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Toxin (Paperback Bestsellers Ser.)
by Robin CookNewly divorced surgeon Dr. Kim Regis is determined to remain a good father to his only son, Selden. On a special night out, Kim takes Seldon to his favorite fast-food restaurant for a feast of burgers and fries. <P><P>But the good time turns to tragedy: the young boy becomes gravely ill and dies as a result of poisoning by E. coli. bacteria found in the meat. <P> Was Seldon's death a result of shoddy food-handling practices? Or was it a sophisticated case of product tampering - by a rival fast-foot giant or a disgruntled employee? Or perhaps by someone with a score to settle with Kim? Taking a leave from his surgical practice, Kim devotes his energies to solving the mystery full time. But he immediately hits a brick walls: a code of silence more impenetrable than anything he has ever encountered in his medical career. Instead of a cold-shoulder reception, however, Kim is soon met with a boot and a fist as thugs attempt to quash his inquiry. <P> Aided by his ex-wife, Kim pursues a trail of deadly evidence, uncovering complicity and guilt stretching from the slaughterhouse floor to the corporate boardroom. Racing against time before more are poisoned, the two come face-to-face with the shocking and elusive truth. And in their life-and-death search for answers, they rediscover the reasons they first fell in love. <P> With trademark pulse-pounding flair, Robin Cook delivers a cutting-edge thriller, borrowing from today's fears and tomorrow's medical technology.
Toxins and Hemostasis
by Francis S. Markland Kenneth J Clemetson Mary Ann Mclane R. Manjunatha Kini Takashi MoritaCirculation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents. With the increase average age of the population coupled with changes in life style in recent years, there has been a significant increase in cardiovascular and hematological disorders. Thus scientists in both academic institutions as well as the pharmaceutical industry are developing better therapeutic agents to improve the quality of life. This impetus has lead to the search for novel agents from various sources that interfere with cardiovascular and hematalogical processes. Although at first glance exogenous factors appear to function as 'villains', several life-saving drugs have been developed based upon these factors. Such drugs or drug leads include those that inhibit the angiotensin converting enzymes (Captopril and Enalapril), that block platelet receptors (Eptifibatide and Tirofiban), or that digest thrombotic plugs (Alfimeprase and bat plasminogen activator) to name a few. Several new and exciting success stories are currently unfolding. In this book, recent studies on some of the exogenous factors that play crucial roles in cardiovascular and hematological disorders are reviewed in order to consolidate the efforts in this area of research and to recruit new, talented researchers. The 25-30 review chapters, each written by experts in their field, compiled herein are devoted to exogenous factors affecting platelet aggregation, anticoagulant and procoagulant proteins, fibrinolytic proteins and hypotensive agents (For details see, Contents of the Book). This book is intended to help to create elevated awareness and enthusiasm in the field of exogenous factors. I believe that this book will provide greater impetus to the search for novel proteins based on naturally occurring exogenous factors. This will be the first book dealing extensively with exogenous factors in the last 25 years. The book will provide a ready reference to the different approaches used to solve complex problems in protein chemistry and pharmacology of exogenous factors. The book will update our understanding of the structure-function relationships and mechanisms of action of exogenous factors and provide great insights into future directions for solving the remaining challenges.
Toxins and Other Harmful Compounds in Foods (Chemical & Functional Properties of Food Components)
by A. Witczak Zdzislaw SikorskiToxins and Other Harmful Compounds in Foods provides information on the contents, distribution, chemical properties, and biological activity of toxins and other harmful compounds in foods that are natural components of the raw materials, accumulated due to microbial actions and environmental pollution, or are generated due to processing. This book shows how different factors related to the production of raw materials, as well as to storage and processing conditions, affect the presence and concentration of toxins and other harmful compounds in foods. It shows how various regulations, as well as unit operations and processes used in food production, may eliminate different toxins or generate new ones. The real health hazards for the consumers resulting from the presence of toxic/harmful compounds in aliments are discussed, and various national and international regulations obligatory in agriculture and industry aimed at increasing food safety are presented. Methods of analysis used for detection and determination of undesirable compounds are also discussed, making it possible to understand the effect of storage and processing parameters, as well as systems of quality assurance, on food safety and to select optimum procedures for analytical control.
Toxins and Targets
by David Maguire Dianne Watters John Pearn Martin LavinFirst Published in 1992. The last decade of the twentieth century has seen an unprecedented advocacy for the preservation of a safe environment, and the prevention of ill-health from toxic chemicals. Human activity, however, is responsible for introducing new toxins into the environment. In order to control competitors for human food sources, an armament of pesticides has been assembled and their widespread and largely uncontrolled application has been permitted. It is only when the health of the population begins to suffer from the effects of these chemicals that the efficacy of their use is questioned. Decision-makers whose roles involve the promotion and control of the environment must look to lessons that can be learnt from biosystems that include animals other than man. Toxins and Targets details the way in which organisms from diverse habitats in the plant and animal kingdoms have adapted to handle toxins safely. Part I, on the aquatic environment, highlights the means by which marine organisms have adapted their toxins to be effective in a world of high aqueous solubility and infinite dilution. Part II deals with venomous terrestrial organisms and the mechanisms by which they damage animal cells, and Part III considers the way in which human society attempts to investigate toxicity and to control both synthetic and naturally occurring poisons. The development of a safe environment depends on increased knowledge and novel approaches to solving escalating problems. This book is a step towards this end.
Toxins in Food
by Waldemar M. Dąbrowski Zdzisław E. SikorskiWhile systems such as GMP and HACCP assure a high standard of food quality, foodborne poisonings still pose a serious hazard to the consumer's health. The lack of knowledge among some producers and consumers regarding the risks and benefits related to food makes it imperative to provide updated information in order to improve food safety.To
Toxisch
by Rainer Biesinger Max KluteDurch den Konsum von Rauschdrogen ballern sich tagtäglich Millionen von Menschen aus ihrer subjektiv gefühlten Realität heraus. Angefangen bei Alkohol und Nikotin haben wir es heute mit einem verantwortungslosen, unkultivierten und gefährlichen Konsumverhalten zu tun. Dieses Buch stellt die durchaus erlaubte und provokative Frage, ob die derzeitige Drogenpolitik noch „up to date“ ist, bzw. wo sie durch ihre restriktive Herangehensweise nicht völlig versagt hat!? Wo liegen die Ursachen dieses Konsumverhaltens und wie ist es um einen liberalisierten und aufgeklärten Umgang mit gewissen Substanzen bestimmt? Mit diesem mutigen und investigativen Werk nehmen die beiden Autoren eine authentische Perspektive zum Thema Rauschdrogen in Deutschland ein. Und sie wissen, wovon sie reden! Ein Buch für User, Neugierige, Eltern, Pädagogen, Therapeuten, Ärzte, Sozialarbeiter, Interessierte der Drogenverbotsdebatte und alle, denen etwas daran liegt, dass die Gesellschaft in Sachen Suchtprävention und Selbstbestimmungsrecht von Konsumenten endlich wach wird und handelt.Inklusive Videointerviews mit den Autoren und Geleitworte von Kriminalbiologe Dr. Mark Benecke, Jugendrichter Andreas Müller und dem Grimme-Preisträger $ick.
Toxoplasma gondii: Methods and Protocols (Methods in Molecular Biology #2071)
by Christopher J. TonkinThis volume covers a diverse collection of protocols currently being used by the Toxoplasma research community, and also looks at innovative methods that are pushing the boundaries of possibilities. Chapters in this book discuss topics such as isolation and genotyping of Toxoplasma gondii strains; assessing rhoptry secretion in T. gondii; plate-based quantification of stimulated Toxoplasma egress; methods to study ocular toxoplasmosis; and metabolic analysis of Toxoplasma gondii tachyzoites. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Cutting-edge and thorough, Toxoplasma gondii: Methods and Protocols is a valuable resource for students or groups starting off in the field, as well as laboratories interested in implementing the latest techniques described in the book.
Toxoplasmosis of Animals and Humans
by J. P. DubeyThis is the only book to cover toxoplasmosis of animals and humans thoroughly in one single source. Found worldwide from Alaska to Australasia, Toxoplasma gondii is the cause of one of the most common parasitic infections in humans, livestock, companion animals, and wildlife, and is included on the list of potential bioterrorism microbes. Furthermore, T. gondii has been and continues to be used extensively as a model for the cell biology of apicomplexan parasites. In the decade since the second edition of this book was published, there has been an explosion of knowledge concerning the parasite Toxoplasma gondii and toxoplasmosis. This update provides unique information on all known host types for this parasite, with an additional chapter on history, substantial updates throughout, and a detailed focus on the biology of the parasite in Chapter 2. The third edition is compiled by author JP Dubey, an authority on T. gondii who has worked with virtually all hosts of the protozoan during the last 55 years, including humans, all livestock species, wildlife, and zoo animals. The book distills the voluminous and potentially confusing scientific literature, that has grown geometrically in the 30+ years since the publication of the first edition, into a comprehensive resource for all professionals, graduate students and researchers working in this field.
Toyota Production System: Beyond Large-Scale Production
by Taiichi OhnoIn this classic text, Taiichi Ohno--inventor of the Toyota Production System and Lean manufacturing--shares the genius that sets him apart as one of the most disciplined and creative thinkers of our time. Combining his candid insights with a rigorous analysis of Toyota's attempts at Lean production, Ohno's book explains how Lean principles can improve any production endeavor. A historical and philosophical description of just-in-time and Lean manufacturing, this work is a must read for all students of human progress. On a more practical level, it continues to provide inspiration and instruction for those seeking to improve efficiency through the elimination of waste.
Trace (Kay Scarpetta #13)
by Patricia CornwellThe thirteenth book in the Kay Scarpetta series, from No. 1 bestselling author Patricia Cornwell. 'America's most chilling writer of crime fiction' The TimesAgainst her own judgement and the advice of Benton Wesley and her niece, Lucy, Scarpetta agrees to return to Virginia as a consultant pathologist on a case involving the death of a fourteen-year-old girl. Accompanied by Pete Marino she finds the once familiar territory of her morgue and her department much changed, and the new Chief Medical Examiner treats her with disdain despite the obvious fact that he is in desperate need of her expertise. But professional as ever, she re-examines the evidence and proves the girl was murdered. She also finds trace evidence which matches that found on an accident victim and at the scene where one of Lucy's operatives was attacked. It is not only a forensic puzzle, but opens up the probability that someone is after those closest to Scarpetta. Praise for the groundbreaking series: 'One of the best crime writers writing today' Guardian 'Devilishly clever' Sunday Times 'The top gun in this field' Daily Telegraph 'Forget the pretenders. Cornwell reigns' Mirror 'The Agatha Christie of the DNA age' Express
Trace (Kay Scarpetta)
by Patricia CornwellThe thirteenth book in the Kay Scarpetta series, from No. 1 bestselling author Patricia Cornwell. 'America's most chilling writer of crime fiction' The TimesAgainst her own judgement and the advice of Benton Wesley and her niece, Lucy, Scarpetta agrees to return to Virginia as a consultant pathologist on a case involving the death of a fourteen-year-old girl. Accompanied by Pete Marino she finds the once familiar territory of her morgue and her department much changed, and the new Chief Medical Examiner treats her with disdain despite the obvious fact that he is in desperate need of her expertise. But professional as ever, she re-examines the evidence and proves the girl was murdered. She also finds trace evidence which matches that found on an accident victim and at the scene where one of Lucy's operatives was attacked. It is not only a forensic puzzle, but opens up the probability that someone is after those closest to Scarpetta. Praise for the groundbreaking series: 'One of the best crime writers writing today' Guardian 'Devilishly clever' Sunday Times 'The top gun in this field' Daily Telegraph 'Forget the pretenders. Cornwell reigns' Mirror 'The Agatha Christie of the DNA age' Express
Trace Elements and Minerals in Health and Longevity (Healthy Ageing and Longevity #8)
by Marco Malavolta Eugenio MocchegianiThis book describes the role of trace elements in health and longevity, pursuing a biogerontological approach. It offers essential information on the impact of trace elements on molecular and physiological processes of aging, and on their impact on health in connection with aging. The major topics covered in its 11 chapters, each dedicated to a specific trace element or mineral, are: a) Role of the element in species longevity, b) Recommended intake for longevity in animal species and in the elderly, c) Deficiency and age-related disease, d) Excess/toxicity and age-related disease, ande) Interactions with drugs prescribed in the elderly. Clinical, animal and other laboratory models of interest in aging are included, which enable a more in-depth analysis to be made. The respective chapters are a mixture of overviews and more in-depth reviews in which the mechanisms of aging are described from the point of view of their specific interactions with trace elements and minerals.
Trace Elements in Brain Health and Diseases (Nutritional Neurosciences)
by Wael Mohamed Rajat SandhirThis book reviews the role of trace elements in brain development, function, metabolism, and neurodegenerative disorders. It explores the molecular mechanisms of the effects of trace elements on metabolic pathways, mitochondrial nutrients, neurodegeneration, Central Nervous System (CNS) disorders, cell signaling, and neuronal functions. The book also discusses transport mechanisms of trace elements within CNS and their impact on neurotransmitter biology. Further, it examines the deleterious effects due to dyshomeostasis of trace elements in the central nervous system (CNS), resulting in damage to neurons and glial cells through the generation of reactive oxygen species and oxidative stress turn leading to neurodegeneration and neurological dysfunction. The book also explores the putative role of trace element deficiency in psychiatric disorders, including depression, and the imbalance of trace elements on neuronal genomic stability.
Trace Elements in Laboratory Rodents (Methods In Nutritional Research Ser.)
by Ronald Ross WatsonWritten by the international community's leading experts, Trace Elements in Laboratory Rodents describes the best and most current methods to provide deficient or supplemental trace elements to laboratory animals, as well as how to assay them. The experts warn of the common pitfalls and hidden problems in nutritional testing and how to avoid them. This how-to approach focuses on the technical details that make good, reliable studies. Common as well as rare or recently recognized minerals are described relating to both dietary supplementation and measurement in tissues.If you are a researcher, professor, or student working in nutrition, food science, biochemistry, or veterinary medicine, you can't afford to be without this excellent hands-on methods manual!
Trace Evidence
by Elizabeth BeckaA forensic thriller that unlocks criminal secrets...and criminal science. In the bestselling tradition of Patricia Cornwell and Kathy Reichs, comes a riveting forensic thriller by a dazzling new talent in crime fiction. This authentic, high-octane debut is inspired by Elizabeth Becka's own career and her experience using physical evidence recovered from crime scenes to unlock the secrets of the dead and bring justice to those who have no voice. "The combination of a credible, likeable hero, and a bizarre, chilling story is rare in crime fiction, but in Trace Evidence Elizabeth Becka makes the tumblers click perfectly
Trace Metals and Fluoride in Bones and Teeth
by Nicholas D. Priest Frank Van de VyverThis volume is a comprehensive introduction to the analysis, binding, uptake, metabolism, kinetics, modeling, distribution, occurrence, toxicity and chelation of metals and fluoride in the body, with special reference to mineralized tissues. Both toxic and relatively harmless polyvalent cations and anions are considered. Included are some which are stable, and others which are radioactive. While a number are essential trace elements, others have no known metabolic role. Most chapters are concerned with the uptake of bone-seeking ions by the living skeleton, but aspects of the post-mortem uptake of metals and the process of fossilization are also considered. Highlighted are the utility of modern analytical techniques and the more important bone-seeking elements including aluminum, lead, cadmium, fluorine and the radioactive heavy metals including uranium and plutonium. This important publication is of particular value to those in the fields of biochemistry, radioactive waste, geology, physiology, dentistry, orthopedics, radiology and nuclear medicine, urology, industrial hygiene, pharmacology, anthropology, paleontology, and archeology.
Traces of Mercury
by Clark HowardA small-town doctor copes with an escalating medical mystery in this thriller by a &“superlative storyteller&” (Publishers Weekly).Lee Madrigal became a doctor in spite of his difficult working-class upbringing, with a mother who died young and a father who fell under the spell of alcohol. Now Lee serves his neighbors in the California community where he grew up, and has reunited with his high school sweetheart. But the medical cases he&’s been handling lately have been bothering him: a baby born with inexplicable birth defects; a young man with symptoms that seem to mimic a venereal disease but whose blood tests come back clean. As the mystery mounts, Lee will discover a terrible secret about his hometown, and a battle to save lives will ensue . . .
Tracheostomy
by Terence Pires de FariasDespite often taken as a simple procedure, techniques on tracheostomy have evolved considerably on the last few years. Consequently, new technical variations and indications for different purposes are being developed and proposed. The current book is proposed to serve as a comprehensive guide exclusively devoted to tracheostomy, discussing its most important details, variations and indications. Here the reader will find a broad discussion ranging from the most basic pre-clinical aspects to post-surgical procedures and complications. Great emphasis is placed on key topics such as the oncologic patient, variations of the technique, and tracheostomy in the intensive care unit, among others. Additionally, some issues that are not commonly discussed in regular textbooks, like tracheostomy in child and in great obese, are also included. With a wealth of photos, illustrations and tables, Tracheostomy – A Surgical Guide provides the material necessary to support a safe and effective surgical intervention in different populations and surgical contexts, with the hope that it will result in improved care for patients who underwent tracheostomy.
Tracheotomy Management
by David Goldenberg Elizabeth H. Sinz Peggy A. SeidmanPatients with tracheotomies are managed by a wide variety of healthcare professionals. As a result, information regarding best practice is scattered throughout the medical literature and can be difficult to identify and implement in the clinical setting. Tracheotomy Management: A Multidisciplinary Approach is a practical review of all tracheotomy procedures and acute and chronic tracheotomy care. It combines evidence-based practice and expert opinion to create an invaluable hands-on guide for any healthcare provider managing patients with tracheotomies. Each chapter is authored by at least two different subspecialists, contains case studies with real-life examples of problematic clinical scenarios, and is enhanced by high quality colour images and algorithms. The rationale for different approaches is discussed to guide the decision-making process. Written and edited by tracheotomy experts from a wide variety of disciplines, Tracheotomy Management: A Multidisciplinary Approach is essential reading for anesthesiologists, nurse anesthetists and critical care and emergency physicians.
Tracheotomy and Airway: A Practical Guide
by Eckart Klemm Andreas NowakIn dem Kompendium wird die sachgerechte Durchführung aller Varianten der Tracheotomie beschrieben. Im Mittelpunkt der interdisziplinären Darstellung stehen insbesondere die Analyse schwerer Früh- und Spätkomplikationen, ihre Vermeidung und ihre Therapie. Auch die logopädische Behandlung sowie neue Aspekte des Airway-Managements werden berücksichtigt.
Track and Trace Management System for Dementia and Intellectual Disabilities (Advanced Technologies and Societal Change)
by Amit Kumar George Ghinea Suresh MeruguThis book reviews humanitarian literature and presents the development of low-cost track & trace management system integrated with accurate GPS location data pinging using Internet of Things (IoT). The first part relates to mobile device configuration with an embedded GPS and wireless Internet connection to transmit its current location. The second part presents web server implementation and development that receives the data, parses it, and stores it for access over the Internet. The third part discusses the user interface that allows one to visually identify the current location of the device.
Tracking Radiation Exposure from Medical Diagnostic Procedures
by National Research Council Division on Earth and Life Studies Nuclear and Radiation Studies Board Committee on Tracking Radiation Doses from Medical Diagnostic ProceduresThe growing use of medical diagnostic procedures is correlated with tremendous and undeniable benefits in the care of most patients. However, it is accompanied by growing concerns about the risks associated with diagnostic computed tomography and other procedures that utilize ionizing radiation. A number of initiatives in radiation safety in medicine have taken place in the United States and internationally, each serving different purposes. Their ultimate goals are to provide higher quality clinical management of the patient and to ensure that reasonable steps are taken to keep the exposures as low as possible without compromising diagnostic efficacy. Tracking Radiation Exposure from Medical Diagnostic Procedures: Workshop Reports provides a summary of the presentations and discussions that took place during the December 8-9, 2011, workshop titled "Tracking Radiation Exposure from Medical Diagnostic Procedures." This workshop was organized by the Nuclear and Radiation Studies Board of the National Academy of Sciences and sponsored by the Centers for Disease Control and Prevention, the U.S. Food and Drug Administration, and the U.S. Department of Health and Human Services. This workshop report was authored by a six-member committee of experts appointed by the National Academy of Sciences. This committee brought together public health regulators, physicians, manufacturers, researchers, and patients to explore "why," "what," and "how" to track exposure from medical diagnostic procedures and possible next steps.
Tracking and Preventing Diseases with Artificial Intelligence (Intelligent Systems Reference Library #206)
by Jerry Chun-Wei Lin Philippe Fournier-Viger Mayuri Mehta Maulika PatelThis book presents an overview of how machine learning and data mining techniques are used for tracking and preventing diseases. It covers several aspects such as stress level identification of a person from his/her speech, automatic diagnosis of disease from X-ray images, intelligent diagnosis of Glaucoma from clinical eye examination data, prediction of protein-coding genes from big genome data, disease detection through microscopic analysis of blood cells, information retrieval from electronic medical record using named entity recognition approaches, and prediction of drug-target interactions.The book is suitable for computer scientists having a bachelor degree in computer science. The book is an ideal resource as a reference book for teaching a graduate course on AI for Medicine or AI for Health care. Researchers working in the multidisciplinary areas use this book to discover the current developments. Besides its use in academia, this book provides enough details about the state-of-the-art algorithms addressing various biomedical domains, so that it could be used by industry practitioners who want to implement AI techniques to analyze the diseases. Medical institutions use this book as reference material and give tutorials to medical experts on how the advanced AI and ML techniques contribute to the diagnosis and prediction of the diseases.
Tractus Immuno-Logicus: A Brief History of the Immune System
by Antonio A. de FreitasThe history of this text started years ago after reading Wittgenstein'sTratactus Logico-Philosophicus. At some time later, it seemed to me a good idea to follow thetratactus structure to attempt to write a minimal description of the immune system. I finally did it for fun and hopefully to be useful to whomever reads it.The text reflects my ow
Trade Agreements and Public Health: A Primer for Health Policy Makers, Researchers and Advocates (Palgrave Studies in Public Health Policy Research)
by Ronald Labonté Deborah GleesonThe need for policy coherence between trade and health has never been greater, yet few public health workers are equipped to navigate this complex field. This book aims to fill this gap, providing a focused and readable introduction to the topic. It introduces the principles underpinning trade treaties and examines the implications of trade rules for health services and access to medicines, unhealthy commodities, labour rights and the environment. It explores the trade policy making process, methods for trade and health research, and recommendations for strengthening policy coherence.