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Uncertainty for Safe Utilization of Machine Learning in Medical Imaging and Clinical Image-Based Procedures: First International Workshop, UNSURE 2019, and 8th International Workshop, CLIP 2019, Held in Conjunction with MICCAI 2019, Shenzhen, China, October 17, 2019, Proceedings (Lecture Notes in Computer Science #11840)
by Hayit Greenspan Ryutaro Tanno Marius Erdt Tal Arbel Christian Baumgartner Adrian Dalca Carole H. Sudre William M. Wells Klaus Drechsler Marius George Linguraru Cristina Oyarzun Laura Raj Shekhar Stefan Wesarg Miguel Ángel González BallesterThis book constitutes the refereed proceedings of the First International Workshop on Uncertainty for Safe Utilization of Machine Learning in Medical Imaging, UNSURE 2019, and the 8th International Workshop on Clinical Image-Based Procedures, CLIP 2019, held in conjunction with MICCAI 2019, in Shenzhen, China, in October 2019. For UNSURE 2019, 8 papers from 15 submissions were accepted for publication. They focus on developing awareness and encouraging research in the field of uncertainty modelling to enable safe implementation of machine learning tools in the clinical world. CLIP 2019 accepted 11 papers from the 15 submissions received. The workshops provides a forum for work centred on specific clinical applications, including techniques and procedures based on comprehensive clinical image and other data.
Uncertainty in Biology
by Liesbet Geris David Gomez-CabreroComputational modeling allows to reduce, refine and replace animal experimentation as well as to translate findings obtained in these experiments to the human background. However these biomedical problems are inherently complex with a myriad of influencing factors, which strongly complicates the model building and validation process. This book wants to address four main issues related to the building and validation of computational models of biomedical processes: 1. Modeling establishment under uncertainty 2. Model selection and parameter fitting 3. Sensitivity analysis and model adaptation 4. Model predictions under uncertainty In each of the abovementioned areas, the book discusses a number of key-techniques by means of a general theoretical description followed by one or more practical examples. This book is intended for graduate students and researchers active in the field of computational modeling of biomedical processes who seek to acquaint themselves with the different ways in which to study the parameter space of their model as well as its overall behavior.
Uncertainty in Pharmacology: Epistemology, Methods, and Decisions (Boston Studies in the Philosophy and History of Science #338)
by Adam LaCaze Barbara OsimaniThis volume covers a wide range of topics concerning methodological, epistemological, and regulatory-ethical issues around pharmacology. The book focuses in particular on the diverse sources of uncertainty, the different kinds of uncertainty that there are, and the diverse ways in which these uncertainties are (or could be) addressed. Compared with the more basic sciences, such as chemistry or biology, pharmacology works across diverse observable levels of reality: although the first step in the causal chain leading to the therapeutic outcome takes place at the biochemical level, the end-effect is a clinically observable result—which is influenced not only by biological actions, but also psychological and social phenomena. Issues of causality and evidence must be treated with these specific aspects in mind. In covering these issues, the book opens up a common domain of investigation which intersects the deeply intertwined dimensions of pharmacological research, pharmaceutical regulation and the related economic environment. The book is a collective endeavour with in-depth contributions from experts in pharmacology, philosophy of medicine, statistics, scientific methodology, formal and social epistemology, working in constant dialogue across disciplinary boundaries.
Uncharted Country, Uncertain Future: News Channel Superstar to International Virus Fighter (Sybil Norcroft Ser. #2)
by Carl DouglassSybil Norcroft, M.D., Ph.D, F.A.C.S. leaves California under a cloud. She has been found innocent of a murder charge there but cannot be certain that she will succeed in her new profession as a Wolf News Medical Consultant. The health news story of the century falls into her lap, and the novice commentator runs with the story of weaponized Marburg virus, murdered pygmy slaves, and a world-wide manhunt for the perpetrators. Sybil succeeds beyond anyone's prediction, gains a new daughter in the Congo, and a host of serious friends and enemies who will be part of the rest of her life. She becomes a media darling and an accidental CIA operative. Sybil has to learn like never before how to keep secrets in the new and uncharted country where she now lives.
Uncle Tungsten: Memories of a Chemical Boyhood
by Oliver SacksLong before Oliver Sacks became a distinguished neurologist and bestselling writer, he was a small English boy fascinated by metals–also by chemical reactions (the louder and smellier the better), photography, squids and cuttlefish, H.G. Wells, and the periodic table. In this endlessly charming and eloquent memoir, the author of The Man Who Mistook His Wife for a Hat and Awakenings chronicles his love affair with science and the magnificently odd and sometimes harrowing childhood in which that love affair unfolded.In Uncle Tungsten we meet Sacks’ extraordinary family, from his surgeon mother (who introduces the fourteen-year-old Oliver to the art of human dissection) and his father, a family doctor who imbues in his son an early enthusiasm for housecalls, to his “Uncle Tungsten,” whose factory produces tungsten-filament lightbulbs. We follow the young Oliver as he is exiled at the age of six to a grim, sadistic boarding school to escape the London Blitz, and later watch as he sets about passionately reliving the exploits of his chemical heroes–in his own home laboratory. Uncle Tungsten is a crystalline view of a brilliant young mind springing to life, a story of growing up which is by turns elegiac, comic, and wistful, full of the electrifying joy of discovery.
Uncommon Causes of Movement Disorders
by Néstor Gálvez-Jiménez Paul TuiteA large number of neurological conditions result in abnormal movements of the body; these are often characterized by changes in coordination and altered speed of voluntary movement. Many obscure diseases, conditions and environmental insults can cause movement disorders but these are often overlooked. This volume expands and differentiates the many varied clinical presentations of movement disorders. Written by an international team of authors, including some of the most prominent clinicians in the field, disorders are defined and expanded in a clinically useful manner. Pathophysiological theories, genetic discoveries, new classifications, differential diagnoses and therapies are discussed extensively. Uncommon Causes of Movement Disorders provides a broad and comprehensive review of the field, concentrating on conditions infrequently seen but essential for practitioners to recognize in order to implement appropriate management. This is a key text for movement disorders specialists and general neurologists at all stages of their career.
Uncommon Causes of Movement Disorders
by Néstor Gálvez-Jiménez Paul J. TuiteA large number of neurological conditions result in abnormal movements of the body; these are often characterized by changes in coordination and altered speed of voluntary movement. Many obscure diseases, conditions and environmental insults can cause movement disorders but these are often overlooked. This volume expands and differentiates the many varied clinical presentations of movement disorders. Written by an international team of authors, including some of the most prominent clinicians in the field, disorders are defined and expanded in a clinically useful manner. Pathophysiological theories, genetic discoveries, new classifications, differential diagnoses and therapies are discussed extensively. Uncommon Causes of Movement Disorders provides a broad and comprehensive review of the field, concentrating on conditions infrequently seen but essential for practitioners to recognize in order to implement appropriate management. This is a key text for movement disorders specialists and general neurologists at all stages of their career.
Uncommon Causes of Stroke
by Louis Caplan José BillerNow in its third edition, this essential and detailed guide provides wide-ranging support for those diagnosing, treating and assessing complex types of cerebrovascular diseases, in a high pressure, time-constrained environment. Authored by leading clinicians in the field of neurology, and supported by advanced in brain-mapping technologies, this cutting-edge manual provides physicians, neurologists and emergency practitioners at all levels with a vital commentary on those relatively uncommon types of cerebrovascular disease that can lead to patients suffering a stroke. This new edition offers chapter-by-chapter imaging findings, evaluation and management advice, alongside insights into new topics such as CARASIL, sickle cell disease, radiation-induced cerebrovascular disease and blue rubber bleb syndrome. Updated and thorough, the guide provides a clear presentation on the nature, diagnosis, and treatment of everyday symptoms, through to more specialised cases. Building upon existing experience, practitioners can confidently assess patient needs, and correctly diagnose symptoms first time.
Uncommon Causes of Stroke
by Louis R. CaplanMost strokes are attributed to atherosclerosis of neck and intracranial arteries, brain embolism from the heart, and penetrating artery disease; these are discussed in detail in many other books. This compendium fills an important niche by providing autho
Uncommon Diseases in the ICU
by Marc Leone Claude Martin Jean-Louis VincentThis book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.
Uncommon Fathers: Reflections on Raising a Child with a Disability
by Donald J. MeyerUncommon Fathers is a compelling collection of essays by fathers who were asked to reflect and write about the life-altering experience of having a child with a disability. Nineteen fathers have taken an introspective and honest look at this deeply emotional subject, offering a seldom-heard perspective on raising children with special needs. (from the publisher)
Uncommon Gynecologic Cancers
by John O. Schorge Marcela Del Carmen Robert H. YoungRare gynecological cancers kill all too commonlyGynecological cancer is a frightening prospect for women. It is terrifying also for physicians who need, but often can't find, guidance on how to investigate and appropriately treat the tumors. Rare cancers provide greater challenges as information can be harder to find and more difficult to verify.Rare Gynecologic Cancers: Diagnosis and Management brings together all you need to know on these life-threatening diseases. Straightforward summaries of pathophysiologic processes lead to the investigations that will improve your diagnostic accuracy. This provides the basis for you to identify effective treatment strategies for your patients. Written by a world-leading team of Editors and Authors and covering cancers of the* Ovaries* Uterus* Vulva* Vagina* CervixRare Gynecologic Cancers: Diagnosis and Management will guide you to the best life-saving treatment for your patients.
Uncommon Pancreatic Neoplasms
by Claudio Bassi Paolo PederzoliUncommon tumors of the pancreas are of increasing interest for clinicians: cross imaging techniques development makes it possible to detect small lesions in the pancreatic gland of asymptomatic patients, and in the last decades a more detailed and specific pathological classification definitivelyopened an unexpected world of more or less rare pancreatic tumors. As a matter of fact, nowadays most surgical procedures deal with these so called uncommon pancreatic tumors such as cystic, endocrine and others unfrequent histotypes, and many patientsexperiencing an accidental discovery of this type of tumor need therefore a specialistic evaluation. The concept behind this volume is the need to give the correct clinical relevance to these "uncommon" tumors, that are ranked at the first place among pancreatic tumors, and that are definitively curable with a multimodal approach. Aim of the book is therefore to get clinicians closer to these pathologies, describing their complexity and the current state of the art in diagnostic, therapeutic and pathological classification strategy, thus providing them with the tools for a modern and updated clinical management of these patients.
Uncommon Psychiatric Syndromes (A\hodder Arnold Publication)
by David Enoch Basant K. Puri Hadrian BallThis book explores the historical background to, and present-day understanding of, a number of unusual psychiatric disorders. This fully revised new edition contains a new chapter on a range of recently emerging conditions as well as updated literature and a collection of new and updated cases. Since the publication of the fourth edition, there have been many developments in the field of psychiatry, including changes in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the advancement of neuroimaging and related research, which have been incorporated into the fifth edition. In this now classic text, each chapter covers an individual disorder in detail, using several case studies gathered by the authors themselves to illustrate and exemplify the disorders discussed. The clear and easy-to-understand writing style ensures that this text is accessible for the wide range of studies and professions who will find it useful. Uncommon Psychiatric Syndromes, Fifth Edition, is essential reading for psychiatrists, clinical psychologists, psychiatric nurses, psychiatric social workers, social workers and other mental health professionals. It will also be of interest to graduate students in the fields of psychiatry and psychology as well as those enrolled in psychiatry resident courses.
Uncommon Therapy: The Psychiatric Techniques of Milton H. Erickson Md
by Jay HaleyMilton H. Erickson, M. D. is generally acknowledged to have been the world's leading practitioner of medical hypnosis. His "strategic therapy," using hypnotic techniques with or without actually inducing trance, allows him to get directly to the core of a problem and prescribe a course of action that can lead to rapid recovery. This book provides a comprehensive look at Dr. Erickson's theories in practice, through a series of case studies covering the kinds of problems that are likely to occur at various stages of the human life cycle. The results Dr. Erickson achieves sometimes seem to border on the miraculous, but they are brought about by a finely honed technique used by a wise, intuitive, highly trained psychiatrist-hypnotist whose work is recognized as a major contribution to the field.
Uncommon Ulcers of the Extremities
by Ajay K. Khanna Satyendra Kumar TiwaryThe book covers all uncommon ulcers of the extremities which remain a difficult diagnosis for clinicians most of the times. A variety of causes like metabolic, infective, rheumatoid, drug induced or inflammation may lead to ulcerations. Diagnosis of these ulceration is difficult as these diseases are systemic, and treatment is carried out by physicians but ulcers are managed by the surgeons. Any lacunae or gap in assessment or work-up may lead to failure in diagnosis and increased morbidity. This book provides a systematic and step wise approach to the differential diagnosis of every possible uncommon ulcers in the extremities with detailed work-up, flow chart and summary. The book is systematically designed to serve the purpose of covering every possible uncommon ulcer with elaborate clinical presentation in the background of etiology and pathogenesis with risk factors included investigations and treatment with medical, surgical options well discussed as per the requirement. The book includes illustrations, flow diagrams, images, charts and tables. The book provides every information clinically relevant and useful about the uncommon ulcers and serves as a complete resource for general surgeons, vascular surgeons, plastic surgeons, orthopedic surgeons, surgical trainees, family physicians. It may also be useful for podiatrists, phlebologists, radiologists, cardiologists, nephrologists, neurologists, wound care nurses, physicians and primary care workers.
Uncommon Wisdom: True Tales of What Our Lives as Doctors Have Taught Us About Love, Faith and Hea ling
by John Castaldo Lawrence LevittIn light of the escalating costs of healthcare in the U.S. and the on-going debate about appropriate health insurance reform, it's easy to forget about the human side of medicine and the importance of the doctor-patient relationship. In Uncommon Wisdom, neurologists John Castaldo and Lawrence Levitt share what they have learned in their many years as doctors, not just from tests and labs, but from years of listening and learning from their patients. These 16 tales show doctors as human beings: flawed and full of doubt, wonder, and reverence about what it means to be alive. The stories remind us that the medical profession should be about treating people with the dignity they deserve and that medical miracles don't always involve medicine. These doctors find cures, solve mysteries, and glean many lessons from listening deeply to their patients.
The Uncomplicated Guide to Diabetes Complications
by Marvin E. Levin Michael A. PfeiferDiabetes complications can be prevented, and they can be treated.First you need to know how serious and life threatening the issues are that you're up against. Learn how to take care of yourself to prevent diabetes complications before they become deadly. Uncomplicated Guide to Diabetes Complications is divided into chapters on major parts and systems of the body and the diabetic complications that may affect them.This new edition covers everything from heart disease prevention, eye problems, and diabetic kidney diseases to gastroparesis, GI problems, and critical diabetic foot care. Also included is the latest information on new diabetes medications, overcoming depression, and even erectile dysfunction.Get the edge you need to protect yourself and to prevent or slow down diabetes complications. Most people affected by diabetes will experience complications as a result of diabetes symptoms. How to treat and prevent those complications seems overwhelming, but The Uncomplicated Guide to Diabetes Complications makes understanding what to do a snap.
The Unconscious: Theory, Research, and Clinical Implications (Psychoanalysis and Psychological Science)
by Joel Weinberger Valentina StoychevaWeaving together state-of-the-art research, theory, and clinical insights, this book provides a new understanding of the unconscious and its centrality in human functioning. The authors review heuristics, implicit memory, implicit learning, attribution theory, implicit motivation, automaticity, affective versus cognitive salience, embodied cognition, and clinical theories of unconscious functioning. They integrate this work with cognitive neuroscience views of the mind to create an empirically supported model of the unconscious. Arguing that widely used psychotherapies--including both psychodynamic and cognitive approaches--have not kept pace with current science, the book identifies promising directions for clinical practice.
Unconscious Crime: Mental Absence and Criminal Responsibility in Victorian London
by Joel Peter EigenA sleepwalking, homicidal nursemaid; a "morally vacant" juvenile poisoner; a man driven to arson by a "lesion of the will"; an articulate and poised man on trial for assault who, while conducting his own defense, undergoes a profound personality change and becomes a wild and delusional "alter." These people are not characters from a mystery novelist's vivid imagination, but rather defendants who were tried at the Old Bailey, London's central criminal court, in the mid-nineteenth century. In Unconscious Crime, Joel Peter Eigen explores these and other cases in which defendants did not conform to any of the Victorian legal system's existing definitions of insanity yet displayed convincing evidence of mental aberration. Instead, they were—or claimed to be—"missing," "absent," or "unconscious": lucid, though unaware of their actions.Based on extensive research in the Old Bailey Sessions Papers (verbatim courtroom narratives taken down in shorthand during the trial and sold on the street the following day), Eigen's book reveals a growing estrangement between law and medicine over the legal concept of the Person as a rational and purposeful actor with a clear understanding of consequences. The McNaughtan Rules of l843 had formalized the Victorian insanity plea, guiding the courts in cases of alleged delusion and derangement. But as Eigen makes clear in the cases he discovered, even though defense attorneys attempted to broaden the definition of insanity to include mental absence, the courts and physicians who testified as experts were wary of these novel challenges to the idea of human agency and responsibility. Combining the colorful intrigue of courtroom drama and the keen insights of social history, Unconscious Crime depicts Victorian England's legal and medical cultures confronting a new understanding of human behavior, and provocatively suggests these trials represent the earliest incarnation of double consciousness and multiple personality disorder.
Uncontrolled Spread: Why COVID-19 Crushed Us and How We Can Defeat the Next Pandemic
by Scott GottliebNEW YORK TIMES BESTSELLER“Uncontrolled Spread is everything you’d hope: a smart and insightful account of what happened and, currently, the best guide to what needs to be done to avoid a future pandemic." —Wall Street Journal“Informative and well paced.”—The Guardian“An intense ride through the pandemic with chilling details of what really happened. It is also sprinkled with notes of true wisdom that may help all of us better prepare for the future.”—Sanjay Gupta, MD, chief medical correspondent, CNNPhysician and former FDA commissioner Scott Gottlieb asks: Has America’s COVID-19 catastrophe taught us anything?In Uncontrolled Spread, he shows how the coronavirus and its variants were able to trounce America’s pandemic preparations, and he outlines the steps that must be taken to protect against the next outbreak. As the pandemic unfolded, Gottlieb was in regular contact with all the key players in Congress, the Trump administration, and the drug and diagnostic industries. He provides an inside account of how level after level of American government crumbled as the COVID-19 crisis advanced.A system-wide failure across government institutions left the nation blind to the threat, and unable to mount an effective response. We’d prepared for the wrong virus. We failed to identify the contagion early enough and became overly reliant on costly and sometimes divisive tactics that couldn’t fully slow the spread. We never considered asymptomatic transmission and we assumed people would follow public health guidance. Key bureaucracies like the CDC were hidebound and outmatched. Weak political leadership aggravated these woes. We didn’t view a public health disaster as a threat to our national security.Many of the woes sprung from the CDC, which has very little real-time reporting capability to inform us of Covid’s twists and turns or assess our defenses. The agency lacked an operational capacity and mindset to mobilize the kind of national response that was needed. To guard against future pandemic risks, we must remake the CDC and properly equip it to better confront crises. We must also get our intelligence services more engaged in the global public health mission, to gather information and uncover emerging risks before they hit our shores so we can head them off. For this role, our clandestine agencies have tools and capabilities that the CDC lacks.Uncontrolled Spread argues we must fix our systems and prepare for a deadlier coronavirus variant, a flu pandemic, or whatever else nature -- or those wishing us harm -- may threaten us with. Gottlieb outlines policies and investments that are essential to prepare the United States and the world for future threats.
Unconventional Leadership: How Henry Ford Taught Me About Reinvention and Diversity
by Nancy M. SchlichtingWhat does it take to lead the successful turnaround of four consecutive organizations? What does it take to run a $4 billion business in Detroit as the city struggles to emerge from municipal bankruptcy and its worst ongoing crisis ever? What does it take to be a female CEO who has come up against discrimination and personal attack? It takes Unconventional Leadership, a style of leadership based on confronting reality and leading headlong through adversity. In this inspiring story, Nancy Schlichting, the CEO of Henry Ford Health System, reveals her unique strategies that drive success: maintaining a focus on people, creating a culture of innovation and reinvention, and embracing diversity as a key strategy for growth. The book describes a leadership paradigm that will motivate, inspire, and drive new thinking in today's disruptive business environment where traditional modes of managing are no longer working. In Unconventional Leadership, Schlichting weaves together three themes that explain how she has become one of the most powerful individuals in healthcare today: (1) deftly conquering the immense challenges within the healthcare industry itself--consolidation, new models of delivery and financing, increasing government regulation and oversight, changing customer expectations, and pressures on cost and quality (2) the exciting and panoramic backdrop of Henry Ford and Detroit--Ford's legacy of invention and innovation combined with ongoing attempts to restore and renew a city in deep decline; and (3) forging a career path and excelling as a female CEO in a world typically dominated by men. An abiding fan of the underdog, Schlichting reveals, above all else, the sheer grit and determination required to lead through adversity and create a successful legacy of leadership.
Unconventional Optical Imaging for Biology
by Corinne Fournier Olivier HaeberléOptical imaging of biological systems has undergone spectacular development in recent years, producing a quantity and a quality of information that, just twenty years ago, could only be dreamed of by physicists, biologists and physicians. Unconventional imaging systems provide access to physical quantities – phase, absorption, optical index, the polarization property of a wave or the chemical composition of an object – not accessible to conventional measurement systems. To achieve this, these systems use special optical setups and specific digital image processing to reconstruct physical quantities. This field is also known as computational imaging. This book presents various non-conventional imaging modalities developed for the biomedical field: wave front analysis imaging, digital holography/tomography, optical nanoscopy, endoscopy and singlesensor imaging. Experimental setups and reconstruction algorithms are presented for each modality.
Uncovering Critical Personalism: Readings from William Stern’s Contributions to Scientific Psychology (Palgrave Studies in the Theory and History of Psychology)
by James T. LamiellThis book brings together the central tenets of William Stern’s critical personalism. Presented for the first time for an English-speaking audience, this selection of original translations and essays encapsulates the critical framework of Stern’s personalistic psychology. The selected works highlight the philosophical basis of Stern’s personalistic views, illustrate their relevance in domains of theoretical and practical importance in psychology, and reveal Stern’s critical stance on certain methodological trends that were gaining favor within psychology during his lifetime. Lamiell’s own chapters contextualise the translations by providing an overview of the most basic tenets of critical personalism, and offering a commentary on paradigmatic commitments within scientific psychology’s mainstream that began to impede Stern’s efforts prior to his death, and that remain obstacles to personalistic thinking in the discipline today. Largely ignored by his contemporaries, this work forms part of an emerging body of scholarship that seeks to reintroduce Stern’s thinking into contemporary psychology. The book is intended for academically oriented scholars with interests in historical, theoretical and philosophical issues in psychology.
Und jetzt Sie! – Selbst- und Zeitmanagement in Gesundheitsberufen: Selbst- Und Zeitmanagement In Gesundheitsberufen (Top im Gesundheitsjob)
by German Quernheim Claudia StyrskySie können mehr als Sie denken! „Arbeitsverdichtung" findet überall statt. Da bilden auch und vor allem die Gesundheitsfachberufe keine Ausnahme. Aber die Beschäftigten haben es stets mit kranken Menschen und deren Bedürfnisse zu tun. Wie also schafft man den Spagat zwischen den eigenen und den Bedürfnissen der anderen? Doch statt vor den eigenen und den fremden Ansprüchen zu kapitulieren, kann man sein "Schicksal" selbst in die Hand nehmen und die eigenen Ressourcen für sich nutzen. Selbstmanagement heißt die Devise! Anhand von Beispielen aus dem Alltag gibt der Autor German Quernheim zahlreiche Tipps und Tricks: knapp, humorvoll und umsetzbar. Mit zahlreichen Selbsttests, Übungen und Trainingsprogrammen.