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Thiamine: Catalytic Mechanisms in Normal and Disease States (Oxidative Stress and Disease)
by Frank Jordan Mulchand S. PatelCompiling landmark research from those laying the foundation for medical science's next leap forward, Thiamine: Catalytic Mechanisms in Normal and Disease States fully explores the pathophysiological aspects of a spectrum of diseases associated with TDP-requiring enzymes. Providing brilliant new insights into neurogenerative diseases, this comprehensive volume associates defects in the function of TDP-dependent enzymes with numerous metabolic disorders and disease states, and offers novel aspects of thiamine enzymes in chiral synthesis, as well as new perspectives on the cellular role of thiamine triphosphate and thiamine triphosphates.
Thiamine Deficiency and Associated Clinical Disorders
by David W. MccandlessThiamine deficiency and related clinical disorders represent an intriguing area of both basic and clinical investigation. Modern imaging strategies have facilitated the rapid treatment, and potential reversal of these clinical disorders. The fusion of laboratory and clinical knowledge serve as an example of how research can translate to successful treatment. The goal of Thiamine Deficiency and Related Clinical Disorders is to bring together cogent results from basic and clinical investigation and to stimulate further investigations in these areas. This data will be useful to neurologists, internists, nutritionists, biochemists, neurochemists, neuroscientists, and others with interest in thiamine deficiency.
Thick: Personal Autonomy in Ethics and Bioethics (Philosophical Studies Series #146)
by James F. Childress Michael QuanteThis book explores, in rich and rigorous ways, the possibilities and limitations of “thick” (concepts of) autonomy in light of contemporary debates in philosophy, ethics, and bioethics. Many standard ethical theories and practices, particularly in domains such as biomedical ethics, incorporate minimal, formal, procedural concepts of personal autonomy and autonomous decisions and actions. Over the last three decades, concerns about the problems and limitations of these “thin” concepts have led to the formulation of “thick” concepts that highlight the mental, corporeal, biographical and social conditions of what it means to be a human person and that enrich concepts of autonomy, with direct implications for the ethical requirement to respect autonomy. The chapters in this book offer a wide range of perspectives on both the elements of and the relations (both positive and negative) between “thin” and “thick” concepts of autonomy as well as their relative roles and importance in ethics and bioethics. This book offers valuable and illuminating examinations of autonomy and respect for autonomy, relevant for audiences in philosophy, ethics, and bioethics.
Thieves of Virtue: When Bioethics Stole Medicine (Basic Bioethics)
by Tom KochAn argument against the “lifeboat ethic” of contemporary bioethics that views medicine as a commodity rather than a tradition of care and caring.Bioethics emerged in the 1960s from a conviction that physicians and researchers needed the guidance of philosophers in handling the issues raised by technological advances in medicine. It blossomed as a response to the perceived doctor-knows-best paternalism of the traditional medical ethic and today plays a critical role in health policies and treatment decisions. Bioethics claimed to offer a set of generally applicable, universally accepted guidelines that would simplify complex situations. In Thieves of Virtue, Tom Koch contends that bioethics has failed to deliver on its promises. Instead, he argues, bioethics has promoted a view of medicine as a commodity whose delivery is predicated not on care but on economic efficiency.At the heart of bioethics, Koch writes, is a “lifeboat ethic” that assumes “scarcity” of medical resources is a natural condition rather than the result of prior economic, political, and social choices. The idea of natural scarcity requiring ethical triage signaled a shift in ethical emphasis from patient care and the physician's responsibility for it to neoliberal accountancies and the promotion of research as the preeminent good. The solution to the failure of bioethics is not a new set of simplistic principles. Koch points the way to a transformed medical ethics that is humanist, responsible, and defensible.
Thieves of Virtue
by Tom KochBioethics emerged in the 1960s from a conviction that physicians and researchers needed the guidance of philosophers in handling the issues raised by technological advances in medicine. It blossomed as a response to the perceived doctor-knows-best paternalism of the traditional medical ethic and today plays a critical role in health policies and treatment decisions. Bioethics claimed to offer a set of generally applicable, universally accepted guidelines that would simplify complex situations. In Thieves of Virtue, Tom Koch argues that bioethics has failed to deliver on its promises. Instead, he argues, bioethics has promoted a view of medicine as a commodity whose delivery is predicated not on care but on economic efficiency. Koch questions the "founding myths" of bioethics by which moral philosophers became practical ethicists who served as adjudicators of medical practice and planning. High philosophy, he argues, does not provide a guide to the practical dilemmas that arise at the bedside of sick patients. Nobody, he writes, carries Kant to a clinical consult. At the heart of bioethics, Koch writes, is a "lifeboat ethic" that assumes "scarcity" of medical resources is a natural condition rather than the result of prior economic, political, and social choices. The idea of natural scarcity requiring ethical triage signaled a shift in ethical emphasis from patient care and the physician's responsibility for it to neoliberal accountancies and the promotion of research as the preeminent good. The solution to the failure of bioethics is not a new set of simplistic principles. Koch points the way to a transformed medical ethics that is humanist, responsible, and defensible.
Thimerosal: Let the Science Speak
by Mark Hyman Martha Herbert Robert Kennedy Congressman Bill PoseyOver a decade ago, following a sharp rise in developmental disorders such as autism and ADHD, the mercury-containing preservative Thimerosal was widely believed to have been eliminated from vaccine supplies in the US and abroad. However, dangerous quantities of Thimerosal continue to be used, posing a significant threat to public health and leading to a crisis of faith in vaccine safety. In this groundbreaking book, Robert F. Kennedy, Jr. , and Dr. Mark Hyman examine the research literature on Thimerosal and make a very clear statement about its potentially dangerous effects. In the past, the CDC, FDA, NIH, and AAP, as well as the US Congress, the American Academy of Family Physicians, the US Department of Agriculture, the European Medicines Agency, and the California Environmental Protection Agency have expressed concerns over the use of Thimerosal in vaccines. But despite the many voices calling for action, the media and policy makers have repeatedly failed to adequately address the issue. Now, with Thimerosal: Let the Science Speak, the goals are to educate parents, doctors, and health policy makers; to eliminate this toxic chemical from the world’s vaccine supplies; to move toward safer alternatives; and to maintain or increase vaccination rates critical to the United States and developing nations. With safer options available, parents shouldn’t have to worry about the devastating effects of vaccinating their children.
Thimerosal: Let the Science Speak
by Jr. Robert F. Kennedy M.D. Mark Hyman Martha R HerbertFrom New York Times bestselling author Robert F. Kennedy, Jr., comes a science-based call for the immediate removal of the dangerous mercury-containing preservative Thimerosal from vaccines.Over a decade ago, following a sharp rise in developmental disorders such as autism and ADHD, the mercury-containing preservative Thimerosal was widely believed to have been eliminated from vaccine supplies in the United States and abroad. However, dangerous quantities of Thimerosal continue to be used, posing a significant threat to public health and leading to a crisis of faith in vaccine safety.In this groundbreaking book, Robert F. Kennedy, Jr., examines the research literature on Thimerosal and makes a very clear statement about its potentially dangerous effects. In the past, the CDC, FDA, NIH, and AAP, as well as the US Congress, the American Academy of Family Physicians, the US Department of Agriculture, the European Medicines Agency, and the California Environmental Protection Agency have expressed concerns over the use of Thimerosal in vaccines. But despite the many voices calling for action, the media and policy makers have repeatedly failed to adequately address the issue.Now, with Thimerosal: Let the Science Speak, the science supporting the elimination of this toxic chemical from the world's vaccine supplies, and its replacement with already available safer alternatives, is all in one place. Making this change should increase vaccination rates by restoring the trust of concerned parents in the vaccine program--a program that is so vitally important to public health.
Thin Calcium Phosphate Coatings for Medical Implants
by Betty León John JansenThis book presents for the first time, the scattered novel results that have been achieved in very recent years in study on various thin calcium phosphate coatings produced by very diverse techniques. The comparison of thin calcium phosphate coatings with the thick plasma-sprayed ones is also included in the book. Readers will find a comprehensive book reviewing the state-of-the-art of the field with critical assessment of the achievements of the different preparation techniques.
Thin Films and Coatings in Biology
by Soroush NazarpourThe surface of materials is routinely exposed to various environmental influences. Surface modification presents a technological challenge for material scientists, physicists, and engineers, particularly when those surfaces are subjected to function within human body environment. This book provides a comprehensive coverage of the major issues and topics dealing with interaction of soft living matter with the surface of implants. Fundamental scientific concepts are embedded through experimental data and a broad range of case studies. First chapters cover the basics on biocompatibility of many different thin films of metals, alloys, ceramics, hydrogels, and polymers, following with case studies dealing with orthopedic and dental coatings. Next, a novel and low-cost coating deposition technique capable of production of several types of nanostructures is introduced through simple calculations and several illustrations. Moreover, chapter 6 and 7 present important topics on surface treatment of polymers, which is a subject that has seen many developments over the past decade. The last chapters target mainly the applications of coatings in biology such as in bio-sensing, neuroscience, and cancer detection. With several illustrations, micrographs, and case studies along with suitable references in each chapter, this book will be essential for graduate students and researchers in the multidisciplinary field of bio-coatings.
Thin Layer Chromatography in Chiral Separations and Analysis
by Teresa Kowalska Joseph ShermaThin layer chromatography (TLC) is well suited for performing enantioseparations for research as well as larger-scale applications. A fast, inexpensive, and versatile separation technique, there are many practical considerations that contribute to its effectiveness. Thin Layer Chromatography in Chiral Separations and Analysis is the first bo
Thin Layer Chromatography in Drug Analysis (Chromatographic Science Series)
by Łukasz Komsta Monika Waksmundzka-Hajnos Joseph ShermaUsed routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date
Thinfluence: Thin-flu-ence (noun) the powerful and surprising effect friends, family, work, a nd environment have on weight
by Walter Willett Malissa Wood Dan ChildsTackling a weight problem is often viewed as a personal responsibility that requires making healthier choices. The latest research, however, shows that external factors—from family and friendships to advertising and the workplace environment—make an equal, if not greater, contribution. Just look at the stats: A person's chance of becoming obese increases by 57 percent if a close friend is obese, 40 percent if a sibling is obese, and 37 percent if a spouse is obese.That's where Thinfluence comes in. Through a research-based examination of various social, environmental, and policy-based issues, renowned Harvard researchers Dr. Walter Willett and Dr. Malissa Wood examine how relationships, workplace, media, and other factors are affecting readers' weights. Thinfluence doesn't tell readers to ditch their friends and family, change jobs, or move to another state. It offers a clear three-step action plan—analyze, act, influence—for readers to identify hidden factors affecting weight, develop a personal toolbox to combat external effects, and become positive influences on others around them.
The Thing About Life Is That One Day You'll Be Dead
by David Shields“David Shields has accomplished something here so pure and wide in its implications that I almost think of it as a secular, unsentimental Kahlil Gibran: a textbook for the acceptance of our fate on earth. ” —Jonathan Lethem Mesmerized—at times unnerved—by his ninety-seven-year-old father’s nearly superhuman vitality and optimism, David Shields undertakes an investigation of the human physical condition. The result is this exhilarating book: both a personal meditation on mortality and an exploration of flesh-and-blood existence from crib to oblivion—an exploration that paradoxically prompts a renewed and profound appreciation of life. Shields begins with the facts of birth and childhood, expertly weaving in anecdotal information about himself and his father. As the book proceeds through adolescence, middle age, old age, he juxtaposes biological details with bits of philosophical speculation, cultural history and criticism, and quotations from a wide range of writers and thinkers—from Lucretius to Woody Allen—yielding a magical whole: the universal story of our bodily being, a tender and often hilarious portrait of one family. A book of extraordinary depth and resonance,The Thing About Life Is That One Day You’ll Be Deadwill move readers to contemplate the brevity and radiance of their own sojourn on earth and challenge them to rearrange their thinking in unexpected and crucial ways.
Things I Did When I Was Hangry: Navigating a Peaceful Relationship with Food
by Annie MahonAfter years of struggling with eating disorders and anxiety around food and eating, Annie Mahon figured that having a path, any path, would be helpful. When she read The Miracle of Mindfulness by Thich Nhat Hanh, she found a path that not only changed her (and her family's) relationship with food, but also transformed nearly every aspect of her life.In Things I Did When I Was Hangry, Annie shares her path to mindful cooking and eating. The tools Mahon offers fit together like a wheel, rather than sequential steps. Readers are invited to just jump in and take what works for them.Each section has a short humorous story about Annie's own journey toward more conscious cooking and eating. She shares practices for developing mindfulness that will support more ease around food, and journal questions to help you look more deeply at the roots of your thinking about food, cooking, and eating. Simple, delicious, vegan recipes complement each section, demonstrating mindful alternatives for every meal and many eating challenges, including eating at work and school, eating at restaurants and on vacation, and mindfully feeding friends and entertaining.Mindful eating has been shown to improve body acceptance, diminish negative self-talk and support weight loss. Mindful cooking is a mindfulness practice in itself, creating more ease in our day-to-day lives. Annie Mahon's recipes and suggestions are scaffolding anyone can use to build their own mindful kitchen and eating practices.
Things I've Learned from Dying: A Book About Life
by David R. Dow"Every life is different, but every death is the same. We live with others. We die alone." In his riveting, artfully written memoir The Autobiography of an Execution, David Dow enraptured readers with a searing and frank exploration of his work defending inmates on death row. But when Dow's father-in-law receives his own death sentence in the form of terminal cancer, and his gentle dog Winona suffers acute liver failure, the author is forced to reconcile with death in a far more personal way, both as a son and as a father. Told through the disparate lenses of the legal battles he's spent a career fighting, and the intimate confrontations with death each family faces at home, THINGS I'VE LEARNED FROM DYING offers a poignant and lyrical account of how illness and loss can ravage a family. Full of grace and intelligence, Dow offers readers hope without cliché and reaffirms our basic human needs for acceptance and love by giving voice to the anguish we all face--as parents, as children, as partners, as friends--when our loved ones die tragically, and far too soon.
Things No Longer There: A Memoir of Losing Sight and Finding Vision
by Susan KriegerEven before the author lost her sight, she was interested in how things are never as we recall them.
The Things That Keep Us Here: HOW DO YOU PROTECT YOUR FAMILY DURING A NATIONWIDE PANDEMIC?
by Carla BuckleyHOW DO YOU PROTECT YOUR FAMILY DURING A NATIONWIDE PANDEMIC?'The story of the Brooks family as they face a nationwide pandemic and fight to survive ... what an amazing read' Amazon reviewer 5 starsMillions are dead. Fear and panic have gripped the nation. An engrossing and emotionally gripping story of one family whose limits are tested to the extreme.It began with a dead bird. Then state-wide school closure. Before long, the whole town is in lockdown and the Brooks family are quarantined in their own home - with a faceless enemy on their doorstep.They must cope as best they can, battling hunger, cold and boredom. But as the threat inches closer, and neighbour turns against neighbour, single mother Ann doesn't know who she can trust - including those taking refuge in her house.With no end in sight, Ann knows that if she is to protect her daughters from untold danger, she must make impossible decisions in order to survive...
Think Big: Unleashing Your Potential for Excellence
by Ben CarsonConduct life with reference to God and your own talents.
Think Like a Nurse: The Caputi Method for Learning Clinical Judgment
by Linda CaputiOver 150 Colleges and Universities adopted the first edition of Think Like a Nurse: A Handbook as a required student textbook. These adoptions demonstrate a need for this clinical judgment framework and have motivated the author, Dr. Linda Caputi, to expand the Caputi Method for Learning Clinical Judgment. The overwhelming support from educational institutions is evidence that students must learn a clinical judgment framework as the basis for thinking in nursing today. Older methods of evaluating student thinking that relied solely on students correctly answering questions with the assumption that if they answer correctly, they can use clinical judgment, are fatally flawed. Students must learn a framework that is used to focus their thinking, stay mindful, and guide them to make sound clinical decisions.
Think Like a Pancreas: A Practical Guide to Managing Diabetes with Insulin (Marlowe Diabetes Library)
by Gary ScheinerThe all-in-one, comprehensive resource for the millions of people with diabetes who use insulin, revised and updatedFew diabetes books focus specifically on the day-to-day issues facing people who use insulin. Diabetes educator Gary Scheiner provides the tools to "think like a pancreas" -- to successfully master the art and science of matching insulin to the body's ever-changing needs. Comprehensive, free of medical jargon, and packed with useful information not readily available elsewhere, such as: day-to-day blood glucose control and monitoring designing an insulin program to best match your lifestyleup-to date medication and technologynew insulin formulations and combinationsand moreWith detailed information on new medications and technologies -- both apps and devices -- surrounding insulin, as well as new injection devices, and dietary recommendations, Think Like a Pancreas is the insulin users go-to guide.
Thinking: Bioengineering of Science and Art (Integrated Science #7)
by Nima Rezaei Amene SaghazadehThe “THINKING: Bioengineering of Science and Art” is to discuss about philosophical aspects of thinking at the context of Science and Art. External representations provide evidence that the fundamental process of thinking exists in both animal subjects and humans. However, the diversity and complexity of thinking in humans is astonishing because humans have been permitted to integrate scientific accounts into their accounts and create excellent illustrations for the effects of this integration. The book necessarily begins with the origins of human thinking and human thinking into self and others, body, and life. Multiple factors tend to modify the pattern of thinking. They all will come into play by this book that brings thinking into different disciplines: humanities, natural sciences, social sciences, formal sciences, and applied sciences. The thinking demands full processing of information, and therefore, the book considers the economy of thinking as well. The book thoroughly intends to explore thinking beyond the boundaries. Specifically, several chapters are devoted to discipline this exploration either by artistic thinking alone or by art and mathematics-aided engineering of complexities. In this manner, the book models variations on thinking at the individual and systems levels and accumulates a list of solutions, each good for specific scenarios and maximal outcomes.
Thinking About Medicine: An Introduction to the Philosophy of Healthcare
by David MisselbrookThis introduction to the philosophy of medicine surveys the landscape of western philosophy as it pertains to healthcare in an accessible way. Written by a doctor for doctors and other health professionals, framing the 'toolbox' of philosophy within the community of medicine, it encourages examination of the implicit assumptions made in the construction of medical knowledge and practice.Taking the reader step by step through the concepts that underpin modern philosophy, they will be challenged to reflect upon the premises within clinical practice which might benefit from scrutiny and challenge, including the nature of scientific knowledge, the limits of our biomedical model, the cultural and relational context, and the failure to recognise or manage adequately the fact/value distinction in medicine and healthcare.The book is an ideal textbook for students of medicine and medical philosophy and will also be of interest to bioethicists, medical sociologists, clinical commissioners and to practicing clinicians in medicine and the allied health professions seeking to improve their understanding of philosophy and ethics and sharpen their critical thinking skills.
Thinking About Patients (Routledge Revivals)
by David MisselbrookIf medicine is so great, why are people getting sick? Why don’t people turn up for follow-up checks or take their pills properly? And why do patients sometimes seem to come from another planet?Medicine doesn’t happen in a vacuum. It happens between doctors and patients, who seem to inhabit very different worlds. It’s not enough to think about medicine. We need to think more about patients.Originally published in 2001 and reissued here with a new preface, Thinking About Patients promotes a multidimensional model of medicine. It offers a practical guide to the psychological and social processes involved in practicing medicine and in being a patient. It will help us to return to what medicine is all about – using our skills to serve patients.
Thinking about Science: Good Science, Bad Science, and How to Make It Better (ASM Books)
by Ferric C. Fang Arturo CasadevallThinking about Science: Good Science, Bad Science, and How to Make It Better A riveting exploration of the world of science, diving headfirst into its triumphs and tribulations. Penned by seasoned microbiologists Ferric C. Fang and Arturo Casadevall, this book offers a comprehensive analysis of the scientific enterprise through various lenses, including historical, philosophical, and personal. From their unique vantage points as researchers, clinicians, and educators, Fang and Casadevall dissect the intricate mechanisms of science, shedding light on its strengths and weaknesses. Through engaging historical anecdotes, personal narratives, and insightful academic studies, they present a candid evaluation of science�s performance, including a thought-provoking examination of its role during the COVID-19 pandemic. A must-read for anyone curious about the present predicaments and future potential of science, Thinking about Science: Good Science, Bad Science, and How to Make It Better is more than just a book; it�s a roadmap to understanding and improving the scientific endeavor for the benefit of society at large. �The authors have given us a thoughtful description of science and the joy of discovery, an unflinching diagnosis of where improvements are needed, and recommendations for remedies well worth considering. Scientists, science and society would benefit if this book were read by both future and established scientists, as well as the administrators, policymakers, and regulators who are in a position to help us do better.� �Michael Kalichman, UC San Diego �With a deep understanding of the profound impact of science on society, the authors provide thought-provoking perspectives on changes in the scientific enterprise that will support sustainable, equitable practices, and engender public trust. An engaging read for everyone with an interest in science or science policy. � �Stanley Maloy, San Diego State University