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Tissue Functioning and Remodeling in the Circulatory and Ventilatory Systems
by Marc ThirietThe volumes in this authoritative series present a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. Volume 5 is devoted to cells, tissues, and organs of the cardiovascular and ventilatory systems with an emphasis on mechanotransduction-based regulation of flow. The blood vessel wall is a living tissue that quickly reacts to loads applied on it by the flowing blood. In any segment of a blood vessel, the endothelial and smooth muscle cells can sense unusual time variations in small-magnitude wall shear stress and large-amplitude wall stretch generated by abnormal hemodynamic stresses. These cells respond with a short-time scale (from seconds to hours) to adapt the vessel caliber. Since such adaptive cell activities can be described using mathematical models, a key objective of this volume is to identify the mesoscopic agents and nanoscopic mediators required to derive adequate mathematical models. The resulting biomathematical models and corresponding simulation software can be incorporated into platforms developed in virtual physiology for improved understanding and training.
Tissue Morphogenesis
by Celeste M. NelsonTissue Morphogenesis: Methods and Protocols highlights major techniques, both experimental and computational, for the study of tissue morphogenesis, divided into several sections, with specific focus on techniques to image, manipulate, model and analyze tissue morphogenesis. Chapters focus on imagining analysis of tissue morphogenesis, culture models of tissue morphogenesis, manipulating cells and tissues in vivo, novel model systems to investigate issue morphogenesis and computational models. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Tissue Morphogenesis: Methods and Protocols serves as a primary resource for both fundamental and practical understanding of the techniques used to uncover the basis of tissue morphogenesis.
Tissue-Protective Cytokines
by Pietro Ghezzi Anthony CeramiWhile many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines. In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs.
Tissue-Resident Macrophages: Methods and Protocols (Methods in Molecular Biology #2713)
by Elvira MassThis detailed book delves into the diverse techniques and applications to target, isolate, image, phenotype, and analyze tissue-resident and monocyte-derived macrophages. The contents aim to describe the current knowledge about macrophage development and function which forces the scientific field to move beyond the previously described M1/M2 macrophage paradigm to be able to dissect macrophage functions within their specific niches during health and disease. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Tissue-Resident Macrophages: Methods and Protocols provides scientists entering the macrophage field with information and tools that allow them to dive into the state-of-the-art methodology used in this vital field.
Tissue Scaffolds (Springer Protocols Handbooks)
by Naveen Kumar Vineet Kumar Sameer Shrivastava Anil Kumar Gangwar Sonal SaxenaThis volume provides a comprehensive introduction into methods and procedures on the preparation and characterization of animal tissue-derived extracellular matrix scaffolds primarily from bubaline, caprine, porcine, ovine, rabbit, rat and fish source. Chapters guide readers through decellularization protocol unique to the particular animal tissue and animal studies outcomes. Authoritative and cutting-edge, Tissue Scaffolds aims to be a useful and practical guide to new researchers and experts looking to expand their knowledge.
Tissue-Specific Cell Signaling
by Joana Vieira Silva Maria João Freitas Margarida FardilhaSignal transduction comprises the intracellular biochemical signals which induce the appropriate cell response to an external stimulus. The players in signal transduction are diverse, from small molecules as first messengers, to proteins, receptors, transcription factors, among many others. The different signaling pathways and the crosstalk between them originates the unique signaling profile of every cell type in the human body. The cell signaling specificity depends on several aspects including protein composition, subcellular localization and complexes and gene promoters.This textbook provides a comprehensive overview of the specific signaling pathways on a variety of human tissues. This information can be of great value for health science researchers, professionals and students to understand key pathways for tissue-specific functions in the plethora of signals, signals receptors, transducers and effectors.Chapter 3 and 15 are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Tissue-Specific Estrogen Action
by Tim Wintermantel Kenneth S. KorachCurrent molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading researchers from industry and academia during an international symposium held in Berlin, 1-3 March 2006 and are featured in this volume.
Tissue-Specific Stem Cell Niche
by Kursad TurksenThis timely volume explores tissue-derived stem cells, summarizing and evaluating the current body of knowledge. Sixteen chapters cover hematopoietic, osteoblast, skeletal, cardiac, pancreatic, epithelial, corneal, hepatic, renal, testicular, ovarian, fingernail, hair follicle and other stem cells- discussing their individual development, functions and pathologies, as well as the commonalities and interdependence between niches. This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Tissue-Specific Stem Cell Niche is an ideal complementary volume to Biology of Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.
Tissue Stem Cells
by Christopher S. Potten Robert B. Clarke James Wilson Andrew G. RenehanTissue stem cells and their medical applications have become a major focus of research over the past decade. With 16 full-color illustrations, this reference provides a thorough and up-to-date overview of the current and emerging technologies for stem cell research and transplantation. Divided into three sections covering general issues, adult stem
Tissue Type Plasminogen Activity: Volume II
by Cornelius KluftThis book is made possible by the enthusiastic contributions of the authors of the chapters. They have been invited from young and active scientists in the field of t-PA research. I am grateful for their contribution and for the fact that all accepted the specifications of their chapter in order to obtain a structured book. Inevitably, some overlap does exist; on the one hand to enable controversial or unsettled areas to be discussed by the different experts with a different approach and background.It is a particular pleasure and honor that Dr. T. Astrup, as an eye-witness and essential contributor to the history of t-PA discovery and research, gives a unique account of the history of t-PA research in the first chapter of the book.
Tissue Type Plasminogen Activity: Volume I
by Cornelius KluftThis book is made possible by the enthusiastic contributions of the authors of the chapters. They have been invited from young and active scientists in the field of t-PA research. I am grateful for their contribution and for the fact that all accepted the specifications of their chapter in order to obtain a structured book. Inevitably, some overlap does exist; on the one hand to enable controversial or unsettled areas to be discussed by the different experts with a different approach and background.It is a particular pleasure and honor that Dr. T. Astrup, as an eye-witness and essential contributor to the history of t-PA discovery and research, gives a unique account of the history of t-PA research in the first chapter of the book.
Titanium: Metallic Pollutants in the Aquatic Environment
by Rachel Ann Hauser-DavisThis book engages readers in an integrated and holistic discussion on titanium properties, applications, bioanalytical approaches and toxicity. Key issues include environmental titanium exposure and associated health risk concerns for both humans and aquatic organisms, exploring ecotoxicological effects. The book delves into the intricate web of ecotoxicological effects, offering valuable insights for researchers and professionals alike. With a broad appeal, this book is an indispensable resource for those immersed in the realms of oceanography, geochemistry, ecotoxicology, and environmental and public health, providing a multidisciplinary perspective on the intricate interplay between titanium and the natural world.
TMD and Orthodontics
by Sanjivan Kandasamy Charles S. Greene Donald J. Rinchuse John W. StockstillThis evidence-based book, featuring contributions from world-renowned experts, discusses in detail the functional anatomy of the temporomandibular joint as well as the aetiology, diagnosis, treatment and medicolegal implications of patients with temporomandibular disorders (TMD). Despite advances in our understanding of the aetiology of TMD and in developing current treatment rationales, a number of issues remain controversial. These include the extent to which the temporomandibular joint should be a central focus of orthodontic diagnosis and treatment, as well as the role that occlusion and malocclusion play in precipitating TMD symptoms. Indeed, few subjects in dentistry and the specialty of orthodontics are open to as many interpretations or misinterpretations as TMD. This textbook provides clinical orthodontists with essential information and guidance that will assist them in understanding and effectively managing this complex multilayered problem. Throughout, clear clinical guidelines are presented on the basis of current scientific and clinical evidence. TMD and Orthodontics will be a highly valuable chairside resource for orthodontists everywhere.
The TNF Superfamily
by Jagadeesh BayryExploring these type II trans-membrane proteins, The TNF Superfamily: Methods and Protocols focuses on various techniques to investigate aspects of the TNF Superfamily members in health and disease. Opening with protocols to understand the signaling process of TNF family members, this detailed volume continues with technical examples of investigating the role of TNF family members in physiopathologies, protocols on modulation of TNF signaling by pathogens, experimental applications of TNF-reporter mice, as well as methodologies for various assays of TNF family members and the production of recombinant molecules Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and ready to use, The TNF Superfamily: Methods and Protocols will aid researchers investigating this key family of proteins, involved in vital processes such as providing signals for activation, differentiation, survival and death of cells, modulation of immune response and inflammation, hematopoiesis and osteoclastogenesis.
TNM: Klassifikation maligner Tumoren
by Christian WittekindDie TNM-Klassifikation ist das weltweit am haufigsten verwendete System fur die Beschreibung der anatomischen Ausbreitung maligner Tumoren, gegliedert in einen klinischen und einen pathologischen Teil. Sie wird in Zusammenarbeit mit der Union for International Cancer Control (UICC) herausgegeben und umfasst im Wesentlichen alle anatomischen Regionen gema? den WHO-Richtlinien zur Klassifikation der Krankheiten in der Onkologie. Die 8. Auflage berucksichtigt die wesentlichen seit 2009 aktualisierten Richtlinien zur Definition der T-, N- und M-Kategorien und der Stadien. Au?erdem werden TNM-Klassifikationen fur einige neu hinzugekommene Tumorentitaten, wie z. B. Thymustumoren, veroffentlicht.
TNM: Klassifikation Maligner Tumoren
by Christian Wittekind Hans-Joachim MeyerDie TNM-Klassifikation ist das weltweit am meisten verwendete System für die Beschreibung der Ausbreitung einer Tumorerkrankung. Die 7. Auflage dokumentiert die aktualisierten Standards und wird in Zusammenarbeit mit der International Union Against Cancer (UICC) herausgegeben. Dieses handliche Taschenbuch enthält wichtige neue Organ-spezifische Klassifikationen, u.a. bei den Tumoren der Leber, Gallengänge, Pankreas, Knochen, Haut und Augen.
TNM Atlas
by H. Asamura Christian Wittekind Leslie H. SobinThis book presents the illustrated version of the TNM Classification of Malignant Tumours, Seventh Edition, promoting the uniform application of the TNM classification in cancer practice. Now featuring beautiful, useful full-color medical artwork, this book is designed as an aid for the practical application of the TNM classification system by illustrating the T and N categories in clear, easily understood graphics. The aim of this presentation is twofold: to reach a more standardized understanding and documentation of the anatomic spread of tumours, and to further enhance the dissemination and use of the TNM classification.
TNM Atlas
by James D. Brierley Hisao Asamura Elizabeth Van Eycken Brian Rous Christian Wittekind Sabine WalterTNM Atlas Der maßgebende Atlas zur aktuellen TNM Klassifikation — jetzt mit noch mehr Illustrationen Das TNM System ist das weltweit am häufigsten verwendete Werkzeug, die Ausbreitung einer Krebserkrankung zu klassifizieren und in Stadien einzuteilen. Herausgegeben in Zusammenarbeit mit der UICC (Union for International Cancer Control) stellt der TNM Atlas, Siebte Auflage, die illustrierte Version der TNM Klassifikation, Achte Auflage, dar. Dieses Werk unterstützt mit erstklassigen anatomischen Darstellungen bei der praktischen Anwendung des TNM Klassifikationssystems. T- und N-Kategorien werden mit klaren und einfach zu verstehenden Abbildungen illustriert, ergänzt durch ausgewählte tomographische Aufnahmen aus der klinischen Praxis. Inhaltlich vollkommen überarbeitet, basierend auf der aktuellen TMN Klassifikation Mit mehr als 300 farbigen Abbildungen, die die anatomischen Besonderheiten jeder Tumorerkrankung akkurat und detailgetreu darstellen Unverzichtbares Werk nicht nur für die Diagnose, sondern auch für Ausbildung und für Aufklärungsgespräche mit Patient⋆innen Die in Genf ansässige UICC ist eine weltweit anerkannte Organisation, deren zentrale Aufgabe die Tumorklassifikation und Krebsbekämpfung ist. Ihr TNM Atlas ist ein wertvolles Nachschlagewerk für Onkolog⋆innen, Chirurg⋆innen, Patholog⋆innen, Mitarbeitende in Krebsregistern und onkologisches Pflegepersonal, sowie für Krebsforschungsinstitute und entsprechende staatliche Einrichtungen und nichtstaatliche Organisationen.
TNM Atlas (UICC)
by James D. Brierley Elisabeth Van Eycken Hisao Asamura Brian RousA fully illustrated guide to the current TNM classification (8th Edition) and staging system The Union for International Cancer Control’s (UICC) TNM classification system is the most widely used cancer classification and staging system in the world. It is used to describe the anatomical extent of disease and is, therefore, essential to patient care, research and cancer control. This seventh edition of the TNM Atlas provides health-care professionals with a detailed pictorial guide to the system, demonstrating its practical application via clear, direct text and an array of full-color medical illustrations. The atlas features: Specially produced content, created to reflect the most recent iteration of the TNM classification of malignant tumours, the 8th Edition More than 300 full-color medical illustrations covering all anatomical sites of cancer involvement Quick-reference material that is ideal for use in clinical and educational settings The revised seventh edition of the TNM Atlas is a valuable resource for all medical, surgical, and radiation oncologists, anatomical and surgical pathologists, cancer registrars, oncology nurses, physician extenders, international cancer care centers and NGOs dedicated to cancer control.
TNM Atlas
by Christian WittekindHerausgegeben in Zusammenarbeit mit der UICC, stellt dieser Atlas wie schon in den Vorauflagen die T und N Kategorien der unterschiedlichen Tumore graphisch akkurat dar. Alle Abbildungen wurden für diese 6. Ausgabe komplett neu gezeichnet und sind jetzt durchgehend vierfarbig.
TNM Classification of Malignant Tumours: Illustrated Guide To The Tnm/ptnm Classification Of Malignant Tumours (Uicc Ser. #Vol. 6)
by James D. Brierley Mary K. Gospodarowicz Christian WittekindTNM Classification of Malignant Tumours eighth edition provides the latest, internationally agreed-upon standards to describe and categorize cancer stage. Published in affiliation with the Union for International Cancer Control (UICC) Arranged by anatomical region, this authoritative pocket sized guide contains many important updated organ-specific classifications There are new classifications for p16 positive oropharyngeal carcinomas, carcinomas of the thymus, neuroendocrine tumours of the pancreas, and sarcomas To facilitate the collection of stage data for cancer surveillance in low and middle income countries there are new sections on Essential TNM and Paediatric Cancer Stage New colour presentation
TNM Classification of Malignant Tumours: Illustrated Guide To The Tnm/ptnm Classification Of Malignant Tumours (Uicc International Union Against Cancer Ser.)
by L. H. Sobin M. K. Gospodarowicz Ch. WittekindTNM Classification of Malignant Tumours, 7th Edition provides the latest, internationally agreed-upon standards to describe and categorize cancer stages and progression. Published in affiliation with the International Union Against Cancer (UICC), this authoritative guide contains important updated organ-specific classifications that oncologists and other professionals who manage patients with cancer need to accurately classify tumours for staging, prognosis and treatment. The major alterations addressed in the 7th Edition concern carcinomas of the oesophagus and the gastroesophageal junction, stomach, lung, appendix, biliary tract, skin, and prostate. In addition, there are several entirely new classifications: gastrointestinal carcinoids (neuroendocrine tumours) gastrointestinal stromal tumour upper aerodigestive mucosal melanoma Merkel cell carcinoma uterine sarcomas intrahepatic cholangiocarcinoma adrenal cortical carcinoma. A new approach has also been adopted to separate anatomical stage groupings from prognostic groupings in which other prognostic factors are added to T, N, and M categories. These new prognostic groupings, as well as the traditional anatomical groupings, are presented for oesophageal and prostate carcinomas. Visit www.wileyanduicc.com for more information about the International Journal of Cancer and our other UICC book titles
TNM Klassifikation maligner Tumoren: Korrigierter Nachdruck 2020 mit allen Ergänzungen der UICC aus den Jahren 2017 bis 2019
by Christian WittekindDie TNM-Klassifikation ist das weltweit am häufigsten verwendete System für die Beschreibung der anatomischen Ausbreitung maligner Tumoren, gegliedert in einen klinischen und einen pathologischen Teil. Sie wird in Zusammenarbeit mit der Union for International Cancer Control (UICC) herausgegeben und umfasst im Wesentlichen alle anatomischen Regionen gemäß den WHO-Richtlinien zur Klassifikation der Krankheiten in der Onkologie. Dieser korrigierte Nachdruck der 8. Auflage berücksichtigt rund 150 Änderungen und Korrekturen aus den Jahren 2017 bis 2019, die nach Erscheinen der 8. Auflage von der UICC bekannt gegeben wurden.
TNM-Supplement: Erlauterungen zur einheitlichen Anwendung
by Vierte Auflage Ch. WittekindWie schon in den vorherigen Supplements ist die 4. Auflage unverzichtbar zur korrekten und einheitlichen Verwendung der Klassifikation von malignen Tumoren. Erstmals wird hier dem Prognostic Factors Project ein Kapitel gewidmet. Unverzichtbar für alle Onkologen und Pathologen.
TNM Supplement
by Christian WittekindThe TNM Supplement, 4th Edition, includes new, detailed definitions of anatomical sites, regional lymph nodes, and TNM categories. It answers questions that frequently arise during daily use of the TNM system. Importantly, the TNM Supplement expands on the minimum requirements for pathological classification of individal tumour sites and enumerates the recommended criteria for each. Published in association with the Union for International Cancer Control, it provides oncologists with complementary material related to TNM staging not covered in TNM Classification of Malignant Tumours, 7th Edition.