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Therapeutic Strategies in Veterinary Oncology
by Nicole Amato Jacob Cawley Steven Dow Joelle Fenger Andi Flory Ira Gordon Kayla Harding Kelvin Kow Cheryl London Nicola Mason Arata Matsuyama Jonathan Mochel Anthony Mutsaers Henrik Rönnberg Wesley WiersonThis book is a comprehensive resource for veterinary oncologists and trainees, covering therapeutic strategies used in the treatment of veterinary patients. In the setting of a rapidly changing field like oncology, this timely text focuses on mechanisms of action and biological rationale rather than current specific clinical recommendations, allowing current and future clinicians to adapt treatment approaches as our understanding of the biology of cancer evolves. With each chapter written by experts in their field, this book provides informative figures that convey this biological understanding and rationale of therapy. It starts from the mechanisms of treatment as we currently understand them, covering radiation therapy, chemotherapy, immunotherapy, targeted therapy, and many more. Dispensing vital, detailed and practical information about the different therapeutic strategies available, this book is a vital resource for practicing veterinarians, while also providing students of veterinary oncology with a better understanding of the key differences between different treatment strategies.
Therapeutic Targeting of RAS Mutant Cancers (Elements in Molecular Oncology)
by Edward C. Stites Kendra Paskvan Shumei KatoThe KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
Therapeutic Targets
by Mabel Loza Luis M. BotanaThe Latest Applications For Cellmechanism Research in Drug DiscoveryDesigned to connect research on cell mechanisms with the drug discovery process, Therapeutic Targets: Modulation, Inhibition, and Activation introduces readers to a range of new concepts and novel approaches to drug screening and therapeutic drug targeting to help inform future avenues of drug research. Highly topical, this accessible edited volume features chapters contributed by respected experts from around the globe.The book helps postgraduate students and professional scientists working in academia and industry understand the molecular mechanisms of pharmacology, current pharmacological knowledge, and future perspectives in drug discovery, focusing on important biochemical protein targets and drug targeting strategies for specific diseases. Examining the pharmacology of therapeutically undefined targets and their potential applications, it includes chapters on traditional therapeutic targets, including enzymes (phosphodiesterases and proteases), ion channels, and G protein-coupled receptors, as well as more recently identified avenues of exploration, such as lipids, nuclear receptors, gene promoters, and more.Since different diseases require different targeting techniques, the book also includes dedicated chapters on strategies for investigating Alzheimer's, diabetes, pain, and inflammation treatments. Concluding with a cross-sectional look at new approaches in drug screening, Therapeutic Targets is an invaluable resource for understanding where the next generation of drugs are likely to emerge.
Therapeutic Targets in Airway Inflammation (Lung Biology in Health and Disease)
by N. Tony Eissa David P. HustonThis reference examines the cellular, molecular, and genetic mechanisms involved in airway inflammation, as well as the pathophysiology, epidemiology, and aetiology of asthma. It explores strategies to prevent cellular injury and oxidative tissue damage, inhibit key inflammatory pathways and identify disease-specific targets to reduce the induction
Therapeutic Treatment for Benign Prostatic Hyperplasia
by Roger S Kirby John D McConnell John M Fitzpatrick Claus G Roehrborn Michael G Wyllie Peter BoyleThe spectrum of available treatment options for benign prostatic hyperplasia (BPH) is matched by the spectrum of disease severity, and with up to 90% of men in their 80s suffering from BPH to some extent, it is imperative that patients are offered the full range of options to manage the disease. Pharmacologic therapies available for the treatment o
Therapeutic Ultrasound
by Jean-Michel Escoffre Ayache BouakazThis book highlights advances and prospects of a highly versatile and dynamic research field: Therapeutic ultrasound. Leading experts in the field describe a wide range of topics related to the development of therapeutic ultrasound (i. e. , high intensity focused ultrasound, microbubble-assisted ultrasound drug delivery, low intensity pulsed ultrasound, ultrasound-sensitive nanocarriers), ranging from the biophysical concepts (i. e. , tissue ablation, drug and gene delivery, neuromodulation) to therapeutic applications (i. e. , chemotherapy, sonodynamic therapy, sonothrombolysis, immunotherapy, lithotripsy, vaccination). This book is an indispensable source of information for students, researchers and clinicians dealing with non-invasive image-guided ultrasound-based therapeutic interventions in the fields of oncology, neurology, cardiology and nephrology.
Therapeutic Ultrasound in Dentistry: Applications for Dentofacial Repair, Regeneration, and Tissue Engineering
by Tarek El-Bialy Eiji Tanaka Dror AizenbudThis book highlights the potential of low-intensity pulsed ultrasound, or LIPUS, to introduce a new era in dentistry by revolutionizing the approach to dental treatment and providing a cure for pathologic conditions long considered untreatable. Readers will find information on all aspects of LIPUS, from its mode of action and biologic mechanisms to the full range of emerging clinical applications. The role of LIPUS in promoting dental tissue repair and regeneration and in tissue engineering is fully explained in a series of chapters focusing on stimulation of cell metabolism in the dentocraniofacial region, bone healing, periodontal regeneration, the temporomandibular joint, pulp cell differentiation, the salivary glands, and orthodontics. The past two decades have witnessed numerous discoveries that have enhanced the scope for use of therapeutic ultrasound in dentistry. In summarizing the latest knowledge in this exciting field, the book will be of interest to dental surgeons, orthodontists, periodontists, and other practitioners.
The Therapeutic Use of Ayahuasca
by Beatriz Caiuby Labate Clancy CavnarThis book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
The Therapeutic Use of Ayahuasca
by Beatriz Caiuby Labate Clancy CavnarThis book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.
Therapeutic Use of Medicinal Plants and their Extracts: Phytochemistry and Bioactive Compounds (Progress in Drug Research #74)
by A.N.M. AlamgirThis book starts with a general introduction to phytochemistry, followed by chapters on plant constituents, their origins and chemistry, but also discussing animal-, microorganism- and mineral-based drugs. Further chapters cover vitamins, food additives and excipients as well as xenobiotics and poisons. The book also explores the herbal approach to disease management and molecular pharmacognosy and introduces methods of qualitative and quantitative analysis of plant constituents.Phytochemicals are classified as primary (e.g. carbohydrates, lipids, amino acid derivations, etc.) or secondary (e.g. alkaloids, terpenes and terpenoids, phenolic compounds, glycosides, etc.) metabolites according to their metabolic route of origin, chemical structure and function. A wide variety of primary and secondary phytochemicals are present in medicinal plants, some of which are active phytomedicines and some of which are pharmaceutical excipients.
The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine
by Richard Eugene Frye Michael BerkFocusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.
Therapeutic Uses of Cannabis
by British Medical AssociationAt the last Annual Representative Meeting of the British Medical Association a motion was passed that `certain additional cannabinoids should be legalized for wider medicinal use.'' This report supports this landmark statement by reviewing the scientific evidence for the therapeutic use of cannabinoids and sets the agenda for change. It will be welcomed by those who believe that cannabinoids can be used in medical treatment. The report discusses in a clear and readable form the use and adverse effects of the drug for nausea, multiple sclerosis, pain, epilepsy, glaucoma, and asthma.
Therapeutic Uses of Music with Older Adults
by Alicia Clair Jenny MemmottIn this comprehensively updated second edition, written by Alicia Ann Clair and Jenny Memmott the extraordinary benefits of music therapy for older adults are detailed. <p><p>Therapeutic Uses of Music with Older Adults not only examines these benefits but also clarifies the reasons that music is beneficial. This important book shows both informal and formal caregivers how to use music to enhance the quality of life of older adults - including people with physical impairments and people with dementia. <p><p>Written by two of the nation's leading music therapists, Therapeutic Uses of Music with Older Adults offers strategies for using music to: provide diversion for inactivity, discomfort, and daily routine; decrease symptoms of depression, anxiety insomnia, and agitation; handle problem behaviors; provide physical and emotional stimulation; help in the rehabilitation of people with cardiac disease, Parkinson's disease, and impairments related to stroke; help in the management of pain; facilitate social integration; communication; and the expression of feelings, including anger and grief; and relieve the stress and tension associated with caring for older adults.
Therapeutic Vaccines as Novel Immunotherapy: Biological and Clinical Concepts
by Hironori NakagamiThis book offers an excellent introduction to the use of novel therapeutic vaccines for common diseases based on their ability to induce antibody production. While the role of vaccines in the treatment of infectious diseases and cancer is well known, vaccines have also recently been developed for a variety of other conditions, including Alzheimer’s disease, hypertension, diabetes, and spondyloarthritis. These therapeutic advances are fully and clearly documented by acknowledged experts in the field, who explain the relevant biology and highlight the challenges involved in deploying this treatment approach effectively and safely. In addition, recent progress in the construction and delivery of DNA vaccines is documented, and the process of developing new peptide vaccines is explored in depth. While the book will be particularly valuable for researchers and scholars interested in immunotherapy, it will also appeal to clinicians seeking effective new medicines to treat patients suffering from chronic diseases.
Therapeutics, Evidence and Decision-Making
by Michael RawlinsThis book is intended to help decision-makers use, assess and appraise the evidence that underpins decisions about the use of therapeutic interventions. It will inform decision-makers about the nature of evidence, the strengths and weaknesses of the available approaches, and how these can be most effectively distilled for the purpose of reaching re
Therapeutics in Pregnancy and Lactation
by Anne Lee Sally Inch David FineganThis book will assist doctors, pharmacists, midwives and other health professionals in dealing with the issue of medicine use in pregnant and breastfeeding women. It gives practical guidance on the principles of safe and effective prescribing, summarises the known effects of widely used drugs, and provides up-to-date information in one accessible source. With an impressive list of contributors, Therapeutics in Pregnancy and Lactation offers clear guidelines and comprehensive advice on a diverse range of topics from drug abuse to hypertension and epilepsy.
Therapeutics of Digestive Endoscopic Tunnel Technique
by Enqiang LinghuThis book elaborates on a whole new understanding of digestive endoscopy, the core of which is to treat quite a number of diseases using minimally invasive methods, provides the walls of the digestive tube are free of perforations. Currently, the tunnel technique has been applied in the treatment of digestive early stage carcinomas, esophageal achalasia and submucosal tumors originating from muscularis propria. And this promising technique would surely be more widely used in the future. The main contents of this book include the history of the digestive endoscopic tunnel technique, the practical anatomy involved, operation steps, indications and contraindications, complications and possible future exploration fields. This book is well suited for doctors and surgeons performing digestive endoscopic therapies.
Therapeutics of Digestive Endoscopic Tunnel Technique
by Enqiang LinghuThis book elaborates on a whole new understanding of digestive endoscopy, the core of which is to treat quite a number of diseases using minimally invasive methods. Currently, the tunnel technique has been applied in the treatment of digestive early stage carcinomas, esophageal achalasia and submucosal tumors originating from muscularis propria. And this promising technique would surely be more widely used in the future. The main contents of this book include the history of the digestive endoscopic tunnel technique, the practical anatomy involved, operation steps, indications and contraindications, complications and possible future exploration fields. This book is well suited for doctors and surgeons performing digestive endoscopic therapies.
Therapeutics of Neural Stimulation for Neurological Disorders
by Yuping WangThis book mainly focuses on diversity of brain diseases, such as sleep disorders, major depression disorder, anxiety disorders, epilepsy, cognitive disorders, etc. It introduces the current pathological mechanisms of various diseases from the perspective of basic theories and research; it introduces the clinical evaluation and treatment of the above diseases from the clinical perspective. In addition, the current frontier research on therapeutics of neural stimulation for the above brain disorder was introduced, such as Transcranial electrical stimulation, magnetic stimulation, ultrasonic stimulation, etc., and the therapeutic strategy and stimuli parameters for reference were proposed.This book is aimed at clinical students, doctors and researchers in the field of neurology. Based on major brain diseases, this book systematically proposed the maneuverability, safety and effectiveness of neural stimulation technologies in the treatment of major brain diseases.
Therapeutische Arrangements im Maßregelvollzug: Studien zur Leerstellengrammatik und den Bezugsproblemen in der forensischen Psychiatrie
by Werner Vogd Martin FeißtAuf Basis von Feldforschungen und Interviews in 6 forensischen Kliniken werden die Herausforderungen der Therapie und Resozialisierung im Maßregelvollzug untersucht. Es werden grundlegende Dilemmata der Therapie unter Zwang herausgearbeitet und typische Probleme und Chancen aufgezeigt, die mit Versuch der Normalisierung der Patienten einhergehen. Es wird eine systemische Analyseperspektive gewählt, die den Blick sowohl auf die konkreten Beziehungen wie auch das organisationale Gefüge und seiner gesellschaftlichen Einbettung lenkt.
Therapeutische Beziehung und die Behandlung chronischer Depressionen
by Valerija Sipos Philipp Klein Antje Demmert James P. Mccullough Jr. Ulrich SchweigerCBASP (Cognitive Behavioral Analysis System of Psychotherapy) hebt das Neutralitätsprinzip des Therapeuten auf Seit mehr als einem Jahrhundert wird die Rolle des Psychotherapeuten dominiert durch Freuds Neutralitätsregel: Ein Therapeut darf die Beziehung zu seinen Patienten nicht persönlich gestalten. James P. McCullough, Jr., hinterfragt dieses weit verbreitete Diktum mit seinem neuen Behandlungsansatz für chronische depressive Patienten: Er empfiehlt eine diszipliniert persönliche Gestaltung der therapeutischen Beziehung statt therapeutischer Neutralität. Die therapeutische Beziehung kann auf diese Weise konkret eingesetzt werden, um pathologische Verhaltensmuster chronisch depressiver Patienten zu verändern. Die neue methodische Gestaltung der persönlichen Therapiebeziehung mit chronisch depressiven Patienten In diesem Buch beschreibt James P. McCullough, Jr., detailliert und anhand zahlreicher einprägsamer Fallbeispiele, wie er eine diszipliniert persönliche Gestaltung der therapeutischen Beziehung definiert und wie sie angewendet wird. Seine psychotherapeutische Erfahrung gepaart mit seinem frischen Blick auf die therapeutische Beziehung machen das Buch zu einer spannenden Lektüre für alle praktizierenden Psychotherapeuten und Psychotherapieforscher. Übersetzt und bearbeitet von den Fachleuten der Methode im deutschsprachigen Raum
Therapeutische Beziehungen: Aktuelle Konzepte im Kontext der Behandlung psychisch kranker Menschen (Psychosomatik im Zentrum #4)
by Friedrich Riffer Manuel Sprung Elmar Kaiser Lore StreiblGute zwischenmenschliche Beziehungen sind von grundlegender Bedeutung für jede Form der therapeutischen Arbeit. Das vierte Buch in der Reihe Psychosomatik im Zentrum widmet sich den Ansprüchen und Realitäten, Chancen und Risiken der therapeutischen Arbeit mit psychisch kranken Menschen. Fritz Riffer eröffnet mit der wichtigen Frage, was die gute Therapeutin und ihre therapeutischen Beziehungen ausmacht. Weitere Beiträge beschäftigen sich mit realistischen Ansprüchen und Erwartungen an Therapeuten, Übertragungsphänomenen sowie Liebe und erotischem Erleben in therapeutischen Beziehungen. Anschließend werden Chancen von achtsamkeitsbasierten und systemischen Herangehensweisen sowie Filmtherapie und tiergestützter Entwicklungsförderung aufgezeigt. Mögliche Risiken, wie etwa Grenzüberschreitungen, Aggression und Gewalt sowie sekundäre Traumatisierung werden ebenso thematisiert.Dieses Buch richtet sich in erster Linie an Ärzte, Psychotherapeuten, Klinische- und Gesundheitspsychologen sowie verwandte Berufsgruppen, die therapeutische Beziehungen mit psychisch kranken Menschen gestalten.
Therapeutische Diagnosen in Pädiatrie, Kinder- und Jugendpsychiatrie: Grundlagen und Modelle (essentials)
by Andreas LeschnikIn Deutschland haben wir zwei Klassifikationsmodelle, um Kinder mit Problemen und Ressourcen ganzheitlich zu erfassen. Zum einen die ICD-10 (International Statistical Classification of Diseases and Related Health Problems 10. Revision) und zum anderen die ICF-CY (International Classification of Functioning, Disability and Health. Children and Youth Version). In der Vergangenheit hat sich aber gezeigt, dass die ICD-10 und die ICF-CY nicht in Kombination miteinander benutzt werden. Somit entsteht automatisch eine nicht vollständige Diagnostik. Beide Klassifikationsmodelle wurden aber so entwickelt, dass sie aufeinander abgestimmt sind und sich somit ergänzen. Allerdings haben diese Model keine Leitlinie, wann und wo man sie in einem Prozess zum Erstellen einer therapeutischen Diagnose einsetzt. Dieses Buch soll aufzeigen, welche Modelle man benötigt, um eine therapeutische Diagnose zu erstellen.
Therapeutische Endoskopie im Gastrointestinaltrakt
by Georg Kähler Martin Götz Norbert SenningerAuch in der 2. Auflage des Buches ist die Vielfalt der etablierten und modernen endoskopisch-therapeutischen Interventionen von Experten aus Viszeralchirurgie und Gastroenterologie systematisch, umfassend und praxisnah dargestellt. Zahlreiche endoskopische Bilder und Schemazeichnungen illustrieren die Beschreibungen der Therapieverfahren.Zu jedem endoskopischen Verfahren sind beschrieben:- Indikationen- personelle, instrumentelle und technische Voraussetzungen- Durchführung- Ergebnisse- Limitationen, Komplikationen und deren Management.Alle Beiträge wurden aktualisiert; neu hinzugekommen ist ein eigenes Kapitel über Hygienemaßnahmen. Praktische Tipps und Hinweise auf alternative Vorgehensweisen sprechen den jungen Facharzt ebenso an wie den erfahrenen Endoskopiker und Endoskopie-Fachkräfte aus anderen Berufsgruppen.
Therapeutische Übungen (FBL Klein-Vogelbach Functional Kinetics)
by Irene Spirgi-Gantert Markus OehlAnleitung zu einem umfassenden Übungsprogramm, das auf den therapeutischen Beobachtungs- und Behandlungsprinzipien des Grundlagenbuchs "FBL: Bewegung lehren und lernen" aufbaut. Erprobte Übungen für den Patientenbeschwerden angepasstes Training aller Körperregionen bei funktionellen Störungen oder Beeinträchtigungen des Bewegungssystems. Konkrete Hinweise zu Patientenschulung, Analyse und individueller Korrektur von Haltung und Bewegung. Neu in der 5. Auflage: großzügiges Format, Layout. Übungsnamen und -anleitungen in gebräuchlicher Physiotherapie-Fachsprache übertragen. Jetzt mit DVD: Viele Übungen in "bewegten Bildern" als Videosequenzen!