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Tuberculosis: Integrated Studies for a Complex Disease (Integrated Science #11)
by Nima RezaeiTuberculosis have been documented since antiquity and the search of the microbes that cause this disease started more than three hundred years ago. Nevertheless, tuberculosis remains an important global health issue, with millions of people affected per year in addition to millions that remain undiagnosed and untreated. Patients with tuberculosis face the full range of recurrence, reinfection, and resistance due to diagnostic, prophylactic, and therapeutic procedures that are not as effective as they should be. In addition, variability in susceptibility to tuberculosis pose a complex problem with numerous interrelated variables. This volume is devoted to the understanding of Tuberculosis focusing on its heterogeneity, its transmission, manifestations, related conditions, diagnosis, treatments, drug resistance and prevention.
Tuberculosis
by Dick Van Soolingen Leonid Heifits Michael Hoelscher Ajit Lalvani Simon Waddell Timothy Mchugh Mike Barer Leonor Amaral Helen Mcshane Isobel Honeyborne Pablo Bifani M Boeree Gerry Davies Andrew Ramsay Paul Van Helden Clare Ling Ruth Mcnerney Stephen Gillespie Geoff Coxon Marc LipmanTuberculosis is a global health threat and the unique features of Mycobacterium tuberculosis and emergence of drug-resistant strains highlight the challenge it presents. Covering a wealth of state-of-the-art knowledge from active international experts, this book captures the latest developments in the advent of bacteriological, immunological and molecular tools for diagnosis and the development of new drugs. It shows how the challenge of tuberculosis is currently being met, providing insight into the evidence base underlying new developments in diagnosis, drug development and treatment.
Tuberculosis and Nontuberculous Mycobacterial Infections: And Non Tuberculous Myobacterial Infections (ASM Books #36)
by David SchlossbergFor Tuberculosis and Nontuberculous Mycobacterial Infections, Dr. Schlossberg assembled an international team of experts to write about nearly every facet of the prevention, diagnosis, and treatment of tuberculosis and nontuberculous mycobacterial infections. In addition to presenting the latest clinical data, epidemiological findings, and policy and strategy recommendations of the World Health Organization, four new chapters cover topics of critical importance: The role of therapeutic drug monitoring in mycobacterial infections The public health issues of refugees and migrants, and their exposure and transmission of tuberculosis resulting from humanitarian crises Diabetes mellitus as a significant risk factor for tuberculosis The increased risk of tuberculosis reactivation in people taking tumor necrosis factor alpha inhibitors and other biopharmaceuticals Other chapters provide detailed information on the clinical, public health, and policy aspects of tracking and treating tuberculosis, including: The many presentations of tuberculosis, from pulmonary to ocular and cardiovascular to urogenital The complications that tuberculosis and antituberculosis therapy cause to the hematologic and endocrine systems Tuberculosis during pregnancy and in infants and children Treatment of multidrug-resistant tuberculosis and extensively drugresistant tuberculosis Development of new vaccines Nontuberculous infections caused by mycobacteria found throughout our environment The seventh edition of Tuberculosis and Nontuberculous Mycobacterial Infections is an essential resource for anyone working to prevent and treat tuberculosis and associated infections, from infectious disease specialists to scientists, policymakers, and epidemiologists.
Tuberculosis and the Tubercle Bacillus (ASM Books #37)
by Jr. Et Al. Helen McShane William R. Jacobs Valerie MizrahiCan today's innovative practices and molecular tools tame this ancient disease? One third of the world's population is infected with tuberculosis (TB), with about 10 million new cases annually. To combat TB and its agent, Mycobacterium tuberculosis, the World Health Organization launched The End TB Strategy, which aims to slash the suffering and cost of TB by 2035. This makes the second edition of Tuberculosis and the Tubercle Bacillus, edited by Jacobs, McShane, Mizrahi, and Orme, an extremely valuable resource for scientists and clinicians. The editors have gathered their colleagues from around the world to present the latest on the molecular biology of M. tuberculosis and related species, the host-pathogen interactions that enable invasion, and the host's immune response to M. tuberculosis infection. The basic, clinical, and translational research presented in this book supports the goals of WHO's End TB Strategy by driving toward the development of effective vaccines, rapid molecular diagnostics, and anti-TB drugs. Creating an effective tuberculosis vaccine. Understand the innate and adaptive immune response to M. tuberculosis infection, its study in established animal models, and how this information is being used to develop new vaccines against TB. Formulating new antituberculosis drugs. Learn the challenges and methods for evaluating new drugs in preclinical trials with a focus on drugs that work against "persisters" and those that act on the electron transport complex and ATP synthase of M. tuberculosis. Overcoming the challenges of diagnosing tuberculosis. Review new diagnostic tools that are simple, rapid, affordable, specific, sensitive, and safe, including molecular-based diagnostic methods such as GeneXpert MTB/RIF. Using molecular, genomic, and bioinformatics tools to understand the biology and evolution of Mycobacterium. Explore current research on the molecular mechanisms that M. tuberculosis uses to evade the immune system, enter a state of nonreplicating persistence, and become reactivated. The second edition of Tuberculosis and the Tubercle Bacillus presents the latest research on a microorganism that is exquisitely well adapted to its human host. This pathogen continues to confound scientists, clinicians, and public health specialists, who will all find much valuable information in this comprehensive set of reviews.
Tuberculosis Control in Migrating Population
by Wei-Ye Yu Pu-Xuan Lu Wei-Guo TanWith the rapid development of economy and international communication, world population mobility increase significantly. As migrating population is one of vulnerable populations to infectious diseases, strengthening monitoring system and intervention approaches will be a key factor in controlling the spread of infectious diseases. This book is intended to provide valuable information on creating effective prevention and intervention strategies of tuberculosis, taking Shenzhen, one of typical immigrant cities, as an example. Followed by overview of tuberculosis, the control strategy, diagnosis and treatment of tuberculosis, drug resistant tuberculosis, and HIV-associated tuberculosis in migrating population is introduced. In addition, application of innovative technologies, for example, internet, molecular biology, and artificial intelligence in tuberculosis control is presented. It will be a useful reference for practitioners in centers for infectious disease control and prevention, hospitals, academic institutions, as well as staff in government agencies and non-government organizations with interests in tuberculosis prevention and control.
Tuberculosis Host-Pathogen Interactions
by Jeffrey D. Cirillo Ying KongThis book summarizes the progress in studies of tuberculosis host-pathogen interactions from several perspectives: molecular microbiology, immunology, animal models, clinical studies, epidemiology, and drug discovery. Tuberculosis (TB) remains a severe global public health problem. Complex interactions between environmental, microbial and host factors lead to clinically relevant infections. Studies on bacterial virulence, host-genetic, and immunological factors contributing to the susceptibility to TB provide an ever-growing foundation of knowledge that is critical to finding new interventions. Studies of immune mechanisms against M. tuberculosis infection have identified immunological markers associated with specific phenotypes in the host, providing insight into how they may be used to augment current treatment strategies. Recent advances in diagnosis, therapeutics and vaccines, as well as basic-research oriented studies have shed light on the development of new directions for prevention, treatment and control of TB. Improved understanding of the interplay between the bacterium and host is a key component of reducing incidence worldwide.
Tuberculosis in Adults and Children
by Dorothee Heemskerk Maxine Caws Ben Marais Jeremy FarrarThis work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
Tuberculosis in Animals: An African Perspective
by Asseged B. Dibaba Nicolaas P. J. Kriek Charles O. ThoenThis book recounts the biology of M. bovis, followed by the status of bovine Tuberculosis (bTB) in African countries, primarily based on zoonotic and epidemiological field reports. Since the accumulation of data is valueless unless it led to practicable control measures, emphasis is put on locally adapted protocols for future control of the disease. In order to systematically evaluate the knowledge base of bTB, Epidemiologic Problem Oriented Approach (EPOA) methodology was used. The methodology is composed of two triads: i) the problem identification/characterization triad, which is mainly descriptive in nature, and ii) the problem management/solution/mitigation triad, which is mainly geared toward problem management/solution (see figure). The first triad comprises three pillars: i) agent ii) host, and iii) environment and the second one: i) therapeutics/treatment, ii) prevention/control, and iii) health maintenance/promotion. The two triads are linked together by the diagnostic procedure linkage. The systematic and detailed studies of the ‘Host-Agent-Environment’ interactions are the building blocks to the understanding of agent transmission pathways and disease spread. These may include data about the disease status of the country, the nature of the disease agent and its hosts, the modes of transmission, the wildlife reservoirs in nature, persistence of infection, and agent survival in animal products and the environment. The problem identification and characterization triad identifies these interactions. Once a problem has been identified and well understood, the next step is to minimize the risk of transmission and spread of a disease. This area, referred to as problem solution/management triad, consists of problem management alternatives that rely upon prevention/control, and health maintenance/promotion of the disease in livestock, wildlife, and humans with the emphasis on resource-poor, developing countries in Africa.
Tuberculosis in Clinical Practice
by Onn Min KonThis book is targeted at ensuring frontline clinical staff including seniors, trainees and specialist nurses can easily reference the optimum investigation and management of potential TB cases. This will mirror the annual London Advanced TB course which aims to equip all of the team delivering care to have a working knowledge of the entire spectrum of the real life aspects of TB management ranging from investigation of active TB to latent screening in pre biologic therapy. It includes an update of MDR TB management and also the approaches needed to ensure the entire medico-social spectrum of TB care is addressed.
Tuberculosis in the Workplace
by Institute of MedicineThis National Institute of Medicine committee report on the resurgence of tuberculosis in the US focuses on the risks of occupational exposure for health- care workers. It reviews responses to resurgent TB and proposed strategies for its elimination in the US and worldwide; provides an overview of TB transmission, infection, and disease; discusses established and proposed federal standards to protect workers from occupational exposure to TB; and considers the effects of existing guidelines for preventing TB exposure in health-care facilities as well as the likely effects of standards proposed by the Occupational Safety and Health Administration. Annotation c. Book News, Inc. , Portland, OR (booknews. com)
Tuberculosis, Leprosy and other Mycobacterial Diseases of Man and Animals
by Michelle Larsen Mark Chambers Harshini Mukundan Ray WatersMycobacteria are bacterial pathogens which cause diseases in humans and non-human animals. This monograph will primarily cover the most important and widely researched groups of mycobacteria: members of the Mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae, across a wide range of host species. M. tuberculosis and M. bovis are particularly relevant with the increasing drug resistance and co-infection with HIV associated with M. tuberculosis and the possible cross-infection of badgers and cattle associated with M. bovis. This book will provide a reference for researchers working in different fields creating a work which draws together information on different pathogens, and by considering the diseases in a zoonotic context provides a One Health approach to these important groups of diseases.
Tuberculosis, Leprosy and other Mycobacterial Diseases of Man and Animals: The Many Hosts of Mycobacteria
by Harshini Mukundan Mark A. Chambers W. Ray Waters Michelle H. LarsenMycobacteria are bacterial pathogens which cause diseases in humans and non-human animals. This monograph primarily covers the most important and widely researched groups of mycobacteria: members of the Mycobacterium tuberculosis complex (MTC) and Mycobacterium leprae, across a wide range of host species. M. tuberculosis and M. bovis are particularly relevant with the increasing drug resistance and co-infection with HIV associated with M. tuberculosis and the possible cross-infection of badgers and cattle associated with M. bovis. This book provides a reference for researchers working in different fields, creating a work which draws together information on different pathogens, and by considering the diseases in a zoonotic context, provides a One Health approach to these important groups of diseases.
Tuberculosis of the Central Nervous System
by Mehmet Turgut Ali Akhaddar Ahmet T. Turgut Ravindra K. GargWritten and edited by leading international authorities in the field, this book provides an in-depth review of knowledge of tuberculosis of the central nervous system, with emphasis on clinical, diagnostics, and therapeutic features. Tuberculosis, one of the most lethal diseases in human history, still poses a serious threat in the world together with economic and social problems, although a great progress in the fight against this infectious disease in the last century. It covers the full range of tuberculosis of central nervous system and the chapters are organized into six sections: (1) the cranial; (2) the spinal; and (3) the peripheral portions of the nervous system; followed by (4) a section on the laboratory studies in tuberculosis; (5) a section on medical and surgical therapy; and (6) further insights into tuberculosis. This comprehensive reference book will be an ideal source for neurosurgeons, neurologists and specialists upon infectious diseases seeking both basic and more sophisticated information and surgical procedures relating to the complications associated with tuberculosis involving the spine, brain and peripheral nerves.
Tuberculosis of the Gastrointestinal system
by Vishal SharmaTuberculosis is an important concern in numerous countries across the globe. Training is usually focused on pulmonary tuberculosis, and the nuances of diagnosis and management of extrapulmonary tuberculosis, including abdominal tuberculosis, are not usually emphasized. This book details the varied presentations and mimics of tubercular involvement of the abdomen and the gastrointestinal system . .The book provides clear guidance to the clinicians to diagnosis and manage the varied forms of abdominal tuberculosis. The chapters also touch on areas of controversy and confusion. Chapters are focused on each of the sites (intestinal, peritoneal, gastroduodenal, hepatobiliary, and pancreatic), modalities for evaluation (histology, microbiology, radiology, endoscopic ultrasound, nuclear medicine), differential diagnosis, and follow-up including response to treatment. Separate chapters have also been devoted to pediatric abdominal TB, therapy-related hepatitis, and considerations in immunocompromised states such as HIV. Therefore, this book will help practice clinicians and serve as a one-stop resource for graduate students in internal medicine and fellows training in gastroenterology.
Tuberculosis of the Spine
by Sarvdeep Singh Dhatt Vishal KumarThis book covers all aspects and dimensions of tuberculosis affecting the spine, starting from its historical perspective to modern trends in early diagnosis, management, and rehabilitation. This book is a treatise fulfilling all the existing wide lacunae in suspicion, clinical examination, diagnosis, and management of this disease which still dwells as a mystery in modern medicine. It presents very easy to follow management plan algorithms and keynotes for easy and ready reference in each chapter. It describes the recent advances in diagnostic modalities and the treatment regimes, along with controversies, that have been elucidated and concluded with firm and sound references from evidence-based literature. This book also showcases the varied presentations of the disease as per varied socio-economic strata and in different geographic regions along with the different, principle-based approach to the disease spectrum shall be discussed at length. It also includes different clinical settings and scenarios in the concerned chapters. This book is a ready reference guide for postgraduate trainees, post-doctoral trainees, and faculty and consultants of orthopedics and neurosurgery.
Tubulin-Binding Agents
by Teresa CarlomagnoThis series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts.
Tubulointerstitial Nephritis
by Mohamed G. Atta Mark A. PerazellaThis book provides comprehensive, cutting-edge scientific data on acute and chronic tubulointerstitial nephritis, an area that has not been fully addressed in many nephrology textbooks. This book covers all relevant aspects of the disease, from historical aspects and pathogenesis to diagnosis, pathological findings, treatment, and prognosis and outcomes. The chapters also discuss both immune and non-immune mediated forms of the disease, as well as entities causing tubulointerstitial disease such as medications and toxins, infectious agents, autoimmune diseases, transplant rejection, genetic diseases, infiltrative disease and chronic kidney disease of unknown etiology. The text features up-to-date educational materials that will benefit both basic and clinical scientists. Written by experts in the field, Tubulointerstitial Nephritis is a valuable resource for clinicians, practitioners, researchers and trainees working in the field of nephrology and internal medicine.
Tuco and the Scattershot World: A Life with Birds
by Brian BrettThe acclaimed author&’s memoir of life with an African grey parrot offers &“a thoughtful and generous celebration of minds and bodies different from our own&” (Times Literary Supplement, UK). For thirty years, Brian Brett shared his office and his life with Tuco, a remarkable parrot given to asking questions such as &“Whaddya know?&” and announcing &“Party time!&” when guests showed up at Brett&’s farm. Although Brett bought Tuco on a whim, he gradually realized the enormous obligation he has to his pet, learning that the parrot is far more complex than he thought. In Tuco and the Scattershot World, Brett not only chronicles his fascinating relationship with Tuco, but uses it to explore the human tendency to &“other&” the world, abusing birds, landscapes, and each other. Brett sees in Tuco&’s otherness a mirror of his own experience contending with Kallman syndrome, a rare genetic condition that made him the target of bullies—and nurtured his affinity for winged creatures. Brett&’s meditative digressions touch on topics ranging from the history of birds and dinosaurs to our concepts of knowledge, language, and intelligence—and include commentary from Tuco himself. By turns provocative and deeply moving, Tuco and the Scattershot World &“is not a straight memoir—it&’s something much more wondrously weird . . . a view of the human predicament that is hilarious, sobering and profound&” (Globe & Mail, UK).
Tui na: A Manual of Chinese Massage Therapy
by Sarah PritchardTui na: The Chinese Massage Manual is a comprehensive and well established handbook for students and practitioners of Tui na in the West. The author describes the roots and development of Tui na, how it works therapeutically with the context of Chinse medicine, and how to become an effective Tui na practitioner. The book contains detailed and clearly illustrated descriptions of Tui na techniques, how to practice them, their clinical applications and therapeutic effects. Foundation area routines are provided to support the development and fluidity of manual skills and to give an initial structure for building treatments. The book has a unique approach to creating and planning Tui na treatments. Avoiding the prescriptive approach usually employed, the author discusses the principles of practice and enables the student practitioner to make choices and formulate treatments by bringing together their knowledge and skills. Frameworks are provided, and techniques, methods and approaches suggested for presenting patterns of disharmony within the treatment of common ailments. The book features - Over 120 photographs clearly illustrating the techniques - THe application of the ancillary therapies of cupping, gua sha and moxibustion - The application of external herbal media - `Tips for Practice' easy reference to support the learning of techniques - Case histories illustrating the treatment of common clinical ailments - Treatment foundation area routines - Yin and yang styles of practice - Demonstration of how to combine Tui na and acupuncture in practice - a related series of videos (available online) showing how to apply all the major techniques
Tui na: A Manual of Chinese Massage Therapy
by Sarah PritchardTui na: The Chinese Massage Manual is a comprehensive and well established handbook for students and practitioners of Tui na in the West. The author describes the roots and development of Tui na, how it works therapeutically with the context of Chinse medicine, and how to become an effective Tui na practitioner. The book contains detailed and clearly illustrated descriptions of Tui na techniques, how to practice them, their clinical applications and therapeutic effects. Foundation area routines are provided to support the development and fluidity of manual skills and to give an initial structure for building treatments.The book has a unique approach to creating and planning Tui na treatments. Avoiding the prescriptive approach usually employed, the author discusses the principles of practice and enables the student practitioner to make choices and formulate treatments by bringing together their knowledge and skills. Frameworks are provided, and techniques, methods and approaches suggested for presenting patterns of disharmony within the treatment of common ailments.The book features- Over 120 photographs clearly illustrating the techniques- THe application of the ancillary therapies of cupping, gua sha and moxibustion- The application of external herbal media- `Tips for Practice' easy reference to support the learning of techniques- Case histories illustrating the treatment of common clinical ailments- Treatment foundation area routines- Yin and yang styles of practice- Demonstration of how to combine Tui na and acupuncture in practice- a related series of videos (available online) showing how to apply all the major techniques
The Tui-Na Manual: Chinese Massage to Awaken Body and Mind
by Maria MercatiA full-color, illustrated guide to Chinese tui na massage techniques for whole-body health • Demonstrates each of the 15 unique Tui Na techniques with rich full-color photos and step-by-step instructions • Explains how to use qi-points to treat conditions in close proximity to the points as well as enact healing in tender or injured regions through the use of distant points • Details how to use Tui Na in all ages to release stress, re-energize the body, invigorate the mind, and relieve pain, sciatica, headache, sports injuries, and other common ailments Tui Na, which means “grasp and push,” is a Chinese system of therapy that uses massage and bodywork manipulation to relieve pain, release tension, and treat common ailments. Often practiced in conjunction with acupuncture and Chinese herbalism, Tui Na is also used as a treatment to address specific patterns of disharmony and stimulate the overall flow of qi, or vital energy, throughout the body. The leading authority on Tui Na in the West, with years of study in China, Indonesia, and Thailand, Maria Mercati combines the individual techniques of Tui Na into an easy-to-use method for whole-body health. Providing rich full-color photos with step-by-step instructions, she demonstrates each of the 15 unique Tui Na techniques, showing clearly where to place your hands as well as offering clear diagrams of the meridian energy channels and more than 100 powerful qi-points, where qi energy can be directly affected to restore balance and harmony. She explains how to use the qi-points to treat conditions in close proximity as well as enact healing in tender or injured regions through the use of distant yet connected qi-points. The author details how to use Tui Na treatments to relieve neck, shoulder, and back pain, sciatica, headache, and many other common ailments, treat sports injuries, and improve athletic performance. She also shows how it can release stress, re-energize the body, and invigorate the mind, as well as provide healing massage for adolescents, the elderly, and babies. Offering a healing method that requires no special equipment and is simple enough to do at home or in a chair at work, this fully illustrated guide provides a hands-on program to help yourself and others find whole-body health.
Tula (LA EDAD DORADA DE HOLLYWOOD #1)
by Hannah HoweA sus veinticinco años, Tula Bowman es considerada la estrella más grande de Hollywood. Sin embargo, termina recluida en un psiquiátrico después de un colapso nervioso. ¿Cuál es la razón que desencadena su colapso nervioso? La perturbadora respuesta se encuentra en Tula, el primer libro de la serie La Época dorada de Hollywood.
Tula: L'âge d'or d'Hollywood (L'âge d'or d'Hollywood #1)
by Hannah HoweJe n'ai jamais rêvé d’être une star. Ce que je voulais, c'était simplement jouer dans des films. Je voulais m’échapper des rues pauvres de Brooklyn et vivre dans un confort relatif. À la fin des années 1920, cependant, j’étais devenue le nom le plus en vue d’Hollywood. Mes films étaient les plus rentables de l’industrie. Les investisseurs comptaient sur moi, les producteurs comptaient sur moi, mes collègues acteurs comptaient sur moi, et peut-être que cette pression incessante a contribué à mon effondrement émotionnel. Mais en réalité, je savais ce qui avait réellement causé ma chute : la mort de mon père. C’est ainsi que je me suis retrouvée dans un asile, sous la surveillance du Dr Brooks. Avec mon fiancé, l’acteur Gregory Powell, le Dr Brooks pensait qu’il y avait un problème sous-jacent à l’origine de mon effondrement, et il m’a demandé de raconter mon histoire, afin de cerner ce problème. Gregory croyait en moi. Il m’a dit qu’il m’attendrait, qu’il savait que je me rétablirais complètement. Mais pour y parvenir, il me fallait affronter cette cause profonde qui m’avait menée à l’asile. C’est pourquoi je vous partage les notes que j'ai rédigées pour le Dr Brooks. Du mieux que je pouvais et selon ma mémoire, j’ai relaté les événements clés de mes vingt-cinq premières années. Et dans ces notes, j'ai enfin découvert la véritable raison de ma dépression.
Tumor Ablation
by Yona KeisariThe growing knowledge on tumor-immune response interactions and on the tumor microenvironment did not translate so far into better control of cancer by anti-tumor vaccination. The percentage of patients who benefited from vaccination strategies is still too small to justify their general use. It is the aim of this book to present an alternative to the conventional approach of developing injected tumor vaccines to activate anti-tumor immunity, which will fight cancer. It is argued that in situ tumor ablation (destruction) that involves tumor antigen release; cross presentation and the release of danger associated molecular patterns (DAMPs) can make the tumor its own cellular vaccine. Tumor ablation methods using chemicals, radiation, photodynamic therapy, cryoablation, high-temperature, radiofrequency, high intensity focused ultrasound, and electric-based ablation have been developed for focal tumors. In this book experts will deal with two main topics: I. What are the principles of the various ablation modalities, and II. How each method affects the tumor cells and their microenvironment, and how these effects are responsible for the induction of specific anti-tumor immunity. The aims of this book are thus: 1. Familiarize the readers with various methods of in situ tumor ablation. 2. Review the literature and stimulate comparisons on the efficacy of different ablation methods for the treatment of tumors of different histotypes. 3. Review the literature on the effects of various ablation methods on systemic and local anti tumor immunity and on other manifestations of the interactions of tumors with their microenvironment. 4. Stimulate comparative studies on the immunostimulatory effects of different ablation modalities.
Tumor Angiogenesis Assays
by Domenico RibattiThis volume aims to provide a range of methods and protocols for studying tumor angiogenesis in vitro and in vivo to reflect advances in the field. The chapters in this book cover topics such as: morphological aspects of tumor angiogenesis, aortic ring assay and its use for the study of tumor angiogenesis, ex vivo tissue culture model for anti-angiogenic drug testing, transgenic zebrafish, orthotopic models of ovarian cancer, and uncovering metabolic effects of anti-angiogenic therapy in tumors by induced metabolic bioluminescence imaging. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting edge and thorough, Tumor Angiogenesis Assays: Methods and Protocols is a valuable resource for anyone interested in tumor angiogenesis assay research.