of replication strategies, compact genome organization, and rapid rate of evolution. At the same time, it also has the potential to deliver decisive clues for developing vaccines and medications against dangerous viral outbreaks, such as the recent coronavirus pandemics. Virus Bioinformatics reviews state-of-the-art bioinformatics algorithms and recent advances in data analysis in virology. FEATURES Contributions from leading international experts in the field Discusses open questions and urgent needs Covers a broad spectrum of topics, including evolution, structure, and function of viruses, including coronaviruses The book will be of great interest to computational biologists wishing to venture into the rapidly advancing field of virus bioinformatics as well as to virologists interested in acquiring basic bioinformatics skills to support their wet lab work.
Virus Detection (Pocket Guides to Biomedical Sciences)
by Charles H. WickViruses do not behave as other microbes; their life cycles require infecting healthy cells, commandeering their cellular apparatus, replicating and then killing the host cell. Methods for virus detection and identification have been developed only in the past few decades. These recently developed methods include molecular, physical, and proteomic techniques. All these approaches (Electron Microscopy, Molecular, Direct Counting, and Mass Spectrometry Proteomics) to detection and identification are reviewed in this succinct volume. It is written in approachable language with enough detail for trained professionals to follow and want to recommend to others. Key Features Covers common detection methods Reviews the history of detection from antiquity to the present Documents the strengths and weaknesses of various detection methods Describes how to detect newly discovered viruses Recommends specific applications for clinical, hospital, environmental, and public health uses
Virus Entry Inhibitors: Stopping the Enemy at the Gate (Advances in Experimental Medicine and Biology #1366)
by Shibo Jiang Lu LuThis book focuses on the important discoveries of the small molecule-, peptide-, and protein-based virus entry inhibitors and discusses advance of the development of different type of virus entry inhibitors as a novel class of antiviral drugs for treatment and prevention of viral infection. It includes entry inhibitors of HIV,HeV, NiV, RSV, EBOV, HCoV, HBV, HCV, HDV, HPV, flavivirus and influenza virus, so on. This book aims at providing an updated knowledge on virus entry inhibitors.
Virus Ground Zero: Stalking the Killer Viruses with the Centers for Disease Control
by Ed RegisAn acclaimed science writer takes readers behind the scenes at the Centers for Disease Control to tell the story of an engrossing odyssey across the viral frontier.
Virus-Host Interactions: Methods and Protocols
by Diana Lieber Susanne M. BailerVirus-Host Interactions: Methods and Protocols covers various aspects of virological research, such as biochemical approaches, including molecular interactions and regulatory mechanisms on the protein as well as the RNA level with a strong focus on the manifold possibilities to study protein-protein interactions, as well as cell biological and immunological methodologies. Viruses represent a reduced form of life that depends on host cells for propagation. To this end, viruses approach and penetrate cells and usurp cellular machineries for their own benefit. Recent technological improvements have enabled the systematic analysis of the virus-host interplay be it on the genomic, the transcriptomic, or proteomic level. In parallel, bioinformatic tools have emerged in support of the large datasets generated by these high-throughput approaches. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Virus-Host Interactions: Methods and Protocols will prove invaluable to professionals and novices with its well-honed methodologies and protocols.
Virus-Host Interactions: Methods and Protocols (Methods in Molecular Biology #2610)
by Marilena Aquino de MuroThis detailed volume spotlights methods to investigate a variety of virus-host interactions in humans, other mammals, fish, or insects. It explores viruses such as white spot syndrome virus (WSSV), honeybee viruses, Nipah virus, EBV, SVCV, HSV-1, HIV-1, A H1N1, and SARS-CoV-2, as well as applications of techniques such as qPCR, serum antibody responses, 4C analysis, cell membrane fusion, biosensors, computational modelling, quantitative proteomics, and other genetic tools to decipher those viral infections and interactions. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Virus-Host Interactions: Methods and Protocols serves as a valuable resource for researchers both in academia and in the biosciences industry who are engaged in the search for a better understanding of threatening virus-hosts interactions, virus detection, their characterization, and ultimately their taming and control.
Virus Hybrids as Nanomaterials
by Baochuan Lin Banahalli RatnaIn Virus Hybrids as Nanomaterials: Methods and Protocols expert researchers in the field detail many of the methods used to study virus for medial and nonmedical applications. These include methods and techniques for genetically engineering viruses for therapeutic purpose and vaccine production, chemically modified viruses for virus-templated nanoparticles production, and genetically engineered or chemically modified viral particles as imaging agents. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Virus Hybrids as Nanomaterials: Methods and Protocols seek to aid new researchers to get involved in this multidisciplinary area.
The Virus in the Age of Madness
by Bernard-Henri LevyAs seen on CNN's Fareed Zakaria GPS Forget the world that came before. The author of American Vertigo serves up an incisive look at how COVID-19 reveals the dangerous fault lines of contemporary society. With medical mysteries, rising death tolls, and conspiracy theories beamed minute by minute through the vast web universe, the coronavirus pandemic has irrevocably altered societies around the world. In this sharp essay, world-renowned philosopher Bernard-Henri Lévy interrogates the many meanings and metaphors we have assigned to the pandemic—and what they tell us about ourselves. Drawing on the philosophical tradition from Plato and Aristotle to Lacan and Foucault, Lévy asks uncomfortable questions about reality and mythology: he rejects the idea that the virus is a warning from nature, the inevitable result of global capitalism; he questions the heroic status of doctors, asking us to think critically about the loci of authority and power; he challenges the panicked polarization that dominates online discourse. Lucid, incisive, and always original, Lévy takes a bird&’s-eye view of the most consequential historical event of our time and proposes a way to defend human society from threats to our collective future.
Virus-Induced Gene Silencing
by Annette BeckerPlants are amazing organisms to study, some are important sources for pharmaceuticals, and others can help to elucidate molecular mechanisms required for a plant's development and its interactions with the biotic or abiotic environment. Functional genomics is vastly lagging behind the speed of genome sequencing as high-throughput gene function assays are difficult to design, specifically for non-model plants. Bioinformatics tools are useful for gene identification and annotation but are of limited value for predictions concerning gene functions as gene functions are uncovered best by experimental approaches. Virus-Induced-Gene-Silencing (VIGS) is an easy to use, fast, and reliable method to achieve down regulation of target gene expression. Virus-Induced Gene Silencing: Methods and Protocols provides detailed protocols for VIGS experiments in several plant species including model and non-model plants. Also included in this book are recently developed protocols for VIGS-derived microRNA production in the plant or protein over expression, as well as chapters devoted to summarizing the molecular mechanisms of VIGS action and the vector systems developed so far. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Virus-Induced Gene Silencing: Methods and Protocols serves as a valuable resource for researchers from diverse fields of plant biology interested in experimental approaches to analyzing gene functions.
Virus Infected Cells (Subcellular Biochemistry #106)
by Swetha Vijayakrishnan Yaming Jiu J. Robin HarrisVirus-infected Cells is a comprehensive and technical exploration of the intricate interactions between viruses and host cells. This book delves into the molecular and cellular aspects of viral infections, providing a wealth of knowledge about various viruses and their effects on cellular mechanisms. The first part of the book covers general/technical aspects, introducing the reader to the field of virology and providing an overview of the techniques used to study virus-infected cells. It covers topics such as the visualisation of virus-infected cells by cryo-electron tomography and the assessment of necroptosis, a type of programmed cell death, in virus-infected cells. In addition, the book explores the role of apoptosis and phagocytosis as antiviral mechanisms, as well as the intricate process of viral membrane fusion and penetration. It also discusses the tracking of viral entry into living cells and the use of correlative cryo-imaging to study the biology of viruses in cells and tissues. Finally, the book examines the cytopathic effect induced by viruses, shedding light on the damage caused to infected cells. The second section of the book explores specific viruses and their interactions with host cells. Each chapter focuses on a specific virus and provides an in-depth look at its behaviour within infected cells. The book covers a wide range of viruses, including human papillomavirus, respiratory syncytial virus, Japanese encephalitis virus, African swine fever virus, coronavirus, influenza A virus and human endogenous retroviruses. Each chapter examines unique aspects of virus-host interactions, such as viral assembly, impact on the cytoskeleton, critical host-virus interactions mediated by viral RNA, mechanisms of cell entry, and the involvement of cholesterol in virus budding and scission. This volume in the Subcellular Biochemistry series is a valuable resource for researchers, virologists and students interested in understanding the complex dynamics between viruses and the cells they infect. With its detailed exploration of general and specific aspects of virus-host interactions, this book provides a comprehensive understanding of the molecular and cellular mechanisms involved in viral infections.
Virus Infection and Tumorigenesis: Hints from Marine Hosts’ Stress Responses
by Xiaobo ZhangThis book reviews the latest research on the molecules and mechanisms of marine host stress responses to viral infections and tumorigenesis. It offers an overview of the state of the art in the field as well as future directions. Metabolism disorder is a characteristic of tumorigenesis. Since viruses complete their life cycle in host cells, such infections cause metabolic disorders in the host. As such, the mechanisms of virus pathogenesis and tumor progression are similar or even identical. In essence, the role of antiviral molecules is to maintain the metabolic homeostasis of infected host cells, and the antiviral molecules induced by virus infection may play an important role in antitumor pathways, resulting in cancer cell death or restoring the disordered metabolism of cancer cells. The molecules generated during host stress responses to viruses can also contribute to the antitumor mechanisms in humans. However, the relationship between host stress responses to virus infection and tumorigenesis has not been extensively explored. In recent years, studies have shown that marine host stress responses to viral invasion can be good models for exploring human antitumor mechanisms. Stimulating further research in the field, this book offers graduate students and researchers with comprehensive insights into host stress responses to viral invasion and tumor progression. It is also a valuable resource for those working in the pharmaceutical industry interested in drug discovery based on molecules derived from host stress responses to viral infection.
Virus-Like Particles: A Comprehensive Guide
by Paul Pumpens Peter PushkoThis book represents the first complete and systematic guide to the virus-like particles (VLPs) and their applications as vaccines, therapeutic tools, nanomaterials, and nanodevices. The grouping of the VLPs follows the most recent virus taxonomy and the traditional Baltimore classification of viruses, which are based on the genome structure and mechanism of mRNA synthesis. Within each of the seven Baltimore classes, the order taxon serves as a framework of the chapter’s arrangement. The term "VLP" is used as a universal designation for the virus-, core-, or capsid-like structures, which became an important part of the modern molecular virology. The 3D structures, expression systems, and nanotechnological applications are described for VLPs in the context of the original viruses and uncover their evolving potential as novel vaccines and medical interventions. Key Features Presents the first full guide to the VLP nanotechnology, classified by current viral taxonomy Outlines specific structural properties and interconnection of the virions and VLPs Explains generation and characteristics of VLPs produced by various expression systems Offers up-to-date summary of VLPs designed as vaccines and delivery tools Unveils interconnection of VLPs with novel organic and inorganic nanomaterials
Virus Thirteen: A Novel
by Joshua Alan ParryVirus Thirteen is an irreverent and contagious thriller from debut author Joshua Alan Parry.Scientists James Logan and his wife, Linda, have their dream careers at the world's leading biotech company, GeneFirm, Inc. But their happiness is interrupted by a devastating bioterrorist attack: a deadly superflu that quickly becomes a global pandemic. The GeneFirm complex goes into lockdown and Linda's research team is sent to high-security underground labs to develop a vaccine. Above ground, James learns that GeneFirm security has been breached and Linda is in danger. To save her he must confront a desperate terrorist, armed government agents, and an invisible killer: Virus Thirteen.At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Viruses: Agents of Evolutionary Invention
by Michael G. CordingleyWhile viruses—the world’s most abundant biological entities—are not technically alive, they invade, replicate, and evolve within living cells. Michael Cordingley goes beyond our familiarity with infections to show how viruses spur evolutionary change in their hosts and shape global ecosystems, from ocean photosynthesis to drug-resistant bacteria.
Viruses: Biology, Applications, and Control
by David HarperViruses: Biology, Application, and Control is a concise advanced undergraduate and graduate textbook covering the essential aspects of virology included in biomedical science courses. It is an updated and expanded version of David Harper‘s Molecular Virology 2e from the Medical Perspectives series. Selected Contents: 1. Virus Structure and Infection 2. Virus classification and evolution 3. Virus Replication 4. Viral Interaction with the Immune System 5. Vaccines and vaccination 6. Antiviral Drugs 7. Beneficial Use of Viruses 8. Emergence, transmission, and extinction 9. Viruses, vectors, and genomics 10. Virus Culture, Detection and Diagnosis Viral Replication Strategies Appe
Viruses: Essential Agents of Life
by Günther WitzanyA renaissance of virus research is taking centre stage in biology. Empirical data from the last decade indicate the important roles of viruses, both in the evolution of all life and as symbionts of host organisms. There is increasing evidence that all cellular life is colonized by exogenous and/or endogenous viruses in a non-lytic but persistent lifestyle. Viruses and viral parts form the most numerous genetic matter on this planet.
Viruses, Allergies and the Immune System
by Jan de VriesWhy are problems such as viruses, allergies and post-viral syndrome increasingly prevalent today? Is it true that a simple allergy might develop into a serious degenerative disease? What part does the immune system play in these processes - and how can it be affected by lifestyle?Jan de Vries places a strong emphasis on the importance of diet, and the effects of food additives and drugs. Did you know that schizophrenia can be treated through diet? Or that the lives of hyperactive children - and their parents - can be returned to normal by eliminating even a single item from their food intake? It has even been proven that diet and allergies can have an influence on crime. Together with other well-known nutritionists from around the world, the author has studied this phenomenon in detail and includes some illuminating case histories in this book.