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Vascular Diseases for the Non-Specialist
by Tulio Pinho Navarro Alan Dardik Daniela Junqueira Ligia CisnerosThis book aims to provide non-specialist healthcare practitioners with current, focused and objective information on the most common vascular diseases encountered in daily clinical practice. In day-to-day clinical practice many healthcare practitioners do not have a working knowledge of the most common vascular diseases that frequently arise in patient care. Some of these topics include: aneurysms, peripheral arterial disease, diabetic foot, venous thromboembolism, cerebrovascular disease, aortic dissection, and acute limb ischemia. These commonly encountered vascular diseases are becoming public health issues due to their high morbidity and mortality as well as increasing healthcare costs. Since patients with vascular diseases are often referred to non-specialists, the general practitioner must know how to proper handle the most common vascular diseases encountered in daily clinical practice. For each disease the concept, epidemiology, natural history, diagnosis and treatment are described, followed by essential advice on what the non-specialist can do for the patient and when to refer the patient to a specialist.
Vascular Disorders of the Liver: VALDIG's Guide to Management and Causes
by Dominique Valla Juan Carlos Garcia-Pagan Andrea De Gottardi Pierre-Emmanuel RautouThis book provides a comprehensive account on individually rare, but collectively frequent diseases of the liver. In the first part, conditions such as hepatic vascular malformations, ischemic cholangiopathy, hepatic artery occlusion, sinusoidal conditions and Budd-Chiari syndrome are discussed among others. The second part examines the causes of vascular liver disease namely, coagulation disorders, neoplasm disorders, non-malignant blood disorders, systemic diseases and toxins, among others. The unique expertise of the authors, who are all members of the Vascular Liver Disease Disorders Group, an independent network of researchers with a common interest in Vascular Liver Diseases, are merged for an optimal pragmatic and individualized approach. This book is of interest to a broad range of experts, such as hepatologists, internists, radiologists and angiologists.
Vascular Disruptive Agents for the Treatment of Cancer
by Tim MeyerTumour survival and growth is critically dependent on an independent blood supply. As such tumour vasculature presents an ideal target for cancer therapy that is widely applicable, accessible and genetically stable rendering it less prone to resistance. Two approaches have been explored for cancer therapy; firstly the prevention of new vessel formation with inhibitors of angiogenesis, and secondly the destruction of existing tumour blood vessels with so called vascular disruptive agents (VDAs). While the first approach appears to delay tumour progression, the second has the potential to cause massive cell death and tumour regression. It si the second approach of vascular targeting that is the focus of this review. Since the tubulin binding agent combretastatin, derived from the bark of the African bush willow, was discovered by George R Pettit to have antimitotic properties over twenty years ago, the field of vascular targeting has expanded steadily. Coincident with the preclinical and clinical development of these agents, there have been advances in our understanding of their mechanism of action and in the technology required to assess their effects.
Vascular Effects of Hydrogen Sulfide: Methods and Protocols (Methods in Molecular Biology #2007)
by Jerzy BełtowskiThis book explores techniques for exploring hydrogen sulfide (H2S) and its effects on the vascular system through numerous experimental animal models and vascular preparations. Alterations of vascular H2S generation/signaling may be involved in the pathogenesis of systemic and pulmonary arterial hypertension, ischemic heart disease, ischemic stroke, preeclampsia, and erectile dysfunction, and H2S also serves as an attractive target for pharmacotherapy of cardiovascular diseases, as well as possible effects on cancer, wound healing, and diabetic retinopathy, among other pathologies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Vascular Effects of Hydrogen Sulfide: Methods and Protocols is an ideal aid for scientists working to extend our knowledge in this valuable and wide-ranging field of study.
Vascular Endothelium in Human Physiology and Pathophysiology
by Patrick J Vallance David J. WebbEndothelial dysfunction is now regarded as an early marker of vascular disease and therefore an important target for therapeutic intervention and discovery of novel treatments. Ideal for both basic and clinical scientists, whether in industry or academia, and physicians, Vascular Endothelium in Human Physiology and Pathophysiology provides an up-to
Vascular Engineering
by Kazuo Tanishita Kimiko YamamotoThis book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions -- atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction -- has generated a focus on developing expertise to both maintain and treat the vascular system. As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
Vascular Hyperpermeability: Methods and Protocols (Methods in Molecular Biology #2711)
by Binu TharakanThis volume focuses on the latest research methods and techniques used by researchers to study vascular permeability/hyperpermeability in a science laboratory setting. The chapters in this book cover topics such as determination of solute permeability of microvascular endothelial cell monolayers in vitro; evaluation of barrier integrity used in a two-layered microfluidic device mimicking the blood-brain barrier; isolation and culture of human umbilical vein endothelial cells; measurement of blood-brain barrier hyperpermeability using Evans Blue extravasation assay; lymphatic vascular permeability determined from direct measurements of solute flux; intravital imaging of leukocyte-endothelial interaction by intravital multiphoton microscopy; and evaluation of tight junction integrity in brain endothelial cells using confocal microscopy. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Thorough and cutting-edge, Vascular Hyperpermeability: Methods and Protocols is a valuable resource that will aid novice researchers with creating new and affordable research projects, and for expert researchers to initiate new strategies and collaborations in their ongoing programs.
Vascular Imaging of the Central Nervous System
by Mauricio Castillo Joana RamalhoThe first book-length reference to thoroughly describe diagnostic and therapeutic advances in the development of vascular radiology over the last decadeThe last ten years has seen vascular imaging of the central nervous system (CNS) evolve from fairly crude, invasive procedures to more advanced imaging methods that are safer, faster, and more precise--with computed tomographic (CT) and magnetic resonance (MR) imaging methods playing a special role in these advances.Vascular Imaging of the Central Nervous System is the first full-length reference text that shows radiologists--especially neuroradiologists--how to optimize the use of the many techniques available in order to increase the sensitivity and specificity of vascular imaging, thereby improving the diagnosis and treatment of individual patients. Each chapter is formatted carefully and divided into two essential parts: The first part describes the physical principles underlying each imaging technique, along potential associated artifacts and pitfalls; the second part addresses clinical applications and novel applications of each method.With a strong focus on the clinical application of each modality or technique in CNS radiology, this book provides in-depth chapter coverage of:* Ultrasound Vascular Imaging (UVI)* Computed Tomography Angiography (CTA)* Magnetic Resonance Vascular imaging (MRV)* Digital subtraction angiography (DSA)* Brain perfusion techniques: CT and MRI* Plaque imaging* Intravascular imaging* Pediatric vascular imagingAlong with numerous illustrations and case studies, Vascular Imaging of the Central Nervous System: Physical Principles, Clinical Applications, and Emerging Techniques is an important book for those faced with choosing from the wide range of choices available for clinical practice.
Vascular Interventional Radiology
by Mark G. CowlingThis new edition of Vascular Interventional Radiology: Current Evidence in Endovascular Surgery provides a thorough yet succinct and accessible review of the latest knowledge in the field of endovascular surgery. All chapters have been updated to reflect the advances that have occurred during the past five years, and new chapters are included on carotid artery stenting and day case intervention. The chapter on lower limb veno-occlusive disease has been expanded to include management of deep venous thrombosis. Among the other topics considered are the endovascular treatment options in different arterial territories, aneurysm repair techniques, and the management of venous stenosis and venous insufficiency. The aim throughout is to tackle issues of evidence-based practice in order to assist trainees and experienced practitioners in making and implementing treatment decisions. This book will be an invaluable source of information for both interventional radiologists and vascular surgeons with an interest in endovascular techniques.
Vascular Ion Channels in Physiology and Disease
by Irena Levitan Alex M. DopicoIon channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions. Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.
Vascular Liver Disease
by Laurie D. Deleve Guadalupe Garcia-TsaoVascular Liver Disease: Mechanisms and Management covers all of the disease entities that stem from abnormalities that affect the hepatic vasculature. This multi-authored text includes the mechanisms and management of intrahepatic vascular disease, including the most common cause of vascular disease of the liver, cirrhosis. Other less common diseases of the liver vasculature are also covered such as sinusoidal obstruction syndrome (previously known as veno-occlusive disease), portal vein thrombosis, the Budd-Chiari syndrome and congenital vascular malformations. These entities, although rare, are a challenge to physicians and physician scientists. Although many textbooks have been written on the consequences of cirrhosis on the liver vasculature, this is the only volume that focuses on the liver vasculature as a separate entity, providing an innovative approach to liver disease management. Vascular Liver Disease: Mechanisms and Management will be of great value to clinical investigators and basic scientists interested in the liver circulation as well as clinical gastroenterologists and hepatologists, hepatobiliary surgeons and transplant surgeons, and to interventional radiologists with a particular interest in the liver.
Vascular Malformations: Advances and Controversies in Contemporary Management
by Byung-Boong Lee, Peter Gloviczki, Francine Blei and Jovan N. MarkovicThis new book on vascular malformations brings together international experts to present advances and discuss controversies in the multidisciplinary management of patients with congenital vascular malformations. Major advances in recent years in medical genetics, and tremendous progress in the fields of imaging and minimally invasive percutaneous interventions have revolutionized both evaluation and management of vascular malformations. The six major parts of this state of the art book ensure that the reader has the most up to date valuable clinical information to ensure the delivery of world class clinical practice. Beautifully illustrated with color line drawings, numerous photographs and informative tables, the advances and controversies of the full spectrum of vascular malformations are presented in 90 definitive chapters. Vascular Malformations brings new information and unparalleled insights to vascular specialists and physicians, trainees and allied health professionals who participate in the care of patients with vascular malformations, either in a private practice setting or at a major institution in an interdisciplinary vascular center.
Vascular Malformations
by Ajay K. Khanna Satyendra K. TiwaryThe book covers all aspects of vascular malformations including classification, embryology, genetics, clinical approach, investigations, management, controversies and key points to remember. Chapters cover recent changes in detail in various aspects, such as classification, genetic decoding, minimal intervention, selective approach and investigations for different types. It offers clear guidance on diagnostic protocol and surgical decision making with changing scenario leading to evolving endovascular and radiological interventions. The book is useful for vascular surgeon, pediatric surgeon, general surgeon, plastic surgeon and intervention radiologist as well as clinical research scholars, surgical oncologists and radiologists.
Vascular Manifestations of Systemic Autoimmune Diseases
by Ronald A. Asherson Ricard CerveraNot too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all
Vascular Mechanisms in CNS Trauma
by Eng H. Lo Josephine Lok Mingming Ning Michael J. WhalenWhile there are a number of books on the market that deal with neuronal mechanisms and targets, the proposed book will be the only one to cover the vascular aspects of CNS trauma. The contributing authors will present basic mechanisms, explain cutting-edge experimental models and techniques, and provide several clinical chapters that provide treating physicians with some insight on the cases that they see in the ICU. The table of contents is diverse and comprehensive with chapters on molecular mechanisms, physiology, pharmacology, stem cells, genomics and proteomics, in vivo MRI and PET, as well as the clinical management of vascular parameters.
Vascular Mechanobiology in Physiology and Disease (Cardiac and Vascular Biology #8)
by Markus Hecker Dirk J. DunckerThis volume of the series Cardiac and Vascular Biology presents the most relevant aspects of vascular mechanobiology along with many more facets of this fascinating, timely and clinically highly relevant field. Mechanotransduction, mechanosensing, fluid shear stress, hameodynamics and cell fate, are just a few topics to name. All important aspects of vascular mechanobiology in health and disease are reviewed by some of the top experts in the field. This volume, together with a second title on cardiac mechanobiology featured in this series, will be of high relevance to scientists and clinical researchers in the area of vascular biology, cardiology and biomedical engineering.
Vascular Morphogenesis
by Domenico RibattiVascular Morphogenesis: Methods and Protocols provides a range of techniques for studying vascular morphogenesis in vivo and in vitro, reflecting advances in the field. Endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Understanding the concept of vascular bed specificity represents a major challenge for future investigations. Indeed, one of the most interesting theoretical perspectives and practical applications of endothelial cell signaling is the possibility for these cells to maintain their inductive potential during adult life. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Vascular Morphogenesis: Methods and Protocols will serve as a instructive and useful reference for cell biologists, anatomists, pathologists and physiologists, as well as all those interested in this area of biological study.
Vascular Neurology Board Review
by Hardik P. Amin Joseph L. SchindlerThis concise, yet comprehensive review covers the diagnostic and treatment information needed for the vascular neurology board exam. The assembled material is easy-to-read with chapters emphasizing clinically relevant scientific principles that must be mastered by the stroke clinician. Neurology, vascular neurology and neuro-critical care residents and fellows will find this text to be an invaluable preparation guide and a succinct source to complement treatment guidelines and protocols.
Vascular Neurology Board Review: An Essential Study Guide
by Hardik P. Amin Joseph L. SchindlerThis book provides a concise review for practitioners in preparation for the Vascular Neurology Boards including the Maintenance of Certification exam. This valuable second edition is expertly written and supplemented with new treatment paradigms as well as new and updated trial results.. Beginning with a general overview on how to prepare for the exam, this practical guide emphasizes clinically relevant scientific principles that must be mastered by the stroke clinician. Subsequent chapters review acute management of ischemic and hemorrhagic stroke, specific epidemiological risk factors, stroke pathophysiology, stroke classification, and vascular neuroanatomy. This edition also reviews cardiac and hematological considerations in stroke patients, genetic stroke syndromes, vascular malformations, cognitive disorders, stroke rehabilitation, and peri-operative stroke management. Vascular Neurology Board Review, Second Edition, is not only written to act as a guide for the neurology resident and fellow, but also as a useful framework for non-neurologists.
Vascular Neurosurgery
by Samer S. HozThis book is a guide dedicated to vascular pathologies affecting the central nervous system. It uses a multiple-choice format with more than 340 genuine MCQs in a convenient format that is ideal for self-study. Seven chapters provide comprehensive coverage of core concepts in vascular neurosurgery. The questions are structured and organized so as to offer a step-by-step description of each disease, from the definition, related anatomy, pathology, clinical features, radiology to surgical decisions and operative tricks. Answers and explanations appear directly below the questions to make reading easy. This book is essential for residents across neurosurgical disciplines as it includes most of the neurovascular information neurosurgical residents need to prepare for their certification exam. It is also beneficial for those seeking a refresher or for those preparing for certification maintenance.
Vascular Neurosurgery in Environments with Limited Resources
by Athanasios K. Petridis Homajoun MaslehatyEmbark on a transformative journey with this groundbreaking guide tailored for seasoned neurosurgeons in developed countries. This book serves as a compass for those inspired to extend their expertise to resource-constrained settings, elevating the standards of cerebrovascular surgery in developing nations. Beyond surgical techniques, it addresses intercultural nuances, language barriers, and the challenges of bridging the medical divide. This is not just a guide; it's a call to action, urging experts to actively share their knowledge with neurosurgeons in less privileged environments.
Vascular Protection: Molecular Mechanisms, Novel Therapeutic Principles and Clinical Applications
by Gabor M. Rubanyi Victor J. Dzau John P. CookeVascular Protection explores advances in vascular biology and how they translate into innovations in drug therapy for vascular disease. It addresses recent advances in the knowledge of endothelial vasoactive factors and other biologically active molecules as well as gene therapy. Written by leading experts in their respective fields, each chapter e
Vascular Proteomics
by Fernando VivancoProteomics is a rapidly expanding investigation platform in cardiovascular medicine. Driven by major improvements in mass spectrometry (MS) instrumentation and data analysis, the proteomics field has flourished in recent years particularly in the study of complex diseases. These recent advances are characterized by the development of quantitative MS-based methods that promoted the field from primarily identifying proteins to also providing measurements of relative changes in protein levels between different cell states. This progress is reflected in the application of proteomic techniques to vascular pathology. Vascular Proteomics: Methods and Protocols provides up-to-date methods and protocols for the analysis of arteries, cells, lipoproteins, body fluids, and metabolites, with a particular focus on MS-based methods of protein and peptide quantification. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Vascular Proteomics: Methods and Protocols is a representative selection of methods that can be a useful resource for experienced proteomics practitioners as well as newcomers interested in becoming acquainted with the practice of proteomic techniques for cardiovascular research.
Vascular Reconstructions: Anatomy, Exposures and Techniques
by Jamal J. Hoballah Carlos F. BecharaWhen the first edition of Vascular Reconstructions was published almost twenty years ago, endovascular surgery was still in its infancy. Endovascular approaches became the preferred initial intervention for many vascular pathologies resulting in a major decrease in open vascular surgical procedures. In order to build upon changes in the management of vascular pathology over the past two decades, this second edition of Vascular Reconstructions was conceived. The first part starts with a review of commonly used vascular instruments and an overview of grafts and sutures used in vascular reconstructions. A detailed chapter on vascular anatomy and exposures is provided to serve as a quick reference before starting a vascular procedure. The remaining chapters in the first part of this book review the basic steps usually performed before and after constructing a vascular anastomosis in addition to thrombectomy and endarterectomy. The second part of this book focuses on the various methods used to conduct a vascular reconstruction, which include primary closure, closure with a patch angioplasty, end-to-end, end-to-side, and side- to-side anastomoses. The various possible modifications used are outlined. The third part of this book reviews the various adjunctive methods used when constructing the proximal or distal anastomoses of an infrainguinal bypass. The fourth part of the book reviews the various modifications that are carried out when constructing the proximal and distal anastomoses of an aortic occlusive or aneurysmal pathology. The vascular anastomoses workshop that inspired the conception of this book is included as an appendix. The fifth part focuses on endovascular therapy and imaging.Vascular Reconstructions: Anatomy, Exposures, and Techniques 2nd Edition aims to make the vascular rotation a pleasant experience for surgical residents, the vascular faculty, recent graduates embarking on conducting vascular reconstructions independently, and healthcare providers who wish to be familiar with the various steps involved in conducting a vascular procedure.
Vascular Surgery
by Alan DardikVascular surgery has experienced remarkable growth and diversification in the last decade, especially with its embracing the disruptive endovascular technological revolution. Vascular surgeons remain the only group of specialists capable of total treatment of patients with vascular disease, providing medical, minimally invasive, and surgical therapy. Although vascular surgeons practice in all areas of the world, practice patterns in different areas naturally have both similarities and differences that reflect both regional patterns of disease, genetic characteristics of local peoples, cultural preferences for treatment, local political and economic situations, different access to resources and devices, as well as different training paradigms. Thus, the practice of vascular surgery has diversified and evolved in parallel in many areas, converging and diverging in many ways. Vascular Surgery: A Global Perspective provides the first review and comparison of the diversity of vascular surgery practice around the world. The book is grouped according to common vascular diseases such as aneurysmal and occlusive arterial disease, as well as venous and lymphatic disease and dialysis access. Each major disease topic includes multiple chapters written by expert specialists from around the world, each discussing their local approach to the disease and its treatment. Similarly, the status of vascular surgery practice is addressed, including discussion of the influence of payment systems on practice, patient access to the internet for information, training paradigms, and the legal system including malpractice. This textbook provides the first worldwide summary of the care of patients with vascular disease and will be of interest to a wide audience including vascular surgeons, vascular medical specialists, cardiologists, radiologists, internists, and family practice physicians.